OPEN ACCESS International Journal of Pharmacology

ISSN 1811-7775
DOI: 10.3923/ijp.2021.643.655

Research Article
Effect of Thevetia peruviana Seeds Extract for Microbial
Pathogens and Cancer Control
1 2,3 4 5 6
T.M. Abdelghany, Reham Yahya, Marwah M. Bakri, Magdah Ganash, Basma H. Amin and
7,8
Husam Qanash

1
Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt
2
Medical Microbiology, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences,
Riyadh, Saudi Arabia
3
King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia
4
University College, Al-Ardah, Jazan University, Jazan, Saudi Arabia
5
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
6
The Regional Centre for Mycology and Biotechnology (RCMB), Al-Azhar University, Cairo, Egypt
7
Medical Laboratory Science, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia
8
Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail, Hail, Saudi Arabia

G
G
 G

G
E
E
E
QC  VP
E TFC 
MP
E
G
G

G
G

E
E

®
GAC  VP
TPC 
MP
 G

"

E
 (a) (b)

11.58
100
90
80
70
Relative abundance

16.18
60
50
40 3.59 13.00
30
14.26
20 9.51 18.39
10 27.30
5.00 19.86 22.83 24.63 28.75 32.13 33.69
0
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38

Time (min)

3.56
100
90
80
70
Relative abundance

60
50
40
30 27.30
20
24.62 28.48
10 5.72 11.51 32.11
7.64 9.72 14.00 16.42 18.71 21.16 22.99 25.97
0
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36

Time (min)
 30
Total phenol content
25 Total flavonoid content

Concentration (mg gG1)

15

10

0
SP Extract SK Extract
Plant sample

G G

G G
 G

110
100
90
80
Cell Viability (%)

70 SP Extract
60 SK Extract

50
40
30
20
10
0
0 0.1 1 10 100 1000

Concentration (µg mLG )

(a) (b) (c)

(d)
(e) (f)
 (a) (b) (c)

(d) (e) (f)

60

50
µTE/mg exteact

40

30

20 G
10 G
G
0
SK Extract SP Extract
Plant sample

2.0
1.8 y = 0.0018x+0.0340
1.6 R2 = 0.9982
1.4
G
Absorbance

1.2
1.0 G
0.8
0.6
0.4
0.2
0
0 200 400 600 800 1000 1200

Trolox concentration (µM)

(a) (b) (c)

(d) (e) (f)

(a) (b) (c)

(d) (e) (f)

G G
 G
G