CVEN/EVEN 301
Environmental Engineering
Instructor: Alan Gonzalez
October 21, 2025
Module 4 – Risk Assessment
Exposure Assessment and Risk Characterization
Overview
Exposure Assessment
• Describe and calculate the chronic daily intake of a
chemical with multiple routes of exposure
Risk Characterization
• Describe the differences between risk characterization
for carcinogens and noncarcinogens
• Calculate risk for carcinogens and the hazard index for
noncarcinogens
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Exposure Assessment
Exposure Assessment
For more involved scenarios, consider multiple sources of exposure
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Exposure Assessment
Example #1: Estimate the lifetime average chronic daily intake of benzene from
exposure to a city water supply that contains a benzene concentration equal to
the drinking water standard. The allowable drinking water concentration
(maximum contaminant level, MCL) is 0.005 mg/L. Assume the exposed
individual is an adult male who consumes water at the adult rate for 63 years,
that he is an avid swimmer and swims in a local pool (supplied with city water) 3
days a week for 30 minutes from the age of 30 until he is 75 years old. As an
adult, he takes a long (30 minutes) shower every day. Assume that the average
air concentration of benzene during the shower is 5 μg/m3. It is estimated that the
dermal uptake from water is 0.0020 m/hr. Direct dermal absorption during
showering is 1% of the available benzene because most of the water does not
stay in contact with skin long enough.
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Exposure Assessment
Example #1
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Risk Characterization
Risk characterization – Data from toxicity and exposure assessments are
evaluated to determine qualitative and quantitative conclusions
Carcinogens (probability)
Risk = (intake)(slope factor) = (CDI)(SF) *For low-dose cancer risk
Table 6-3 provides the SF for some carcinogens
Noncarcinogens (quotient)
Hazard index (HI) = (intake) / (reference dose) = (CDI) / (RfD)
Table 6-4 provides the RfD for some noncarcinogens
HI < 1: No significant risk
HI ≥ 1: Significant risk
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Risk Characterization
Example #2: Using the results from Example #1, estimate the risk from exposure to water that
is contaminated with benzene at the MCL.