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Probability and Combinatorics Tutorial

The document contains a tutorial with various problems related to probability and combinatorial arrangements in biological contexts. It covers topics such as disulphide bond arrangements in proteins, coin toss probabilities, word formation probabilities, DNA sequence probabilities, and mutation probabilities in synthesized DNA strands. Each problem requires calculations and understanding of basic probability principles.

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4 views1 page

Probability and Combinatorics Tutorial

The document contains a tutorial with various problems related to probability and combinatorial arrangements in biological contexts. It covers topics such as disulphide bond arrangements in proteins, coin toss probabilities, word formation probabilities, DNA sequence probabilities, and mutation probabilities in synthesized DNA strands. Each problem requires calculations and understanding of basic probability principles.

Uploaded by

mustimprove69
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Tutorial 5(TD2213)

1. Protein has n number of cysteines that can pair to form disulphide bonds. How many
pairing arrangements are possible?

2. In a N coin toss, what is the probability that there are n heads and N-n tails?
Say in a 4 coin toss, what is the probability of 2 being heads?

3. I have 5 alphabets, 1-S, 1-W, 1-T and 2 E. What is the probability to form the word
SWEET?

4. Assume that there are 4 bases A, G, T, C with equal likelihood in a DNA sequence of 9
monomers. What is the probability of finding any sequence that has 4 As’ two Ts’, two Gs’
and one C.

5. Suppose you synthesize a strand of DNA that is 1000 bases long. A process you use
introduces a wrong base on average every 1000 bases synthesized.
(a) Calculate and draw a bar graph indicating the yield (probability) of each product DNA,
containing 0, 1, 2 and 3 mutations.
(b) Calculate how many combinations of DNA sequences of 1000 bases long contain exactly
2 mutant bases.
(c) DNA with 2 mutations has identified (distinguished) as Mutation-A and Mutation-B.
What is the probability of having a DNA with two mutations beginning with Mutation-A (1st
base) and ending with Mutation-B (1000th based)?
(d) What is the probability of having two mutations side-by-side in the pool of DNA which
has only two mutations?

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