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Comprehensive Liver Function Tests Guide

This document provides information on standard liver function tests and additional tests that may be included. It lists the components of a standard liver panel including albumin, total protein, alkaline phosphatase, alanine transaminase, aspartate transaminase, and gamma-glutamyltransferase. Additional tests that may be included are bilirubin levels, BUN, serum ammonia, coagulation studies, immune markers, and tumor markers. Further details are given on normal ranges and clinical significance of each test.

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Danielle Foster
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5 views12 pages

Comprehensive Liver Function Tests Guide

This document provides information on standard liver function tests and additional tests that may be included. It lists the components of a standard liver panel including albumin, total protein, alkaline phosphatase, alanine transaminase, aspartate transaminase, and gamma-glutamyltransferase. Additional tests that may be included are bilirubin levels, BUN, serum ammonia, coagulation studies, immune markers, and tumor markers. Further details are given on normal ranges and clinical significance of each test.

Uploaded by

Danielle Foster
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPTX, PDF, TXT or read online on Scribd

LIVER

FUNCTION
TESTS
DANIELLE FOSTER
STANDARD LIVER
PANEL
INCLUDES
- Albumin- Total Protein
- Alkaline phosphatase (ALP)
- Alanine transaminase (ALT)
- Aspartate transaminase (AST)
- Gamma-glutamyltransferase (GGT)
MAY ALSO INCLUDE:
- Bilirubine levels- Blood and Urine
- BUN
- Serum Ammonia
- Coagulation Studies: PT, Factor V
- Serum IgM
- Antibody Titers (Antimitochondrial, Anti-smooth muscle, ANA)
- Tumor Markers
ALBUMIN- PROTEIN
- TOTAL PROTEIN

ELECTROPHORESIS
- 6.4-8.3g/dL or 64-83g/L (SI units)

- GLOBULIN TOTAL: 2.3-3.4g/dL


Alpha 1 globulins
Standard blood test- then - Alpha-1 globulin: 0.1-0.3g/dL
1-antitrypsin to show the protein
- electrophoresed
- Alpha2 globulin: 0.6-1g/dL
- ranges
Alpha 1-antichymotrypsin
- Beta globulin: 0.7-1.1g/dL
- Normal
Orosomucoid (acidg/dL
range =3.5-5.0 glycoprotein)
- Serum amyloid A
Decreased in Liver Damage-
- because
Alpha 1-lipoprotein
liver makes it
Also Decreased In:
- Acute Infections, necrosis, burns,
sugery, stress, MI Beta Globulins
Alpha-2 globulins
- beta-2 microglobulin
- 2-macroglobulin
- Chronic Inflammatory states
(Infection, granulomatous diseases, - plasminogen
- Ceruloplasmin
rheumatoid collagen diseases) - angiostatins
- Thyroxine-binding globulin
- Nephrotic Syndrome - properdin
- Alpha 2-antiplasmin
- sex hormone-binding globulin
- Protein C
transferrin
- Alpha 2-lipoprotein
- Angiotensinogen
ALT
AST
GGT
ALP
BILIRUBIN LEVELS
BUN & SERUM AMMONIA
COAGULATION
STUDIES
The liver makes many (if not all) of the coagulation factors
Particularly Prothrombin
And Factor V
Decreased Platelets- BECAUSE?
- Hypersplenism
- And TPO is produced by the liver, when TPO is low,
marrow production of platelets decreases
IMMUNE STUDIES
What is Increased in Primary Billiary Cirrhosis?
Serum IgM Titer
Antimitochondrial Antibody
Autoimmune Hepatitis?
Anti-Smooth muscle Antibody
Antinuclear Antibody
TUMOR MARKERS
What is increased in Heptocellular Carcinoma?
- Alphafetoprotein

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