🧰 ENDOCRINE SYSTEM – DETAILED NOTES
🌈 I. Overview
The endocrine system is a network of glands and organs that use
hormones to control many body functions.
Hormones act as chemical messengers, regulating growth,
metabolism, reproduction, mood, and homeostasis.
Works closely with the nervous system but acts more slowly and over
longer durations.
⚖️II. Key Endocrine Glands & Hormones
1. Hypothalamus
Located in the brain; links the nervous and endocrine systems.
Controls the pituitary gland through releasing and inhibiting
hormones (e.g., TRH, CRH, GnRH).
2. Pituitary Gland (“Master Gland”)
Located at the base of the brain.
Produces many hormones that regulate other endocrine glands.
Anterior Pituitary:
o Growth hormone (GH)
o Thyroid-stimulating hormone (TSH)
o Adrenocorticotropic hormone (ACTH)
o Follicle-stimulating hormone (FSH) & Luteinizing hormone
(LH)
o Prolactin (PRL)
Posterior Pituitary:
o Antidiuretic hormone (ADH)
o Oxytocin
3. Pineal Gland
Produces melatonin: regulates sleep-wake cycles (circadian rhythm).
4. Thyroid Gland
Located in the neck.
Produces:
o Thyroxine (T4) & Triiodothyronine (T3): regulate
metabolism.
o Calcitonin: lowers blood calcium levels.
5. Parathyroid Glands
Four small glands behind the thyroid.
Produce parathyroid hormone (PTH): raises blood calcium levels.
6. Adrenal Glands
Located on top of each kidney.
Adrenal cortex:
o Cortisol: stress response, metabolism.
o Aldosterone: regulates sodium & potassium balance.
Adrenal medulla:
o Epinephrine & Norepinephrine: fight-or-flight response.
7. Pancreas
Has both endocrine and exocrine functions.
Endocrine cells (Islets of Langerhans) secrete:
o Insulin: lowers blood glucose.
o Glucagon: raises blood glucose.
8. Gonads (Ovaries & Testes)
Ovaries: produce estrogen and progesterone (female sex
hormones).
Testes: produce testosterone (male sex hormone).
🧲 III. Functions of the Endocrine System
Function Description
Growth & Development GH regulates tissue growth.
Metabolism Thyroid hormones control energy use.
Reproduction FSH, LH, estrogen, progesterone,
testosterone.
Homeostasis Maintains internal balance (e.g., blood
sugar, calcium).
Stress Response Cortisol and adrenaline prepare the body
to cope with stress.
⚠️IV. Endocrine Disorders
Disorder Description
Diabetes Mellitus Insulin imbalance causing high
Disorder Description
blood sugar.
Hypothyroidism Underactive thyroid; slows
metabolism.
Hyperthyroidism Overactive thyroid; increases
metabolism.
Cushing’s Syndrome Excess cortisol.
Addison’s Disease Adrenal insufficiency.
Gigantism/Acromegaly Excess GH in children/adults.
Summary
The endocrine system plays a critical role in regulating body functions
through hormone secretion. Each gland has a specific role and works in
harmony with others to maintain balance. Disruption in this system can lead
to various metabolic, developmental, or stress-related disorders. Proper
endocrine function is vital to overall health and well-being.
Sources: - Cleveland Clinic:
[Link] - Johns
Hopkins Medicine: [Link]
prevention/anatomy-of-the-endocrine-system