URINARY SYSTEM
URINARY SYSTEM
NEPHRON
RENAL CORPUSCLE
• Enclosing a tuft of capillary loops and
the site of blood filtration
• Location: Cortex
• Glomerulus
• Bowman’s capsule
RENAL CORPUSCLE
GLOMERULUS
• Afferent arteriole
• Efferent arteriole
• Simple squamous epithelium
• Fenestrated capillaries
BOWMAN’S CAPSULE
• Parietal and Visceral layer
• Simple squamous epithelium
• Fenestrated
• Podocytes
RENAL CORPUSCLE
RENAL FUNCTION
FILTRATION
• Water and solutes
• From blood vessels to tubular lumen
TUBULAR REABSORPTION
• From tubular lumen to blood vessels
TUBULAR SECRETION
• From blood vessels to tubular lumen
NEPHRON
PROXIMAL CONVOLUTED TUBULE
• Simple cuboidal epithelium
• Location: Cortex
Functions:
• Reabsorption of all organic nutrients,
all proteins, most water, and
electrolytes
• Secretion of organic anions and
cations, H+, and NH4+
NEPHRON
LOOP OF HENLE
1. Thin Limbs (Ascending & Descending)
• Simple squamous epithelium
• Location: Medulla
• Function: Passive reabsorption of
Na+ and Cl-
2. Thick Ascending
• Simple cuboidal epithelium
• Location: Medulla
• Active reabsorption of various
electrolytes
NEPHRON
DISTAL CONVOLUTED TUBULE
• Simple cuboidal epithelium
• Location: Cortex
• Function: Reabsorption of
electrolytes
URETER
• Walls – mucosal, muscular, and
adventitial layers
• The walls gradually becomes thicker
closer to the bladder
• Mucosa – stratified urothelium or
transitional epithelium
URETER
• Mucosa – stratified urothelium or
transitional epithelium
3 layers:
1. Single layer of small basal cells
2. Intermediate region – one to several
layers of cuboidal or low columnar cells
3. Superficial layer – large bulbous or
elliptical umbrella cells
- sometime binucleated to protect the
underlying cells
BLADDER
• Submucosa
• Lamina propria and dense irregular
connective tissue are highly
vascularized
• Muscularis
• 3 layers – Detrusor muscle
• Contracts to empty the bladder
• With valves to prevent backflow of
urine to ureter
URETHRA
• Carries urine from bladder to the exterior
• Urethral mucosa has prominent
longitudinal folds
• In men, two ducts for sperm transport
during ejaculation join the urethra at the
prostate gland
URETHRA
MALE
• Male urethra is longer than female
• Prostatic urethra – Transitional epithelium
• Membranous urethra – Stratified columnar
and pseudostratified columnar epithelium
• Spongy urethra – Stratified columnar and
pseudostratified columnar epithelium, then
nonkeratinizedstratified squamous
epithelium distally
FEMALE
• Transitional epithelium to nonkeratinized
stratified squamous
END.
URINARY SYSTEM