RECENT DEVELOPMENTS IN NANOPLATFORMS FOR
DIAGNOSIS AND TREATMENT OF PANCREATIC DUCTAL
ADENOCARCINOMA (PDAC)
Ruchi Bohidar - S21007
EXSP Batch XXXI
Highly malignant tumor of
pancreas
Offer a Referral
Program
Excessive ECM
Deposition(Collagen)
Immune-suppressive tumor
microenvironment
Detection at later stage
Serological treatments and
imaging have limitations
[Link]
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Oridonin-Loaded and GPC1-Targeted Gold Nanoparticles
Isolation Of Exosomes from Whole Blood
Nucleus-Targeted Ultra-Small Metal Organic Framework
Topically Applicated Curcumin/ Gelatin-Blended Nanofibrous Mat
Fe2P Nanorods Based Photothermal Therapy
Extracellular Matrix Modulating Enzyme Functionalized Biomimetic Au
Nanoplatform
Dual-Targeting Biomimetic Nanomedicine
Nanoparticle (NP) based on gold
nanocages (AuNCs)
Theranostic platform ORI-GPC1-
NP
Cancer cells drastically reduced in
Oridonin-Loaded and GPC1- viability and increased in apoptosis
Targeted Gold Nanoparticles
Nonspecific protein binding and
reticuloendothelial system
clearance of NPs
Cellular absorption of the GPC1-
targeted NPs
Antigen-antibody mediated
endocytosis
Isolation Of Exosomes from Whole Blood
• Exosome-binding antibody (anti- • Microchannel with NdFeB
CD9) with magnetic nanoparticles permanent magnets
• CA19-9 protein analysed from the • High sensitivity of PC-marker
exosomes detection in collected exosomes
[Link]
Ultra-small,
nucleus-targeted
Titetrakis(4-
Metal-organic carboxyphenyl)
porphyrin Sonodynamic
framework Therapy (SDT)
(MOF) platform (TCPP)
mediator
Nucleus-Targeted
Ultra-Small Metal
Organic
Framework
Promotes SDT Produce ROS in
in response to an oxygen-
low-intensity independent
Direct DNA manner
ultrasound damage cause in
vitro cellular
death.
Topically Applicated Curcumin/ Gelatin-Blended
Nanofibrous Mat
[Link]
Fe2P Nanorods Based Photothermal
Therapy
PD-L1-based
immunotherapy with Fenton reaction boosted
nanorods (NRs)- immunogenic tumor cell
mediated photothermal killing
therapy
PDL1 potentiated Quicken activation
NRs improved
alleviation of and invasion of
antigen capture
immunosuppression antigen-presenting
and boosted cells and elicit a CTL
antimetastatic response
efficacy
Extracellular Matrix Modulating Enzyme
Functionalized Biomimetic Au Nanoplatform
Collagenase-functionalized biomimetic drug-loaded Au nanoplatform
Anticancer therapy and diagnosis with ECM degradation
PDAC tumor cells were isolated, coated with doxorubicin (Dox)-loaded Au
nanocages, and then functionalized via lipid insertion by collagenase
Dense ECM broken down by collagenase
Chemotherapy medicines released effectively under NIR irradiation
Dual-Targeting Biomimetic Nanomedicine
[Link]
CONCLUSION
• PDAC, extremely lethal due to its malignancies
• Element nanoparticles, microfluidic devices, exosome isolation, targeting particular cell
organelles, specific treatments, bioengineered nanomedicines or the therapy for cancer treatment
• Positive results on the model organisms
• All studies have shown incredible results
• Advancements in technology and science for better solutions to PDAC
REFERENCES
• Bisht, S., Schlesinger, M., Rupp, A., Schubert, R., Nolting, J., Wenzel, J., Holdenrieder, S., Brossart, P., Bendas, G., & Feldmann, G. (2016). A liposomal formulation of the synthetic curcumin analog
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ROS production and endoplasmic reticulum stress mediated apoptosis. Journal of Nanobiotechnology, 18(1). [Link]
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THANK YOU