II.

Mass
ANSWER KEY III. Volume
IV. Boiling Point
Diagnostic Exams for PhLE 2022 A. I, II, III
Module 1: Pharmaceutical Chemistry (100 items) B. I, II, IV
by C. I, IV
Jonathan Israel F. Tordilla, RPh D. III, IV
Our Lady of Fatima University – Antipolo Campus, BS Pharmacy,2018 E. II, III
University of the Philippines (Manila), MS Pharmacy (Major in Pharmaceutical Chemistry), Ongoing
9. Which of the following Silver-Containing Compounds is also
Question Type: Multiple Choices known to be part of "Crede's Prophylaxis"?
A. Howe's Solution
Choose among the given choices the letter which B. Mild Silver Proteinate
corresponds to the answer to the given question. Write C. Lunar Caustic
your answer to the separate sheet provided for you. D. Colloidal Silver Proteinate
E. NOTA
1. Which of the following medical terms is used to describe 10. Which of the following matched classifications of drugs
lead poisoning? is/are correct?
A. Plumbism A. Irinotecan - Topoisomerase Inhibitor
B. Saturnism B. Griseofulvin - Microtubule Inhibitor
C. Itai-Itai Disease C. Etoposide - Microtubule Inhibitor
D. A and B D. A and B only
E. B and C E. AOTA
2. Which of the following is/are not the component/s of the 11. In terms of isomerism, N-butane and 2-methylpropane are
Universal Antidote? what?
A. One-part Tannic Acid A. Position Isomers
B. Two-parts Activated Charcoal B. Functional Isomers
C. One-part Magnesium Oxide C. Chain Isomers
D. EDTA D. AOTA
E. AOTA E. NOTA
3. What law states that when elements combine, they do so in 12. Which of the following is known to be the energy needed or
a ratio of small whole numbers? This governs how elements required for an element to remove an electron from a
in Organic Compounds form. neutral atom?
A. Law of Conservation of Mass A. Electron affinity
B. Law of Multiple Masses B. Ionization potential
C. Law of Multiple Proportions C. Kinetic Energy
D. Law of Definite Proportions D. Electronegativity
E. Proust’s Law E. NOTA
4. Which of the following is an inherited disorder in which 13. Which of the following is the name of the given chemical
excessive amounts of copper accumulate in the human structure below?
body? A. Resorcinol
A. Wilson's Disease B. Thymol
B. Minamata Disease C. Para-cresol
C. Itai-Itai Disease D. Ortho-Cresol
D. Hemochromatosis E. NOTA
E. Hypermagnesemia 14. Which of the following is true about Carbon Dioxide (CO2)?
5. Which of the following is/are true about antioxidants? A. Produced in the incomplete combustion of fossil fuels
A. Ascorbic Acid is a true antioxidant B. Can undergo oxidation reactions
B. Citric Acid is an example of an antioxidant synergist C. Stored in Gray Containers
C. True antioxidants terminate free radicals D. Has lower affinity to hemoglobin than Oxygen
D. A and B E. AOTA
E. B and C 15. Which of the following chemical compounds is also known
6. The following are examples of Penicillase-Resistant as “Salt Peter?”
Penicillins, except: A. KMNO4
A. Pen G B. KNO3
B. Oxacillin C. NH4Cl
C. Methicillin D. NaCl
D. Dicloxacillin E. CaCO3
E. NOTA 16. Which of the following metals gives a “brick-red” non-
7. Which of the following is preferred to be used to dissolve luminous flame?
difficult water-soluble substances such as iodine, in the A. K
preparation of Iodine tincture and Iodine solution? B. Na
A. KI C. Ca
B. NaI D. Sr
C. NaI + KI (50:50) E. Li
D. NOTA 17. Aspirin is an acidic drug. Once taken, in the stomach it will
E. AOTA exist most in what form?
8. Which of the following is classified as not an extrinsic A. Non-Ionized form
property of Matter? B. Ionized form
I. Density C. NOTA
 D. AOTA C. Erythromycin
18. The following is/are characteristics of Non-Metallic D. Gentamicin
Elements, except: E. Tobramycin
A. Brittleness 28. Which of the following is a 2nd Gen Cephalosporin?
B. Ductility A. Cefadroxil
C. Known to be Oxidizing Agents B. Cefotaxime
D. A and B C. Cefoxitin
E. B and C D. A and B
19. The following elements are commonly used in E. B and C
Radiopharmaceuticals, except: 29. Which of the following is not a part of the Vitamin B6
A. Gallium molecule?
B. Indium A. Hydroxymethyl
C. Technetium B. Hydroxy group
D. Xenon C. Methyl Group
E. NOTA D. Pyridine
20. Which of the following is the type of organic reaction E. NOTA
where Pi bonds are formed? 30. Which of the following is the Mechanism of Action (MOA)
A. Substitution Reaction of the Anti-TB drug, Pyrazinamide?
B. Elimination Reaction A. Mycolic Acid Synthesis Inhibitor
C. Addition Reaction B. Small Ribosomal 30s Subunit Inhibitor
D. A and B C. RNA Polymerase Inhibitor
E. NOTA D. Fatty Acid Synthase 1 (FAS1) Inhibitor
21. Which of the following allotropic forms of Phosphorus, E. Arabinosyl Transferase Inhibitor
formerly known in the military as “Willie Peter”, that is highly 31. Which of the following choices is the parent structure of
poisonous thus stored under water due to its high reactivity the given chemical structure?
when exposed in air?
A. White Phosphorus A. Nalidixic Acid
B. Red Phosphorus B. Dibenzazepines
C. Black Phosphorus C. Barbituric Acid
D. AOTA D. Diazepene Ring
E. NOTA E. Iminostilbenes
22. The following are Group IIA elements, except:
A. Calcium 32. What is the relationship of hydrocarbon branching in
B. Barium Alkanes, to its boiling point?
C. Lithium A. Directly Proportional
D. Radium B. Inversely Proportional
E. Beryllium C. No effect
23. The following is/are true regarding solubility, except: D. AOTA
A. Like Dissolves Like 33. Which of the following nitrogenous bases is susceptible to
B. High Temperature → High Solubility of Gas Alkylating Antineoplastic Agents?
C. More Surface Area → High Solubility of Solid A. Adenine
D. AOTA B. Guanine
E. NOTA C. Thymine
24. Which Law of Thermodynamics explains that the entropy of D. Cytosine
the universe increases in a spontaneous process and E. Uracil
remains unchanged in an equilibrium process? 34. Which of the following is an antifungal agent that inhibits
A. First Law 𝛽-Glucan Synthase?
B. Second Law A. Fluconazole
C. Third Law B. Terbinafine
D. Zeroth Law C. Nystatin
E. NOTA D. Micafungin
25. Which of the following is the novel antimalarial drug E. Amphotericin B
isolated from Artemisia annua? 35. Which of the following is the drug that paralyzes helminths
A. Artemisinin by inhibiting its GABA receptors?
B. Chloroquine A. Mebendazole
C. Acetylsalicylic Acid B. Ivermectin
D. Camptothecin C. Piperazine
E. Quinine D. A and B
26. How many carbon atoms does the dicarboxylic acid E. B and C
“Azelaic Acid” have? 36. Which of the following anticancer agents causes
A. 6 peripheral neuropathy?
B. 7 A. Busulfan
C. 8 B. Paclitaxel
D. 9 C. Vinorelbine
E. 5 D. A and B
27. Which of the following antibiotics is known for its large E. B and C
lactone ring? 37. Which of the following criteria determines if the structured
A. Vancomycin compound is aromatic?
B. Bacitracin A. Passes Huckel's Rule
 B. Planar or Cyclic C. Clofazimine
C. Passes Cahn-Ingold-Prelog Rule D. A and B
D. A and B E. B and C
E. A and C 47. Which of the following four main types of hydrocarbons is
38. Which of the following microorganisms is the source of a also known as olefins?
topical antibiotic active against MRSA, that can't be taken A. Alkanes
orally due to rapid hydrolysis by esterases? B. Alkenes
A. Streptomyces lincolnensis C. Alkynes
B. Streptomyces venezuelae D. Aromatics
C. Pseudomonas fluorescens E. NOTA
D. Streptomyces Orientalis 48. Which of the following is the test that is used to distinguish
E. NOTA aldehydes from ketones in a solution?
39. Which of the following agents is chemically also known as A. Benedict's Test
isopropyl meta-cresol? B. Tollen's test
A. Catechol C. Iodoform Test
B. Hydroquinone D. Salkowski’s Test
C. Eugenol E. AOTA
D. Thymol 49. Which of the following is/are the product/s of the complete
E. NOTA combustion of hydrocarbons?
40. The following chemicals used for bacterial control have a A. CO
Mechanism of Action (MOA) of protein denaturation, B. CO2
except: C. H2 O2
A. Metals D. A and B
B. Phenol E. B and C
C. Alcohol 50. Which of the following is the most common Phase 2
D. Halogens metabolic process?
E. NOTA A. Glucuronidation
41. Which of the following compounds exist with two or more B. Sulfation
chiral centers? configuration may include, R,R and S,S. C. Oxidation
A. Diastereomers D. Hydrolysis
B. Enantiomers E. Reduction
C. Configurational Isomers 51. Which of the following is the correct oxidation number of
D. A and B Chromium in Sodium Dichromate?
E. B and C A. +2
42. The following are examples of Penicillase-Resitant B. +3
Penicillins, except: C. +4
A. Benzylpenicillin D. +5
B. Oxacillin E. NOTA
C. Methicillin 52. Which of the following is a property of carbon that shows
D. Dicloxacillin the ability to form chains?
E. NOTA A. Isomerism
43. Which of the following azole antifungals doesn’t have an B. Catenation
imidazole ring? C. Hybridization
A. Miconazole D. NOTA
B. Ketoconazole 53. Which of the following Sulfates is also known as “Glauber’s
C. Oxiconazole Salt”?
D. Voriconazole A. Magnesium Sulfate
E. Clotrimazole B. Sodium Sulfate
44. Which of the following is the appropriate prefix for the C. Potassium Sulfate
designation of functional group position in the benzene D. Copper Sulfate
ring that is used when the functional groups are positioned E. NOTA
next to each other? 54. Which of the following is the Anthelminthic drug that inhibits
A. Ortho- glucose uptake in helminths leading to its glycogen
B. Para- storage?
C. Meta- A. Niclosamide
D. AOTA B. Mebendazole
E. NOTA C. Piperazine
45. Which of the following is a derivative of two carboxylic D. A and B
acids, in which the compound is formed by the removal of E. B and C
one molecule of water in two RCOOH? 55. This a method of separation which allows the mixture of
A. Esters solid and liquid, or two immiscible liquids to settle and
B. Acyl Halides separate via gravity:
C. Acid Anhydrides A. Distillation
D. Amides B. Decantation
E. Alcohols C. Centrifugation
46. Which of the following agents is/are used as 2nd line D. Chromatography
drugs for Tuberculosis Therapy? E. Sieving
A. Isonicotinic Acid Hydrazide (INH) 56. The following is/are the properties of a colloid, except:
B. Para-aminosalicylic Acid (PAS) A. Absorption
 B. Adsorption B. 42.1%
C. Brownian Movement C. 80%
D. Tyndall Effect D. 3.5%
E. A and C E. NOTA
57. Which of the following information about the methods of 66. Which of the following is the adverse effect of taking
Water Content Determination is/are true? Metronidazole alongside with Alcoholic Drinks?
I. Method I - Distillation A. Otitis Externa
II. Method I - Azeotropic B. Disulfiram-Like Toxicity
III. Method II - Implements the use of Toluene Apparatus C. Hypermagnesemia
IV. Method III - Gravimetric Method D. AOTA
A. I and II E. NOTA
B. II and III 67. Which of the following Technetium radiopharmaceuticals is
C. III and IV used in Hepatobiliary studies?
D. I and III A. Tc-99m-Etidronate
E. AOTA B. Tc-99m-HIDA
58. Which of the following elements that toxicity causes the C. Tc-99m-Heptagluconate
tongue to turn green and alopecia? D. Tc-99m-Phytate
A. Thallium E. NOTA
B. Beryllium 68. Which of the following quantum numbers that determines
C. Zirconium the angular momentum and describes the shape of the
D. Manganese orbital?
E. NOTA A. Spin Quantum Number
59. What are the components of Sterling Silver? B. Azimuthal Quantum Number
A. 90% Ag and 10% Cu C. Magnetic Quantum Number
B. 92.5% Ag and 7.5% Cu D. Principal Quantum Number
C. 95% Ag and 5% Cu E. NOTA
D. 99% Ag and 1% Cu 69. Which of the following is the molecular geometry of
E. NOTA Ammonia?
60. Which of the following principle states that no two electrons A. Cuboid
can have the same set of 4 quantum numbers, that each B. Trigonal Planar
atomic orbital can only accommodate two electrons? C. Trigonal Pyramidal
A. Pauli’s Exclusion Principle D. Tetrahedral
B. Hund’s Rule E. Linear
C. Aufbau Principle 70. The Lucas' Reagent is used to classify alcohols of low
D. Heisenberg’s Uncertainty Principle molecular weight. Upon its use in test, which of the following
E. NOTA alcohols is most reactive to it?
61. Which of the following is also known as p-hydroxyphenol? A. Propanol
A. Catechol B. Ethanol
B. Eugenol C. Isopropyl Alcohol
C. Hydroquinone D. Tertbutyl Alcohol
D. Resorcinol E. NOTA
E. NOTA 71. Which of the following drugs is classified as an osmotic
62. Which of the following is the component of Type I glasses laxative?
that make it highly resistant to heat, chemicals, and A. Milk of Magnesia
leaching? B. Senna
A. SiO2 C. Docusate Sodium
B. B2O3 D. Castor Oil
C. SO2 E. Ricin
D. CO2 72. Which of the following forms of mercury caused the
E. NOTA “Minamata Disease” when it was first discovered in 1956?
63. The following chemicals used for bacterial control have a A. Elemental Mercury
Mechanism of Action (MOA) of protein denaturation, B. Organic Mercury
except: C. Inorganic Mercury
A. Metals D. AOTA
B. Phenol E. NOTA
C. Alcohol 73. Which of the following gas law stating that the pressure of
D. Halogens a given quantity of gas varies inversely with its volume at
E. NOTA constant temperature?
64. Temporary hard water contains soluble Ca2+ and Mg2+ salts A. Charles’s Law
of what? B. Mariotte's Law
A. Carbonates C. Boyle's Law
B. Sulfides D. A and B
C. Bicarbonates E. B and C
D. Chlorides 74. How much (in %) is ionized if the pH of the medium
E. NOTA containing a weak acid (pKa = 3.2) is 2.5?
65. What is the percentage of Carbon in Table Sugar A. 16.6%
(C12H22O11) if the atomic weight of C=12, H=1, and B. 8.3%
O=16? C. 83.4%
A. 51.9% D. 91.7%
 E. NOTA 84. Which of the following ions give the positive result "cobalt
75. What will happen to a weak acid if the pH of the medium is green" to Rinmann’s Test?
greater than its pKa? A. Zirconium
A. Ionized B. Zinc
B. Unionized C. Chromium
C. No effect D. Manganese
D. NOTA E. NOTA
76. Which of the following is the correct buffer equation for 85. Which of the following antimetabolite agents is/are
weak acids? analogs of pyrimidine?
[𝑠𝑎𝑙𝑡] A. Methotrexate
A. pH = pKa + log
[𝑎𝑐𝑖𝑑] B. Cytarabine
[𝑎𝑐𝑖𝑑]
B. pH = pKa - log C. Thioguanine
[𝑠𝑎𝑙𝑡]
[𝑠𝑎𝑙𝑡] D. A and B
C. pH = pKw - pKb + log E. B and C
[𝑎𝑐𝑖𝑑]
D. AOTA 86. Which of the following vitamin/mineral increases the
E. NOTA absorption of Selenium in the human body?
77. Which of the following is the only water-soluble azole A. Vitamin E
(triazole) which is an agent of choice for cryptococcal B. Vitamin D
meningitis? C. Vitamin A
A. Fluconazole D. Magnesium
B. Clotrimazole E. Potassium
C. Miconazole 87. Which of the following is a major anion found in the
D. Itraconazole extracellular fluid?
E. Ketoconazole A. HPO4-2
78. Which of the following is true about Basic Compounds? B. SO4-
A. Yielders of Hydrogen Ion C. Cl-
B. Accepts Proton D. Ca+2
C. Electron Pair Donor E. Na+
D. A and B 88. Which of the following anions form a white precipitate
E. B and C upon addition of 1M of Silver Nitrate and 6M of Nitric
79. Which of the following silver-containing compounds that Acid?
can be used as an ears & throat antiseptic, known for its A. Chlorides
name "Protargol"? B. Oxalates
A. Colloidal Silver Proteinate C. Phosphites
B. Strong Silver Proteinate D. A and B
C. Mild Silver Proteinate E. B and C
D. Silver Nitrate 2% Solution 89. Which of the following metals is the cause of “Itai-Itai”
E. NOTA disease?
80. Which of the following is known as the combination of A. Thallium
trimethoprim and sulfamethoxazole that is commonly used B. Mercury
in the treatment of PCP? C. Cadmium
A. Clotrimazole D. Chromium
B. Miconazole E. Vanadium
C. Cadralazine 90. Which of the following anticancer agents causes peripheral
D. Cotrimoxazole neuropathy?
E. NOTA A. Ribavirin
81. Which of the following drugs is used for the treatment of B. Docetaxel
Varicella zoster Chicken Pox? C. Cyclophosphamide
A. Zidovudine D. A and B
B. Lamivudine E. B and C
C. Acyclovir 91. Which of the following compounds is also known as
D. Rimantadine Potash Lye?
E. NOTA A. Sodium Hydroxide
82. Which of the following is a common side effect of Cisplatin B. Potassium Hydroxide
chemotherapy? C. Potassium Chlorate
A. Ototoxicity D. Potassium Permanganate
B. Nephrotoxicity E. NOTA
C. Pulmonary Fibrosis 92. Which of the following inorganic compounds is also
D. A and B known as "Hematite"?
E. B and C A. Ferrous Sulfate
83. Which of the following is the antimalarial drug is effective B. Ferrous Oxide
against both exoerythrocytic and erythrocytic forms of C. Ferric Oxide
malaria? D. Ferric Sulfate
A. Cycloguanil E. Lead Oxide
B. Sulfadoxine 93. Which of the following is true about Cobalt?
C. Primaquine A. Component of Prussian Blue
D. Mepacrine B. Part of the Second Triad, GROUP VIIIB
E. Artemether C. In coordination complex with Cobalamin
D. A and B
 E. B and C
94. Which of the following elements is not a member of the
Chalcogens?
A. Oxygen
B. Sulfur
C. Carbon
D. A and B
E. B and C
95. Which of the following inorganic compounds is also
known as the "Berlin Blue" or the "Prussian Blue"?
A. Ferric Ferrocyanide
B. Ferrous Ferricyanide
C. Ferric Ferricyanide
D. Ferrous Ferrocyanide
E. NOTA
96. According to the Lewis Theory, which of the following
appropriately describes an “acid”?
A. Proton Acceptor
B. Proton Donor
C. Electron Acceptor
D. A and B
E. B and C
97. Which of the following sodium-containing compounds is a
known diuretic and electrolyte replenisher?
A. Sodium Acetate
B. Sodium Lactate
C. Sodium Iodide
D. Sodium Hypochlorite
E. Sodium Sulfate
98. Which of the following term best describes as the nucleus
of a specific isotope of an element?
A. Nucleon
B. Nuclide
C. Isotope
D. Isobar
E. Isomer
99. Which of the following anti-viral agents is commonly used
for the treatment of Hepatitis?
A. Rimantadine
B. Oseltamivir
C. Lamivudine
D. A and B
E. B and C
100. Which of the following sulfonamides is being used for
wounds and burns?
A. Sulfadiazine
B. MTX
C. Sulfamethazine
D. A and B
E. B and C

================== END OF EXAM =================

Jonathan Israel F. Tordilla, RPh, MSc ©