Scribd
Upload
5 views9 pages

Bioinformatics Course Overview and Resources

The document outlines a bioinformatics course led by Prof. Gianfranco Politano at Politecnico di Torino, detailing the materials, exam format, and course content. Key topics include DNA/RNA sequencing, machine learning applications in bioinformatics, and case studies in oncology, cardiology, and psychiatric diseases. It also features guest lectures and discussions on the clinical implications of bioinformatics.

Uploaded by

Alessandro Manera
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
5 views9 pages

Bioinformatics Course Overview and Resources

The document outlines a bioinformatics course led by Prof. Gianfranco Politano at Politecnico di Torino, detailing the materials, exam format, and course content. Key topics include DNA/RNA sequencing, machine learning applications in bioinformatics, and case studies in oncology, cardiology, and psychiatric diseases. It also features guest lectures and discussions on the clinical implications of bioinformatics.

Uploaded by

Alessandro Manera
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

BIOINFORMATICS

❖ Prof. Gianfranco Politano


❖ DAUIN, Politecnico di Torino
mail: <name>dot<surname>@[Link]
Material
❖ Course slides
❖ Scienti c research papers
❖ Web documents
❖ Short educational movies
❖ Optionally, ML and deep learning books:
❖ "Deep Learning" by Ian Goodfellow, Yoshua Bengio and Aaron Courvill, MIT Press;
❖ "Deep Learning Illustrated: A Visual, Interactive Guide to Arti cial Intelligence" (Addison-Wesley
Data & Analytics Series) by Jon Krohn, Grant Beyleveld, Aglaé Bassens. Addison-Wesley
Professional; 1 edition (August 5, 2019);
❖ others suggested during the course.
fi
fi
Exam

○ Exam
❖ Computer test on Exams platform - open/close questions about the entire course

○ When?
❖ Written test -> according to Polito exam sections’ scheduling
Course Content Overview (1)

❖ Introduction to biology and bioinformatics


❖ DNA and RNA Sequencing:
❖ Description of Next Generation Sequencing (NGS) and Third Generation Sequencing
technologies,
❖ Algorithms and tools for Sequence alignment: global and local alignment
Course Content Overview (2)

❖ Pattern Recognition and Learning algorithms:


❖ Machine Learning:
❖ Evaluating classi cation and prediction performance
❖ The classi cation paradigm: methods for feature extraction - feature selection – categorization – class balancing
❖ Supervised learning vs unsupervised learning (brief recap)
❖ Applications in bioinformatics
❖ Neural Networks (recap)
❖ Deep Learning: i.e., CNNs, BCNNs, Autoencoders, GANs
❖ Applications in bioinformatics (i.e., see below)
fi
fi
Course Content Overview (3)
❖ Networks
❖ History
❖ Theoretical Application
❖ Real examples in Bioinformatics

❖ Biostatistics:
❖ Basics of biostatistics
❖ Main problems
Course Content Overview (4)

❖ Lecture by Ferdinando Di Cunto - Molecular Biologist (Neuroscience Dept. "Rita


Levi Montalcini”) on: "Biological meaning of Sequencing data”
Course Content Overview (4)
❖ Research applications of bioinformatics
❖ Discussion about challenging real case studies derived from the clinical
practice. The case studies will concern the following fields:
❖ Oncology (markers of breast/gastric/lung cancer; precision oncology).
❖ Cardiology (e.g., diagnostic and prognostic biomarkers in ischemic stroke).
❖ Psychiatric diseases (depression, schizophrenia, autism spectrum disorders).
❖ Neurodegenerative diseases (Dementias, Parkinson’s).
❖ Expert clinicians seminars to discuss bioinformatics advantages and drawbacks
from a clinical perspective.
Let’s start with…
❖ Introduction to Biology
❖ DNA, RNA, central theorem of biology, genetic code, gene expression
❖ Gene regulatory networks, transcription factors, non coding RNAs, epigenetics
❖ CNV, ampli cation, mutations, gene fusions

❖ Introduction to Bioinformatics
❖ Sequencing data processing tools
❖ Gene regulation analysis tools
❖ Applications: personalized and precision medicine, drug design
fi

You might also like