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Cytokine Functions and Effects Overview

The document outlines various cytokines, detailing their sources, target cells, and biological effects. Key cytokines such as IL-1, IL-2, IL-6, IL-10, IL-12, IFN-α, IFN-γ, and TNF-α are discussed, highlighting their roles in inflammation, immune response, and tissue regulation. Each cytokine's specific activities, such as fever induction, lymphocyte activation, and macrophage modulation, are also summarized.

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abdullahjavid221
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2 views2 pages

Cytokine Functions and Effects Overview

The document outlines various cytokines, detailing their sources, target cells, and biological effects. Key cytokines such as IL-1, IL-2, IL-6, IL-10, IL-12, IFN-α, IFN-γ, and TNF-α are discussed, highlighting their roles in inflammation, immune response, and tissue regulation. Each cytokine's specific activities, such as fever induction, lymphocyte activation, and macrophage modulation, are also summarized.

Uploaded by

abdullahjavid221
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Cytokine Produced / Secreted by Targets / Activities / Effects

Activates vascular endothelium (inflammation); tissue


Monocytes, macrophages,
destruction; increased effector cell access; fever
IL-1 endothelial cells, epithelial
(hypothalamus); lymphocyte activation; mobilization of
cells
PMNs; induces acute phase proteins (CRP, MBL)
T-cell proliferation; induces proliferation of T and NK
IL-2 T cells cells; NK cell activation and proliferation; B-cell
proliferation
Induces proliferation and differentiation of hemopoietic
IL-3 T cells, thymic cells
cells
Liver induction of acute phase proteins; induces
Macrophages, endothelial lymphocyte activation; fever; influences adaptive
IL-6
cells; T cells, macrophages immunity (proliferation and antibody secretion of B-cell
lineage)
Induces B-cell activation; suppression of macrophage
IL-10 Th2 cells, macrophages
activity; Th2 production; inhibits Th1 responses
Macrophages, dendritic cells; Acts on NK cells; induces Th1 responses; activates NK
IL-12
B cells, macrophages cells; inhibits Th2 responses
Not mentioned in provided
IL-24 Not mentioned in provided tables
tables
Macrophages, dendritic cells, Induces antiviral state in most nucleated cells; increases
IFN-α
virus-infected cells MHC class I expression; activates NK cells
Activates macrophages and PMNs; increases expression
Th1 cells, CD8⁺ T cells, NK
IFN-γ of MHC class I and II molecules; induces Th1 responses;
cells
inhibits Th2 responses; increases antigen presentation
Macrophages, monocytes, Activates vascular endothelium; inflammation;
neutrophils, activated T cells, increased vascular permeability; liver induction of acute
TNF-α
NK cells; macrophages, T phase proteins; cachexia; induces cell death; neutrophil
cells activation; fever and shock

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