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Animals Unable to Synthesize Vitamin C

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Rushi Kapdi
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0% found this document useful (0 votes)
10 views12 pages

Animals Unable to Synthesize Vitamin C

Uploaded by

Rushi Kapdi
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

 HOME ASSIGNMENT 1

 NAME OF FACILITOR: - Dr. Riddhi

 Vitamin C (Ascorbic Acid): -


Vitamin C, also known as ascorbic acid, is a water-soluble vitamin essential
for various bodily functions. Unlike most animals, humans cannot synthesize
it and must obtain it through diet.
 Functions of Vitamin C:
✅ Antioxidant – Neutralizes free radicals and reduces oxidative stress.
✅ Collagen synthesis – Vital for healthy skin, blood vessels, tendons,
ligaments, and bones.
✅ Iron absorption – Enhances absorption of non-heme (plant-based) iron.
✅ Immune support – Boosts immune defense by supporting various cellular
functions.
✅ Wound healing – Supports tissue repair and healing processes.
✅ Neurotransmitter synthesis – Involved in production of norepinephrine
and other brain chemicals.
 Sources of Vitamin C:
Fruits: Oranges, guavas, kiwi, strawberries, lemons, amla (Indian
gooseberry)
Vegetables: Broccoli, bell peppers, spinach, kale, tomatoes
 Daily Requirements:
Adults (Male): ~90 mg/day
Adults (Female): ~75 mg/day
 Deficiency – Scurvy
Symptoms: Fatigue, gum bleeding, poor wound healing, joint pain, anemia,
skin spots
Seen in: Malnourished individuals, alcoholics, elderly, people with restrictive
diets
 Excess Intake (Toxicity):
Rare due to water solubility, but very high doses (>2000 mg/day) may cause:
Nausea, diarrhea
Kidney stones (especially in people with kidney issues)
 Special Notes:
Not part of the Vitamin B complex because it differs in function and chemical
structure.
Heat and light destroy vitamin C, so raw fruits/vegetables are best.
 HOME ASSIGNMENT 2
 NAME OF FACILITOR: - Dr. Parin

 Here’s a concise yet complete overview of Iron:


 Iron
Iron is an essential mineral required for numerous physiological functions,
most importantly the transport of oxygen in the blood.
 Functions of Iron:
🔴 Hemoglobin – Carries oxygen in red blood cells
🧠 Myoglobin – Stores oxygen in muscles
⚙️ Enzymes – Part of enzymes involved in energy production and DNA
synthesis
🛡️ Immunity – Supports immune system function
🧠 Cognitive performance – Crucial for brain development and mental
performance
 Types of Dietary Iron:
Heme iron – Found in animal sources (e.g., meat, liver, fish); easily absorbed
Non-heme iron – Found in plant sources (e.g., spinach, lentils, beans); less
efficiently absorbed
 Absorption Enhancers & Inhibitors:
✅ Enhancers:
Vitamin C (ascorbic acid) – Converts iron into a more absorbable form
Animal protein – Helps in heme iron absorption
❌ Inhibitors:
Phytates (in cereals, legumes)
Calcium (milk, supplements)
Polyphenols (tea, coffee)
 Daily Requirements (RDA):
Adult men: 8 mg/day
Women : 18 mg/day
Pregnant women: 27 mg/day
 Deficiency – Iron Deficiency Anemia:
Symptoms:
Fatigue, pale skin, weakness
Shortness of breath, dizziness
Cold hands/feet, brittle nails
Causes:
Poor diet, blood loss (e.g., menstruation, ulcers), absorption issues
 Excess Iron (Iron Overload):
From excess supplements or hereditary hemochromatosis
Can cause:
Liver damage, joint pain
Diabetes, heart disease
Children are at higher risk of toxicity from overdose
 HOME ASSIGNMENT 3
 NAME OF FACILITOR: - Dr. Nandita

Folic Acid (Vitamin B9) –


Folic acid is the synthetic form of folate, a B-complex vitamin (B9) that is
water-soluble and essential for DNA synthesis, cell division, and red blood
cell formation.
 Functions of Folic Acid / Folate:
🧠 DNA & RNA synthesis – Crucial for cell growth and repair
🧠 Red blood cell formation – Prevents megaloblastic anemia
👶 Fetal development – Prevents neural tube defects (e.g., spina bifida) in
early pregnancy
🧠 Brain health – Supports neurotransmitter function and mental clarity
⚙️ Amino acid metabolism – Works with B12 in converting homocysteine
to methionine
 Daily Requirements (RDA):
Adults: 400 mcg/day
Pregnancy: 600 mcg/day
Breastfeeding: 500 mcg/day
 Natural Sources of Folate (Vitamin B9):
Leafy greens: Spinach, kale, mustard greens
Legumes: Lentils, chickpeas, black beans
Fruits: Oranges, bananas, avocados
Others: Eggs, fortified cereals, liver
 Deficiency of Folic Acid:
Causes:
Poor diet
Alcoholism
Malabsorption (e.g., celiac disease)
Certain medications (e.g., methotrexate, phenytoin)
Symptoms:
Fatigue, weakness
Irritability, shortness of breath
Pale skin
Megaloblastic anemia (large, immature red blood cells)
In pregnancy: ↑ Risk of neural tube defects (NTDs)
 Folic Acid Supplementation:
Recommended before and during pregnancy (start at least 1 month prior to
conception)
Common dose: 400–600 mcg/day
Used in combination with Vitamin B12 for treating anemia
 HOME ASSIGNMENT 4
 NAME OF FACILITOR: - Dr. Dhruvin

🧠 Calcium –
Calcium is the most abundant mineral in the human body, essential for bone
health, muscle function, nerve transmission, and blood clotting. About 99%
is stored in bones and teeth.
 Functions of Calcium:
🧠 Bone and teeth formation – Major structural component
💓 Muscle contraction – Including heart muscle
🧠 Nerve impulse transmission
🧠 Blood clotting – Activates clotting factors
🧠 Enzyme and hormone function
 Dietary Sources of Calcium:
🥛 Dairy: Milk, cheese, yogurt
🐟 Fish with bones: Sardines, salmon
🧠 Leafy greens: Kale, bok choy (note: spinach is high in oxalates, lowers
absorption)
🌰 Nuts/seeds: Almonds, sesame
🍊 Fortified foods: Orange juice, cereals, plant milks (soy, almond)
 Calcium Absorption:
✅ Enhanced by:
Vitamin D
Acidic environment (stomach acid)
❌ Inhibited by:
Phytates (in grains, legumes)
Oxalates (in spinach, rhubarb)
Excess sodium, caffeine, or iron supplements
 Deficiency of Calcium (Hypocalcemia):
Causes:
Poor intake, Vitamin D deficiency
Malabsorption (e.g., celiac, Crohn’s)
Postmenopausal women (estrogen drop)
Symptoms:
Muscle cramps, spasms (tetany)
Numbness/tingling (paresthesia)
Weak bones → Osteopenia, Osteoporosis
Delayed growth in children
 Calcium Excess (Hypercalcemia):
Usually due to over-supplementation or hyperparathyroidism
Symptoms:
Kidney stones
Constipation
Confusion, fatigue
Abnormal heart rhythm

 Types of Supplements:
Calcium carbonate – Requires food for absorption
Calcium citrate – Better absorbed, even without food
 HOME ASSIGNMENT 5
 NAME OF FACILITOR: - Dr. Riddhi

Vitamin B12 –
Vitamin B12, also known as cobalamin, is a water-soluble B vitamin essential
for nerve function, red blood cell formation, and DNA synthesis. Unlike most
other vitamins, B12 contains cobalt, hence the name cobalamin.2. Functions
of Vitamin B12:
🧠 Maintains nerve cells and forms the myelin sheath
🧠 Helps in red blood cell production – Prevents megaloblastic anemia
🧠 DNA synthesis – Works with folate (vitamin B9)
⚙️ Amino acid metabolism – Converts homocysteine to methionine
🧠 Energy production – Helps convert food into usable energy
 Daily Requirements (RDA):
Adults: 2.4 mcg/day
Pregnant women: 2.6 mcg/day
Breastfeeding women: 2.8 mcg/day
 Sources of Vitamin B12:
Vitamin B12 is found only in animal-based foods, unless fortified.
🧠 Meat: Liver, beef, chicken
🐟 Fish: Salmon, tuna, sardines
🥚 Eggs and dairy: Milk, yogurt, cheese
🧠 Fortified foods: Breakfast cereals, plant-based milk (e.g., soy, almond)
💊 Supplements: B12 tablets or injections (for deficiency or vegan diets)
 Absorption Process:
Requires stomach acid and a protein called intrinsic factor (IF) produced by
stomach lining
Absorbed in the terminal ileum of the small intestine
Problems with IF or stomach surgery (e.g., gastrectomy) can cause deficiency
 Deficiency – Causes & Symptoms:
Causes:
Vegan or vegetarian diet (no animal products)
Pernicious anemia (autoimmune destruction of IF)
Gastric surgery (e.g., bariatric surgery)
Elderly – Decreased stomach acid
Malabsorption disorders – Crohn’s, celiac
Symptoms:
Fatigue, weakness
Numbness/tingling in hands and feet (neuropathy)
Memory loss, confusion
Glossitis (inflamed tongue)
Megaloblastic anemia
Gait disturbance or balance problems
 Treatment of Deficiency:
Oral supplements (cyanocobalamin or methylcobalamin)
Intramuscular B12 injections – For severe or malabsorption-related cases
Dietary adjustment – Include more B12-rich foods or fortified options
 Special Notes:
Works closely with folic acid (B9) – Both needed for red blood cells
Long-term deficiency can lead to irreversible nerve damage
B12 is not toxic even in high doses

Common questions

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Folate and Vitamin B12 are crucial in the conversion of homocysteine to methionine, an essential process in amino acid metabolism. Deficiencies in either vitamin result in elevated homocysteine levels, a risk factor for cardiovascular diseases. Both vitamins are needed for DNA synthesis and red blood cell formation, and their deficiencies can lead to megaloblastic anemia and neurological issues .

Calcium is essential for bone formation, but its absorption in the intestines is enhanced by Vitamin D, which promotes calcium uptake. Factors inhibiting calcium absorption include phytates and oxalates found in certain plants, excessive sodium, caffeine, or iron supplements. Vitamin D deficiency can also lead to reduced calcium absorption, compromising bone health .

Vitamin C enhances the absorption of non-heme iron by converting it into a more easily absorbable form. This is particularly important for individuals consuming plant-based diets where iron is primarily in the non-heme form, which is less efficiently absorbed compared to heme iron from animal sources .

The intrinsic factor is a protein required for Vitamin B12 absorption in the small intestine. Lack of intrinsic factor, due to conditions like pernicious anemia or gastric surgery, leads to B12 deficiency, resulting in symptoms such as megaloblastic anemia, neurological issues (e.g., numbness/tingling, memory loss, gait disturbances), and potentially irreversible nerve damage if untreated .

Vitamin C toxicity is rare due to its water solubility, allowing excess amounts to be excreted through urine. However, very high doses (>2000 mg/day) may cause symptoms such as nausea, diarrhea, and increase the risk of kidney stones in susceptible individuals. This contrasts with fat-soluble vitamins, which are stored in tissues and have a higher potential for toxicity with excessive intake .

Vitamin C deficiency leads to scurvy, which manifests with symptoms such as fatigue, gum bleeding, poor wound healing, joint pain, anemia, and skin spots. It commonly occurs in malnourished individuals, alcoholics, the elderly, and people with restrictive diets .

Calcium can be obtained from dairy products like milk, cheese, and yogurt, as well as fish with bones and fortified foods such as orange juice and plant milks. Vegetarians and vegans can ensure adequate intake by consuming fortified foods, leafy greens like kale and bok choy, and calcium-fortified plant-based milk .

Iron is crucial for cognitive performance because it is part of enzymes involved in energy production and is necessary for brain development and mental performance. Iron deficiency, particularly severe forms like iron deficiency anemia, may impair brain function, leading to issues such as reduced attention span, difficulty in learning, and delayed cognitive development .

Folic acid supplementation is critical during pregnancy as it prevents neural tube defects (NTDs) such as spina bifida. The RDA for folic acid increases to 600 mcg/day for pregnant women to support DNA synthesis, cell division, and fetal development. Supplementation is recommended at least one month prior to conception to ensure adequate folate levels during early pregnancy, a period crucial for neural tube closure .

Heme iron, found in animal foods, is absorbed more efficiently than non-heme iron from plant sources. Vitamin C and animal proteins enhance non-heme iron absorption, while phytates, calcium, and polyphenols inhibit it. Balancing the diet with enhancers such as Vitamin C-rich foods can improve the bioavailability of non-heme iron for those relying on plant-based sources .

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