Scribd
Upload
12 views8 pages

Colony Stimulating Factors Overview

Colony Stimulating Factors (CSFs) are hematopoietic growth factors that promote the proliferation and activation of white blood cells, particularly used to treat neutropenia caused by chemotherapy or bone marrow failure. Key types include G-CSF and GM-CSF, which stimulate neutrophil and granulocyte production, respectively. Common adverse reactions include bone pain and fever, while serious reactions can involve splenic rupture and allergic reactions.

Uploaded by

thomasjoesebastian
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd
12 views8 pages

Colony Stimulating Factors Overview

Colony Stimulating Factors (CSFs) are hematopoietic growth factors that promote the proliferation and activation of white blood cells, particularly used to treat neutropenia caused by chemotherapy or bone marrow failure. Key types include G-CSF and GM-CSF, which stimulate neutrophil and granulocyte production, respectively. Common adverse reactions include bone pain and fever, while serious reactions can involve splenic rupture and allergic reactions.

Uploaded by

thomasjoesebastian
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

COLONY STIMULATING

FACTOR

JOE SEBASTIAN THOMAS (52)


Definition

Colony Stimulating Factors are hematopoietic


growth factors that regulate the proliferation,
differentiation, and activation of
hematopoietic cells, especially white blood
cells. They are particularly used to combat
neutropenia induced by chemotherapy or
bone marrow failure.
Types and Examples

Types Examples Action

G-CSF Filgrastim, Stimulates


Pegfilgrastim, neutrophil
Lenograstim production and
funtcion

GM-CSF Sargramostim Stimulates


granulocytes
(neutrophils and
eosinophils) and
M-CSF Experimental macrophages

Stimulates
production of
IL-3 Experimental monocytes and
macrophages

Multiple
hematopoietic
Mechanism of action

CSFs bind to specific receptors on progenitor


cells in the bone marrow, activating
intracellular signaling cascades (e.g.,
JAK/STAT pathways) that promote
proliferation and maturation of myeloid
lineage cells, especially neutrophils.
Therapeutic uses

1. Chemotherapy-induced neutropenia – To


reduce incidence, severity, and duration of
neutropenia.
2. Bone marrow transplantation – To accelerate
neutrophil recovery.
3. Peripheral blood stem cell mobilization – For
harvesting progenitor cells.
4. Chronic neutropenia – Congenital, cyclic, or
idiopathic forms.
5. HIV-associated neutropenia
6. Myelodysplastic syndromes (GM-CSF in
particular)
Adverse Drug Reactions

Common ADRs :
• Bone pain (most common) •Fever, fatigue •Nausea
•Headache *Injection site reactions

Serious ADRs :
• Splenic rupture (rare, associated with G-CSF)
•Leukocytosis
•Allergic/anaphylactic reactions •Capillary leak
syndrome (mainly with GM-CSF) •Acute respiratory
distress syndrome (ARDS) *Hypotension and edema (with
sargramostim)
G-CSF AND GM-CSF

G-CSF GM-CSF

Neutrophils, monocytes and


Neutrophils only eosinophils.

Better tolerated More systemic ADRs

Splenic rupture is rare but Less reported


possible.

Fever – less frequent More common

You might also like