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Nucleophilic Addition in Carbonyl Compounds

The document discusses the reactivity of various carbonyl compounds, including aldehydes and ketones, in nucleophilic addition reactions. It outlines the mechanisms and compares the reactivity of different compounds towards HCN addition, as well as the formation of derivatives like semicarbazones and cyanohydrins. Additionally, it includes instructions for drawing structures and products formed from specific reagents.

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4 views3 pages

Nucleophilic Addition in Carbonyl Compounds

The document discusses the reactivity of various carbonyl compounds, including aldehydes and ketones, in nucleophilic addition reactions. It outlines the mechanisms and compares the reactivity of different compounds towards HCN addition, as well as the formation of derivatives like semicarbazones and cyanohydrins. Additionally, it includes instructions for drawing structures and products formed from specific reagents.

Uploaded by

bbabbabbabbaba2
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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tadanmn
compounds
mechanism N.A R in Carbonyl
1 Write the of order
the following in the increasing
02 Arrange nucleophilic addition mxn
in
of their reactivity Butanone
Ethanal propanal propanal propanone
ketone methyl tert butyl
Acetaldehyde
Acetone Di terbutyl
Ketone
HCHO CHICHO CH
COCH

benzaldehyde
Propanal Acetone
Acetophenone Acetone
Benzaldehyde
Acetaldehyde
CHICOCHS HCHO CHI CHO
LI Cock

Benzaldehyde p tolualdehyde p nitrobenzaldehyde


Acetophenone

03 Accounts for the followings


reactive than Cascock toward
CHICHO is more
exn with HCN
Hint Aldehyde ketone
Hcn Example ofNAR
is less reactive than ethanol toward
Propanone
addition of HCN
HCHO is more reactive than CHSCHO toward
addition of HCN
form cyanohydrin
in good yield but
Cyclohexanone
does not
2,216 trimethylcyclohexamone
semicarbazide However
are two NH group in
There semicarbazone
one is involved
in the formation of
only
controlled while
be carefully
PH of Mxn should compounds
ammonia
derivative of Carbonyl
preparing
Nareso on aldehyde
is useful for
Addition of aldehyde
separation and purification of

the addition of Guignard's


4 Desiribe the mechanism
of comp to form an
to the carbonyl group of a
reagent to alcohol
adduct which on hydrolysis yield
the terms Give an
QS What is meant by following
in Eachcase
example of Mxn
Semicaybazone
Acetal
Cyanohydrin
Oxime Ketal
Hemiacetal
NPderivative Schiff's base
Imine 2,4 D
derivatives
structure of the following
06 Draw
2,4 dintrophenylhydrazone of benzaldehyde
oxime
Cyclopropanone
Acetaldehydedimethyl acetal
Semicarbarazone butanone
of cyclo
Ethylene Ketal of hexan 3 one
hemiacetal
methyl of
formaldehyde
Ethernal
Semicarbazone of
when CHICHO react with
7 Write the products formed
the following reagents
HLN NHL OH
ran
complete the following

0
5 m

0 01 8
41
ten

THEN

To than 04

COYSCHO
Eh
a
EDI
Kinte Entrances
non
mn NH

R CH CH ero NH Inn Nn

CHz Creo t Nh Nh

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