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Managing ADR and Drug Interactions

This document discusses methods for detecting adverse drug reactions and drug interactions, including cohort studies and case control studies. Cohort studies gather data over time to assess causality but require large sample sizes. Case control studies are quicker and cheaper but more susceptible to biases. The document also discusses strategies for managing drug interactions, such as considering severity, dose, timing, classification, dose spacing, and titration.

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rajeswari
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2 views13 pages

Managing ADR and Drug Interactions

This document discusses methods for detecting adverse drug reactions and drug interactions, including cohort studies and case control studies. Cohort studies gather data over time to assess causality but require large sample sizes. Case control studies are quicker and cheaper but more susceptible to biases. The document also discusses strategies for managing drug interactions, such as considering severity, dose, timing, classification, dose spacing, and titration.

Uploaded by

rajeswari
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

Detection and Managing of ADR and

Drug Interactions
Cohort studies
Case control studies
• Advantages
• Gather data regarding sequence of events; can
assess causality
• Examine multiple outcomes for a given exposure
• Good for investigating rare exposures
• Can calculate rates of disease in exposed and
unexposed individuals over time (e.g. incidence,
relative risk)
• Disadvantages
• Large numbers of subjects are required to study rare
exposures
• Susceptible to selection bias
• Prospective Cohort Study
• May be expensive to conduct
• May require long durations for follow-up
• Maintaining follow-up may be difficult
• Susceptible to loss to follow-up or withdrawals
• Retrospective Cohort Study
• Susceptible to recall bias or information bias
• Less control over vari
Case control studies
• Advantages
• Good for examining rare outcomes or outcomes
with long latency
• Relatively quick to conduct
• Relatively inexpensive
• Requires comparatively few subjects
• Existing records can be used
• Multiple exposures or risk factors can be
examined
Case control studies
• Disadvantages
• Susceptible to recall bias or information bias
• Difficult to validate information
• Control of extraneous variables may be
incomplete
• Selection of an appropriate comparison group
may be difficult
• Rates of disease in exposed and unexposed
individuals cannot be determined
Managing drug interaction
• Severity and risk
• Dose and timing
• Operational classification of drug interactions
• Erythromycin+ terfinidine-class1
• Dose spacing
• Titration miconazole oral gel+warfarin

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