Cell membrane structure
and permeability
D e fi n i t i o n a n d p r o c e s s o f
s i m p l e d i ff u s i o n
Demonstration (Laboratory)
Place a drop of food coloring in a
beaker of water and observe how it
spreads. Students record their
observations.
1. Structure of the Cell Membrane
It is also called the plasma membrane, and it plays a
key role in regulating what enters and leaves the cell. It
is made up of a phospholipid bilayer, with hydrophilic
(water-loving) heads facing outward and hydrophobic
(water-fearing) tails inward. This creates a semi-
permeable membrane, meaning only certain
substances can easily pass through.
2. Definition of Simple Diffusion
One of the ways substances move
across the membrane is through a
process called simple diffusion.
Simple diffusion is the movement of molecules
from an area of high concentration to a low
concentration, without the use of energy. This
process continues until equilibrium is reached,
when the concentration is equal on both sides.
3. Particles Involved in Simple Diffusion
Not all substances can move through the membrane by simple
diffusion. Only small, non-polar, and uncharged molecules can.
Examples include:
Oxygen (O₂) – diffuses into our cells so they can do cellular
respiration
Carbon dioxide (CO₂) – diffuses out of cells as a waste product
Small lipids or fat-soluble molecules
4. Factors Affecting the Rate of Diffusion
Several factors affect how quickly diffusion
happens.
1. Concentration Gradient
- The bigger the difference in concentration,
the faster the diffusion.
(Think of spraying perfume in a small room
vs. a big room, where does it spread faster?)
4. Factors Affecting the Rate of Diffusion
Temperature
- Higher temperature means particles move faster,
increasing the diffusion rate.
(Why do smells spread faster in a hot room than in
a cold one?)
Particle Size
- Which would diffuse faster—oxygen or a large
protein molecule?
(answer: oxygen)