Pediatric Case: Febrile Seizure & Pneumonia
Pediatric Case: Febrile Seizure & Pneumonia
• J.A a 1 year old male child, Filipino, Roman Catholic, Born on AUG/22/2023,
PEDIATRIC GRAND ROUND residing in Abellana ST Suba, Cebu city, Cebu
INFORMANT: MOTHER
RELIABILITY: 80%
FEEDING HISTORY
• Exclusive breastfed since birth with a frequency of >12x per day, for
almost 10-15 minutes of duration, with good appetite
GROWTH AND DEVELOPMENTAL HISTORY: IMMUNISATION HISTORY
• The child development is at par with age developmental milestone • Patient’s mother doesn’t have the vaccination card of the child but claims to have fully
vaccinated for age in nearby health center
completed on time No motor delays No speech delay gross motor: • Vaccines given at Health centre:
1. roll back to stomach at 6 months • BCG (at birth),
• 2. sits without support at 7 months • rotavirus(6,10Weeks)
• 3. Stands alone, walks alone at 1 year • DPT(6,10,14 weeks)
• 4. Could run or walk fast at 1.2 yrs • polio(6,10,14 weeks)
• Fine motor: transfer object hand to hand at 5 months • H. Influenza b (Hib)(6,10weeks, 12-15months)
• language: monosyllabic babble 6 months • hepatitis B(0,1,6 months)
• Cognitive stares at on hands at 4 months • pneumococcal conjugate(6,10,14weeks)
• measles (9months)
• MMR(9,12 months)
FAMILY HISTORY
• History of hypertension and DM in maternal side
R.O.S
No history of Asthma, thyroid disorders on both maternal and paternal side. No
history of genetic disorders • General: (+) fever, (-) chills, (-) weight loss.
• Skin: (-) Skin lesions, (-) rash, (-) laceration, (-) bruising, (-) burn, (-) Cyanosis
• Head: (-) Injury
PERSONAL AND SOCIAL HISTORY
• Eyes: (-) redness, (-) discharge ENT: (-) nasal discharge (-) feeding difficulties
Mother is 30 years old, homemaker. Father is 35 year old, E bike driver. Both
parents are non smoker, occasional alcoholic beverage drinker. • Neck: (-) swelling
• Pulmo: (+) DOB, (+) cough, (-) hemoptysis
• GI: (-) Nausea, (-) vomiting, (-) diarrhea, (-) melena, (-) hematochezia
• ENVIRONMENTAL HISTORY • Genital: (-) dysuria, (-) hematuria
• Total of 15 household members and they reside in 1BR house that has a CR
• Neurologic: (+) Seizure, (-) Dizziness
inside the house, efficient garbage disposal system. Primary care taker of the
house is Father. They drink mineral water
PHYSICAL EXAM NEUROLOGICAL EXAM
• General: Awake, febrile, in respiratory distress. • Cerebral: Very active and attentive baby, (-) decreased muscle tone.(-) disorientation
• Vitals: T- 37.8*c, RR-42cpm, HR- 110bpm, O2:96% at room air • Cerebellar: Baby can give hand shakes and hifi, (-)Abnormal gait, (-) nystagmus. (-) Slurred speech, (-) Babinski reflex
• Anthropometric measurements • Cranial Nerves:
• Height-73cm • I-was not assed
• II- bilateral blinking of eyes
• Weight-8kg
• III [Link]- EOMs Intact V-Able to feed well
• HC-45cm
• VII-Facial symmetry is normal, can laugh and cry
• Skin: Warm to touch, Good turgor (-) jaundice (-) pallor
• VIII-Tums to source of sound
• HEENT: Anicteric sclera, pink palpebral conjunctiva, moist lips and tongue
• IX,X-Able to swallow
• Chest & lung Equal chest expansion, (+) rales BLF, (+) subcostal retractions • XI-symmetric shoulders
• Cardiovascular: Adynamic precordium, Distinct heart sound, (-) murmur • XII-Tongue in midline
• Abdomen: Flat, soft, non distended, non- tender, Normoactive bowel sound • Sensory: Able to feel heat. Pain and vibration
• Genitourinary: Grossly male • Motor: Good muscle tone in all extremities
• Extremities: Strong peripheral pulses, Crt-<2sec • Primitive Reflexes
• (+) palmar grasp reflex, (+) plantar grasp reflex, (+) rooting reflex, (+) moro reflex
SALIENT FEATURES
• Cough with whitish sputum
• High-grade fever
• Seizure episode x1
• Age 1 yrs
• (+) Rales BLF
• (+) Subcoastal retractions
• (+) DOB
Febrile Seizure
• High-grade fever preceding seizure.
PRIMARY IMPRESSION Age (6 months to 5 years is typical for febrile seizures).
• No focal neurological deficits post-seizure.
• PCAP- HR
• SIMPLE FEBRILE SEIZURE SECODARY TO PCAP HR • KEY RECOMMENDATION: Pediatric community-acquired pneumonia (PCAP) is considered in a patient
who presents with cough or fever, PLUS any of the following positive predictors of radio graphically-
confirmed pneumonia: (Conditional recommendation, very low-grade evidence)
• Tachypnea
• 1.1. 3 months to 12 months old: ≥50 breaths per minute
• 1.2. 1 year old to 5 years old: ≥40 breaths per minute
• 1.3. 5 years to 12 years old: ≥30 breaths per minute
• 1.4. 12 years old: ≥20 breaths per minute
• 2. Retractions or chest indrawing
• 3. Nasal flaring
• 4. O, saturation <95% at room air
• 5. Grunting
DEFERENTIAL DIAGNOSIS
• Complex Febrile Seizure
RULE IN: Influenza with Secondary Encephalitis
Fever preceding the seizure is a shared feature between simple and complex febrile seizures.
Rule OUT: Rule In:
• Seizure duration was less than 5 minutes (complex febrile seizures last >15 minutes). • 1. Respiratory Symptoms
• No focality: Complex febrile seizures are often focal, but this patient had generalized seizure features (upward • 2. Seizures and CNS Involvement
rolling of eyes, stiffening of extremities). • 3. Fever
• No recurrence: Complex febrile seizures may occur multiple times in 24 hours, but this patient had only one episode. • 4. Age
• Normal sensorium post-seizure: In complex febrile seizures, patients often have a prolonged post-ictal state or
neurological deficits. • Rule Out
• Aspiration Pneumonitis • 1. Absence of Specific Neurological Findings
Rule In: • 2. Tests like Negative Influenza Testing
• Persistent cough with possible history of aspiration (e.g., during feeding or reflux, common in young children).
• Fever secondary to inflammation or infection. • 3. Lack of Post-Infectious Complications
• Seizure could be triggered by hypoxia or fever.
• Rule Out:
• No history of choking or feeding difficulties.
• Test like CXR is needed to rule out
• No hypoxia
DIAGNOSTIC
• Complete Blood Count (CBC): To assess for signs of infection or anemia.
• C-Reactive Protein (CRP) or Erythrocyte Sedimentation Rate (ESR): To assess
for systemic inflammation, which is typically elevated in bacterial infections.
• Chest X-ray: To assess for pneumonia, consolidation, or signs of respiratory
distress.
• URINALYSIS: for detecting UTI, dehydration, or renal complications
• Covid 19 Rapid Antigen Test: to rule out COVID
• Biofire FilmArray Pneumonia Panel: to find the causative organism
Ampicillin 600mg iv drip q6hr (AD: 300mkd)
• Weight= 8kg
Course on the ER 11:48 pm Calculations • Rcommended dose for severe infections: 300-
Ivf D5lr 1l at 50cc/hr (MR+ mild) 400mkd
• PLAN l:
• MR = 100 mL/kg/day x 8kg = 800 mL/day • Give dose = RECOMENDED DOSE X
• Please admit the px to pedia ward under the service of [Link]
• Deficit = 0.05 x 8 kg = 0.4kg (5%of body weight) WEIGHT/PREPARATION
SUBJECTIVE: (+) fever (+) cough, (-) seizure • Please get consent to care
recurrence • Since 1 kg = 1000 mL of fluid, the deficit is: 0.4 kg x 1000 = 300x8/500 =4.8mg
• Trp for q4 hrs mL/kg = 400 mL • Actual dose = G.D x prep/Wt
OBJECTIVE: • O2 at 2 lpm • Total daily fluid = MR + Deficit = 800 mL/day + 400 mL =
• awake, febrile, in respiratory distress mild 1200 mL/day
= 4.8x500 /8 =300MKD
• Vital Signs: • Ivf D5lr 1l at 50cc/hr (MR+ mild) = 300x8/4= 600mg per dose
• Hourly fluid rate = 1200 mL/day /24 hours
• T-37.8 PR-120bpm • Labs CBC,COVID RAT
• RR-42cpm 02-96% • =50cc/hr
• Skin: Warm to touch, Good turgor (-) jaundice (-) • CHEST XRAY APL
pallor Paracetamol 100mg/ml, 0.8ml q 4hrs
• MEDS Diazepan 1.6mg iVTT (AD. 0.2mkd)
• HEENT: Anicteric sclerae, pink palpebral conjunctiva,
• Weight: 8kg
moist lips and tongue • Paracetamol 100mg/1drip give 0.8ml q4 hrs prn for temp >38c • Wt: 8kg
• Chest & lung: Equal chest expansion,(+) Rales (+) • recommended dose: 10-15mkd q 4 hrs
subcoastal retraction (+) wheezes • Ampicillin 600mg iv drip q6hr (AD: 300mkd) • R.D = 0.2-0.5mkd
• Abdominal: Normoactive bowel sound soft • GIVEN DOSE = RECOMENDED DOSE X
nontender • Diazepam1.6mg ivtt prn for active seizure (AD:0.2mkd) WEIGHT/PREPARATION • Give dose =RECOMENDED DOSE X
• Genitourinary: Grossly Female • CBS now then q 8 HR while on npo • = 10 x 8/ 100 = 0.8ml WEIGHT/PREPARATION
• Extremities: Strong peripheral pulses, CRT <2 Sec.
• ASSESSMENT: SIMPLE FEBRILE SEIZURE SECODARY TO • Monitor vs for q4 • actual dose = given dose x preparation/ weight = = 0.2x8/5 = 0.32mg
0.8x100/8 = 10MKD
• Actual dose = G.D x preparation/Wt
PEDIATRIC COMMUNITY ACQUIRED PNEUMONIA
• Monitor i&o qshift
• Inform pedia resident for admission =0.32x 5/ 8 = 0.2MKD
• Secure consent for lumbar puncture = 0.2x8= 1.6mg per dose
• = 800 ml/kg/day
jaundice (-) pallor Seizure precautions
• HEENT: Anicteric sclerae, pink palpebral
conjunctiva, moist lips and tongue Refer accordingly
• 800 ml/24 hrs = 30cc/hr • Chest & lung: Equal chest expansion, (+) rales
BLF, (+) subcostal retractions (+) wheeze
• Cardiovascular: Adynamic precordium,
Distinct heart sound, (-) murmur
• Abdomen: Flat, soft, non distended, non-
tender, Normoactive bowel sound
• Genitourinary: Grossly Female
• Extremities: Strong peripheral pulses, Crt 2
Sec.
Course in ward day 2 8:20am Calculations
ASSESSMENT: SIMPLE FEBRILE SEIZURE SECODARY TO
SUBJECTIVE: (+) FEVER (-)LBM PEDIATRIC COMMUNITY ACQUIRED PNEUMONIA
(-) VOMITING Plans • Start ferrous sulphate 1ml OD
OBJECTIVE:
• awake, afebrile, in respiratory distress
O2 at 2LPM via nasal cannula • Preparation dose- 75mg/1ml(15mg elemental iron)
•
• Vital Signs: Ivtt D5LR 1L 30cc/hr
• T-38.4C PR-134bpm Continue medications
R.D- minimum dose: 2-30mkd
• RR-44cpm 02-96%
• Skin: Warm to touch, Good turgor (-) Seizure, precaution • Give dose = R.D x wt/preparation
•
jaundice (-) pallor Start salbutamol nebulisation 1 neb q4hr
• HEENT: Anicteric sclerae, pink palpebral = 2x8/15 = 1.06mg
conjunctiva, moist lips and tongue Refer accordingly
• Chest & lung: Equal chest expansion, (+) rales
BLF, (+) subcostal retractions (+) wheeze Discontinue folic acid start ferrous sulphate 1ml OD • Actual dose = G.D x prep/Wt
• Cardiovascular: Adynamic precordium,
Distinct heart sound, (-) murmur • = 1.06x15/8 = 2MKD
• Abdomen: Flat, soft, non distended, non-
tender, Normoactive bowel sound
• Genitourinary: Grossly Female
• Extremities: Strong peripheral pulses, Crt 2 • = 2x 8/1 = 16mg per dose
Sec.
Course on the ward Day 2 4:45pm Course on the ward Day 3 11:30 am
SUBECTIVE (-) cough, (-) DOB (-) seizure (-) fever, (-
)seizures recurrence ASSESSMENT: SIMPLE FEBRILE SEIZURE SUBECTIVE (-) cough, (-) DOB (-) seizure (-) fever, (- ASSESSMENT: SIMPLE FEBRILE SEIZURE
OBJECTIVE: SECODARY TO PEDIATRIC COMMUNITY )seizures recurrence
• awake, afebrile, in respiratory distress ACQUIRED PNEUMONIA SECODARY TO PEDIATRIC COMMUNITY
OBJECTIVE: ACQUIRED PNEUMONIA
• Vital Signs:
• T-36.7C PR-123bpm PLAN: • awake, afebrile, in respiratory distress
• Vital Signs: PLAN:
• RR-38cpm 02-99% • May have Breast feeding with SAP • T-36.7C PR-123bpm
• Skin: Warm to touch, Good turgor (-) jaundice (-) • Continue direct proceeding with SAP
pallor • O2 1LPM nasal cannula • RR-38cpm 02-99%
• HEENT: Anicteric sclerae, pink palpebral conjunctiva, • Skin: Warm to touch, Good turgor (-) jaundice (-) • Maintain O2 at 1lpm via nasal Cannula
moist lips and tongue • IVTT D5LR 1L at 30c/hr pallor
• Chest & lung: Equal chest expansion, (+) rales BLF (+) • HEENT: Anicteric sclerae, pink palpebral conjunctiva, • Ivtt :D5LR 1L @ 30CC/HR
shallow subcoastal retractions • Continue medication moist lips and tongue
• Cardiovascular: Adynamic precordium, Distinct heart • Chest & lung: Equal chest expansion, (+) rales BLF (+) • Continue medication
• Refer according Subcoastal retractions
sound, (-) murmur
• Abdomen: Flat, soft, non distended, non-tender, • Cardiovascular: Adynamic precordium, Distinct heart • Moderate high back rest
• Refer accordingly
Normoactive bowel sound sound, (-) murmur
• Genitourinary: Grossly Female • Abdomen: Flat, soft, non distended, non-tender,
Normoactive bowel sound
• Extremities: Strong peripheral pulses, Crt <2 Sec.
• Genitourinary: Grossly Female
• Extremities: Strong peripheral pulses, Crt <2 Sec.
Course on ward Day 4 9:59am Calculations
SUBECTIVE (-) cough, (-) DOB (-) seizure (-) fever, (- ASSESSMENT: SIMPLE FEBRILE SEIZURE
)seizures recurrence SECODARY TO PEDIATRIC COMMUNITY
OBJECTIVE: ACQUIRED PNEUMONIA Cefuroxime 270mg iv drip q8hrs nst (AD:100mkd)
• awake, afebrile, in respiratory distress R.D= 100-200mkd
• Vital Signs:
PLAN: Preparation: 750mg
• T-36.7C PR-123bpm Given dose = R.D x wt/ prep
• RR-38cpm 02-99%
• Skin: Warm to touch, Good turgor (-) jaundice (-) • Continue direct breastfeeding with sap = 100x8/750= 1.06mg
Actual dose = G.D x preparation/Wt
pallor
• HEENT: Anicteric sclerae, pink palpebral conjunctiva, • Maintain O2 at 1LPM via nasal Cannula = 1.06 x 750/8 =100MKD
moist lips and tongue
• Chest & lung: Equal chest expansion, (+) rales BLF
• Maintain IVF rate at 30 cc/hr
= 100x 8/ 3 = 267≈270mg per dose
with wheeze (+) subcoastal retractions
• Cardiovascular: Adynamic precordium, Distinct heart
• Hold Ampicillin and start cefuroxime 250mg
sound, (-) murmur iv drip q8hrs nst (AD:100mkd)
• Abdomen: Flat, soft, non distended, non-tender,
Normoactive bowel sound • Start salbutamol nebulization 1neb q4hrs
• Genitourinary: Grossly Female • Continue medication
• Extremities: Strong peripheral pulses, Crt <2 Sec.
• Moderate high back rest
• Refer accordingly
SYMPTOMS
• Usually, a child having a febrile seizure shakes all over and loses
consciousness. Sometimes, the child may get very stiff or twitch in just
one area of the body.
• A child having a febrile seizure may:
• Have a fever higher than 100.4 F (38.0 C)
• Sudden rise in temperature
• Lose consciousness
• Shake or jerk the arms and legs
• Febrile seizures are classified as simple or complex:
CAUSES RISK FACTORS
• Usually, a higher than normal body temperature causes febrile seizures. Even a low- • Factors that increase the risk of having a febrile seizure include:
grade fever can trigger a febrile seizure.
• Infection • Young age. Most febrile seizures occur in children between 6 months
• The fevers that trigger febrile seizures are usually caused by a viral infection, and less and 5 years of age, with the greatest risk between 12 and 18 months
commonly by a bacterial infection. The flu (influenza) virus and the virus that causes of age.
roseola, which often are accompanied by high fevers, appear to be most frequently
associated with febrile seizures. • Family history. Some children inherit a family’s tendency to have
• Post-vaccination seizures seizures with a fever.
• The risk of febrile seizures may increase after some childhood vaccinations. These
include the diphtheria, tetanus and pertussis vaccine and the measles-mumps-rubella
vaccine. A child can develop a low-grade fever after a vaccination. The fever, not the
vaccine, causes the seizure.
• Social determinants: Living conditions, parental health behaviors, and access • Children who respond well to initial outpatient therapy
Tachycardia or hypotension (signs of sepsis or shock)
to healthcare services and have no evidence of severe infection typically fall Altered mental status (e.g., lethargy, confusion)
into this category.
May require intensive care unit (ICU) admission if there
• Vaccinations: Not being fully vaccinated is concern for respiratory failure or need for mechanical
ventilation.
2. Classification by Etiology: Classification by Location/Extent:
Viral Pneumonia: Bacterial Pneumonia:
Common Viruses: • Common Bacterial Pathogens:
Lobar Pneumonia: Interstitial Pneumonia:
• Respiratory syncytial virus (RSV) • Streptococcus pneumoniae (most common in children under 5 years old)
• Influenza virus • Haemophilus influenzae type b (Hib)
• Involves a single lobe of the lung and typically • Involves the interstitial tissue of the lungs,
presents with more localized symptoms (e.g., leading to more diffuse infiltrates on chest X-
• Parainfluenza virus • Mycoplasma pneumoniae (more common in older children and pleuritic chest pain, focal crackles on ray.
adolescents)
• Adenovirus auscultation).
• Chlamydia pneumoniae Common in viral infections, especially RSV or
• Rhinovirus Often caused by Streptococcus pneumoniae. influenza virus.
• Staphylococcus aureus, including methicillin-resistant Staphylococcus
• Human metapneumovirus aureus (MRSA) • Bronchopneumonia: • Pleural Effusion/Empyema:
• Viral pneumonia is more common in infants and young children and• Group A Streptococcus (GAS)
tends to present with mild to moderate symptoms. • A more diffuse infection affecting multiple areas When infection extends to the pleural space, it
• Escherichia coli (more common in neonates) of the lungs (patchy infiltrates on imaging). may lead to a pleural effusion or empyema (a
• Bacterial pneumonia generally presents with higher fever, more severe collection of pus in the pleural cavity).
Atypical Pneumonia: respiratory distress, and sometimes bacteremia or sepsis. • It may be seen in viral infections or with bacterial
Caused by Mycoplasma pneumoniae, Chlamydia pneumoniae, and Fungal Pneumonia:
infections like Staphylococcus aureus or Staphylococcus aureus and Streptococcus
Legionella pneumophila. These pathogens may present with more Haemophilus influenzae. pneumoniae are common
subtle symptoms, such as: • Less common but may occur in immunocompromised children.
Persistent dry cough • Pathogens may include Histoplasmosis, Coccidioides, or Cryptococcus.
Mild fever • Tuberculosis (TB) Pneumonia:
Sometimes, extrapulmonary signs (e.g., rashes, joint pains)
Often affects children older than 5 years.
PROGNOSIS TREATMENT
• Mild to Moderate Cases: Most children recover fully with appropriate • Reduce respiratory symptoms
treatment (antibiotics, antivirals, supportive care). Full recovery is expected Eradicate infection with antimicrobials, if indicated
with no long-term complications. • Prevent complications
• Amoxicillin is the first-line choice of oral empiric treatment in school-aged children with coverage for S. Pneumoniae
• Severe Cases: Children may require hospitalization or ICU care if they have • IDSA guidelines recommend the use of macrolide antibiotics for the treatment of atypical pneumonia in children
respiratory failure, sepsis, or pleural effusion. Recovery is possible with timely
treatment, but complications may prolong recovery. Admission criteria
• Complications: Severe infections (e.g., from MRSA, Streptococcus • Respiratory distress
pneumoniae) may lead to pleural effusion, empyema, or sepsis, increasing the • Tachypnea
risk of prolonged illness or death. • Age 0 to 2 months: more than 60 breaths per minute
• Long-Term Outlook: Most children recover fully, but some may have lingering • Age 2 to 12 months: more than 50 breaths per minute
symptoms (e.g., cough, fatigue) for weeks. Repeated severe episodes may lead • Age 1 to 5 years: more than 40 breaths per minute
to chronic conditions like asthma or bronchiectasis. • Older than 5 years: more
PREVENTION
Vaccination:
• Pneumococcal vaccine (PCV13) protects against Streptococcus pneumoniae.
Influenza vaccine reduces the risk of influenza-associated pneumonia.
• Haemophilus influenzae type b (Hib) vaccine prevents Hib pneumonia.
Good Hygiene Practices:
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• Hand washing to reduce viral and bacterial transmission.
Cough etiquette (covering mouth/nose when coughing).
• Avoid Smoking Exposure:
• Second-hand smoke increases the risk of respiratory infections in children.
• Breastfeeding:
• Exclusive breastfeeding during the first 6 months boosts the immune system.
• Prompt Treatment of Respiratory Infections:
• Early diagnosis and treatment of upper respiratory infections can prevent progression to pneumonia.
1. Virus Detection
• Overall Detection Rate**: At least one respiratory virus was identified in **82.7% (144/174)** of children with febrile seizures. 3. First Febrile Seizure:
• 41.6% had one virus detected. • Influenza B was the most common virus identified in children experiencing their first febrile seizure (p < 0.05).
• 31.3% had two viruses. 4. Complex vs. Simple Febrile Seizures:
• 20.8% had three viruses. • Simple Febrile Seizures: RSV A was more common.
• 4.8% had four viruses. • Complex Febrile Seizures: Human Bocavirus (HBoV) was frequently observed (p < 0.05).
• 1.4% had five viruses. 5. Seasonal Trends
• This highlights the high prevalence of co-infections among children with febrile seizures. • Influenza Viruses: Primarily seen during autumn and winter.
2. Most Frequently Detected Viruses • RSV Predominantly detected in winter and spring.
• Adenovirus: Found in 55.5% of positive cases, making it the most common virus detected. • Other viruses did not show significant seasonal variation
• Influenza Viruses (A and B) Detected in 47.2% of cases (24.3% influenza A and 22.9% influenza B). 6. Key Findings
• Respiratory Syncytial Virus (RSV): Found in 16% of cases. • Adenovirus: Detected as a single or co-infecting pathogen in more than half of the cases.
• RSV B: 9.7% • Influenza B: Strongly associated with first-time febrile seizures.
• - RSV A and B combined: 6.25% • Human Bocavirus: Associated with complex febrile seizures but often found alongside other pathogens..
• Coronavirus OC43: More common in younger children (<12 months).
• RSV A: Predominantly associated with simple febrile seizures
DISCUSSION AND CONCLUSION
• Discussion
• The findings reinforce the strong link between respiratory viral infections and febrile
seizures in children. RSV emerged as a prominent etiological agent, which has
implications for public health strategies, including vaccination and infection
prevention. The authors discuss the role of viral load, age-related susceptibility, and
immune response in the pathogenesis of febrile seizures.
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• Conclusion
• Respiratory viral infections, particularly RSV, are significant contributors to febrile
seizures in children. Early diagnosis and prevention strategies can reduce the burden
of these seizures. Further research is needed to explore the pathophysiological
mechanisms and to evaluate the effectiveness of preventive measures, such as
antiviral treatments and vaccines.