LITERATURE REVIEW ON
CHITOSAN AND ITS APPLICATION
IN DRUG DELIVERY
MRITUNJOY ROY
164107062
Author Title Preparation method Remarks
Khaled Synthesis of Chitosan Succinate Natural chitosan was reacted with succinic • The altered chitosan
Aiedeh et and Chitosan phthalate and their and phthalic anhydrides. Sodium matrices did not dissolve
al.,(1999) evaluation as suggested matrices diclofenac was used as the model drug. in acidic conditions
in orally administered, colon- • Improvement in the drug
Specific Drug Delivery Systems. release profiles in the
basic conditions
Rapee Chitosan-clay nanocomposite Chitosan and magnesium aluminium • Addition of MAS causes
khlibsuwann microparticles for controlled silicate(MAS) were mixed to form a more irregular shape of
et al.,(2017) drug delivery: Effects of the dispersions which were cast and dried to the microparticles , lower
MAS and TPP crosslinking. form nanocomposite films. Propranolol microparticle swelling
HCl was used as the model drug. and slower drug release
• A sustatined drug release
ranging upto several
hours was observed in
low and neutral Ph.
Author Title Preparation method Remarks
J. A. Ko et Preparation and characterization Chitosan microparticles were prepared Release behaviours of drug
al.,(2002) of chitosan microparticles with triphosphate (TPP) by ionic decreased as the MW and
intended for controlled drug crosslinking. The model drug was concentration of chitosan
delivery. feodipine. solution and curing time was
increased
Xiaoying Chitosan/organic rectorite Chitosan/organic rectorite( In vitro drug-controlled
wang nanocomposite films: chitosan/OREC) nanocomposite films release showed a slower and
etal.,(2006) Structure, characteristic and drug with the corresponding drug loaded more continuous release for
delivery behaviour films were successfully obtained by a the nanocomposite films in
casting/solvent evaporation technique. comparison with pure
chitosan film.
The cumulative drug release
was proportional to the
amount and the interlayer
distance of OREC.
Author Title Preparation method Remarks
Xiaoying Biopolymer/montmorillonite Hot intercalation technique was used • Nanoparticles showed
wang et nanocomposite: preparation, to prepare quaternized higher drug loading capacity
al.,(2008) drug-controlled release property chitosan/montmorillonite(HTCC/M and better drug controlled
and cytotoxicity MT) nanocomposites. The release properties
nanocomposites were modified with • The HTCC/MMT
the model drug to form the nanoparticles proved to be
nanoparticles. biocompatible and most
effective one for
encapsulating and releasing
the drug .
Debi prasan Preparation of starch-chitosan Starch, chitosan and MMT were • The extent of
mohanty et nanocomposites for control drug blended by varying the proportion of biodegradation increased of
al.,(2015) release of Curcumin. MMT. curcumin is used as the model the blends increased as the
drug . content of chitosan
increased.
• The percentage of swelling
increases with the increase in
drug loading .
Author Title Preparation method Remarks
Mehdi Facile synthesis of chitosan/ZnO chitosan/ZnO hydrogel beads were • CH/ZnO
yadollahi bio-nanocomposite hydrogel prepared by using sodium nanocomposite hydrogel
etal.,(2015) beads as drug delivery systems. tripolyphosphate (STPP) as the cross beads revealed a higher
linking agent and NaOH as oxidizing swelling capacity in
agent. comparision with that of
the neat chitosan.
• The nanoparticles
increased the time of
drug release.
Rehab Modified Chitosan-Clay Chitosan is intercalated into the layered • Ibuprofen was released
abdeen Nanocomposite as a Drug silicate (MMT) to prepare nanocomposite from the prepared
etal.,(2013) Delivery System Intercalation and drug carrier. Ibuprofen is used as the nanocomposites steadily
In Vitro Release of Ibuprofen. model drug. and was pH dependent
Author Title Preparation method Remarks
Richard Strong and conductive chitosan– Chitosan-rGO nanocomposites were • The drug release amounts of
Justin reduced graphene oxide prepared by mixing chitosan solution nanoco -mposites increased
etal.,(2014) nanocomposites for transdermal with graphene oxide(GO) were stired with increase in Rgo content
drug delivery. for 72 hrs at 37 OC , which reduces and drug loading ratio
the graphene oxide . microneedle decreased.
arrays were also made for transdermal • Microneedle array are srong
drug delivery enough to with -stand
insertion into the dermal
layers.
Maria J.A. Influence of chitosan/clay in the hydrogels of poly(N-2-vinil- • Crosslinking is observed
Oliveira drug delivery of glucantime from pirrolidone)(PVP) containing chitosan between PVP/Clay and
etal.,(2014) PVP membranes. and clay nanoparticles were obtained. PVP/Chitosan/clay due to
The matrices were then crosslinked by the clay particles which
gamma irradiation process. reduces the space between
Glucantime was used as the model the polymeric chains.
drug. • Higher gel fraction was
observed for PVP/ Chitosan
and clay nanocomposites.
Author Title Preparation method Remarks
Ren Wang pH-Controlled drug delivery with Hybrid aerogels of chitosan(CS), • The hybrid aerogels exhibit
etal.,(2017) hybrid aerogel of chitosan, carboxymethyl cellulose(CMC), the highest cumulative release
carboxymethyl graphene oxide(GO) are synthesised at Ph 7.4.
cellulose and graphene oxide as using electrostatic self assembly • The release kinetics of the
the carrier. approach followed by freeze-drying drug from the hybrid
treatment.5-fluorouracil was used as hydrogels is controlled by
the model drug. Fickian diffusion.
Lena neufeld Pectin–chitosan physical hydrogels Hydrogels of chitosan and pectin were • Pectin is fully negatively
et al.,(2017) as potential drug delivery vehicles. prepared. Mesalamine ,curcumin and charged and chitosan is partly
progesterone were used as model positively charged which lead
drugs. to reduction of hydrogel’s
mesh size.
• The release of curcumin and
progesterone was classified as
classical Fickian behaviour.
Author Title Preparation method Remarks
Zahra Controlled release of chitosan and poly(ethylene glycol)- • The nanocomposite films only degraded
Shariatinia et metformin from block-poly(propylene glycol)- in the acidic environment.
al.,(2017) chitosan–based block-poly(ethylene glycol) were • It was found that among all
nanocomposite blended and nanocomposites nanocomposite films, the film
films containing containing mesoporous MCM-41 containing 4%MCM-41 NPs had the
mesoporous MCM-41 nanoparticles and greatest tensile strength and Young’s
nanoparticles as novel metformin(MET) was used as modulus.
drug delivery systems. model drug. Glycerine was also • The film containing 4%MCM-41-APS
and 10%MET was chosen as the most
added to be used as the plasticizer.
favourable drug delivery system.
Sougata Jana Chitosan — Locust The solutions of chitosan, locust • Increasing LBG content decreased the
et al.,(2017) bean gum bean gum(LBG) and aceclofenac drug encapsulation efficiency (DEE).
interpenetrating was mixed unsder continuous • The composite systems efficiently
polymeric network magnetic stirring. Glutaraldehyde suppressed the burst release of drug in
nanocomposites was added and then stirred again acidic medium.
for delivery of for 1 hour. The cross linked • The drug delivery from the
aceclofenac polymer nanocomposites were nanocomposites occurred via
centrifuged and washed . anomalous transport mechanism in
vitro.
Author Title Preparation method Remarks
Marjan Motiei Novel amphiphilic amphiphilic chitosan nanoparticles • LTZ loaded ACNs showed strong
et al.,(2017) chitosan nanocarriers for were prepared by dissolving cytotoxicity against MCF-7 cells in
sustained oral delivery of chitosan in acetic acid and then comparison to free LTZ
hydrophobic drugs mixing it with palmitic acid, • Sustained release of drugs was
Letrozole and tripolyphosphate observed
which is the cross linking agent.
The solution is magnetically stirred
and then ultrasonication for 20
min. the solution was then freeze
dried.
• CHITOSAN –LDH NANOCOMPOSITES
Author Title Preparation method Remarks
Yi-Xuan Chen MgAl layered double LDH was produced by coprecipitation method. • LDH-CS –PFTα scaffolds allowed
et al.,(2017) hydroxide /chitosan The LDH was mixed with chitosan solution in adhesion and proliferation of
porous scaffolds acetic acid and then injected into molds and hBMSCs .
loaded with PFTα to freeze dried. The scaffolds so formed are cut • LDH-CS-PFTα scaffolds exhibited
promote bone into smaller pieces and washed with NaOH for prominent osteoinductive capacity
regeneration. 7 days. The drug PFTα was mixed with the in a rat calvarias defect model
scaffolds and were shaked orbitally and then
freeze dried.
Zolfaghar Bionanocomposites Ciprofloxacin is intercalated in LDH matrix • The release rate from the LDH-
Rezvani et Based on Alginate and using the coprecipitation method. It is then CFX/chitosan nanocomposite is
al.,(2014) Chitosan/ associated with a different biopolymer to remarkably lower than the other
Layered Double protect the effect of the LDH on the matrix. prepared composites .
Hydroxide with
Ciprofloxacin Drug:
Investigation of
Structure and
Controlled Release
Properties
Author Title Preparation method Remarks
Tingting Xu Multifunctional Chitosan-glutathione-valine and chitosan- • In vivo precorneal retention on
et al.,(2016) properties of organic- glutathione –valine-valine were synthesised. rabbits revealed that the
inorganic hybrid These chitosan derivatives are used to prepare ophthalmic drug carrier of LDH
nanocomposites based nanocomposites with LDH and Pirenoxine could improve the precorneal
on chitosan sodium as the model drug. retention of PRN.
derivatives and layered • In vitro corneal penetration on
double hydroxides for rabbits was confirming the
oculardrug delivery modified CG by L-Val and Val-Val
could enhance the permeability of
PRN .
Kamellia Preparation and Chitosan and LDH nanocomposites with a • The release study demonstrated
Nejati et characterization of model drug cetirizine was intercalated into the that the rlease rete of cetrizine
al.,(2015) cetirizine intercalated matrix of the nanocomposites. LDH was from CT-LDH at Ph is slower.
layered double prepared by the coprecipitation method. • CT–chitosan–LDH
hydroxide and nanocomposites, increase in
chitosan chitosan concentration causes
nanocomposites decrease in the drug release rate.
Author Title Preparation method Remarks
Lígia N.M. Pectin-coated Mg-Al LDH was prepared by the • The kinetics of the drug release
Ribeiro et chitosan–LDH coprecipitation method at a constant Ph . can be also tuned by changing
al.,(2013) bionanocomposite Nanocomposite beads of chitosan ,LDH the thickness of the pectin
beads as potential and the drug 5-Aminosalicylic acid was coating.
systems for colon- preapared by first mixing the solution of • The efficiency of drug release
targeted drug chitosan and adding the drug and LDH was higher for the final
delivery resulting in a gel which is dropwise poured in nanocomposites as compared to
a NaOH solution to form beads. the singular biopolymers or the
direct immobilization of drug
without using LDH.