a

-·~
,,,,,, .
, cncc on Pharmaccuhcal Technology' Ph Ytoph
. al conicr armaccuticals and 0iologicals· Trends PTPPOT • 2023
,uon •
101,fll d diseases have been reported and explained• IL•6 , cleaved cnspasc 3 cit press ion TBARS, nn d
.,.date
,S5"" OP-4 dccrcased SOD, CAT, nnd OSI I levels' manifes ted the
Jll·ANTAGONIST REDUCES injury, inflammation, apoptosis, and oitidativ c stress
pJIOSPJlAMIDE-INDUCED CARDIAC to confirm cardiotoxicity. HI-anta gonist and standar d
crCJ..O AJ'OPTOSIS, AND INFLAMMATION treatment were reversed to nonnal and showed a
~J()JtY, )]'I swiss ALBINO MICE significant protective effect against CP.
1 Conclus ion: Our results indicate d the potenti al
. Akram', Syed Ehtaishamul Haque' protective role of HI-anta gonist in restorin g CP·
was1rn . ., '
Abul Kalam Na1m1 induced cardiac toxicity, inflamm ation, apoptos is,
........ent of Pharmacology, School of generation of oxidative stress, cardiac injury, a nd
'DeP"''' " .
...., ceutical Education and Research
pha••··3 . preventing histopathological damage .
•
•a l{amdard, New Delhi I I 0062, India Keywords: Cardiotoxicity, HJ-anta gonist, Oxidati ve
Jal!'II
. Objective: Cancer incidence and mortality st ress, Cyclop hospha mide, Cardia c apopto sis,
1
lo bStrllC in •
problem 111 .
the world. Several anticancer Cleaved caspase 3.
·s we rna ••
1 have been used chmcall y for the treatment of
dr\lgs
OP-5
. iypes of cancer, but they have severe cardiac USE OF TEXTILE SCIENCES IN
various
. effects. Cyclophosphamide (CP) has also a PHARMACEUTICAL APPLICATIONS
to~IC . • , •
. c toxic effect, so 1t has lumted uses as an
card. 13ancer and 1mmuno • 'Ashrit Nair, 'Pooja Yadav, 'Navnee t Shanna ,
suppressant. Therefo re a
anuc 'Bhupen dra Singh Butola
•fie rnedicine that can lower cardiotoxicity and' be
spCCI . • 'Department ofTeitti le and Fibre Enginee ring,
utilised as adJuvant treatment m cancer patients must
Indian Institute of Technology, llauz Khas,
bC developed. Herc, we planned to evaluate the
cardioprotective effect of the HI-antagonist against New Delhi, 110016
'Departm ent ofMcdi eal Elcmen tology and
er-induced cardiac toxicity in Swiss albino mice.
Toxicology, Jamia Hamdar d, Delhi- I I 0019
tJetllods: Swiss albino mice were treated with H).
'Amity Institute of Pharmacy, Amity Univers ity,
antagonist (50 and 100 µg/kg, i.p.) daily for 14 days
and CP (200 mg/kg, i.p.) once on the 7th day. On the Noida 201303
Sth day, animals were sacrificed, blood withdrawn Abstract: Researchers are rapidly expand ing their
1
and the heart removed for the estimation of various horizons by experimenting with new materia ls to
biochemical, and histopa thologi cal parame ters improve clinical outcom es as the efficacy of
a
including inflammatory (TNF-a, and IL-6), oitidative therapeutic molecul e is highly depend
ent on the
(TBARS, SOD, CAT, and GSH), apoptotic (cleaved choice of the carrier
systems . Textile and fibre
,aspase 3), and cardiac injury (Troponin T, LDH, and engineering can be
used to develop drug deliver y
CK-MB) markers. Jmmunohistochemistry and ELISA systems that
can be tailored to meet the specific needs
techniques were used for the estimation of cleaved
ofthe patients.
caspase 3, inflammatory (TNF-a, and IL-6), and
The idea is to use the textile and fibre enginee ring
cardiac injury markers (Troponin T).
concepts towards the develop ment of cost-eff ective,
Results: In vivo study showed CP significantly
easy to use, high efficacy novel drug delivery systems .
increased cardiac troponin T, LDH, CK-MB, TNF-a,