Phaumaeol ogy heneual phaumacoogy

Koute ek drug almintstralon

Loca!

Tofea Jitro arteu (or In troheca!

Skin 6ntexa Darentra
Anphoterein
menbrene 9Geuotds -IV
-IM
-St
-Sobga
-[ransderTe
- Nceya!
co kineHc
Phorn
Breic,
hk kor khano
dealy ol th fbsorpion, Mercabolsm, body khang otu
Distri buo0, Gxreho

biological mem btane

.

>ony toprd solobe can cross fhe

Tonlzed orm Coatey Solub|
lays
> onionieed orm Altoays sat soluble
 Aci8ie drugs Oue mosy4 unionized in actdle poeltom
m
Bowbihoreedes, CM Cpenicitlin)
Lea
Qerds
1
As pirtn,
weak be: Aro ploe, Mor phsrt

Bioavalabiliy
Bioe

It is the trocton o he ra' fhet recaches the Systeme cireoht

Drg 2

oralg
Absorhed in porta! cirevaHon N2 vvri

reahes, lver
(vol•

blrst pass
netábo lr87

pans metabolisn
ooisn |-Drogs T hygh i Mo Sa Ni Lyo
:Sa
Salbotamd Morphe
NHrae)
(0#Absorphon Haroyo -Hydrocorhsone
k (St pars metabolis
une the inportant letermincunt
ok biooyalcbi iy
(00'} bioavailabilt
ISE pays metbobolism
 Bi0availabiliy
Areg0 de cU ve bat roue po-

Areg uney curve

or.V –oral

Bio equivalence
6argeenee in bioavai la blib % too prepaaion is leas fheo
20 9 [Link] valenee

Distribuboo
deteumined by hypoheteat paiameter vo (ume os
distri buhon le
(volrok alistt
Va = Amount o drg aiven ([Link]
butony
pleoria concentrattor(ng)

V?

Jcahe
Concen trattoo (00
(o0 mglst
epends
Apading dose de
(0o 15 o 'Qstriburion
Vot

ose lepends 60
Maintenane, d
=SL
 Dia
conc So/

= (0 L

cross bfocd vesel

3Drugs thot aue Qind solubie, keyto
have bigh Va.
V4.
Drugs oith peo te: bin&inAEUese
9- Plagmne

chinee V

Ploomg Peotein bindi

>makeo a
drog long hinge\
drg' (or

Droys

n
vaeuloy compautment

beneyted catys
 Dral yss cT Potein Ql6ça
gioça So, loo ploatma prote

- Amphetamine
A

HoV- Veuapcmil
poisonigj, opioid
I- Tmipra min e
D Dgitals
-

Dia - Diozepar
Drug
PoiSoni

(3) Meta bol;9)

Aiven
-Prtmary i je is
o drogs, acHuation tom prodr
Prodryg : : ACE iobi bitors
(erept eaptopri!)
Prednisolone, PPL, Proguanil, Dipivegine,

oc jor vveihs ot susa

QAPPP G) coma -Bet Dug
Eause DM neilynio
methyl dopa, inoi 1,
ylophosphamoe
zine
 Metabol1sm

Phase
- oxl da
Non-
mierosom redu
-tyd
Mierosomal
- prerent in Smah be

Enggme, in luces
here oe th meta bol'an oß drogs
4 dereaje)
@GP RS Ceil Phore

chronfe acohol consuphon

Snoig
Carba hazopine
Phenobat

enme nb:bir|
4 Jese anes the metabolisn o
m

du VICks
Ftutona20 re
ISoniq2id
Aute Aoho) abu se
ClmetiQire Chloromphentcaj
ketoconazole yCcause Gjrey
bahy
Sulphoncmile Snd)
 Phases oft metabollSm

Phase -L phere
-Oxldaton -gueoreniJattn
redueon +Auetytation

(VSxeretio0
>Major route o exereon kioney
ohieh okthe ootoeg
• Date, os imnatfo0 : fnountof dru
933
oote. hes maki abser)
eliminated
Time isosi 'a)oral
• decuanee (cL)= late
o elminoHon Lynheao
plasma'concentraion"

Ordes ok knectes CThey aue relcted to elsminaton)

wEO20 Orleu ktneteo conetal amoont ok Qug s etininated

peu onit timp. So, The rate of eliminaHo ineependent o pluma
peu
Ofirst orQey [Link] epondo
consfant ractonis entoninated
unit ttme Rate of Cond.

torgik
 oncenfraton
concenfraflon
hah
orrdeu klnefcs
) talb e congtant in irst
foltouw aTs Drgs (zero torT)
# 2eu0 ordey tineteo
-waukauio
-Ateohol kaspin
-hepbyne
-Totboamide

Hok LIe
hne toredvee concentrattonto hat o
plas ma ojgna
I talees 4-5 halk ves t reoch steady store

Skady stale_
Drg administeued at raglax, latencla
plaama concentro,tlon increaning n

qdmints tered Dng eltminated

Playm on CenttotHon
tablli2e
8fate
 phauna codnamics
cohat drug docg to he bo
7
or ula,eephors or dire ch emical
enchion (antacils)

tnzyme inb'bihoo

) Competetive tohlbirionenls to he active sie o eneyme

enzy or,
Subsaf
<
not t en me
-subsrahe complex

-Sobibitor strUure is Similar tolsobstrate e

Jnhibion. ne by
oveucome by. TQose ok Sobsirct
Vmax

substrate, i-e req to -marimum reacion, velory

amt ok
Produee o% matma vetohy
(low mat ela But .J16t
coor
ke so tio produet

(comp eitve race ei So, race

Competitve
Km )
Vma Constort

Non comp ehHve nbibior

birds ro bofh en entym -substrate comple
alloste
sie °fo enzyme
oveycome Hon
inbtb}
7hrcai dose docan't m.
mar
bd doenlt ahtect
 Recepor Pharmacology
combe coib re or.
cep
to 0se lesporse

No o esr' bin o recepror

Jotrinsic Gtivky:
abtiby toachvate: the režébloir
reepoir sttqu
8birdinq
Pages rom-to +)
Based inthnc QcHuilry,vi
on ti SuiU
bind to receptor k aLivate marimaly
htrrhi actvity =i
DPrlagpnist bnd to 'receptor but pro&vce no
se
M
(htriosie autviby =o)
>Pautia! gonist: aetiv ote sobrnaximaly
Sntrinsia acuiby o to t)
ypntt : inds k produee nggatve (opposite eet)
Jhtrssc

Prevents
choreol is ghsorption

Chemical : combine chemicay tprevents he ation, HCJ E antais.

ogent
helatg
rystologtcal produee achon oposite to he abstrate:
 bindptD Scane receptyr
9.
Pharmacoloqy produce. oppo site acton by

Dbse lesponve
Cunve (DR)
T) Dose regpone
lesponse

DOse

MU

poteny
Eantacid,
egicot reponse re
reponse
foter amount neelrd to produre
 T
heuapeutit Jnlex
Cri LB Au
ype Da
A:
ant

heapeute nden elenotes

he saftey B
B:
Uintcal Tial
: ch
phane L: Aiven [Link] fhy humin vo lunteu
So, Ihe no toil| be [Link]
B00-S00)- Fanda
phaye T[: Qone in ne patent, homgytoar6trof Binded
phare II :Done 'on patent, but in hetecggenos grovp aug) s00:
survellance, to check (öngten sileele
phane Iv:post marketng
or roee
Vug
Dmportanae ok phae
phare ] : o lenoo about phaumalco [Link] cpe"
Uy

phare || kanlomníeed control tia Ir estab|ihey he eicoa

: conirm the etficaey also Ranlon eed controltedoal Nuele
phare ll -vitami
o Microdo : Smeulle dose given
phane $n Thyro
Corto

P- drvg: panonalleel drg

 v
AQvexye Dcug leacoo
Augmente
related sea iop
Hpe A:Doše
ant deprusan
o The dnyg

Hpe B: Biz204e rot dose selated): Alegte reaion

sot
THpe c: chronsc, Dose & Trne related Teactionsh
Jes suppresston E cortieosteuofees
seg: adrenál
tme related, reair
Pe D: DeoyelThey ae also
Tardive yskinesta yom antipsychohes ?:
D00
ype E: GQminahon, seen agor etiminatig the drag

heapy eq: Antibioic resistance

Recepto

Membrane
Nuleus
vltamin AD
Thyroxhe Ty)
Lon chcnoel Tranjmembranp
corHcasteuoids: Sooped
eceptor
- Glutamate -JAC-STAT
-
G1ycne Growth hormone, Tetepror

- GJABA Polain
kingre.
-I4
Tyoe
is 3
-Nicehnic
Ssine LOf-)
rsuin, - Gstt mulatoy
 Al
znhtbiory UcAMP
-I simut ate phos Fhollpare C
Nieo

MOrOutonomic Neuwous System

Pauasympathetio Neuvous Syster

nevoUS
Stem .SympatheHe
:
Ortgto Cranio satrat
CN : 3, 4, Onitn Thora colbm bar (nleuro
tnt

NeUrotrandmitor ; Syele
Acelchollre • Neurorars mittor! Nor adrena
ttofadreroTE)
Pragangtionte Long
ehorte
Post gagiers
Secretions:
c ghort /3mal

Tnrease (t)
Pre gongilon
post
jontonc - Lorg

•Sere tioo! Decreae ()exet

Sueatig
Ngurotrans miire in SympaheHc newvous

ysten
NeuroneUrona! (joneho
art PgongWonic
 Ach Recepor
2

0MUSearinic
NieoHnie receptor
che -protein coupled
> gand goated thanne! CGpce)
2 Typ
em

Nn Mg GT-Heaut
Nm neuroa
(Neuromusulau) (Ntcotinic
tnt in auoromk
aArenal , ge sphinche,
JAliy
Serela muse medollg Allaugy musles
ire muSles
past

Keceptoes (sympeheh)
Pdteneugta
Blood vesels nT Sn ooh mus le (-e
4 pre,ent in he cause) vanoconstrition
ept vaseu laut Snoofh mosle y
moofh muste CGuses gnoo[h musue contretion
Vsceua
Pre gnapho Teminals,Paupt 4 al Salvauy gbnds
I inhibit Decrect Salhvauy
nookn Serekon neurotranarmite
SeGreson
Teteof

F Heant- it increane theheaut rote

kâney - it înereane. cotracilt 1 Terfn Sereion
 P2: Bronthides: Bronhol Hon
iveu : iycog enolysis vano &H at on Mefoch
Alrteia moofh mesue:
Bebéne
P3 : Alipose Ttssue !

Paysos

aue GPcl

Colineygte Drugs CAch

sadad oue choin
ergto
Edrop
Direct tgonít
atedy vla recepor.
- Ach
-Plocarpine 2yps5
-Bethonechol
-Merhqhollre Pevestbe
-Caubuho Jre veslble
p-physostgmine
- Qañgmine OP poisopg
Sofuble Dons
L-Donepez:"
Neosgmine

Soluble
Oconstrs

Pch8nort aing, méta boligm

meke bolign by iaceejl ehotineleuanf
- Me
Mekagkol ire rha chol ire
Mefha chasonge teyt [Link]
Repanechd- Bladder
Pileaapire-Gila ucom a
AT ac
stt lead to
nicturl Hon

Paygmine - ipid soluble, cross byood breinþaiñeu

o esed in atrepire pojso nin"

Negstigmf
[Link] esht cross bloo brain barter (coate Soluble)
-Usedin Treatment ok iMijag fhente Girev's
-leveusl o compehive dkesetal
mus cle elanant8
Pyrlostgmine long actiä
Edrophonlum. vsed in th Diognosis o Myasthenig Graus
Thís is Tengtlon test 999 edrop honum

fmprouementin
"92 "Skeleral musue cathuy

ble
Diagnost d. a kyuy
Girous
 (ouasympaholyteo
PoHeholgneysfe DrusS

n uscaulnic andnicotnic receptor.

oHtrepin pradvces mydrias ylop egia (topgejt aing)
mine to
-.Usel coth neostg
mus side
ulsion
Qeereane he taninie
So, don't atve in alo}

oTopieomide Shortest acting mydrfaHc

Trhe xlpbeniL| Ben zkropie

he ce centrael anticolneuce
t Treatment in Drog todced Paule'sonism
6 Gycopyrolake Premediceton fo
;
revee sereHon
moHo
fn mstte.
Seopolormie Ause sfnes
Spratropium Ariotaplm usel in COPD Asthme
•Soleenacinused Gn ouer
acig btodten efraTG iar)

peptic utceu

Gue Controtrdteate d n RPH

 os anlcho inegic
Advese drg reaton
Vseereion
dcy moulh, edued soeay, &
viefo
9atiya ion, Vlatrimaion, .blure
on
Ornany eention, constipai
SunpaheHC Nevovs stem
- Neurotrans miHeu >
Nor adrenalle
6
amino acid

Sympathornimetie Drg

acfig
Drectly he
-Adrenalie rteleonorease
elthe in
They Qup s oT action
-Nor- adrenali e Ctechol amine,
- Dopamirne the seuprake
-Dobutcmine

Non catech ola mfnes

Lyphenyl ephinf
LBalbutemol
Lyyonidine
ylome to zolire
Adrenclire r at s| ,, B,

Nor a drenaline

- P, B2
butamine
Do at Ja
 or anaphyl'aata shot
Alrenalie P Doc
IM -

cureyt
ANen in Caudrac
|34000

Dopamine
Doc er auliogento
jor Shock oth oligorto renad galore

oyymeto zoline, xylorretaroline

, agons

Nonel deconaes tar

ans Protonged
used coll cause Rinits AMeearento &

2 agonist
-yontdiene, omehyl doa

- Ppacjonir, Bnmoreline Gsed Gl4u c0mg

Conte inlicote

CNS de)res
 bronchodi osto r
|4gonr brontad e
ayhns
Salbutamo, salmelsuol, formereuol >,usel in
Ko drige, Isox Seire Tocolytieg
soteine controtior)

Tnlretg achisg
eMeyohenidote use & in ADHD

alci
Sympafholyfic Drugs
N- blo cey 3ivceveube
Non Selectlvel -0phen
ox benzamine pevent TN e pisiode
in pheohromoytom 4
heochromouytorna. 711 Sympahette
Sypalhe tle ado
Tadrenating
CTthat's hA use blocke)
phentola mine
HTN'ersrS In thees e recton

ol4 Mono am no oxtlaje aloig

Tyramine AIÇT 8p T
rch jood
 |Seectve
block er Prazo in, Teczog'n used in BpH
Ly Advense D

Ace
Tamsul o stn, Silo
don nhibst 4A
bla ddeu nect

hypotouian

B- blode Clol
• stgeneuafion, : Non-setetives p-btockewy
Timolol, PrupanololL ,Nadol o|

Erallet
Ealsat in typey hyroldsm
Doe

(Chy oid 8torm)

Doc inmgroine
blocleey

fea ls to
brer
PRsleado to broncho
Corbtrion
-So, contrain dicated in
dreone AV þtockDrobete
 en eration Selectlve P btocleeu

C
M
A
Betayolol ceteprolo| eSmolo Metoprolo| Nebivolo|
Ptenofol
Enortet
Acebutorol B6oprolo|
Cadiosel ectve

B-bjodcey Usey
Ghiaucoma –Timolo| moleling
Heaut jultoe prevet caudiae
Hem -(ypeutrophic caudiomyopathy)
Throtd stoim
, VHR,tremoriPropcnolo

B- biock eu E membrane atabilizieg pcapeuty

-posses s Nat h anne! oockèng propety G

(ie ioccut anastretic pron eay

-he Anfioutmic acko

Drug het
plosse) memhrene Cfabilieirg ar LA ptenety
Proponolo|

Labe olol
Aceputalol /
Pn dolo) J
 Ciptd Joluble Bblocke
NQdolo}

Thirel geneuson
Aastionaf vanodHakory ejec
(apta) q+ bockey! abelo
Calcium channel blockeu
- Çanvelol
Bekarolol

bio
+Lebetedo

Auto Go t
Anshs am inict NSAS
A

Recep tor

prooson"
bra choconstcio)
to, Prut HS
 A ntt hl9 tamtne

OH anAhis ks
ni ntc.
( geneals) 2d
Got-histaminC
Highly Sedatlve: Diomond
Dimen hydrinate, prom efha zro
binaine
Feroena dire eTALC
Molectely selatlue : Pheniramine
Cinarizlne,Meizine -6baine
-Aaeja» tire (Topseat) 9
Mldy aeletva : chior heniramie
- Lora ine
Que contrain ccated Jo
-
cetieire t metbozed atd
d rtveuo, Machlne oeuators
MOst ok
dryg reacton (he
>Advee K
ue produ etcept ce trtzire
Sedaton, Animus cautnic ekied
>
No cNS depreas ant ativthy
No
antimascarinic sie efe
(Ony,mouth,urhasy retnion
co
nstpaHon, blurrel vtion).

Hy antihisda ntoic

-lanltidie t Ghastrtc qutl Secreton

pamotlire
 NSADS
Araeht donic Qtiel paheooy
PGie, Misoprostol
PGe,-Dnoprs tone
us e n pul HTN
P GIs

•PDA CPatent
u us Ar tetosts) aill
P on€,
PG keep the du ous
Qutertess open/p

hao
Plaei ét Low dose ay pirln antplatejet aeton

oteuvy P
Gb, PG powenbvl vteine Lontraeton
L
carbapros
tPPH
P 9b
jMisop rosfol| boron

Brorehus phI PGEBronbo ditators

FA-Borsto constieHon

GIT opego Teatmen

most %.PoD
de to chronte
-Msoproto
Doc
 Pouacehmol: No antt nfammahy e
fod
meta boll2ed o
- An tidote
:N AC (N- acetyl eystelne)9
9
Aspinn
Treveusible in bibitor ok coX )
-Used in pre elampsla
- Antiplarelet at lo dose . dase
ypeuuricemi at theuepeutic
- Cantoindicadel n <y due to ssk o Peye 's Syndrome

0thes .
• Mefenaßa add : ed in Dysmenor hoec
eforolat can be ven v S
Preeuenia! cox -2 nbibitor (

Nimesuli de,

Didojenads
Sel etve coX-2 nbibitor tu

hance oß stroe in prolonge use3,

-eg: celecoxb, etori coyl b, Po oxtb
 Antmterobi alo
O celwal synthets
Peni
in hbitor
bibi
Meha

peptidoglyean
Synfhe Pephidloglycan cross Itald'rg
in bibjtor.
Pente

• Gycopephde
• penteilLio
-Vancomycio
-Baeitrocin D pen nieininane sensiive
mpenleiltoG, Penielptn V,
Bactortos fatta -
Min: inhibtor
fmpictltnAlmoxleil;ó
Conc S more
Methfeil|i. lonceilfo oxali
Conc
Vo
V
Meo
McOND
) Aotpsevlomona
Argonsm
Bacderioldel + Baheuogrti
carba þene
m
Jmipenen Meropent.

IMonobuchom i

celrend rone tnhibkor-papknyes

 Penieltlo
9
Mechanlsm ok otkn bindo o penieilin binding protein'

peptidogycon crots,dinltg
and prevent Peptargyycn
Pentcilto G,V is druh o choice gor- Lepospíro
G-N, V-orcl -aetn
ornycis
-trepto Louws LASJ MAtN

el4 -Yphits
- TefanuS
- MentngocoLeus

-Anthrax
o Pentetlfo s sene tont, penîcillto >us ed in staph aurees
er cept MPSA (mefhici1 in re) is fan t Staph Aurevs)

Aotipsevdomond penieill darbenk tn, Thesrclin, Meziodit",

Aocllh, pheualin @TMAp

A
dveye Dryg Reaion ok penici(lio (6de ele u
ype ens tivi reaction
o Thteuo fttHal, nephchsmosty coth melhtciio

Jarts h
heuyheer 6eue, myagis, lachycaucdia,
> in the tre atmnt syplts
mosty 9een to
 |Cephalospot
ce
st _geneuGHon -lav
ceja nolln, celal exin, Hrom tve
-Avit
Second generaion
: ekastor, ceoriko, ckurorin, - Ghrom e -Sull
Grom +ve -Ta
Thic&
Ihte geneuoHon : cehriagone, celpturing, cettdine, cepabyie,
Ceop ciazone, etjs[Grom -ve acton Gom tve
-Im
Footh geneuttoncejepime, ce ptrome)
Gromve Qtton
Tactast sgainst pseulomonas

Hhgenexahon Piprole,
ceftaroline
en
rale.

Not pseulonsrad

Cephalcsporin doesot coveu

 Brlactam ane tnhibiror

- Auibalam
-
Tazoboem t pipeuaeil'in

| Cau bapene .foinshsdo

Imipenem, Meuop enem
areaslt p-loctomae reistant
aclmiotsteuel oilh. claytatn
aue prevent inavatton of fhe
yit
drug ing renal tubules by q
Johtboglenal dthydopeptugl

jVancomyein eyeeptoc agsite -heue itS

oganism (out
osed in MpSA, Jostri dtum disclle

Adu euse drug reafton /Srde elpet: Nephrooxio'ty, fotokiel ty

Synrone
.

9Banann Syndrome, DRESS

 Adves

Proteh Synthesis hbbitor

MOA

309
guy AL 30, CLL at Sooc
Terayline State
Chlora
mp kentco, - bolh da! tshart
cindamy cín
Oryhemycin State.
Une zo tl
Armiaycps e
Bactel6l la! (Pest autofheu aue baefeuis la Hcy

4u
QoerntQon @naerobey
Cobramiycin, Steptony ig
y: Gentamy cin, Neormyen, Amitocdn,
kaunamycn
neomyen gsfrepmyain) hus it s d
curare
e ebjet Cmasiy

Uses ot AnHbio

steui teatio
Neomyun- Got
Sreprarmnyun
 og Aruinogly cas tile
Aavese rug vfn

N -Nephrotoxlelry
neuromswtau bloclea e
O-ootoity

Tetrayuin

Doyedine, ingcclinen
can be used Renal
in fai (ore Doxyytine
Tetta yline Jhat

tozis excreed by key

choteua
L Rieketsia

be given mik antacio k iron COZ Jhey

Teraycne can't
decren, e) absorprlon og Tekra uyctinl

- Dovydine Doc jor send Typhúj

Adveuse Da
- Discolouraton ok teerh & inhl bift bone Jraan.
Neçhrogente iabetes naipidus
DNS fan club
- photosenwitiby
funconi Synlrome
 baby Sinde
Sre ebeet ok
Dogycy dire NABion2e 2
M

Drugs or psevdomem

Dveno nymefron:
Chloromphenico|

i-Aoaemta Aplas tie anetA

TCusg babyyndome mosfg in
e prematvce inft

Uingoiyun
(Bueteuoiler,
Pnerobic atecon Baerotde, lostridium peutnng, ung ahs
oork best
ora! inkecthon) dl)
w
eg Lung
Anaerobic n best
pindomydn
Anaeroie Fo below Claphrggm Mettoniozole bet
TntetHne,Wue

Pseo domembranous
Adueuse coliS VW
Dg

Unezo
ld
MPSA VRE
Moty
ancomyinretstoudr
Adveuse Dug cQuse fhomoy

peuigheral neoropahy
 Erythromycin
| Moero leleAzihromycln, oithrornyein,
Atpleals CMycap las ma, cblarmyde, legionla)
032: masty usel in

S1I Cehlamy die)

Advenye drug kini Teo tne nE motility (Nausen, Diorrhes, uomitan)
- Arr hyrhmia Cdue or prolonged T inteva)
( MAeo cause
Can Acute cholestaic hep atis
(4
-Rashhbsse
-BOsinohilia
ont inga montos immorornoßualogy aton

Gosino philia caued

by
Synthejis Tobibitos

pteutdIne + PABA (fDOmiro b Marolsds

Lothydcopteuate synfhekeae
ohieh hay anti
Dihydra ptertc aud in gammaoy

Sthyroglte
Dthyroplake redutagy .;Trimeroprin
hbra Pyrinerhanre in hibit
in Dshyd ogole redwetar

Soifhonarnt@e dapsonf

Dihydropieote Synfhetoe
m
solphameftoa 201e f Tonthiopr
Combincotion
 Types fote A Nuele ASynhefane inhíhh
JSop honam lde)

Drug anema, bilrcbjn

2 Ady. RarAplotte Alsplguement.
FR ys kalto Paoh (steven Jobnson Srronne )
ri,
kenteteus too
Mgooblato fraemia
2 Dapsone
Usel o teprosy
be used in phevmo eys tre zeuoveat'prophylay/s
Ady e:Hemotysis tn seD deuHAM
toMehhe moglobinen A1

Trimehoßtm
alyo a bactertostatlc drugs
(rimehoprtra also Su :
-osel tncombinaton E sulphonarnley
Timethoprim -Salphomethor brete
o(e9,bateniola
(ImpsMx) usel in'
pnemoyshc gexovlc
pneumonia>AT (Tp kproph
yta)
prophytay is oß Toxo plagmox
Adveye
G|ranulo eytopenia, Megal oblont cnem
n dose totl cause Hypeutalekdia
 noloePnevmouystic (jeovl s
Plvoro4uin olones to
portun istHo tateuen in

: cpoorocin, horklora en,7 HIV AIDs

A
cohich crtbi otic
kalem(
Cive
> Respíraloy oro quinolpne >rfmerhoprm
rlevotoraetn
DNA Gyrae (Topois omeuare ))
y Mechanism Tt inbibtt
Masty used in Gran ngaive Cgm ve) sod) of
urina or GlT: orine U gram e rod

Advewe DrA Rao. Gl gm ve rad T /Saro

i Damage to cautlage, shigerna)
So mosty tontraintcated in children eI8yr)shs C

>pralong
9T9nas
com monty, can cavse
Les if
)

Metroni Qozóle
S)

has onfiproroz pal atlon Fadlicles,mekabolite fn bateja!

Mechants m! korms riC .jree
R

cell
They Qumage to u pateel
ba DNA

Gup TA
 G - Gitorlia, audnereita vsginal!S
M

p- Ps
elomembranous coliHs

T Trtchomoniots (tro wbeury Bke)toidt YOr

A Amoebionts,Anaerobtc
C
clostrt Qiun Bacteoien
61T hypotensi:
Adveye Drug ko-Daolkuram ile in aleoho|-> Tachyeandi:
-
Metojlc feyt fiusthing

|Ant-TubeNculum DrúgS

> buls onde gou Kiamyen (aimgln

he
MOn: DNA Qepenbont eNA polumereneE
Pomerar
Plve ee Sympbms
Advese i
Hepatoroydhy
Teytochome Pts0(ocp fa enetve ecite
.orange coloured goid hen pt cn be pregant

but ifo busn doen

toibf
RA polyneu Teytohrome Puso
-Pojseicytohome Puso
- led co tbured
ofc
e,tsfonce chance s
 fsonlazt
MOA: o mycollc
VBynfhesfs % acl
UE
Mechapis
m

reafstange
k !

Batentol peuoxl ane

INH Bateug

Bacteuta! cnal are peuowl

dre- ts encoles b kAT G)

Co z acue metabolit sssUA

Advepe Dnyg
kA:tepatotosieity
Tohbit Gytochrome Puso
indused St6
case anjon gop metatbolie Qeldosss
ac'dos
- Ufamn B6 descienyiwll causpyridorine
coe add
Pepheual neoopahy So
S;lenoblasie Anemia
.causes Seieures fn lose

>acts test at a
ic PH led-reen bindres?
[a.E{hambuol
phospholiesteu ase
n hbfor e
Sildenaj!

DMOA Ara binagalaton Syntheg 15

t inntbrt
Optic neuropahy, (Re& green golour bliolnes)
P: caujed by Sidenc|
C3
 Streptorny cn CAminoqly
- F bloks
Adveuse dru
30s.& read to
asi de)
protein synthesis
inbibior
on
ry
tspnrofont
T

Sntenstve phat 3onttnvatloO

Complf cated/Sevene Bi,

Doc

TMP- SMX
 po bogi

eygos teuo) (bind

Grnfhototn)
4
Qemeshylae dr
fizol)
Syuaene
Squalenerc
[Link] Squalene
a

(Teubi nare

Azole)
eg: dlotrimzole |oonaole, ketocona eole, Itraconazole
Vort conaole

EluonozoleD0C kor candidios s,

spreg ton ok cryorococat meningits n
-ch ranli
peopie iinA e
efocona zóoje : ynae comasta
 .
Vorlconazola: D00
T
7prolong intauval
• Tracona blato my co S19, 9porotrt choSi3
zole: DOc Kor

• Ampho [Link] B
Jpolene binda| to
pores lo cel membrane
Aldv
Dr o: Nephrotoxieity
Renc tubulau addo c

Anisepeypokalemie'" R
hypomagna
feven,'thilts, Hpo teslon lt relese ok bistermf
Histamntre relea,i
Drug Amphoteie

>Morphie
prevent :(NQ loadia, fluyrosine combinction, or
Gmphoteniin 8 Liposomal amphoteaten
b

Gyiseo yluin
Pyso inducer
atue onty goinst demato phyte
MOA J tsrupt he mierotuboles stroctore. srupts The mitus

doulutam ike
310
 [Malauta
7Symptoms of malaula correjponds
with
eyhroytta stoge 9
2eopse ts due to

Tt is not present in Planmodiun utcipcnm

Duge
•

Chloroquine han (auygest vol- oh istribution?

I prevent polymeuizaton
o heme to hemozoigranaito,

Heme aceumulatlon

Toywe to (he pa atte

> Adu Draug Rao + 9kin ranhes, eipheral nevro padhy,
g hypotenaton

-Rolong ose can lead f rehinl damage

-Doc kor molota n Venant Cw0men

 utnIn e
i-n is albo sahe
&aje in
in Prenany
hypotenslo,
Primaqulne
:-Tt mefhemogtobin ernla
- Cause
hemolysrs
hemol iá Ga0D deliuent Payent

o
Atemes Inso leuvatve +used in chtoro quine
resist ant
hy Seveue malau la 1| Used

CArtemesinio com
banel baaion heuapy

fAnti-Vicol Drys inhibit

Mauaviroc
pener
enfuvirilé|

penetraton
uneoathy Am coraine
Nudele
ad
Synthesis Pagmeuort
reeane uiral evese Treettoe inhsy
Po ten synheg
Ate
uromiDie .ansembly 4k'proeesng
inhbib/for
dare Homan
host ceil
pro fecne tnbblor
 Potiheuper, drug i TAot viline Aydove h antydosr,fos comct
Pohin uenza drug :
Amantare, Osetta nsvir

Non-8electtve anfivlral: 2:bavrin, Cioivul Sne, JFN -d

Entecavir, Tenotoutr"PeG IFN tis lire)
uepatts B
ving:
13112

Aoh. lertoviral drugS

) NTI uteotide Nudeoside eveuse Trans eriptuse inbibitor)

Ly Abacavir, Diaanosine, amivuline, Ziaove Jine Sfavuline
Teno gouir

NNLTI (Non- nuleos e

kevese Transriptye inhibftu)
Nevirapine, Gauirenzr CNeN)
o Proteane inb:
, qu
bitoc Inlinavir, Lopina vir Sa Inavir.

Doultiegravlr

:
fuston nbi bitor Enkuvirtide,, Nauavico eite

Aåveuje
Dug
SHovudi ne Donosine > peuipheual neuropafiy
 marroe supresslòn Agrnuloytos/s -
eBone
e

pancreaHH3
o Drdanosne, Lomiuuolne

• proteare inhibitorypeuriAgceut dem (a

• zdovudtne yopchy
2NTL + I NNRTL
HIV TG
ATr
cointeton)
is Stanted beore AnH Reroulrol heuapy (bue
fea
(IRIS
agamgein s replacéd b abut
ithautnzis sel

vlrus
Can cUse

|Antheg mtobc
Mebenda ole
If inbibits of prerents pogmeui autian of
B-Fubutin oh toorm
es Ly Now (ea to esputson o

busel n Rounloor m, hookoorm, Pincoor r

(Nema to d)
•yrantal pamoafe:t inhibit eholinestew ase engme
Coorm doi paualysis
Saote
Live, cO orn e;pe iled
g: caris, enteObius, an ylostoma

o
Pipeuaz ne GABA

causes
0ses hypeupolauization

Coorm aue expeied out

o
Iyeumein:TGABA trarzmíssion

ypepoluizahon

(Oor md ue erpealed out

.

Qs pedicutosis, Scabie,
o Praziquantal:.
It aye
înere U)e he Catt;

T Muyle contratlon

Opanti paucl ys/s

dead coor m
eppel
)usel tn Trem atole ces to
(tokes), de (Tope Loorm)

Atben Qorole ls
he Doc kor al nematode exeept
pf

mependaole tn eneuobius MOn

Cpin cOor m)

Diefhyyroarbama zine t as on
boh nítrok|are
Vádoltorm
IVermechn acts ony on microjlarq
biirdnes s)
Used In on hoceci ais (Rivey MOA

Doc kor Lalary

B
Liposom Amphotetin
But MC used
 ntiouhrnic

TU

Ic

Mof: Na channel blockeu

|aria

'MOA: B-b(ocke

tirchea)MoA :
MOA: Potan slum

chanre bo key
Uas 1V
3 Ca.
honne blokey

MIScel cneous drys

 inQoce)
Dgoyin
Procainomi&e Ds epyramide
A ulatdne,
Lidoeaine, Mexiterine
:
Ie fe cainile h caln ide
2AAS
frop anolol, emolol, Qceboolol

Amtodavone
Sotauo| ponedauone

Uans I
vecpcntl
Torgacl
yaus

-> Alenossne
depoin te,.

Drag uSed in loscs

5B-bohey

ventrteotcy UTochyeculr
AdenoJine

thanne blobey
 Dtgoyin inoce vcntricul o
y "hog
A docalne

|Aottbypenlenslve Drg Có = H
3troke vol

Bp X gstemto vasculau Zesistane

LAAS

N Renay petuston delecteel

Be en)
k Nac delveuy in mecula

Jh cels secres Pentn

cOnveuts o
Argionn

e -4cE
enee)
(Agiorengin Conyety
onves
c
ansiotenstn I fno

AldosteuóNe Sereto)
Agitondin ILreteptor
eintescalatel cens

Vayo constieon8e Nqt reabsgp

H'Serdton -ketsecrete
 Diuretico
,neOgabsorb

Pe

Ocela otamleD

Thsazte iurete)
Qlureesl
Acetazolonles
Nop > Carb onk anhydrae
iohbcor.
CausesNa
Nat. Ho, diureis
3
he i al lelanke
urire
e
Glavcoma, AtttUde
sicknes SiyreHcd
Ady
Icauses roxtma sen a
Tubulay
sulgha a aulos (0e 9
lg
y po
kal ema
toll (ea fo caletu m
phos phatesfor
insolob (e In h
becor
 furosemi Qe

It in creanes he ca
2t excreH on 0

Advese Drg leaHon

injesiia nephrit gouF*

inon Sul konami de iobbhor ok NaTel2d

Co
trans port
ymogh optoxje

Thiaztle dlureics

Advese Leacton

gpeipileme
pe 9 yperurieeia
ciloss (

beco
 Ade
Qieretice.
y ANQosteucone
receplor antgon
Adv. Drug

Meabol [Link]

Manoitol
ok osmote dhureHes
m
Mechonis

Tseuum o9mojauity
Adve
frotd shit jom nteutHom to nravaaa spacp
9
unne

Ace
geapoprl, enalqpal, lisinopr"
Jhpbit Ace Ca

frgtoteoin T

: HTN, # prevent cardiac vemoJeting Jo chronic

hypeatensan
iprotelnuria 9
Dra behic
Heaut Kaiore (ALE
tnkbitor enortkaliby ) "palny,
N
 Aduebe Dryq
Dg Rar

og (ony )
Teout,
-Añgioelera
Terato
-Tcreatine (So
af2)

typotenston

Angtoteroin || Rceptor brockeeu

: Losautan,
prerent
recep tor
Adveye Dng
Dryg
Re
ypeukalem}a.
2enso tnhibir
Direct ren tn
nbibitor 9o, t
goteninggn
bok hene
to aggioensin
I
Caucum
chonnel biockey
2ty pe

nydrpynire Non ihyaropyridr

mestly it ason heaut

Nimodipire g:reupamil, di#oee
 MOA_:
cau dta hes coill biocde
votage guted
%m00 L ipe ca hannel o
h
mse
:vitroycere
Umuwde con
traelihy
MOA : veodit
Aro loAighe = Nijediptne Dtiazeny
pduese Dra
oirnboVerapon)
Heat: Veuapamiz DAHozem lejer rabyja
> Amtoipire = -yPotenyiar?
Uses
Diydropy ridine eroep -Headache
h oimodigF Used fn nTN,
- Mordoy Drseo
1

ay Argno,
ncudhenoore non.
Conra tncatior
-N no ipine Sub
auachno
haemortog e concurent p

Nleordipirne :
HN em apeutaçhic
-bJod Jon dthydropyri
dire TN, angna, Ara!
bbllaton
Adseuye
GPH:
Dihy dropyrelire
1ene peuiphewa edemg
Non dffydro pyrtdire
: judhng,. diezines
can olso (ead to
cau dioo
(ead io
fo conattpakon
le presion, Av blode, Jn Post MI
3 hpeuprolocHinermla
Caosed ewa pcumf ) Prgnansy
 hnne

Airate
J: Nitrogyceuine, Isosorble
Iso inirale, Iso sorbse nonontrate
eipine7IRi)MOA: voodilatt on
NO n Vaycutauu gmooth mostes
Diates veh auteies Upreioad'
Advese
lejyer rachtaido) mchhemgglobiremto
-ypotengtor
froshig
-Headache
-

Containdtcattons

concurrent Phospro teyteuae

-5

Anthypeutensve.
Io angina: Cat chan ne! blockeu, B- bocker

, Hngrotendi ne
rèce ptr boken, Cal chael
blodee
In Pos ME: B-bloke
AVbol,
Tn hyrofo xicoSS(Propano lo|) B byekehd teata
chhemte
n Pgnaneg memyldop9, Cc8, ondrne, B blo iten(eaudto

seetve P blo CEeu)

 Chronstopfc 4qent
Congotve Heat failere Drugs
Lytes ate
of
?con raHo
) Diurefey: furosemide sptroolacome
W Tonotropte sgent: They aue the agen t coheh Te orLe
g: Dobutamine, Dopamtne, Dig
onh,
Digovìn
iret inhtbster Natt
Sle efjo
Fators pre
Tndlreek in blbftor ok Na lea erchang 0.

to cell

Posttve ton otropy

vagus (PaMasympaheHo ahato)

|Chrontc

vosoila
-Ac6 inh
:0 Heaxt
alure
)A26
Atral brillaHon
NAdosf
Pblot
 -yeow uson
- Aurythmiag
yppalenit
-Ghynaccomantta
NGUSe vorsk
ven triolay biemhy

: Ltve do Ctlan
Side efjeat o Are ntaeiro

Qenal kalure it Qeçe aney hei ooin's ercreton

Vypomgneremio

an tilrgerin Antibo8y
:3evere toriay 1
|Chrorte Conqive
:
i vonolilaforsNitotes, cal chnnel biockexs
it Ac6 inbsbirS

ivAldos ferone inbibíor: Spirloolautore

 Nepritysin inhi
inbibitor
Short
prerens Jhe degradaton o yani0,
bra Hydrobor
Thteumele
vasoHatton predntsolone,
Tramcsno lore
ong coth vas autan
Contran cnte
Dexomelhe
BefameTho
bcoz bon nereone bra dykinn
Mineual

DocA
con be eithee glueo corf Deorycortteos
cdo mnenasocorheot.
Gluco corHeois fluro
bydrocortisone
AQveeue
Inteunedtate 8 pre
dnso|ore, Trta mchojene

long ong Dexamehascne, Betame hcsore Steop

Groor
(hinot
Tmm
Cajara
System
 Chlucocorticods Mineyalo tortteotd

Short
Hydrorsore

Jntesmediae

ionfate Pedsisalone,
Trtamcsno lore

Cong ing

Denomehasore B
25
Befamefhasone

Mineualo corticds

DocA
DeorycortteosTeuo e)

fludrocortsone

Aduenue ejats o glucocortcolda

rorme
omchuert ushig Syrd
osteo poress, Myopaly
• Groolh retarlation
.
Thinning ok s8n (skin arophy)

Coma
Catarac Gcu yTopsecad Steuos
 typol
Glema
• Suppresion of HpA ayis Crypotholumus, pltolt ouy, alrert)
mueosa & ulcey ation MOA

dle esset e
etal abnormales
•.Tes sn halr (ArsuHsm)
• gPyycenmia
ie DM prectpitratlen
Srae.

contrainli catlon ok cortoeuo i

-Pregnanay
-Psychosis
-puD
oSteoporeais
-Penay' gilue
io test

-DM 9 fAbrote)

-TB
-ttepes Simplex keuatts
Adv
 typoli pidemio Drgo

ci
:Aforvastaunin Simvastatin
:
MOA
I nbtbis tonvesion HMGO to Mevdonde

ormattn

Ihcreane 9L recep tor.

reytws:
Adv

i Bile acdrest chaletgromine colstpol

It prevent (he tntestinat Teabsorp rion ok brie act so

v.
Ad Dog
R: GI vpgek, Uabsorbtfon ok
at soluble ultam

tt tnbbft choletöuol absor ptfon

at smallyn
iotestna brush borde
9
ibrote) ! It activate pPAR
losas

TTO decuance t HDL Synhests

Adv R1 Tey store Cchojestera

isk ok Gyaul
 Nac Oral
Inhi bit Mipolysis n adipose
It awo redve, vLDL kormatton In
brssuebh
ven
Advese
(Ae, typergycemla
Secret

pcs ka tobibitor

- Iractt vaton ok LDL reiep tor degraQatos

Te removal LoL bom bjoo&

Adveyse Drug Ran

:gatga, Deitrtom,
' fnentso

fypoglg cenic Drugs

@ LAG
Papicl actrg : ts po, tispaud G|otisire
 oral hat2gtycento)

)oultn setreHon
• |9t gen Sulphonyl ureosi Tol hhorp roRmd e
butenie,
Disulguram yan B
ADR
ke oriseo fulhinabs)
ecreig 9 BP,PT, Dygnea, 6 pe
genSulphonyl oreas" Ghlipiele, Gyburdegllcan

I) 1 Juln seltaty
T

bgoanide,9 Megormn
dendrogerto.
• It inbibts oitochonrial 4yceO] 3-phosphale

qluconeeqeresis. a otion o

yoglegonst
A increanes lyooly peipheual luc os
upake(re 1
ins|in Sehuih)
A DR
Late acj osis
- vttamin By2 Qedeny
hta oldretore Progltb, Rosgtlazone

Decre
)

ary acið s rage

edmg
- Heaut jai(oe

Detayel.

cose incued indolin .secrefion

|nA
GqLP -1 an adogus : xen
aie, ogluhe
vgocogon reloe
depen@ant nsuttne
reler
AD Nausea, vomitng, paneren

DP P -y nhtbitor

reje
,deayed on fric eptyy
vgluggon rejecae,
 gtucose absorpton.
t) Decreae

fhe reabs orpion

o ucos in PcG
Thy bok
e ttanee
ADR hucosu rta, Dehydration,
b torfhostate hypoterio)
vulvoyairal andilasi)

• goosidawe inbibitor acarbose, waglibose msital

it inbibit brush bordey glucost dare

carbohydrae. hydrolysis
ábsorptiör oq9:9*
So, Nglucose

Amyn aralge FPromlintlediini enpryg

rereane, gotie
. dcogsa
ADR: tyrayoemia, tsaHery
 caubarna2epin
ADP:
Înhbu r Te

r
An
tepileptie Drugsod
:
Oxeitoory Giluramate

thasoyimtle
Nat channel blockeu (exitatory trhibí
fn b3x4s)
arbono2eplre
-phesytot etsho Used n
Val proafesHtsofn AD
- fastgue
- Gl ist
(erefalury lohtbi
- Heala
S, A receptor bjpckey, Levetiacetc on- Modt commanly töaí 3 - Tting
-Steven
qaßA agornfst Ben20dia zepine, phenoboubiret.
oLamotrgre
BBA reupiake înhi bihr Tra gabine
Leve Hraceta
Val pro k
h aBA trsamineye tnbibitor gaban
A DR

Phenobu blt
:
lbojse elampsta sei2ure ADß:
Doc -
 Cauboma2epine
ADR: qyP4so nducer
Diplopta
Tergentc
Steven Johnb on
Synlrometla
SIADH

drg or Trgemiad nuratgio

-t bloles T- type ok Catchannelsi 12

USed io Absenee seizure (duraton coibio, min

But absence seizure

fatque, DOc valproot

- Healache
- Stevèn ohrson Synrome.
-bial otametrgene
• leve tiraceum
symptms.
ADR: Neuropsychiarie chg
•Phenobaubltal
Apß: ayPyso indvce
candiores piratoy depesion
neo tata Selzore 99
 Vigaba
Gia
AD
eytbchome Paso inducew

H -Hirsuts m
-nsgm
yetow broon -Skn
T TeHalagenle (Reral hyQoatota Syne
Osteopenta

N Neoopahy

Valprocte
ADR
-Vomihg 2) Mcro fu
A - Alopecda 98
- Uverlamagt
L
P
- Pancreatt HS ) Toppisor

-p4so nbibitor
To poise
obesty
Tremor Antblot
Textogenie (Neral tobe ebect)
orh e
 Vgabalrtn
GiaBA rans amlnae datbitor.
(
A0R peu panent visua! (os 99

Aoi Cance
Claosifcahloo
O
Aoi mefabolites. O Mefhotrex
ate, S-fu, Cyrgrabire
II inhlbit
dihydo jolate
ase
reductase
>Pyrimidine
porf re

5Aaerostp
Pyiniline
rotobole damgatng agent
Mierotubule
MTV
T ens tine,

3 Topoisomeuas
I
inbibibr To potecan, rinocan,iisIqei3

9 o pois o rneu auye

I inbjbors !
toposile
9 Antboi: Doxoubicin Daun ongbicin,
Blpomycin mitbmycin C
(6) orheus
e
Ao utdinrea, oporeglnane, Arsznic triontde.
cei) A
Fnbbit Bbonveohide Ihhibitonh protedn
redo te Syntess Rhypeu coggube Stak
 Bomycin
o
Arsenic frioylde

State

gpgiycnt Ar2A co)

fanereaHHS
Bjeonge
au
o Doxorubiin, Daunorubici
.
ADR Caudio toxo

.Merhotrenahe
ADR: So mahHS
Pu bros/s
:Put
tepafotoyic

yto
glophospharmile
ADR: Hemorbogte gystih
used to he toyity Trantoe

CSplaho
a

eoR : ooroey, nephro fuytdry

vin ca
Periphe d europahy
SvincHSi

Suppres
viodastnE Bonemorroo
o
B|omycin
ADR: IF causes Pol: jbrosf'
L>Bußul phan auso cause

Breongcin. M
aus 612

acts on
cAnterneta bolikes

olieic acid

o
far acton
me hotrsae

Trandtoe umcb

L act a fte rg
s/6! cauliotoric
 Lmp levis fpn or Phouma Thromb

Ant
Lupus

Toxtety
Di'seane
oTC|33 Drug
Dobejes Jncipdus inhiom (naroo fhe rapev Hc
nlen)

Gynaecomastla >- ketoco narole

Spsrinolactore
cimetdire Ho
feyton popil
Rypeglycem
ia Glvcocorteobs
Kypen
Thlazdes
ypelhyoi smAmiodauone Celars IL bntioylami)
otre
Ublum
pancre
Amiodauone

SIPPY carbamazepine, cydophosphamide

Megaloblagt ic anemia - Pheny tod, Mehotreyat

Sol ba drgs
Metpr
 Thrombouyo penia Line zoli&, Hepauit
Hepcudn inlee hromhouyopenta Creng

Lups
ngs
- Hydralazre
k
erapeutHe Isontazile
inle antiauyhmie)
P-Procanam de Ca
Oigiuad tyreuplasta
Calc'um channel blo cker
(
-PhenyosopovdoTH
Ho

ospoin,
Hypeyure cem ia
Pyrazina mlle
Thia zile
-furosentdle

pancreafHHS
Didanosire
Vasprocte

tocoorticoSterosd
R(coho
Dhvretfas T fresemrde
 Osheopores B

-CorHcoesojay
-Hepajo Nphrotori.

Sfeven fobrson
Synlrome
Aotie pile prt
dng
pentcatt tn.

Teefh discoloroten
efracydir 3Pce
Ten Qon cartoge domage The
fluoroqwinolones a
paripheray neoropafhyIsontazl, patnum, Coimpoònd.
phen yroin Visua D

TnteusHihal nep Dgotin

hlH S. Pen ie
tin (merhicltlia Ison fazide

Posphodfejterp

Seizuro Ehambuo!

Isono zt. Hdiopan

Jmipenem cilaat atn
Dry coyth
Myopahy
 Arnio arene
trerate, Bieoryein, Busolphen,
Pot: sbosisMefho
Nephro ori cy o}otowel ty
: Loob oiureH) Arnirgsy coclen,

Amphoteeso, vancomyu
n

Cillhsittiit

> Sulphagaatire
>Aorosemtde
Pcetaotamide
Thazidey (Coop diuretes
so ljonyl

Compourd Visual Disturbanee

yertouo tinged
Digovin
Isontazide; opie
PDE -
!
Blve
Stohibitor .

Dhosphodieyteree)

Efhambuol : ReQ cofour vfst on

intcocronial ypeuterion ita min A

Tdiopahic

Myopathy sfatt ns, 8terosds,tbroks, Niacin

 Menco
Tou alve dyskinegia u:oteQ. Caudpmyo Pahy
Merhotre
Alcohol
- Mebdopromile Doxarubiei

oi- Daunorubsetn
p seudoreM be nous colit9 Trastuzwm ob

- Amptetl| in
-Cephalosoriny
-Atuoro quo loney
-PPL S

Anido)
Aceto minophen
(Pe - N
aceyl ysteine
ropt e
pois onig / 4ctyl chelire es teuarein hbior-

Anhhainagie agent Physosgmne (pais bb2)

dor
Ars entc Dimencapro |

B2D - flumazent

100 0, (yperbauie O,)

Copeu
Dgosin Digoxs specifte Ab brogment
kepautn - pro tamine Suate
 fomepieole)Ehonol
ac
Methotrerate :
ley tovorin /fo linfc
Nalox one
vita rmin k Cgect delayed or fomnediate eyet:
fresh frozen jarg)