How to make LSD

Note: the techniques described here are potentially dangerous. It

It is highly recommended that the physical and chemical properties of
the reagents used and the reactions employed will be subject to a more in-depth study
by people not familiar with them. For the layperson to try these
procedures without preparing well beforehand is inviting
almost certain disaster. The publishers, therefore, deny
responsibility for any damage or loss arising from improper
manipulation of chemical products and the techniques described, and strongly
to exhort all people who are not qualified to carry out the reactions of use
extraction instead of synthesis.

Chemical kitchen

Extraction of LSA (lysergic acid amide)

Morning Glory (Ipomoea Purpurea) seeds
Hawaiian Baby Woodrose seeds (Argyreia Nervosa)

NOTE: morning glory seeds may be coated with a toxic chemical

the seed company, in order to prevent ingestion. If a package of
seeds contain coated seeds this fact must be declared in
container. Soaking the seeds in hot water for 1/2 hour and
rinsing in a filter should remove this coating.

NOTE: while many varieties of morning glory contain the active LSA
Amanita of lysergic acid, the yield varies a lot. Therefore, the use
Only pearly gates, Wedding Bells, and varieties of Celestial Blue for
The best results.
Chemical kitchen follows.

Materials: blender, funnel, filter paper, petroleum ether or

lighter fluid, methanol (wood alcohol), glass bottle,
Pyrex baking dish

Moer Morning Glory or Hawaiian baby woodrose seeds in a

blender until they become a fine powder, and spread them to
dry.
Dip the powder in lighter fluid or petroleum ether. Cap
the container to avoid smoke, and do not smoke nearby, or
you are going to be very sad.

In a well-ventilated area (neither ether nor lighter fluid are

good for you), filter the solution through filter paper in a
funnel. Discard the filtration (the liquid).

Mix completely dry.

Soak in the methanol (wood alcohol) mixture for 2 days. Be careful.

-
its vapors are toxic and can be explosive.

Filter and save the filtered.

Soak the mash in methanol again for 2 more days.

Filter. Discard the mash, save the filtered.

Pour both filtered liquids onto a large flat dish and evaporate.
the absence of direct sunlight. Sunlight will break the
LSA. Preferably, perform all procedures in a cool and well...
ventilated and away from sunlight.

After evaporation, a yellow gum will remain on the plate.

Grate it.

For the dose in LSA, add a little bit of harmless filler (starch, flour,
milk sugar), for the gum until it is no longer sticky. Put in gelatin
capsules or take as it is. 30 g of morning glory seeds or 15
Havaianas seeds Woodrose baby should have a pleasant trip, so
adjust the dose accordingly.

If you want to turn LSA into LSD, you can [see below], but
It is much more difficult and much more dangerous.

2: Extraction of Amides from Lysergic Acid

Start with Morning Glory domestic seeds, the young seeds of

the Hawaiian of the wooden baby Rose, cultured carving or naturally

occurring compounds of the rye tillage.

NOTE: morning glory seeds may be coated with a toxic chemical

the seed company, in order to prevent ingestion. If a package of
seeds contain coated seeds this fact must be declared in
container. Soaking the seeds in hot water for 1/2 hour and
Rinsing in a filter should remove this coating.

NOTE: while many varieties of morning glory contain the active LSA.
(Lysergic acid amide), the yield varies greatly. Therefore, the use
Pearlized gates only, Wedding Bells, and varieties Celestial Blue for
The best results.
Reduce the seed material to a fine powder in the blender, and spread it out.

It needs to dry. Grind again if not good enough after the first.

time due to humidity.

Soak seed material in powder with lighter fluid, naphtha or

Ligroin. When fully saturated, it should have the

soup consistency.

Pour into a chromatographic column and let it rest overnight.

Remove the greasy oils from the material by dripping.

slowly solvent through the column, and testing the liquid that

comes through fats by evaporation of a drop on clean glass

until it doesn't leave a greasy film. (It must have several

grams of solvent for each gram of seeds.

Mix 9 volumes of chloroform with 1 volume of concentrate

ammonium hydroxide and agitation in a separating funnel. When

settle, the chloroform phase will be at the bottom. Drain

the layer of chloroform and discard the upper layer.

Drip the chloroform wash through the column and keep the

extract. continuously test by evaporating a drop in cleaning

glass until it stops fluorescing.

She is not explicit in the source, but if you extract

from the sowing of rye, I would like to start with the alkaloid base of the cravage
I do rye in

this point. - Ed.

Evaporate the chloroform extracts and dissolve the residue in

the minimum amount of a 3% tartaric acid solution. If all the

the residue does not dissolve, put it in suspension by stirring

vigorously.
Color of the solution with an acid-base indicator, and titrator of

find the approximate number of moles of the present alkaloid.

Transfer the solution to a decantation funnel, and wash it.

another ship with acid, in order to obtain all the alkaloids out.

Pour the washing liquid into the funnel as well.

Bring the pH to make the solution basic by the addition of sodium

a solution of bicarbonate, and add an equal volume of chloroform.

Shake well, let it settle, remove the background layer and

reserve.

Again add an equal portion of chloroform, shake, let's solve it.

and remove the bottom layer.

Combine chloroform extracts (lower layer) and evaporate.

The remaining residue, after evaporation, is a semi-pure.

LSA concentrate (lysergic acid amide). The amide requires

some experimentation for the dosage, but 1 mg of the concentrate
it's a reasonable starting point. 1 mg LSA will produce effects

comparable to 100 micrograms of LSD.

3: Ergot culture

NOTE: Contact with the compounds of rye clearing can be dangerous. Only after
is of one
basic understanding of the techniques used in manipulation of
dangerous or toxic organisms is achieved if one should proceed with
the culture of rye cultivation.

The need for absolute sterility cannot be emphasized.

any elementary text on bacteriology for the correct equipment and
procedures. Avoid prolonged contact with compounds from the rye seed.
like them
they are toxic and can be fatal.
A) Obtain a source of the fungus Claviceps Purpurea

If no source can be found, you can take a field trip to obtain

he

this from rye or other cereal grasses. Ryegrass is the best

choose. The stamping will appear as a dark growth in

rye fields, where the seeds are. They are approximately

the same way as the seeds and are referred to as "heads" or

"Ergot". From these heads or spikes sprout the Claviceps.

Purple fungi.

They have long stems and bulbous heads when viewed under a

strong glass or microscope. These are the ones that must be removed.

from the planting, free from contamination, and used to inoculate

the culture material.

B) Make a culture medium

Combine the following ingredients in about 500 ml of distilled liquor.

water in a small bottle neck to 2 L:

Sucrose 100 g

Chickpea meal 50 g

1 g calcium nitrate

Calcium nitrate

Monopotassium phosphate 0.25 g

Potassium Dihydrogen Phosphate

Magnesium sulfate 0.25 g

Magnesium sulfate

Potassium chloride 0.125 g

KCl

Ferrous sulfate heptahydrate 8.34 mg

FeSO4? 7H2O

Zinc sulfate heptahydrate 3.44 mg

ZnSO4? 7H2O

Add water to make one liter

Adjust to pH 4 with a solution of ammonia and citric acid

Sterilize in autoclave

C) Make a culture

Inoculate the sterilized medium with Claviceps purpurea in

sterile conditions, cork with sterilized cotton and

incubate for two weeks, monitor the test periodically and maintain

pH 4. After two weeks of a surface culture, it can be seen in

Medium. Large-scale production of the fungus can now begin.

D) Large-scale production

Get several common gallons 1.

Place a two-hole cork in the neck of the jars.

Mount a short tube (6 inches) in a hole, leaving two centimeters.

On top of the lid. Install a short rubber tube for this. Fill it with a

small flask (500 ml) of Erlenmeyer with a diluted solution of

sodium hypochlorite (NaClO). Extend a glass tube from the

rubber so that the end is immersed in hypochlorite.

Mount a long glass tube into the other cork hole. It should

get close to the bottom of the nozzle, and have about two centimeters

showing above the cork. Attach a rubber tube to the glass

tube and fit a short glass tube to the end of the rubber tube.

Fill a large glass tube (1" x 6") with sterile cotton and fit it in.

stoppers of a hole at the ends. Fit the small glass tube in

the end of the rubber tube in a cork of the large tube.

Mount another small glass tube for the other stop. The rubber
the tube is connected to this and fixed to the small air pump

(Obtained from a tropical fish store).

With this aeration equipment, you can ensure a supply of clean energy.

to the fungus Claviceps purpurea, maintaining a

sterile environment inside the solution.

Dismantle the aerators. Place all the glass and rubber tubes.

tubes, corks, and cotton in a paper bag, close tightly with

wire staples and sterilize in autoclave.

Fill the 1-gallon jars from 2/3 to 3/4 with the culture medium

and autoclave.

While these things are being sterilized, homogenize in a

blender the culture already obtained and use it to inoculate

the material in the containers. The mixer must be sterile.

Everything must be sterile.

Install the aerators. Start the pumps. A slow bubbling

each jar will provide enough oxygen for the crops. A single

the pump can be connected to several filters.

Let everything rest at room temperature (25 º C) in a dark place

(Never expose alkaloids from rye ergot to bright light - they will

decompose) over a period of ten days.

After ten days, the culture is adjusted to 1% ethanol using 95%.

ethanol under sterile conditions. Maintain the growth for another

two weeks.

E) Alkaloid extract of rye clover

After a total growth period of 24 days, the crop must be

considered mature. Make the acid culture with tartaric acid

and homogenize in a mixer for an hour.

Adjust the pH to 9 with ammonium hydroxide and extract with

benzene or chloroform / iso-butanol mixture.

Extract again with alcoholic tartaric acid and evaporate in a ...

vacuum until dryness.

The dry material is salt (tartaric acid salt, the

(tartaric acid) of the alkaloids from rye ergot, and it is stored in this form

because the basic free material is very unstable and decomposes

promptly in the presence of light, heat, moisture, and air.

To recover the free base for the extraction of the amide or

synthesis of LSD, make the basic tartrate with ammonia at pH

9, it is extracted with chloroform, and evaporated in vacuum.

4: Synthesis of LSD from rye grass alkaloids or LSA

(Including sections on isomerization, separation,

purification and crystallization

NOTE: the chemical products and reactions described below are potentially
dangerous even for an organic chemist in a well-equipped laboratory.

As editors, therefore, deny responsibility for any damage or

injury resulting from improper handling of chemicals and
described techniques, and I highly recommend them to all people without reservations
carry out the reactions, instead of using the comparatively easier one,
safe cravagem culture and LSA extraction process.

A) Synthesis of LSD

(Iso-e diethylamide of lysergic acid-dextro)

PREPARATORY: obtain a red and a yellow photographic safety

light is a weak long-wave ultraviolet light. These are used for
prevent the hydrolysis of lysergic acid compounds.

NOTE: Aluminum foil should be used to cover the chemicals when the l
uz
is present. Rubber gloves must be used, these compounds are
extremely poisonous.

The source implies, but does not state that it can be replaced

Alkaloid ergot

Pure LSA concentrate #2. - Ed.

Using the YELLOW light:

Place a volume of alkaloid from the rye clove in a small round base.

Balloon. Add two volumes of anhydrous hydrazine and reflux for 30.

minutes, or the mixture can be heated in a sealed tube at 112

Heat at Celsius for 30 minutes. If the reflux technique is used,

maintain atmospheric pressure through an open container or

fractionation of the column.

After heating/reflux, add 1.5 volumes of water to

mix and let simmer for 15 minutes. After boiling it is

completed, cool the mixture in a refrigerator until

solidification. The solid material obtained is iso-lisergic

hydrazide of the acid.

Using RED light:

Cold all chemical products (reagents), to be used at 0 degrees Celsius

Place

In an open jar in an ice bath. Add 100 ml of concentrate.

hydrochloric acid (cooled to 0 °C).

Quickly add 2.82 g of lysergic acid hydrazide.

hydrochloric acid, taking care to maintain a temperature

0 Celsius.

100 ml of a 0.1 N (1/10th Normal) sodium solution is added.

nitrite (cooled to 0 °C) and shaken vigorously for 3 minutes.

Continue stirring at 0 degrees Celsius and add 130 ml drop by drop.

hydrochloric acid.

When the addition of acid is complete, stirring continues for 5

minutes, then neutralize the solution with baking soda,

using a saturated aqueous bicarbonate solution.

Extract the solution with ether, remove the water layer, and

dissolve the pasty substance in ether. Add ether to this

layer.

Add 3 g of diethylamine for every 30 ml of the ether extract.

Leave this support in the dark and gradually heat it to 20

Celsius for at least 24 hours.

This solution is evaporated in a vacuum.

The remaining material is a mixture of inactives.

lysergic acid diethylamide and the active lysergic acid

diethylamide (LSD-25). The inactive isomer must now be

converted (isomerized) to the active isomer for much

increase yield, since the inactive compound predominates

in this synthesis.

B) Isomerization of iso-LSD to the active LSD-25

USE OF RED LIGHT:

Dissolve the synthesized material in the minimum quantity of

ethanol.

Mix a 4 normal solution of potassium hydroxide in ethanol.

The amount of solution needed is twice the volume of the

iso-LSD/ethanol solution.

Add the two solutions together and let the mixture rest for 4.

hours at room temperature.

The mixture is neutralized with diluted hydrochloric acid, then

they become slightly basic with ammonia hydroxide.

The mixture is extracted with chloroform, the chloroform separates.

layer and extract these four times with a volume of 25% water.

Chloroform evaporates under vacuum. Discard the water.

extracts. The material left after evaporation in a mixture of

iso-LSD and LSD-25, the predominance of active LSD.

The mixture can now be separated by chromatography and the

iso-LSD again isomerized by the above process.

C) Separation, purification and crystallization of LSD-25

USE a dark room:

The material obtained from the isomerization process is now

It dissolved in a solution prepared from 3 parts of benzene / 1 part.

chloroform. Use 50 ml of solvent per 1 gram of LSD material.

Mix a basic aluminum paste in benzene. Pack it in a 1-inch one.

chromatography column up to 6 inches filled.

When the leachate settles, drain the benzene / chloroform until

the level of basic alumina, and carefully add an equal

amount of LSD / solvent solution.

USING A WEAK, LONG-WAVE ultraviolet light:

(Next to the blue stripe only)

Drain the solution through the column. The fastest in motion,

The blue fluorescent band contains LSD-25. Collect this.

fraction and evaporated in the vacuum. The remaining syrup

crystallize spontaneously, but slowly. Do not heat.

Use only the welcoming UV light, it is necessary to follow the blue band.

to prevent the decomposition of the compounds.

Dissolve the syrup or a crystal in a solution of tartaric acid and

It recrystallizes to form the stable final product (dextro lysergic)

diethylamide tartrate of acid

The remaining material in the column can be removed with

methanol, evaporated in a vacuum, and recycled through the

isomerization and subsequent procedures by themselves or combined

with fresh material.

Furthermore, all solutions and the remaining waste can be neutralized.

sodium with bicarbonate, evaporated under vacuum, and extracted

with ammoniacal chloroform, the extract was evaporated to dryness,

and the waste was reused.

5: Preparation of lysergic acid from the amide

NOTE: this synthesis is as difficult and dangerous as the rest, and
It is for use only if using one of the following two LSD syntheses.
methods that require lysergic acid as the starting compound. The
amides of lysergic acid obtained from the extract of clove or seeds
it does not need to be converted to acid before its use in the synthesis
do LSD, since the synthesis is used as 4 given above, and
give the starting material "ergot alkaloid".

Dissolve 10 g of lysergic acid amide in 200 ml of methanol.

potassium hydroxide solution.

Remove the methanol under vacuum as soon as the amide is.

dissolved.

The residue left in 200 ml of an 8% solution dissolves.

potassium hydroxide solution in water.

Heat this mixture in a steam bath for 1 hour.

Pass a stream of nitrogen gas through the flask during the

heating process. (The ammonia, which is formed in the gas

flow can be titrated with hydrochloric acid in order to

follow the reaction.)

Neutralize the mixture with tartaric acid (neutral for Congo)

red) and execute it through a filter paper.

The mixture is extracted with ether in a separating funnel. Save.

the layer of water, remove the layer of ether.

Filter the solution through a paper filter and evaporate.

After evaporation, the dry crystals of lysergic acid will be

obtained.

# 6: Synthesis of LSD
using lysergic acid

the fastest way to make pure LSD-25

PREPARATORY: see # 4

NOTE: The chemicals and techniques described are potentially

dangerous. It is highly recommended that physics and chemistry
properties of the reagents used to be studied by those people
familiar with them before the synthesis is attempted.

USING the yellow light:

5.36 g of d-lysergic acid are suspended in 125 ml

acetonitrile, and the suspension is cooled to about -20

Celsius in a bath of acetone cooled with dry ice.

A cold solution (-20 °C) of 8.82 g is added to the suspension.

of trifluoroacetic anhydride in 75 ml of acetonitrile. The

mixture is left to rest at -20 C for approximately 1 1/2 (one and

half) hours.

(During this time, the suspended material dissolves and the

d-lysergic acid converted into mixed anhydride

lysergic and trifluoroacetic acids.

The mixed anhydride can be separated in the form of an oil by

evaporation of the solvent in vacuum at a temperature below about

0 degrees Celsius.

Everything that must be kept anhydrous.

USE OF RED LIGHT:

The solution of mixed anhydrides in acetonitrile from above is

added to 150 ml of acetonitrile containing 7.6 g of

diethylamine.

The mixing is done in the dark at room temperature for about

2 hours.

The acetonitrile is evaporated under vacuum, leaving a residue of

LSD-25, besides impurities.

The residue is dissolved in 150 ml of chloroform and 20 ml of

of cold water.
The chloroform layer is removed and the aqueous layer is

was extracted with several portions of chloroform. The chloroform

They are portions that are combined and, in turn, were washed with 50 ml of four.

cold water portions.

The chloroform solution is then dried over anhydrous sodium sulfate.

potassium sulfate and evaporated in vacuum.

NOTE: after completing this summary, follow the
procedures described for separation, purification, and
crystallization of LSD-25. If a higher yield is desired, follow
the procedure in isomerization after making the separation,
purification and crystallization.

7: Synthesis of LSD

using lysergic acid

high yield and fast

PREPARATORY: see # 4

NOTE: The chemicals and techniques described are potentially

dangerous. It is highly recommended that physics and chemistry
properties of the reagents used to be studied by those people
familiar with them before the synthesis is attempted.

NOTE: The following procedure yields good results and is very quick,
with little iso-lysergic acid to be produced. However, the
stoichiometry must be exact or the yield will drop

Using WHITE light:

Sulfur trioxide is produced in an anhydrous state with care.

decomposition of anhydrous ferric sulfate at about 480

Celsius. Store under anhydrous conditions.

Using WHITE light:

A round bottom dry balloon per liter carefully equipped with a bath
and ice,

a funnel for addition, a mechanical stirrer, and it is loaded with 10 to

11 liters of dimethylformamide (freshly distilled under

reduced pressure).

The condenser and decantation funnel are both protected against

atmospheric humidity.

2 £ of sulfur trioxide (Sulfan B) is introduced, drop by drop,

cautiously, with agitation, for 4 to 5 hours. The

the temperature is maintained at 0-5 degrees Celsius during the addition.

After the addition is complete, the mixture is stirred for 1

from 2 hours to some separated-crystalline sulfur trioxide

dimethylformamide complex dissolved.

The reagent is transferred to a watertight automatic pipette.

convenient to dispense, and kept in the cold. Although the

reagent, which is colorless, can change to yellow and red.

efficiency remains intact for three to four months of cold

storage.

A sample is dissolved in water and titrated with the standard solution.

NaOH to a phenolphthalein endpoint.

Using the RED light:

A solution of 7.15 g of mono-hydrate of d-lysergic acid (25 mmol)

1.06 g of lithium hydroxide hydrate (25 mmol) in 200 L of

MeOH is prepared.

The solvent is removed by distillation in a steam bath under reduced pressure.

pressure.

The glass waste such as lithium is dissolved in lysergate.

400 ml of anhydrous dimethylformamide.

From this solution, about 200 ml of dimethylformamide is

distillation at 15 millimeters of pressure through a 12-inch helix

packed column.

The resulting solution of anhydrous lithium lysergate left

it is cooled to 0 degrees Celsius and treated with agitation

quickly with 500 ml of SO3 solution? DMF (1.00 molar).

The mixture is stirred in the cold for 10 minutes and then

9.14 g (125.0 mmol) of diethylamine is added.

The agitation and cooling continue for another 10 minutes.

when 400 ml of water is added to decompose the reaction

complex

After carefully mixing, 200 ml of saturated aqueous saline solution

solution is added. The amide product is isolated by repeated

extraction with portions of 500 ml of dichloroethane.

The combined extract is dried and then concentrated into a syrup.

under reduced pressure. Do not heat the syrup during

concentration. LSD can crystallize, but the crystals

and the mother liquor can be chromatographed according to the

instructions on the synthesis of LSD # 4.