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Overview of Cell Anatomy and Function

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10 views4 pages

Overview of Cell Anatomy and Function

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© All Rights Reserved
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ANATOMY AND PHYSIOLOGY

TOPIC: CELL
REFERENCE: ESSENTIAL OF HUMAN ANATOMY (EIGHT EDITION) BY ELAINE MARIEB
PROFESSOR: MA. ROSARIO MEÑEZ-QUEJADO, RMT, Ed.D.

Cell
Functional unit of all living things.
Cell Theory:
a. All living things are made up of cell.
b. Cell is the smallest unit of structure and function of life.
c. The cell came from a pre-existing cells.
Types of Cell
1. Prokaryotic
- no true nucleus
- energy is produce in reaction with in the cell membranes.
2. Eukaryotic
- with true nucleus
- energy produced with in the mitochondria
Major Parts of Eukaryotic Cell
1. Cell Membrane
2. Nucleus
3. Cytoplasm
Cell Membrane
Composed of bilayer phospholipids attached to or embedded in protein.
Regulates passages of nutrients, waste products and secretion in and out of cells.
With selective permeability.
Also called plasma membrane
Can easily pass through are the glucose, amino acid, minerals, nutrients, O₂, CO₂
Bilayer Phospolipids
Head part- hydrophilic , loves water, pole near water.
Tail part- hydrophobic, hates water, pole away from water.
Protein
Floating in lipid portion
Can be:
enzyme carrier receptors transport
binding site: hormones and chemical messenger
GLYCOPROTEIN
Determine the blood type, receptors for bacteria, viruses, toxins cell to cell interaction
* any changes that occurs may transformed into Cancer Cell.
Diffusion
Movement of water from higher concentration to lower concentration
Diffusion Process:
Passive diffusion
Facilitated diffusion
Active transport
Endocytosis/Exocytosis
Osmosis
Diffusion of water to a semi permeable membrane.
Solution
A homogenous mixture of two or more substances.
Ex. Air we breath (mixture of gases)
Sea water( mixture of salts and H₂O)
Rubbing alcohol ( mixture of H₂O & alcohol)
Composition:
Solute- the dissolved substance in a solution.
Solvent- dissolving medium in a solution.
Type of Solution
Isotonic- equal concentration of solute and solvent. (NO CHANGE on CELL)
Hypertonic- ↑ solute,↓ solvent (CELL will SHRINK)
Hypotonic- ↓ solute, ↑ solvent ( CELL will SWELL )
Factors Influencing permeability of cell
Lipid solubility
Size of the pores
Electrical charges
Nucleus
Nuclear membrane
- contains holes through which large molecules can enter
Nucleoplasm
- with gelatinous matrix this is like the cytoplasm.
a. Nucleolus-sites where ribosomes are assembled. Ribosomes migrates
in cytoplasm and serve as protein synthesis.
b. Chromatin/ Chromosomes
if cell is not dividing : DNA + protein forms CHROMATIN (scattered in the nucleus)
if cell is dividing : Chromatin threads coils & condense to form CHROMOSOMES
Cytoplasm
Semi fluid, gelatinous nutrient matrix . Site of most cells metabolic reactions
Composition:
a. Cytosol – semitransparent fluid with H₂O, nutrients, dissolve substances (solutes)
b. Inclusion- this is not a functioning units , stores nutrients or cell products like:
fat droplet, glycogen granules, pigments (ex. Melanin), mucus, crystals
c. Organelles- metabolic machinery of cells.
1. Ribosomes- free in cytoplasm or in membranes.
2. Endoplasmic Reticulum- mini circulatory system.
2.1 Rough Endoplasmic Reticulum- abundant in cells that export
protein product. ex. Pancreas cells- deliver digestive enzymes to
be deliver to the small intestine.
2.2 Smooth Endoplasmic Reticulum
- cholesterol synthesis and breakdown fat metabolism and detoxification of drug.
- abundant in LIVER
- steroid based hormones- cell testes that manufacture testosterone.
2.3 Golgi Apparatus
- traffic director for cellular protein.
- the protein accumulate in golgi apparatus with swollen ends travel
to the plasma membrane-> pinch off and form secretory vesicle
which travel to the plasma membrane. (Exocytosis)
2.4 Lysosomes
- demolition site - WBC
- membrane of lysosomes are stable but become fragile if without O₂ and ↑ Vit. A and results in self
digestion of
the cell.
2.5 Peroxisomes
-seen in kidney cells and liver
- membranous sacs with powerful oxidase enzymes that use O₂ to detoxify poisonous substances including
alcohol an formaldehyde.
- disarm dangerous free radicals (by products of cell metabolism harmful if accumulated,
unpaired electrons that scramble the structure of proteins & nucleic acids).
*Peroxisome convert free radicals to hydrogen peroxide (H₂O₂) and in the presence of enzyme catalase
convert excess H₂O₂ to water.
2.6 Mitochondria
- double wall equal to 2 plasma membrane
outer membrane- smooth
inner membrane- shelf like protrusion called CRISTAE.
- Enzymes in the fluid of mitochondria plus enzymes of cristae membrane will carry
reaction in which O₂ is used to breakdown food.
Food breakdown -> energy release-> some energy will become HEAT
other will be captured and used to form ATP molecules that is used for all cellular works.
Ex. Liver & Muscles with huge ATP .
cell like unfertilized eggs- mitochondria is few.
2.7. Cytoskeleton
- bones and muscle cell
- function: cell shape, support organelles, provide machinery needed for intracellular transport and
cellular movement.
- made up of :
a. Microtubules- cell division, overall shape and distribution of organelle.
b. Intermediate Filaments-desmosomes
c. Microfilaments- (Actin & Myosin)- cell motility and change in cell shape.
2.8. Centrioles
- directs the formation of mitotic spindle.
- with fine microtubules internally.
a. Cilia- formed by multiplying centrioles and line beneath the plasma membrane and
free at the cell surface. Ex. Lung cell.
b. Microtubules- sprout from centrioles and pressure on membrane forming
projections .
c. Flagella- longer projections.
ex. Sperm cells.
Cell life cycle
Cells have two major periods
Interphase
Cell grow, Cell carries on metabolic processes
Cell division
Cell replicates itself
Function is to produce more cells for growth and repair processes
Genetic material duplicated and readies a cell for division into two cells
Occurs toward the end of interphase
DNA uncoils and each side serves as a template
Events of Cell Division
Mitosis
Division of the nucleus
Results in the formation of two daughter nuclei
Cytokinesis
Division of the cytoplasm
Begins when mitosis is near completion
Results in the formation of two daughter cells
Stages of Cell Division
Interphase
No cell division occurs
The cell carries out normal metabolic activity and growth
Prophase
First part of cell division
Centromeres migrate to the poles
Metaphase
Spindle from centromeres are attached to chromosomes that are aligned in the
center of the cell
Anaphase
Daughter chromosomes are pulled toward the pole
The cell begins to elongate
Telophase
Daughter nuclei begin forming
A cleavage furrow (for cell division) begins to form
Protein Synthesis
Gene – DNA segment that carries a blueprint for building one protein
Proteins have many functions
Building materials for cells
Act as enzymes (biological catalysts)
RNA is essential for protein synthesis
Types of RNA
Transfer RNA (tRNA)
Transfers appropriate amino acids to the ribosome for building the protein
Ribosomal RNA (rRNA)
Helps form the ribosomes where proteins are built
Messenger RNA
Carries the instructions for building a protein from the nucleus to the ribosome
Transcription
Transfer of information from DNA’s base sequence to the complimentary base
sequence of mRNA
Translation
Base sequence of nucleic acid is translated to an amino acid sequence
Amino acids are the building blocks of protein.

Common questions

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ATP is generated in mitochondria through a process known as oxidative phosphorylation, which involves the breakdown of food in the presence of enzymes and oxygen. The inner mitochondrial membrane's cristae provide a site for reactions where nutrients are oxidized, releasing energy. This energy is used to convert ADP to ATP, which is the main energy currency for cellular activities, sustaining processes such as muscle contraction, nerve impulse propagation, and biochemical synthesis, indicating its critical role in cellular functions .

Lysosomes contain digestive enzymes that break down waste materials and cellular debris, functioning as the cell's demolition site. They play a role in cell self-digestion if deprived of oxygen or in cases of excess vitamin A . Peroxisomes, on the other hand, contain oxidase enzymes that detoxify harmful substances and neutralize free radicals. They convert free radicals to hydrogen peroxide, which is then converted to water by catalase. Although both are involved in detoxification, lysosomes degrade larger organic materials, while peroxisomes deal with smaller toxic substances .

The Golgi apparatus is critical in modifying, sorting, and packaging proteins for secretion or for use within the cell. It functions as a 'traffic director,' determining the destination of proteins produced in the endoplasmic reticulum. By adding molecular tags, the Golgi ensures that proteins are accurately targeted to specific locations, such as lysosomes or the cell surface. This precision in protein targeting prevents malfunctions and is fundamental for correct cell function and intercellular communication .

The phospholipid bilayer is essential for maintaining cellular integrity and function by providing a barrier that regulates the entrance and exit of substances. Its amphipathic nature, with hydrophilic heads and hydrophobic tails, creates a selectively permeable membrane, crucial for homeostasis. It supports cell signaling, ion conductivity, and energy transduction. By compartmentalizing cellular environments, it facilitates efficient functioning and separation of different biochemical pathways .

Centrioles play a pivotal role in cell division by directing the formation of the mitotic spindle, a structure composed of microtubules. This spindle apparatus is crucial for the segregation of chromosomes during mitosis, ensuring that each daughter cell receives the correct number of chromosomes. The formation of the spindle fibers from centrioles helps align chromosomes in the metaphase stage and facilitates their movement in anaphase, underscoring the importance of centrioles in accurate genetic material distribution .

Ribosomal RNA (rRNA) facilitates protein synthesis by forming the structure of ribosomes, which are the sites where protein assembly occurs. During translation, rRNA ensures the proper alignment of messenger RNA (mRNA) and transfer RNA (tRNA), which brings amino acids to the ribosome. The ribosomes use the sequence of mRNA to determine the specific order of amino acids needed to form a protein, demonstrating rRNA's crucial integrative role in the translation process of protein synthesis .

During cell division, chromatin condenses into distinct chromosomes to facilitate the accurate distribution of genetic material. This transformation compacts the DNA, making it easier to segregate without entangling or breaking. Chromosomes ensure that each daughter cell receives the exact genetic information, which is crucial for maintaining genetic continuity and ensuring the organism's development and function .

The cell membrane's selective permeability is facilitated by its structure, composed of a bilayer of phospholipids with embedded proteins. The hydrophilic head of the phospholipids faces outward towards the aqueous environment, while the hydrophobic tails face inward, creating a barrier that prevents the free passage of ions and polar molecules. This structure allows small nonpolar molecules, such as O₂ and CO₂, to diffuse easily, while other substances require specific transport proteins to cross the membrane .

The rough endoplasmic reticulum (RER) is studded with ribosomes, which are sites for protein synthesis. This organelle plays a crucial role in the synthesis and export of proteins. Cells that produce large quantities of protein for secretion, such as pancreas cells that deliver digestive enzymes, have an abundant RER. The proteins synthesized are transported within the RER to various parts of the cell or are exported outside the cell, demonstrating its significance in cellular function .

Diffusion involves the movement of particles from an area of higher concentration to an area of lower concentration, which can apply to various molecules such as gases and solutes across the cell membrane. Osmosis, a specific type of diffusion, refers strictly to the movement of water molecules across a semi-permeable membrane from an area of lower solute concentration to higher solute concentration . Both processes are passive, but osmosis specifically pertains to water, whereas diffusion encompasses a broader range of substances.

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