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Clinical Chemistry Quiz Insights

The document provides an overview of clinical chemistry quiz ratios related to total protein, albumin, and globulin levels, along with their disease correlations. It also discusses specific plasma proteins such as haptoglobin, ceruloplasmin, and alpha-2-macroglobulin, detailing their functions and conditions associated with increased or decreased levels. Additionally, it mentions gas chromatography-mass spectroscopy as a gold standard for drug detection and highlights the sensitivity of fluorometry compared to spectrophotometric methods.

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4 views68 pages

Clinical Chemistry Quiz Insights

The document provides an overview of clinical chemistry quiz ratios related to total protein, albumin, and globulin levels, along with their disease correlations. It also discusses specific plasma proteins such as haptoglobin, ceruloplasmin, and alpha-2-macroglobulin, detailing their functions and conditions associated with increased or decreased levels. Additionally, it mentions gas chromatography-mass spectroscopy as a gold standard for drug detection and highlights the sensitivity of fluorometry compared to spectrophotometric methods.

Uploaded by

kristinedacumosnavarro
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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CLINICAL CHEMISTRY

QUIZ RATIO

Emmanuel Hans Munoz, RMT


Total protein Albumin Globulin DISEASE CORRELATION

Normal / Decreased Decreased Increased Hepatic damage (cirrhosis = Beta gamma bridging)
Burns, trauma, infections

Decreased Decreased Normal Inadequate diet, nephrotic syndrome

Decreased Normal Decreased Immmunodeficiency syndrome

Increased Increased Increased Dehydration

Increased Normal Increased Multiple myeloma, monoclonal and polyclonal gammopathy


Alpha 2 Globulins

Plasma Proteins Description Increased Decreased

Haptoglobin ● APR ● Stressful conditions, myoglobinuria ● Burns and trauma,


● Independent risk factor for cardiovascular intravascular hemolysis, liver
disease disease, low RBC production,
● Used in paternity testing hemoglobinuria
● Marker for intravascular hemolysis (HDN ● Hemolytic anemia
and HTR)

Ceruloplasmin ● APR ● Inflammatory response ● Malnutrition


● Copper carrying protein with enzymatic ● Cancer. ● Wilson’s disease - Kayser
activities ● Pregnancy fleischer rings in cornea
● Menke’s syndrome - kinky
hair
● Nephrotic disease

a2-macroglobulin ● Protease inhibitors ● Nephrotic syndromes (10x


● Largest non-Ig plasma protein increase), diabetes, liver disease
● Major component of a2 globulin fraction
- MEDLINE PLUS
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky (2nd
edition)
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky (2nd
edition)
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky (2nd
edition)
RATIO
● Gas Chromatography-Mass Spectroscopy (GC-MS)

- is the gold standard for confirmation of screening methods such as TLC and
EMIT.

- it allows for detection of low levels of drugs like cocaine and drug metabolites. .
Fluorometry is 1000x more sensitive than most spectrophotometric methods
From: Henry’s Clinical Diagnosis and Management by Laboratory Methods
(24th Edition)
From: Henry’s Clinical Diagnosis and Management by Laboratory Methods
(24th Edition)
From: Henry’s Clinical Diagnosis and Management by Laboratory Methods
(24th Edition)
Photo from LABCE website
From: Henry’s Clinical Diagnosis and Management by Laboratory Methods
(24th Edition)
From Bishop (enhanced 8th edition)
From Bishop (enhanced 8th edition)
From Bishop (enhanced 8th edition) pg 349
From National Library of Medicine (National Center for Biotechnology
Information)
From: Henry’s Clinical Diagnosis and Management by Laboratory
Methods (24th Edition)
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky (2nd
edition)
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky
(2nd edition)
RATIO

Definition :
● Iodophor = Iodine+detergent
● Iodine tincture = Iodine+alcohol
From: Fundamentals of Clinical Chemistry by TIETZ (6th Edition)
Quick Review Cards for Medical Laboratory Science by Valerie D. Polansky (2nd
edition)
From: Henry’s Clinical Diagnosis
and Management by Laboratory
Methods (24th Edition)
From: Henry’s Clinical Diagnosis and Management by Laboratory Methods
(24th Edition)
From Bishop (enhanced 8th edition) pg. 39

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