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WEEK CASE VIGNETTE TRIGGER/GUIDE QUESTIONS LEARNING OUTCOMES REFERENCE
13
Feb 10, WEEK 13 I. BIOENERGETICS: THE ROLE OF ATP Harper’s
2022 Illustrated
A. Role of entropy, and enthalpy in
Kyle, a 29-year-old male, was Biochemsitry.
biochemical reactions
brought in the Emergency 31st Edition
department for unresponsiveness. B. Fundamental principle of Gibbs
Wife of the patient noted that while free energy (ΔG), standard free energy Chapters &
at home, the patient suddenly (ΔG0), and the equilibrium constant (Keq).
developed headache, dizziness, C. Gibbs free energy equation to
weakness, nausea, vomiting, and calculate free energy and equilibrium in Others:
diarrhea. En-route to the Emergency coupled reactions. 1. Textbook
Department, he lost consciousness of
D. Structure of ATP and the role of
and experienced urinary and fecal Biochemistry
high-energy phosphates.
incontinence. Patient works in a with Clinical
mango plantation and is responsible II. BIOLOGIC OXIDATION Correlation.
for pest control using Malathion. 7th Edition.
A. Definition of Standard redox
potential vs. Standard free energy change.
Patient is a known asthmatic with 2.
maintenance with variable B. 4 Classes of Oxidoreductases, its Lehninger’s
compliance. functions, and biologic importance: Prinicples of
Biochemistry.
1. Oxidases
Pertinent physical findings include: 6th Edition.
fixed pinpoint pupils, generalized 2. Dehydrogenases
paralysis, fasciculations, and is 3. Marks’
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unresponsive to deep pain. Corneal 3. Hydroperoxidases Basic
and gag reflexes are absent. He has Medical
4. Oxygenases
profuse salivation, diaphoresis, and Biochemistry:
excess lacrimation. IV. RESPIRATORY CHAIN/ELECTRON A Clinical
TRANSPORT CHAIN (ETC) & OXIDATIVE Approach. 4th
Vital signs include the following: PHOSPHORYLATION Edition
A. Structure of mitochondrial
BP: 140/90 mm Hg, membranes and its associated enzymes.
Temp: 37.2
Heart Rate: 58 beats/minute B. Components of the ETC embedded
Oxygen saturation: 89% into 4 Complexes:
1. Complex I
2. Complex II
3. Complex III
4. Complex IV
C. Flow of Electrons: The
Chemiosmotic Theory
D. Function of ATP synthase in the
transport of electrons forming ATP.
E. Mechanism of respiratory control:
1. Availability of ADP
2. Conditions limiting the rate of
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respiration
3. Mechanism of action of poisons,
genetic defects and disorders such as Fatal
Infantile Mitochondrial Myopathy and
Renal Dysfunction, MELAS, Alzheimer
disease
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