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Bivariate Statistics Exercises 2024-2025

The document contains a series of biostatistics exercises focused on bivariate statistics, including predicting weight based on age, blood glucose levels based on fasting duration, bacterial population growth, systolic blood pressure related to age, and cholesterol levels in relation to BMI. Each exercise involves plotting data, applying regression methods, and making predictions based on the models developed. The exercises emphasize the use of least squares method and discuss potential deviations from linearity in relationships.

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0% found this document useful (0 votes)
8 views2 pages

Bivariate Statistics Exercises 2024-2025

The document contains a series of biostatistics exercises focused on bivariate statistics, including predicting weight based on age, blood glucose levels based on fasting duration, bacterial population growth, systolic blood pressure related to age, and cholesterol levels in relation to BMI. Each exercise involves plotting data, applying regression methods, and making predictions based on the models developed. The exercises emphasize the use of least squares method and discuss potential deviations from linearity in relationships.

Uploaded by

Smart Besma
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Biostatistics Exercices Series No.

2
Bivariate Statistics

2024/2025

Exercise 1
A pediatrician wants to predict the weight of a child based on their age using the following data:

• Age (years): 2, 3, 5, 6, 8, 10
• Weight (kg): 12, 14, 20, 22, 26, 30

Questions:
1. Plot the data on a scatter plot.
2. Use the Mayer method to find the approximate regression line (Mayer’s line).
3. Use the least squares method to calculate the coefficients of the linear regression model.
4. Predict the weight of a child who is 7 years old.
5. Discuss whether the relationship between age and weight is linear. What other factors might influence
this growth pattern?

Exercise 2
A doctor wants to predict blood glucose levels based on fasting duration:

• Fasting duration (hours): 2, 4, 6, 8, 10


• Glucose level (mg/dL): 140, 130, 120, 110, 100

Questions:
1. Plot the data on a scatter plot.
2. Use the least squares method to calculate the coefficients of the linear regression model.
3. Predict the glucose level after 5 hours of fasting.
4. Discuss whether this relationship might deviate from linearity beyond 10 hours of fasting.

Exercise 3
A biologist wants to model the growth of a bacterial population over time. The following data were recorded
during an experiment:

• Time (hours): 1, 2, 3, 4, 5
• Bacterial population: 120, 200, 320, 500, 800

1
Faculty of medecine University of Batna 2

It is suspected that the growth follows an exponential function of the form y = aebx , where y is the
bacterial population, x is the time in hours, and a and b are constants to be determined.
Questions:
1. Plot the data on a scatter plot.
2. Transform the exponential model into a linear form by taking the logarithm of the population y.

3. Use the least squares method to calculate the coefficients a and b of the exponential regression.
4. Write the final equation of the model.
5. Predict the bacterial population after 6 hours.

Exercise 4
A doctor is studying the relationship between a patient’s age and their systolic blood pressure. It is suspected
that this relationship follows a power model of the form y = axb , where y is the systolic blood pressure, x is
the age in years, and a and b are constants to be determined.

• Age (years): 30, 40, 50, 60, 70


• Systolic blood pressure (mmHg): 120, 130, 145, 160, 175

Questions:

1. Plot the data on a scatter plot.


2. Transform the model into a linear form by taking the logarithms of both age and blood pressure.
3. Use linear regression to determine the coefficients a and b.
4. Write the final equation of the power regression model.

5. Use the equation to predict the systolic blood pressure of a patient who is 55 years old.

Exercise 5
A doctor is studying the relationship between a patient’s Body Mass Index (BMI) and their cholesterol level.
The data collected are as follows:

• BMI (kg/m²): 22, 25, 27, 30, 35, 40

• Cholesterol level (mg/dL): 180, 195, 210, 230, 265, 290

Questions:
1. Plot the data on a scatter plot, with BMI on the x-axis and cholesterol level on the y-axis.
2. Use the least squares method to find the equation of the regression line of cholesterol level y as a
function of BMI x (i.e., the first regression line).

3. Using the first regression line from question 2, estimate the cholesterol level for a patient with a BMI
of 32.
4. Find the correlation coefficient between BMI and cholesterol level.
5. Estimate the BMI for a patient with a cholesterol level of 240 mg/dL.

MEDOUER NAWEL
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Common questions

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The Mayer's method can be used to determine the approximate linear relationship between age and weight in a pediatric population. This method involves using two points to create a regression line, typically by selecting points that visually represent the middle of the data set on a scatter plot, and then estimating the line of best fit that runs through these points .

In the linear model estimating cholesterol level from BMI, the regression coefficient for BMI represents the expected change in cholesterol level (mg/dL) for each one-unit increase in BMI (kg/m²). The intercept gives the estimated cholesterol level when BMI is zero, which might not be meaningful directly but is part of the calculation of the regression line. The coefficients help understand the strength and direction of the relationship between BMI and cholesterol level .

An exponential regression model can forecast future bacterial growth by estimating the parameters a and b of the model y = aebx and using them to predict y for future time values. The model assumes that growth rates remain constant over time, which implies continuous and unlimited resource availability, a population in the exponential growth phase, and that no limiting factors come into play, such as nutrient depletion or waste accumulation. These assumptions may limit real-world applicability if conditions change .

To apply the least squares method to determine the parameters of a power model for systolic blood pressure and age, first transform the power model y = ax^b into a linear form by taking the logarithm of both variables to get ln(y) = ln(a) + b ln(x). Then, use the least squares method on this linear model to estimate ln(a) and b, allowing for the back calculation of a by exponentiating ln(a).

The assumption of a linear relationship between fasting duration and blood glucose levels may be limited by physiological factors that cause the relationship to deviate from linearity beyond a certain fasting duration. For example, the glucose levels might stabilize or increase again after longer fasting due to metabolic adjustments in the body, such as glycogenolysis and gluconeogenesis. Thus, a linear model may only be valid within a specific range of fasting durations .

To predict a child's weight at 7 years old, the least squares method can be applied to the age-weight dataset to create a linear regression model. Steps involved include plotting the age versus weight data on a scatter plot, calculating the slope and intercept of the regression line using the least squares criteria to minimize the sum of squared residuals, and then substituting x=7 into the derived linear equation to predict the weight .

The correlation coefficient between BMI and cholesterol level signifies the strength and direction of the linear relationship between these two variables. A value close to 1 implies a strong positive linear relationship, while a value close to -1 indicates a strong negative relationship. A value around 0 would suggest little to no linear relationship. Understanding this correlation helps assess the potential predictive power of BMI regarding cholesterol levels .

Using simple linear regression to model complex biological data, such as glucose levels over fasting durations, can be problematic due to biological variability and non-linear relationships. Biological systems are influenced by multifactorial dynamics, where simple linear models might not capture essential interactions and thresholds, leading to inaccurate predictions outside the observed data range. Moreover, linear regression assumes constant variance and independence which may not hold true in biological contexts, necessitating more complex models or transformations for accurate analysis .

To transform an exponential growth model of bacteria into a linear form, you would take the natural logarithm of the bacterial population data. This means that if the growth model is y = aebx, you would transform it by taking ln(y) to obtain a linear model of the form ln(y) = ln(a) + bx. This allows the application of linear regression techniques to estimate the parameters a and b .

Besides age, a child's weight can be influenced by factors such as genetics, nutrition, physical activity, and overall health conditions. Socioeconomic factors and environmental factors, such as access to quality food and healthcare, also play a significant role. These factors could introduce non-linearity into the model, making a simple linear model potentially inadequate for predicting weight accurately across diverse populations .

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