Dominant or Recessive
Co-dominance Incomplete Dominance
Hitchhiker’s thumb No Hitchhiker’s thumb
Genetic
Inheritance
Sex-linked
In humans, for every chromosome
in our nucleus there are 2, one from
mom and one from dad
Homologous chromosomes
Each chromosome has a number of
genes.
Genes
Loci (locus) is the area of the chromosome
the gene resides.
Since homologous chromosomes are the
same chromosome,
AT AT
GC GC
TA TA
GC GC
GC GC
GC GC
CG CG
TA TA
AT AT
AT AT
AT AT
TA TA
GC GC
CG CG
CG CG ♀ ♂
TA TA
GC AT Alleles
CG CG
AT AT
TA TA
AT AT Homozygous –
CG CG
CG CG
GC GC
AT ♀ ♂ AT
Heterozygous –
When an allele acquires a mutation, it becomes a new allele because it will now
code for a different version of the original protein
A T A T
T A T A
A T C G
C G C G
G C G C
C G C G
T A T A
Allele A Allele a
Gregor Mendel (1822-1884)
• Organisms have
• Alleles could be
• Alleles determine an individual’s
• Genotype will determine an individual’s
Aa Aa
A a
Genotype frequency:
A
??
a Phenotype frequency:
NOTE: THIS IS HISTORCIAL ONLY – GENETICS HAVE ADVANCED – MUCH MORE COMPLEX
Genotype – Phenotype –
• Heterozygous –
• Homozygous –
Mendel’s First Law - Law of Segregation
•
Mendel’s Second Law - Law of Independent Assortment
•
Complete dominance
Dominant allele –
Recessive allele –
P – purple flowers
p – white flowers
F1 Parents
(P generation)
Offspring
(F2 generation) Offspring
(F1 generation)
Co-dominance
Codominant
Example: Human blood type
There are three alleles in the population:
Blood Can Can receive
Genotype(s) Anti-A Anti-B
Type donate to from
AB
O
Incomplete dominance
Incomplete dominance –
curly straight
wavy
Inheritance – Sex-linked inheritance
Many genes that are found on the X chromosome are NOT found on the Y chromosome
Women
Males
Red-green color blindness is a sex-linked trait
• This trait is linked to the X sex chromosome
•
•
What parental genotypes can produce
a colorblind female?
Approx. 5-8% of males have color-
blindness
Less than 1% of females are color-
blind
Polygenic inheritance –
Example – skin color
AABBCC - very dark skin color
AABBCc, AaBBCC etc. - dark skin color
AaBbCc, AABbcc etc. - intermediate skin color
AaBbcc, AAbbcc - light skin color
aabbcc - very light skin
Epistasis
Gene 1 controls deposition of
pigment :
D - pigment
d - no pigment (albino)
Gene 2 controls amount of
pigment deposition:
A - much pigment (black)
a - little pigment (brown)
Environmental impact –
Terminology
Allele
Co-dominance
Complete dominance
Dominant
Epistasis
Gene
Gene expression
Genotype
Hemizygous
Heterozygous
Homologous chromosomes
Homozygous
Incomplete dominance
Law of Independent Assortment
Law of Segregation
Phenotype
Polygenic inheritance
Recessive
Sex-linked