Final Abstract — Curcumin Project
Abstract:
Breast cancer remains one of the most prevalent and life-threatening malignancies
among women worldwide. Although modern therapeutic approaches—such as
chemotherapy, radiotherapy, hormone therapy, and targeted molecular therapy—have
improved survival rates, the recurrence of tumors, metastasis, and development of
multidrug resistance continue to pose major challenges. These limitations necessitate
the exploration of safer, cost-effective, and more efficient treatment alternatives.
Natural phytochemicals have emerged as promising candidates due to their
multi-targeted mechanisms, low toxicity, and ability to modulate cancer-related
signaling pathways. Among them, Curcumin, a polyphenolic compound derived from
Curcuma longa (turmeric), has demonstrated potent anticancer, anti-inflammatory,
and antioxidant properties.
In this study, an in silico approach was adopted to design and evaluate Curcumin
derivatives as potential inhibitors for breast cancer. Molecular modeling, Density
Functional Theory (DFT) calculations, and docking studies were performed to analyze
the structural stability, binding interactions, and pharmacokinetic properties of these
derivatives against key breast cancer targets such as HER2, EGFR, and AKT. The
findings aim to provide insights into the molecular basis of Curcumin’s anticancer
activity and to identify optimized derivatives with enhanced therapeutic efficacy,
bioavailability, and drug-likeness. This research contributes to the development of
Curcumin-based compounds as potential agents for breast cancer prevention and
treatment.
📚 Suggested References for Citation
1. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of Curcumin:
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preclinical and clinical studies. Anticancer Res. 2003;23(1A):363–398.
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2. Rahman MA, et al. Phytochemicals as a Complement to Cancer Chemotherapy:
Pharmacological Modulation of the Autophagy–Apoptosis Pathway. Front
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Pharmacol. 2021;12:639628.
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3. Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery,
bioavailability, absorption and metabolism of Curcumin: the golden pigment
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from golden spice. Cancer Res Treat. 2014;46(1):2–18.
[Link]
4. Younas M, Hano C, Abbasi BH. Mechanistic evaluation of phytochemicals in
breast cancer remedy: current understanding and future perspectives. RSC
Adv. 2018;8:29714–29744.
🔗 [Link]
5. Ravindran J, Prasad S, Aggarwal BB. Curcumin and Cancer Cells: How Many
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Ways Can Curry Kill Tumor Cells Selectively? AAPS J. 2009;11(3):495–510.
[Link]
OR
🧬 Best Abstract (General — Breast Cancer Research Project)
Abstract:
Breast cancer is the most frequently diagnosed malignancy and one of the leading
causes of cancer-related deaths among women globally. Despite major advances in
screening, diagnosis, and treatment strategies—including surgery, radiotherapy,
chemotherapy, hormone therapy, and targeted therapy—challenges such as
metastasis, recurrence, and drug resistance continue to limit therapeutic success.
The heterogeneous nature of breast cancer, influenced by genetic, hormonal, and
environmental factors, demands more personalized and less toxic treatment
approaches. Recent research has increasingly focused on molecular and
computational (in silico) studies to identify new bioactive compounds with selective
anticancer activity and reduced side effects. Natural phytochemicals, such as
curcumin, resveratrol, quercetin, and genistein, have shown promising potential due
to their multi-targeted mechanisms, antioxidant and anti-inflammatory properties, and
ability to modulate cancer-related signaling pathways. This study aims to explore the
molecular mechanisms and therapeutic potential of such compounds through
computational modeling, docking studies, and ADME analysis, providing insights into
their possible development as novel anticancer agents for breast cancer
management.
📚 Recommended References / Sources
1. Waks AG, Winer EP. Breast Cancer Treatment: A Review. JAMA.
🔗
2019;321(3):288–300.
[Link]
2. Rahman MA, et al. Phytochemicals as a Complement to Cancer Chemotherapy:
Pharmacological Modulation of the Autophagy–Apoptosis Pathway. Front
🔗
Pharmacol. 2021;12:639628.
[Link]
3. Younas M, Hano C, Abbasi BH. Mechanistic evaluation of phytochemicals in
breast cancer remedy: current understanding and future perspectives. RSC
🔗
Advances. 2018;8:29714–29744.
[Link]
4. Bridg’ette BI, Syreeta LT, Kitani PL. Phytochemicals: Current strategies for
🔗
treating breast cancer. Oncol Lett. 2018;15(5):7471–7478.
[Link]
5. Ghoncheh M, et al. Epidemiology, incidence, and mortality of breast cancer in
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the world. Asian Pac J Cancer Prev. 2016;17(8):43–46.
[Link]