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Photodynamic Therapy with Nanomaterials

Photodynamic therapy uses photosensitizer drugs and light to treat diseases, as the drugs accumulate selectively in diseased tissues and are activated by light. Nanomaterials are often used to improve the solubility of photosensitizers, and can be organic or inorganic. The therapy works through two mechanisms - type 1 involves radical formation, and type 2 involves generating reactive oxygen species like singlet oxygen via energy transfer between the excited photosensitizer and oxygen.

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Harshit Garg
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9 views8 pages

Photodynamic Therapy with Nanomaterials

Photodynamic therapy uses photosensitizer drugs and light to treat diseases, as the drugs accumulate selectively in diseased tissues and are activated by light. Nanomaterials are often used to improve the solubility of photosensitizers, and can be organic or inorganic. The therapy works through two mechanisms - type 1 involves radical formation, and type 2 involves generating reactive oxygen species like singlet oxygen via energy transfer between the excited photosensitizer and oxygen.

Uploaded by

Harshit Garg
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

PHOTODYNAMIC

THERAPY
ABSTARCT

 Photodynamic therapy (PDT) is an emerging, non-invasive therapeutic


strategy that involves photosensitizer (PS) drugs and external light for the
treatment of diseases.
 Poor water solubility of PS drugs so functionalized nanomaterials are used.
 Two types:
1. Organic Nanomaterials
2. Inorganic Nanomaterials
 Nanomaterials have hydrophilic properties.
Mechanism

 Type-1 reactions :-
Transfer of Hydrogen atom or an e- b/w the excited PS and the substrate
leading the generation of free radicals.
This radicals then react react with Oxygen to form (ROS) like superoxide/
hydroxyl radicals.
 Type-2 reactions :-
The energy transfer b/w excited PS and the molecular oxygen in the ground
state, resulting in the formation of highly reactive singlet oxygen (ROS).

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