ASTRO

CHECK USAGE RESTRICTIONS LISTED IN THE PESTICIDES LIST OF

PARANÁ

Registered with the Ministry of Agriculture, Livestock and Supply/MAPA under number 000498

COMPOSITION:
0,0-diethyl thio phosphate 0-3,5,6-trichloro-2-pyridyl
(CHLORPYRIFOS)............................................................... 450 g/L (45.0% w/v)
Inert Ingredients.............................................................................. 688 g/L (68.8% m/v)

CONTEÚDO:1, 5, 10, 20, 50, 100 e 200 litros.

CLASS: Contact and ingestion insecticide of the organophosphate group.

FORMULATION TYPE: Oil in Water Emulsion.

REGISTER HOLDER:
Bayer S/A.
Domingos Jorge Street, 1100
CEP: 04779-900 – São Paulo/SP
CNPJ: 18.459.628/0001-15
Registered with the São Paulo Secretary of Agriculture under no. 663.

MANUFACTURER OF THE TECHNICAL PRODUCT:

Dow Chemical, Midland, USA
DowElanco, Kings Lynn, Norfolk, England

FORMULATOR:
Dow AgroScience Industrial Ltd.
Pres. Tancredo de Almeida Neves Highway, km 38
ZIP Code 07803-990 - Franco da Rocha/SP
CNPJ: 47.180.625/0021-90
Registered with the Department of Agriculture of São Paulo under number 025

Batch or lot number:

Manufacturing date: EMPTY PACKAGING
Due date:
BEFORE USING THE PRODUCT, READ THE LABEL, THE PACKAGE INSERT,AND THE PRESCRIPTIONAND KEEPTHEM.
THEY IN YOUR POWER.

[Link].
THE RETURN OF THE EMPTY PACKAGE IS MANDATORY.

Brazilian Industry

TOXICOLOGICAL CLASSIFICATION: III - MODERATELY TOXIC

CLASSIFICATION OF ENVIRONMENTAL DANGEROUSNESS POTENTIAL: II – PRODUCT

VERY DANGEROUS TO THE ENVIRONMENT

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PRODUCT USE INSTRUCTIONS:

CULTURES CONTROLLED PESTS DOSES

Commercial Prod. Active Engineer
Curuquerê 0.75 l/ha 337.5 g/ha
Cotton Alabama argillacea
Military caterpillar 1.0 l/ha 450 g/ha
Fall armyworm
Green and yellow cow (adult) 0.8 – 1.0 l/ha 360 – 450 g/ha
Potato Diabrotica speciosa
Green and yellow little cow (larva) 3.0 – 4.0 l/ha 1350 – 1800 g/ha
Diabrotica speciosa
Mining larva 1.5 – 2.0 l/ha 675 – 900 g/ha
Lyriomyza huidobrensis
Coffee Mining bug of coffee 1.0 – 1.5 l/ha 450 – 675 g/ha
Leucoptera coffeella
Petty stuff
Citrus Gray scale insect 100 – 150 ml/100 l of 45 – 67.5 g/100 l of
Brown mealybug water water
Selenaspidus articulatus
Cartucho caterpillar 0.3 – 0.5 l/ha 135 – 225 g/ha
Corn Fall armyworm
Green and yellow cow 2.6 l/ha 1170 g/ha
Diabrotica speciosa
Soybean Soybean caterpillar 0.25 L/ha 112.5 g/ha
Anticarsia gemmatalis
Tomato (*) Small berry of the fruit 150 ml/100 l of water 67.5 g/100 l of water
Neoleucinodes elegantalis
(*)Tomato: authorized use only for tomato (trailing) for industrial purposes.

NUMBER, PERIOD AND APPLICATION INTERVAL:

Cotton:
Curuquerê – start the application when the pest reaches the economic damage level, that is,
when 2 caterpillars (> 15 mm) are found per plant, or when the level of defoliation
reach 25%, or when 10% defoliation occurs reach 25%, or when
10% leaf loss occurs in the lower third.
Military caterpillar - apply when the caterpillars are in the 1st instar.

Potato
Green and yellow little cow - the application, aimed at controlling the larva, should be done
immediately after planting and before the furrow closes. As for the control of the adult,
the application should be made at the beginning of the infestation, at any stage of
development of culture.
Leaf miner - as soon as the first signs of infestation are observed. If
necessary, reapply with an interval of 7 days.

Café:
The control must be initiated within the citrus period of each region, when the
maximum attack intensity reaches 20% of mined leaves. To achieve this, one must
consider only the new leaves in the middle and upper thirds of the coffee plant.

Citrus
Picuinha - apply at the beginning of the infestation, with the spray directed at the trunk and primary branches.
Reapply, if necessary.
Brown soft scale - apply at the beginning of the infestation. Reapply if necessary. Apply until

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the point of runoff.

Corn:
Caterpillar of the cartridge - apply during the period after germination until 60 - 70 days of age.
culture based on the level of infestation. The application interval will depend on the level
of infestation. The application interval will depend on the reinfestation.
Green and yellow little cow – apply before planting, directing the spray towards the furrow.

Soy
Start the application when 40 large caterpillars are found per sampling (2m
linear aspects of the culture). Reapply if necessary.

Tomato
Apply preventively starting from the onset of flowering, reapplying every 7 days, if
there is a need.

APPLICATION METHOD:

Cotton, potatoes, corn, and soybeans: apply using tractor-mounted equipment with a bar
equipped with cone-type nozzles or similar, aiming to achieve an even spray. The
Recommended volume of solution is 90 to 125 l/ha for cotton, 80 l/ha for soybean and 300 to
400 l/ha for corn.
For the control of Diabrotica larvae in the potato planting furrow, it is recommended to apply
about the tubers before closing the furrow, using 1000 l of solution/ha.
For controlling the corn earworm in corn, it is recommended to use nozzle fan series 80.03 or
80.04, directing the application to the plant cartridge.

Coffee, citrus, and tomato: apply using suitable tractorized equipment.

crops. In tomato cultivation, it is recommended to use 1000 l of solution/ha and in coffee 300 l/ha.

SAFETY INTERVAL:
Cotton, Potato, Coffee, Citrus, Corn, Soybean, and Tomato.............................. 21 days

RE-ENTRY INTERVAL OF PEOPLE IN CULTURES AND AREAS TREATED:

In the conditions of product application and wearing boots, there are no restrictions of
reentry of people in the treated area.

USE LIMITATIONS:
There are no other limitations besides strictly following the product usage instructions.

INFORMATION ABOUT PERSONAL PROTECTIVE EQUIPMENT TO BE

USED:
Observe the recommended equipment in the different phases of the item 'PRECAUTIONS'.
GENERAL USAGE AND RECOMMENDATIONS.

INFORMATION ABOUT THE APPLICATION EQUIPMENT TO BE USED:

Mode of Application.

INFORMATION ON RESISTANCE MANAGEMENT:

Any pest control agent can become less effective over time if the
target insect to develop some resistance mechanism. Implementing the following
Insecticide Resistance Management (IRM) strategies could extend the lifespan.
two insecticides:
Any insect control product of the same class or mode of action not

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 It must be used in consecutive generations of the same pest.
−Use only the recommended doses on the label/package insert.
Always consult an agronomist for guidance on the
local recommendations for the MRI.

INFORMATION ON INTEGRATED PEST MANAGEMENT:

Include other pest control methods (e.g. Cultural Control, Biological, etc.) within
of the Integrated Pest Management (IPM) program when available and appropriate.

DATA RELATING TO THE PROTECTION OF HUMAN HEALTH

MECHANISMS OFACTION, ABSORPTION, AND EXCRETION FOR HUMANS:

Chlorpyrifos is a phosphorated insecticide and as such acts as a cholinesterase inhibitor.
human beings who accidentally ingested formulations of Chlorpyrifos, it was found that
the main route of excretion was through diethyl phosphonate metabolites in the urine, with a half-
life for elimination of 6.1 +/- 2.2 hours in the fast phase and 80 +/- 26 hours in the slow phase.
Chlorpyrifos is quickly metabolized to chlorpyrifos-oxo, a highly reactive substance, through
oxidative desulfuration. The oxo undergoes deactivation by hydrolysis to diethyl phosphate and 3,5,6-
trichloropyridinol. Another less important hydrolysis route produces monoethyl 3,5,6-trichloro-2-
priridinol phosphorothioate.

ACUTE AND CHRONIC EFFECTS:

Acute effects:
Test conducted with the formulation, using rats, found an acute oral LD50 of 275.
mg/kg. The clinical signs of intoxication in rats that received high doses of the
Product taken orally or dermally included ataxia, tremors, hyperreflexia, exophthalmos.
tearing, salivation, and piloerection.
The formulation is considered moderately irritating to the eyes and skin, due to the
used solvents.

Chronic effects:
In studies conducted with laboratory mice over two years, the primary effects
of product administration at the highest dose tested, of 10 mg/kg of body weight/day, in
males, were: decrease of weight gain, depression of plasma cholinesterase, RBC
the brain, and growth of the size of the adrenal gland, accompanied by changes
histological. Plasma and brain cholinesterase decreased, but not that of
erythrocytes. There was no increase in the incidence of tumors of any kind in males or
females at any dose level. The no observed effect level for all parameters
in males and females in this study was 0.1 mg/kg/day.

SIDE EFFECTS:
Since it is not for therapeutic purposes, there is no way to characterize its side effects.

ALARMING SYMPTOMS:
Weakness, headache, chest tightness, blurred vision, non-reactive pupils, salivation
abundant, sweats, nausea, vomiting, diarrhea, and abdominal cramps.

USE PRECAUTIONS AND GENERAL RECOMMENDATIONS REGARDING THE FIRST ONES

HELP, ANTIDOTE AND TREATMENT:

GENERAL PRECAUTIONS:
Exclusively agricultural use.

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Do not eat, drink, or smoke while handling the product.
Do not use damaged personal protective equipment (PPE).
Do not use equipment with leaks.
Do not clear nozzles, openings, and valves with your mouth.
Do not distribute the product with unprotected hands.
Do not transport the product together with food, medications, feed, animals and
people.

PRECAUTIONS IN HANDLING:
The product is irritating to the eyes.
If the product comes into contact with the eyes, rinse them immediately and SEE
FIRST AID.
Hazardous product if inhaled or aspired.
If the product is inhaled or aspirated, seek a ventilated area and SEE FIRST AID.
HELP.
Irritating product for the skin.
Upon contact with the product, wash it immediately and SEE FIRST
HELP.
When opening the package, do so in a way that avoids splashes.
Use personal protective equipment - PPE (hydro-cotton overalls)
repellent with long sleeves, waterproof apron, eye protection or visor
face mask, disposable for organic vapors covering nose and mouth and
rubber gloves/boots.

PRECAUTIONS DURING APPLICATION:

Avoid contact with the application area as much as possible.
Do not apply the product in the presence of winds or during the hottest hours.
Apply the product only at the recommended doses and observe the interval of
security.
Use personal protective equipment – PPE (hydro-cotton overalls)
repellent with long sleeves, waterproof hat with a wide brim, eye protector
face shield, disposable mask for organic vapors covering nose and mouth and
rubber gloves/boots.

PRECAUTIONS AFTER APPLICATION:

Do not reuse the empty packaging.
Keep the remaining product properly closed in its original packaging,
in a locked place, out of reach of children and animals.
Take a shower, change, and wash your clothes separately from the rest of the family's clothes.
Wash the personal protective equipment after each use. Stay attentive to the period.
of the useful life of the filters, correctly following the manufacturer's specifications.
Do not discard packaging, use personal protective equipment - PPE
(water-repellent cotton overall with long sleeves, gloves and boots of
drunk).

FIRST AID:
INGESTION: Do not induce vomiting, seek medical attention immediately, bringing the packaging, label,
this is the agronomic prescription of the product.

EYES: Rinse with plenty of water and seek medical attention immediately, bringing the packaging.
label, leaflet, and agronomic prescription of the product.

PELE: Wash with plenty of water and soap and seek medical attention, taking the packaging with you.

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label, leaflet, and agronomic prescription of the product.

INHALATION: Seek a well-ventilated area and go to the doctor, taking the packaging, label, and insert.
agronomic prescription of the product.

ANTIDOTE AND TREATMENT:

ATROPINE SULFATE IS THE EMERGENCY ANTIDOTE IN CASE OF
INTOXICATION.

NEVER ADMINISTER ATROPINE SULFATE BEFORE THE APPEARANCE OF

Symptoms of intoxication.

If the injured person stops breathing, apply artificial respiration immediately. Transport him/her.
immediately for the nearest medical assistance.

ANTIDOTES AND TREATMENTS (Information for medical use):

Atropine sulfate, via intramuscular and/or intravenous (eventually also through
orally): 1 to 6 mg every 5 to 30 minutes, until mild atropinization.
Oximas (Contraction): 1 to 2 g/day, for the first 3 days.
Contra-Indicações: morfina, aminofilina, tranqüilizantes.

COMPANY PHONES FOR MEDICAL INFORMATION:

Free calls. São Paulo: (0xx11) 5694.5333
Rio de Janeiro: (0xx21) 2761.4023

DATA RELATED TO ENVIRONMENTAL PROTECTION

USE PRECAUTIONS AND WARNINGS REGARDING PROTECTION CARE

TO THE ENVIRONMENT:
This product is:

( ) Highly Dangerous to the Environment (CLASS I)

VERY DANGEROUS TO THE ENVIRONMENT (CLASS II)
Dangerous to the Environment (CLASS III)
( ) Slightly Dangerous to the Environment (CLASS IV)

- This product is HIGHLY TOXIC to aquatic organisms.

- This product is HIGHLY BIOCONCENTRABLE in fish.
- This product is HIGHLY TOXIC to birds.
- Avoid environmental contamination - Preserve nature.
Do not use equipment with a leak.
Do not apply the product in the presence of strong winds or during the hottest hours.
Only apply the recommended doses.
Do not wash the packaging or application equipment in lakes, springs, rivers, and other bodies of water.
water bodies. Avoid water contamination.
The improper disposal of packaging or product remnants causes contamination.
of soil, water, and air, harming the environment, fauna, flora, and health of the
people.

PRODUCT STORAGE INSTRUCTIONS FOR CONSERVATION

AND ACCIDENT PREVENTION:
Keep the product in its original packaging, always closed.
The location must be exclusive for toxic products and should be isolated from food.
drinks, feed or other materials.

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The construction must be made of masonry or non-combustible material.
The location must be ventilated, covered, and have waterproof flooring.
- Put up a warning sign with the words: WARNING POISON.
Lock the location, preventing access to unauthorized persons, mainly
children.
There must always be suitable packaging available to wrap the packages.
broken or for the collection of spilled products.
In the case of warehouses, the instructions in NBR 9843 must be followed.
Brazilian Association of Technical Standards - ABNT.
Observe the provisions of state and municipal legislation.

INSTRUCTIONS IN CASE OF ACCIDENTS:

Isolate and mark the contaminated area.
- Contact the competent local authorities and the Company BAYER CROPSCIENCE
LTDA. - emergency phone: 0800-243334.
Use personal protective equipment - PPE (waterproof overalls, gloves, and boots)
of PVC, protective goggles and mask with filters.
In case of spillage, pooling, or runoff, do not allow the product to enter into
drains, channels or bodies of water. Follow the instructions below:

• Paved floor - absorb the product with sawdust or sand, collect the material with
use a shovel to place it in a sealed and properly labeled container. The product
spilled should no longer be used. In this case, consult the registrant through the
phone indicated on the label for your return and final destination.

• Only remove the contaminated layers of soil until reaching the uncontaminated soil, collect
this material and place it in a sealed and properly identified container. Contact the
registrant company as indicated above.

• Water bodies - immediately suspend the collection for human and animal consumption.
and contact the company emergency center, as the measures to be taken
depend on the proportions of the accident, the characteristics of the water body in question and
of the quantity of the product involved.

In case of fire, use water extinguishers in mist form, CO2 or powder.

facing the wind to avoid intoxication.

WASHING, STORAGE, RETURN, TRANSPORT AND PROCEDURES

DISPOSAL OF EMPTY PACKAGING AND REMAINS OF UNFIT PRODUCTS
FOR USE OR OUT OF USE:

WASHABLE RIGID PACKAGING (1, 5, 10, 20, and 50 liters)

WASHING OFTHE PACKAGING:

During the washing procedure, the operator must be using the same PPE.
Personal Protective Equipment – recommended for preparing the product solution.

Triple Wash (Manual Washing):

This packaging must be submitted to the Triple Washing process immediately.
after its emptying, adopting the following procedures:

Completely empty the contents of the packaging into the spray tank,
keeping it in an upright position for 30 seconds;
Add clean water to the container until it reaches ¼ of its volume;

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Seal the packaging well and shake it for 30 seconds;
Pour the wash water into the sprayer tank;
Do this operation three times;
Disable the plastic or metal packaging by puncturing the bottom.

Pressure Washing:
When using sprayers equipped with pressure washing equipment, follow the
following procedures:
- Fit the empty packaging in the appropriate place of the funnel installed in the sprayer;
- Activate the mechanism to release the water jet;
- Direct the water jet to all the internal walls of the packaging for 30.
seconds;
- The wash water must be transferred to the tank of the sprayer;
- Invalidate the plastic or metal packaging by puncturing the bottom.

When using independent equipment for pressure washing, adopt the following
procedures:
- Immediately after emptying the original contents of the packaging, keep it
inverted over the spray tank's mouth, in vertical position, for 30
seconds;
- Keep the packaging in this position, insert the tip of the washing equipment.
under pressure, directing the jet of water to all the internal walls of the
packaging, for 30 seconds;
- All wash water is directed straight to the sprayer's tank;
- Dispose of the plastic or metal packaging by puncturing the bottom.

STORAGE OF EMPTY PACKAGING

After the Triple Wash or Pressure Wash is carried out, this packaging must
to be stored with the lid in a collective box, when available, separately from
unwashed packaging.

The storage of empty packaging, until return by the user, must be

carried out in a covered, ventilated location, protected from rain, with an impermeable floor, or in the
place where the filled packages are stored.

RETURN OF THE EMPTY PACKAGE

Within one year from the date of purchase, the return of the packaging is mandatory.
empty, with lid, by the user, to the establishment where the product was purchased or at
location indicated on the invoice, issued at the time of purchase.

If the product has not been fully used within this period, and is still within
its expiration date, the return of the packaging will be allowed within 6 months after the
expiration date.

The user must keep the return receipt for inspection purposes.
minimum period of one year after the return of the empty packaging.

TRANSPORT
Empty packaging cannot be transported together with food and beverages.
medications, feeds, animals and people.

NON-WASHABLE RIGID PACKAGING (100 and 200 liters)

THIS PACKAGING CANNOT BE WASHED

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STORAGE OF EMPTY PACKAGING
The storage of the empty packaging, until its return by the user, must be
carried out in a covered, ventilated location, sheltered from rain and with a waterproof floor, at the
the exact place where the full packages are stored.

Use gloves when handling this packaging.

This packaging should be stored with its lid, in a collective box, when
existing, separately from the washed packaging.

RETURN OF THE EMPTY PACKAGE

Within one year from the date of purchase, the return of the packaging is mandatory.
empty, with lid, by the user, to the establishment where the product was purchased or at
local indicated on the invoice, issued at the time of purchase.

If the product has not been fully used within this period, and is still within
its expiration date, the return of the packaging will be allowed up to 6 months after the
expiration date.

The user must keep the return receipt for inspection purposes.
minimum period of one year after the return of the empty packaging.

TRANSPORT
Empty packaging cannot be transported together with food and beverages.
medications, feed, animals, and people.

SECONDARY PACKAGING (TRANSPORT BOX - NOT CONTAMINATED)

THIS PACKAGING CANNOT BE WASHED

STORAGE OF EMPTY PACKAGING

The storage of the empty packaging, until its return by the user, must be
carried out in a covered, ventilated location, protected from rain and with an impermeable floor, at
the very place where the filled packaging is stored.

RETURN OF EMPTY PACKAGING

The return of the empty packaging by the user, where the product was purchased, is mandatory.
at the location indicated on the invoice, issued by the commercial establishment.

TRANSPORT
Empty packaging cannot be transported together with food and drinks.
medications, feed, animals and people.

FINAL DESTINATION OF EMPTY PACKAGING

The final destination of empty packaging, after being returned by users, only
may be carried out by the Registrant Company or by legally authorized companies
by the competent authorities.

The user is prohibited from reusing and recycling this packaging.

EMPTY OR THE FRACTIONATION AND REPACKAGING OF THIS PRODUCT.

EFFECTS ON THE ENVIRONMENT RESULTING FROM DISPOSAL

INADEQUATE EMPTY PACKAGING AND LEFTOVER PRODUCTS

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The improper disposal of empty packaging and product remnants in the environment
causing contamination of the soil, water, and air, harming the fauna, flora, and health of
people.

PRODUCTS UNSUITABLE FOR USE OR OUT OF USE

If this product becomes unfit for use or is unused, consult the
register through the phone indicated on the label for its return and final disposal.

The deactivation of the product is done through incineration in ovens intended for this.
type of operation, equipped with flue gas washing systems and approved by
competent environmental agency.

TRANSPORT OF PESTICIDES, COMPONENTS AND RELATED ITEMS:

The transport is subject to the rules and procedures established in the legislation.
specific, which includes monitoring the product's emergency data sheet, as well as
determines that pesticides cannot be transported alongside people, animals,
feed, medication or other materials.

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