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Rapid Mixer Granulator SOP Guide

The document outlines the Standard Operating Procedure (SOP) for the operation and cleaning of a Rapid Mixer Granulator at Glocare Pharma Manufacturing. It includes detailed steps for ensuring cleanliness, proper operation, and maintenance of the equipment. The SOP emphasizes the importance of following safety and quality protocols during the granulation process.

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firehiwot6125
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0% found this document useful (0 votes)
8 views6 pages

Rapid Mixer Granulator SOP Guide

The document outlines the Standard Operating Procedure (SOP) for the operation and cleaning of a Rapid Mixer Granulator at Glocare Pharma Manufacturing. It includes detailed steps for ensuring cleanliness, proper operation, and maintenance of the equipment. The SOP emphasizes the importance of following safety and quality protocols during the granulation process.

Uploaded by

firehiwot6125
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

GLOCAREPHARMAMANUFACTURI

NGP.L.
C
ግሎኬርፋርማሲማኑፋክቸሪንግፒ.ኤል.ሲ
H.
[Link]/
Kil
int
oIP,Wer
eda09,SubCi
ty:AkakiKal
it
y,
Addi
sAbaba,
Ethi
opi
[Link]
:+251-
09-
06-06-
66-60
ኤች.
አይ.አዲስ/
ቂሊን
ጦ አይፒ፣ወረዳ09፣ክፍለከተማ አቃቂ
ቃሊቲ፣

አዲስአበባ፣ኢትዮጵያ።ስልክ፡251-
09-
06-
06-
66-
60
STANDARDOPERATI
NGPROCEDURE
መደበኛየአሠራርሂደት
PROCEDUREFOROPERATI
ONANDCLEANI
NGOFRAPIDMIXERGRANULATOR.
የፈጣንማደባለቅግራኑላተርአሰራርእናየማጽዳትሂደት።

SOPNo. : GPM-
SOP-
PRD-TAB-
047-
00
5.
1 OPERATI ONOFRAPI DMI XERGRANULATOR
የፈጣንድብልቅግራኑላተርኦፕሬሽን
5.
1.1 Product i
onper sonshal lensur et hecl eanl
inessoft heGr anulat
or,i
ts
parts,
areaandCLEANEDl abel oni t
.
የምርትሰው የግራኑሌተርንን ፅህናን፣ክፍሎቹን፣
አካባቢእናየጸዳመለያበላዩላይ።
5.
1.2 Remov et heCLEANEDl [Link] ainl i
neclearancefr om QAand
updat ethest atusl abel,
ment ioningt hedet ail
sofPr oductName, BatchNo, Bat chSize,Mfg
Date, Expiry,Act i
vit
yStat us,NextSt ageandCheckedPr oducti
on
Officer/Chemi stDat eandSi gnat ureasperl abel f
[Link]-
QAD- 038- F-
001
የCLEANED መለያውንያስወግዱ።ከ QA የመስመር ማጽጃ ያግኙ እናየሁኔ ታ
መለያውንያዘምኑ፣
የምርትስም፣ባች ቁጥር፣ባች መጠን ፣Mf gቀን ፣ጊዜው የሚያበቃበት፣የተግባር
ሁኔ ታ፣ቀጣይ ደረጃ እና የተረጋገጠ የምርት ኦፊሰር/ የኬሚስትሪ ቀን እና ፊርማ
በመለያው ቅርጸትቁጥርGPM- QAD- 038- F-001በመጥቀስ።
5.
1.3 Opent hecompr essedairv alveandcheckt heairpr essurebetween3-
2
4kg/ cm
የተጨ መቀውንየአየርቫልቭይክፈቱእናየአየርግፊቱንከ3- 4ኪ. ግ/ሴ. ሜ ያረጋግጡ
5.
1.4 Ensur ethatbowl l
idisclosedandl ockedwi ththetoggl eclamp.
Ensur ethatt he
dustcol lectorv entisfi
t t
edwi tht hef il
terproperl
y.
ጎድጓዳሳህኑመዘጋቱንእናበመቀያየርማያያዣመቆለፉንያረጋግጡ።መሆኑን
ያረጋግጡ
Page1of1
የአቧራአሰባሳቢው ቀዳዳበትክክልከማጣሪያው ጋርተስተካክሏል.

5.
1.5 Ensurethatthecl
eanedFBDbowli
splacedbelowthedi
schar
gepor
t
[Link] he
i
ntegri
tyoftheFBDbowl meshbef
oreusingt
hebowl.
የፀዳው የFBDሳህንከአርኤምጂ መውጫ ወደብበታችመቀመጡንያረጋግጡ።
ይመልከቱ
ሳህኑንከመጠቀምዎበፊትየFBDጎድጓዳሳህንትክክለኛነ ት።
5.
1.6 Switchonthemains,.

ForDr
ycy
cle
በአውታረመረቡላይይቀይሩ,
.

ለደረቅዑደት
a)I
mpell
ermotorsl
owsett i
me(min)
የኢምፔለርሞተርዘገምተኛየቅን ብርጊዜ( ደቂቃ)
b)I
mpell
emotorfastsett
ime(min)

ForWetcy
cle

ኢምፔልሞተርፈጣንየዝግጅትጊዜ(
ደቂቃ)

ለእርጥብዑደት
a)Impellermot orslowsett i
me( min)
የ ኢምፔለርሞተርዘገምተኛየቅን ብርጊዜ( ደቂቃ)
b)Impellermot orfastsettime(min)
የ ኢምፔለርሞተርየተወሰነጊዜ( ደቂቃ)
c)Choppermot orslowdel ayti
me( min)
ቾፐርሞተርየዘገየመዘግየትጊዜ( ደቂቃ)
d)Choppermot orslowsett ime(min)
ቾፐርሞተርዘገምተኛየተቀናበረጊዜ( ደቂቃ)
e)Choppermot orfastdelaytime(min)
የ ቾፕርሞተርፈጣንመዘግየትጊዜ( ደቂቃ)
f)Choppermot orfastsett i
me(min)
የ ቾፕርሞተርፈጣንየተቀናበረጊዜ( ደቂቃ)
5.
1.7 Checkfort heproperoperat i
onofthebeater
,chopperanddi
schar
ge
portoftheRMGby
operati
ngt herespecti
vetouchkey sprovi
ded.
የRMGየሚደበድበው፣ቾፐርእናማስወጫ ወደብትክክለኛአሠራርመኖሩን
ያረጋግጡ
የቀረቡትንየን ክኪቁልፎችንመሥራት።
Page2of2
5.
1.8 Switcht hemodeofoper ati
ont omanual .
የአሰራርሂደቱንወደማን ዋልይቀይሩ.
5.
1.9 Opent helidoft heRMGandl oadal ltheshi f
tedmat er i
alsintot he
RMGas
ment ionedi ntheBMR.
የRMGክዳንይክፈቱእናሁሉን ም የተቀየሩቁሳቁሶችንወደRMGእን ደይጫ ኑ
በBMRውስጥ ተጠቅሷል.
5.
1.1 Closet hel i
dpr oper l
yandt ightt hel ocki ngknobs.
0 ሽፋኑንበትክክልይዝጉትእናየመቆለፊያቁልፎችንያጥቡት.
5.
1.1 Nowsett hetimerandt hespeedoft hei mpel lerf ordr ymixingas
1 specifiedi ntheBMR, startmi xi ng, mixerwi l
lbest oppedaf terthe
mixingt imei sov eraut omat i
cal ly .
አሁንለደረቅድብልቅጊዜቆጣሪውንእናየi mpel l
erፍጥነ ትያዘጋጁ
በBMRውስጥ ይገለጻል፣መቀላቀልይጀምሩ፣የማደባለቁጊዜ በራስ- ሰርካለቀ
በኋላቀማሚው ይቆማል።
5.
1.1 Wai tforami nutet oset tl
et hepowder ,proceedf orwetgr anulat i
on.
2 ዱቄቱንለማቆም ለአን ድደቂቃያህልይጠብቁ, እርጥብጥራጥሬንይቀጥሉ.
5.
1.1 Startthemi xi
ngi nsl owspeed, opent hebi nderaddi tionpor t/openthe
3 l
idincaset hebi nderi sthicker ,
addt hebi ndersl owl yundermi xingasspeci fi
edi nt heBMR, change
thespeedt ofasti fr equiredf ort he
[Link] heendpoi ntf orgr anul ati
onbyv isuall
y.
ድብልቁንበቀስታፍጥነ ትይጀምሩ፣ማያያዣው ተጨ ማሪወደብይክፈቱ/ማሰሪያው
ወፍራም ከሆነ፣ክዳኑንይክፈቱ፣
በቢኤምአርውስጥ በተገለፀው መሠረትማሰሪያውንበቀስታበማደባለቅይጨ ምሩ፣
አስፈላጊከሆነፍጥነ ቱንወደፍጥነ ትይለውጡ
granulation.የጥራጥሬውንየመጨ ረሻነ ጥብበእይታያረጋግጡ።
5.
1.1 Oncet hegr anul ationendpoi nti sachi ev ed,st opt heRMG,opent he
4 l
id,checkt hewetgr anulesphy si call
y ,scrapoutt headher edpowder
tothel idandsi desoft heRMG, andcl oset hel i
d.
የጥራጥሬው የመጨ ረሻነ ጥብከደረሰበኋላRMGንያቁሙ ,ክዳኑንይክፈቱ,እርጥብ
የሆኑትንጥራጥሬዎች በአካልይፈትሹ,የተጣበቀውንዱቄትበአርኤምጂው ክዳንእና
ጎኖችላይያስወግዱ እናክዳኑንይዝጉ.
5.
1.1 Runt hei mpel l
eri fr equired( granul ati
onnotachi ev ed) ,compl etethe
5 granulation.
Oncet hegr anulat i
oni scompl et ed, opent hedi schar gepor tand
unloadt hegr anul es
Page3of3
i
nt ocleanFBDbowl placedundert hedi schar
gepor t
.
አስፈላጊከሆነአስመጪ ውንያሂዱ ( ጥራጥሬው አልተሳካም)፣ጥራጥሬውን
ያጠናቅቁ።
ጥራጥሬው ከተጠናቀቀበኋላየመልቀቂያውንወደብይክፈቱእናጥራጥሬዎችን
ያውርዱ
በማፍሰሻወደብስርየተቀመጠ ን ጹህየFBDሳህንውስጥ።
5.
1.1 Opent hel id,
scr apoutal ltheadher edmat eri
alandremov efr
om the
6 RMGand
dischargei nt
ot heFBDbowl .
ክዳኑንይክፈቱ፣ሁሉን ም የተጣበቁትንነ ገሮችያፅዱ እናከRMGያስወግዱት።
ወደFBDሳህንውስጥ መልቀቅ።
5.
1.1 Tr ansfert heFBDbowl l
oadwi t
hwetgr anulestodryi
ng.
7 የFBDሳህንጭ ነ ትበእርጥብጥራጥሬወደማድረቂያያስተላልፉ።
5.
1.1 Updat et hestatusl abel ofRMGasTOBECLEANEDasperf ormat
8 [Link]- QAD-038- F-003.
የRMGየኹናቴመለያእን ደTOBECLEANEDእን ደቅርጸትያዘምኑ
ቁጥርGPM- QAD- 038- F-003.
5.
2 CLEANI NG
ማጽዳት
5.
2.1 CLEANI NG DURI NG PRODUCTTO PRODUCTCHANGEOVER( Type-B
Cleaning)
ለውጥንለማምረትበምርትጊዜማጽዳት( ዓይነ ት-ቢጽዳት)
5.
2.1.
1 Remov ethestat usl abel TOBECLEANED.
ለመጽዳትየሁኔ ታመለያውንያስወግዱ።
5.
2.1.
2 Connectt hemai nsandswi tchONt hemachi ne.
ዋናውንያገናኙእናማሽኑንያብሩ።
5.
2.1.
3 Cl oset heli
dandt hedi schargepor toftheRMG.
የRMGክዳንእናየማስወጫ ወደብዝጋ።
5.
2.1.
4 Fi lltheRMG 1/ 4th wit
hpot ablewat erandoper at
etheRMG f or2
mi nutesi nslow speedt horoughlyt or emovealladheredmat eri
als
from t hemachi ne.

RMG1/ 4ኛንበሚጠጣ ውሃይሙሉእናሁሉን ም የተጣበቁቁሳቁሶችንከማሽኑ


ውስጥ ለማስወገድRMGለ2ደቂቃዎችበዝግታፍጥነ ትበደንብያንቀሳቅሱ።
5.
2.1.
5 Nowwasht hemachineinsi
deandoutsi
dewith0.
1%SLSsolut
ionin
water thor
oughl
y,f ol
l
owed by washi ng wit
h potabl
e water
thor
oughlyt
oremovealltr
acesofSLS.
አሁንማሽኑንከውስጥ እናከውጪ በ0. 1% የኤስኤስኤስመፍትሄበውሃውስጥ
Page4of4
በደን ብ ያጥቡት፣ በመቀጠልም በን ፁህ መጠጥ ውሃበመታጠብ ሁሉን ም የSLS
ምልክቶችያስወግዱ።
5.
2.1.
6 Clean t he wor king platform oft he machi ne with potabl e water
thor oughl y.
የማሽኑንየሥራመድረክበን ፁህመጠጥ ውሃያጽዱ.
5.
2.1.
7 Rinset hemachi neandt hepl atfor
m wi thpur i
fi
edwat ert horoughly
andal lowdr yi
[Link]/r i
nsesampl et obesentt oQCf oranalysis
ofpr eviouspr oduct.
ማሽኑንእናመድረኩንበተጣራውሃበደን ብያጠቡእናማድረቅይፍቀዱ. የቀድሞውን
ምርትለመተን ተንስዋብ/ያለቅልቁናሙናወደQCይላካል.
5.
2.1.
8 Cleant hepanel withcleanl intfreesclothtodr y.
ፓነ ሉንለማድረቅን ጹህከተሸፈነጨ ርቅያጽዱ.
5.
2.1.
9 Cleani nsi
deandout sideoft hemachi newi thdrycl eanl i
ntf r
ee
cloth.
ማሽኑንከውስጥ እናከውጪ በደረቅን ጹህከተሸፈነጨ ርቅያፅዱ።
5.
2.1.
1 Taket hel i
necl earancef orcl eaningfrom QA.
0 ከQAለማፅዳትየመስመርማጽጃውንይውሰዱ።
5.
2.1.
1 Ent ert hecleaningdet ailsint heequipmentl ogbook.
1 የጽዳትዝርዝሮችንበመሳሪያው መዝገብውስጥ ያስገቡ።
5.
2.1.
1 Closet helidandt hedi schar gepor toft hemachi ne,Updat ethe
2 stat usoft hemachi net o CLEANED asperequi pmentcl eani
ng
stat usl [Link]- QAD- 038-F-
004.
ክዳኑንእናየማሽኑንማስወጫ ወደብ ይዝጉ፣የማሽኑንሁኔ ታወደክሊነ ድ ያዘምኑ
እን ደመሳሪያየጽዳትሁኔ ታመለያቅርጸትቁጥርGPM- QAD-038-
F-004።
5.
2.1.
1 Updat et hest atusoft hemachi netoCLEANEDasperequi pment
3 cleani ngst atuslabel
[Link]- QAD-038- F-004.
እን ደመሳሪያየጽዳትሁኔ ታመለያየማሽኑንሁኔ ታወደcl eANEDያዘምኑ
ቅርጸትቁጥርGPM- QAD-038- F-004.
5.
2.2 BATCHTOBATCHCLEANI NG:( TypeACl eaning)
ባችለባችማጽጃ፡( የጽዳትአይነ ት)

5.
2.2.
1 Aft
ercomplet
ionofbatch,remov
eallmat
eri
alsandthedocuments
fr
om thear
ea.
ክምችቱከተጠናቀቀበኋላሁሉን ም እቃዎችእናሰነዶችከአካባቢው ያስወግዱ.
5.
2.2.
2 Scrapoutmat er
ial
sadheredtotheRMG incl
udingthedischar
ge
portusi
ngscr
apper.
ከRMGጋርየተጣበቁቁሳቁሶችንጥራጊንበመጠቀም የመልቀቂያወደቡንጨ ምሮ
Page5of5
ያስወግዱ።
5.
2.2.
3 Closet hel i
dandt hedi schar
gepor toft hemachi ne,cleant he
outsi
deofmachi neandt hepanelwit
hcl eandryl
intf
reeclot
h.
ክዳኑንእናየማሽኑንማስወጫ ወደብ ይዝጉ ፣የማሽኑንእናየፓነ ሉንውጭ በደረቅ
ከተሸፈነጨ ርቅያፅዱ።
5.
2.2.
4 Updat ethest atusoft hemachinetoCLEANEDasperequi pment
cl
eani ngstatuslabel formatNo.
GPM- QAD- 038-F-004.
የማሽኑንሁኔ ታወደcl eANEDያዘምኑእን ደመሳሪያየጽዳትሁኔ ታመለያቅርጸት
ቁጥር.
ጂፒኤም- QAD- 038- ኤፍ-004.
5.
2.2.
5 Updat etheusageandcl eani
ngdetai
lsintheequipmentlogbookas
perAnnexur eIandpr ocessparametersinBMR.
የአጠቃቀም እናየጽዳትዝርዝሮችንበመሳሪያመዝገብ ደብተርውስጥ እን ደአባሪI
እናበBMRውስጥ መለኪያዎችንያዘምኑ።
5.
2.2.
6 Preventivemai ntenanceofRMGi scarri
edoutMont hly,Quarter
ly&
Yearlyasperpr ev enti
vemai nt
enanceschedule.

በመከላከያጥገናመርሃግብርመሰረትየRMGየመከላከያጥገናበየወሩ,
በየሩብእናበየአመቱይከናወናል.

Pr
epar
edby Rev
iewedby Appr
ovedby

አዘጋጅ የተገመገመው በ ያረጋገጠው ሰው

Name

ስም

Desi
gnat
ion

ስያሜ

Si
gnat
ure

ፊርማ

Dat
e

ቀን

For
matNo:
GPM-
QAD-
001-
F-001-
00

ቅርጸትቁጥር:
GPM-
QAD-
001-
F-001-
00

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