GENETICS Study Guide
1. DNA Basics
● DNA = deoxyribonucleic acid
● Double helix structure
● Made of nucleotides (A, T, C, G)
● A↔T and C↔G
● Stored in the nucleus
2. Genes & Chromosomes
● Gene = segment of DNA that codes for a trait
● Allele = version of a gene (dominant or recessive)
● Humans have 46 chromosomes (23 pairs)
3. Protein Synthesis
Transcription
● DNA → mRNA
● Happens in the nucleus
Translation
● mRNA → protein
● Happens on ribosomes
4. Mendelian Genetics
Key Terms
● Genotype = genetic makeup (TT, Tt, tt)
● Phenotype = physical trait (tall, short)
● Homozygous = same alleles
● Heterozygous = different alleles
Inheritance
● Dominant = expressed if at least one allele present
● Recessive = expressed only when homozygous
Punnett Squares
● Predict offspring genotypes/phenotypes
5. Non-Mendelian Genetics
● Incomplete dominance – blended traits
● Codominance – both alleles expressed (ex: AB blood)
● Multiple alleles – more than 2 possible alleles
● Polygenic traits – controlled by many genes (height, skin color)
● Sex-linked traits – on X chromosome (colorblindness)
6. Mutations
● Changes in DNA
● Can be harmful, helpful, or neutral
● Types: substitution, insertion, deletion