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Cardiac Output Integration Example

The document explains how to calculate cardiac output using integration of blood flow rate modeled as Q(t) = 400·sin²(πt / 0.8). By integrating the flow rate over one heartbeat cycle, the stroke volume is determined to be 160 mL/beat. With a heart rate of 75 beats/min, the cardiac output is calculated to be 12,000 mL/min or 12 L/min.

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2 views1 page

Cardiac Output Integration Example

The document explains how to calculate cardiac output using integration of blood flow rate modeled as Q(t) = 400·sin²(πt / 0.8). By integrating the flow rate over one heartbeat cycle, the stroke volume is determined to be 160 mL/beat. With a heart rate of 75 beats/min, the cardiac output is calculated to be 12,000 mL/min or 12 L/min.

Uploaded by

fareenanawaz405
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© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Example 2 : Cardiac Output Calculation Using Integration

In biology, integration is often used in modeling and analyzing


physiological processes. One important application is the calculation of
cardiac output, which is the volume of blood the heart pumps per unit
time.
Let the blood flow rate Q(t), in mL/sec, from the left ventricle be
modeled as:
Q(t) = 400·sin²(πt / 0.8)
To find the stroke volume (SV), we integrate the flow rate over one
heartbeat cycle.
Using the identity sin²(x) = (1 - cos(2x)) / 2, we rewrite Q(t) as:
Q(t) = 400·(1 - cos(2πt / 0.8)) / 2
= 200·(1 - cos(2πt / 0.8))
Now integrate over one full cycle [0, 0.8] seconds:
SV = ∫₀⁰.⁸ 200·(1 - cos(2πt / 0.8)) dt
Let’s compute the integral:
SV = 200 ∫₀⁰.⁸ (1 - cos(2πt / 0.8)) dt
= 200 [t - (0.8 / 2π)·sin(2πt / 0.8)] from 0 to 0.8
= 200 [0.8 - 0]
= 160 mL
So, the stroke volume SV = 160 mL/beat.
If the heart rate (HR) is 75 beats/min, then the cardiac output (CO) is:
CO = HR × SV = 75 × 160 = 12,000 mL/min or 12 L/min

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