This study examined factors influencing role adaptation in 86 Thai patients receiving radiation therapy for cervical cancer. The patients completed questionnaires assessing severity of side effects, self-esteem, social support, education, and role adaptation. The results showed that the patients had a good level of role adaptation. A multiple regression analysis found that social support, self-esteem, and severity of side effects accounted for 55% of the variance in role adaptation, but education did not. The findings were consistent with Roy's Adaptation Model and suggest nurses should support patients' social support, self-esteem, and manage side effects when caring for them.