Scribd
Upload
19 views1 page

Testosterone's Role in Anxiety and Depression

Uploaded by

bokilag280
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as TXT, PDF, TXT or read online on Scribd
19 views1 page

Testosterone's Role in Anxiety and Depression

Uploaded by

bokilag280
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as TXT, PDF, TXT or read online on Scribd

Compelling evidence exists for pervasive sex differences in pathological

conditions, including anxiety and depressive disorders, with females more than
twice as likely to be afflicted. Gonadal hormones may be a major factor in this
disparity, given that women are more likely to experience mood disturbances during
times of hormonal flux, and testosterone may have protective benefits against
anxiety and depression. In this review we focus on the effects of testosterone in
males and females, revealed in both human and animal studies. We also present
possible neurobiological mechanisms underlying testosterone's mostly protective
benefits, including the brain regions, neural circuits, and cellular and molecular
pathways involved. While the precise underlying mechanisms remain unclear, both
activational and organizational effects of testosterone appear to contribute to
these effects. Future clinical studies are necessary in order to better understand
when and how testosterone therapy may be effective in both sexes.

You might also like