DOSE CALCULATION PROBLEMS
10 MARKS IN PRACTICALS
Department of Pharmacology
ACSR GMC, Nellore
1) What is the quantity of Mannitol present in 60ml
of 20% Mannitol?
2) You need to administer 400 mg of erythromycin PO.
You have on hand a suspension of 125 mg/5 mL. How
many mL should be given?
3) How many µg of Adrenaline is present in a 30mL vial
of 2% Lidocaine with adrenaline?
Adrenaline available as 1:200000
4) A patient with 60Kg body weight is to be given Diazepam
at a dose of 0.3mg/Kg body weight. The strength of the
solution is 5mg/mL. What volume of drug to be
administered?
5) A person with 50Kg body weight is to be given IV
Thiopentone sodium in a dose of 3mg/Kg body weight.
The strength of the solution is 2.5%. What is the volume
of the drug used?
6) Heparin sodium, 1000 units/hour IV, is ordered for a
patient with a blood clot in the leg. It is supplied as 50,000
units in 500 mL of dextrose and water. How many milliliters
per hour should be set on the controller on the electronic
infusion device?
7) A 30 year old man weighing 50Kg develops hypotension
after myocardial infarction. He was prescribed [Link]
8µg/min/Kg. Calculate the rate of infusion in drops per
minute if strength of Dopamine ampoule(1mL) = 200mg
= 15 or 20 drops per minute (depending on drop factor of IV Set)
8) For a 6 month old infant with moderate dehydration,
150ml of Ringer Lactate I.V. for 2 hours followed by 150ml
sodium chloride I.V. for 3 hours is to be given.
The I.V. set yields 20 drops/ml. Calculate the drops per
min. of both solutions.
8) For a 6 month old infant with moderate dehydration,
150ml of Ringer Lactate I.V. for 2 hours followed by 150ml
sodium chloride I.V. for 3 hours is to be given.
The I.V. set yields 20 drops/ml. Calculate the drops per
min. of both solutions.
9) Prepare a solution of Lidocaine to be infused at a rate of
1mg/mL/min for a case of premature ventricular depolarization.
Lidocaine present as 2% solution in 30mL vial
[Drop factor = 16 drops/mL]
10) A 22 year old lady with advanced pregnancy with
anaemic, with a haemoglobin (Hb) of 7gm%. Calculate
the parenteral iron dosage for this patient. Body
weight of the patient is 50kg.
11) Calculate the Paediatric dose of INH and Rifampicin for
a 10 year old child using Dilling’s formula.
Adult dose of INH - 300mg OD and Rifampicin - 600mg OD
12)Using Young’s Formula Calculate the dose of
Paracetamol and Metronidazole for a 3 year old child.
Adult dose of Paracetamol is 500mg TID
Metronidazole is 400mg TID.
13) The adult dose of Gentamicin is 80mg/BD. How much
Gentamicin should a 1 year old child weighing 12kg
receive?
Calculate using body surface area formula.
14) A 35 year old male diagnosed to have acute maniac
episode & was put on tab. Lithium 600mg/day. On day 7,
the symptoms still persisted and the plasma concentration
of lithium was found to be 0.6 mEq/L. Calculate the revised
dosage regimen for this patient. Desired plasma
concentration is 1.0 mEq/L.
15) Calculate the Creatinine Clearance with the
following data; Age:60 years, Weight: 54 Kg, Normal
serum creatinine= 0.6-1.2 mg/dL
Note: In females the equation has to be multiplied by 0.85
Thank ‘u’