-

"I

=AIDS
.
Q manifestations
Mucocutaneous of H

Infections.
① Acute
-
exaumens
· within 2- weeks
infecti
of
·

maculopapules ,
symmetrical
· Enaumeus : -
ulcerative one moun
palate , playe
,

Orectionish of wanthin a
HIV hav
som

initial HIV grouped vesicles - heal is 2weeks

Stage of : -

advance
stage : -

:
- atypical lesions >
-

longer cause >

-
to It
-

poor response
large deep were

* illness"
#Ds -

any non-healing wher .

I month

buttock abdin
[ quar
Lesions involv
-
-
,

orfacial: becompolycyclis
-

ngue:- Geometric pattern-modular ,

hypereratori
-

condylomatous
Fingers :
- Hespetic whitlow

oral kion-ooplay-orophages
E
Diagnosis
-
① Trank smeen
-
-

=
Late
Mini
counte
OPCR
.
③
Alf
④ viral cursue
-
⑤Per
⑥ Hestacycoprotein 1 ,
.
2

Chepe SelectSA) -

MX : -
Similar to normal just longer (ie :
10 days instead
of 7).
Iv foscomet cidotovir
,
oirtmut

③Infection
VIV .

T - ax
Chicken
-
-

in HIV
·

prolonged covere

T complications Ibneumonilis ,
back

superinfection mariugins)
,

frequent recuences =

significantly how CDY counts

zoster .

a
- Jumpalian
-

in in HIV
·
can occul
younger age
multidematomal lesions
·

systemic marifestative Complication -

·

longer cour
Trigeminal neive=MKC
·
 ·

Necovir/creative/vesuous lesions
·

Heals I
scaes
·
Disseminatio
·
It : Need extended course

IV foscamet , IU in resident cases

STER
VaccineHi I S

be used the
VIV oka strain can

④ Human Papilloma Virus

↓ 4count 20
Dixie elemesites
↓
&
.

Presenting lessions >o

-
VEGETATING Type
·
Anal condylomata
·
common wasts
Plantar waits
riste
HigherUPV
↑

ORAL >
- vermou
plaques - may become malignant
[Link] ↓

infi EPDERMODYSPRASIA ERRUFORMIS

the

Epidemodysplashe recuniformis
↓
I Common , may
be
associated I
lymphoproliferative ds .

A canalso occur in IRIS

.
 ·
Risk of invasive Ca of cuixa
and
canal-
·
Routine cervical , cytology
and
,
PAP sereau-must .

HPV vaccine= safe in HIV

Quadrivalent
= more
effective
mouscum
contagiosum
·

By Poxviry
Extragenital/Emptive MC
-
=
1st
of
-
HV
Sign infection)
IRIS Y

InHN
·

,
Mc =

atypical
-
,
location morphology
(extensive giart, y genita

Periobiations common
- ,

&

-
Hairy Leukopakia
⑥W al (OHL
·
By EBV

Tedicates
·

declining immunity along with oral candidiasis

Indian
-

-
⑨ viral load CD count <200
--
-
 · CDC category B marker of HIV
.

·
asymptomatic ,
raised , corrugated white

on
atual
-
-

-
lesions side of tongue
,
-

①TOMECALOVIRUS
Infection
In AERS
onset insidion
>
infectives disseminated occurs in
-
severely immunosuppresser (CD4 < 50 cal (me)

>
-
MK manifestation
-
nic
use in
perincal aver

(extension of proctoconinis)
ver on
this ,
tochs cavity
TCt : CIDOFOVIR ; FOSCARNET.

# CACTERIAL INFECTIONS
bact inf
O aph ancus (Staph -
Skin infection MK . HIV
.

BOTRYOMY COSIS
folliculins
Echymagauge en
-
-
a

PELDOMONAS freunde .
-

· -

AEURUGINOSA carbunce
sysheasmen
-
-

impetigo US
&
-
-

·
incidence ese
immunodeficiency.
-

ectmen
euitis
PtC CD4 cells/mm3
-

count <200
-

BowYongosis

PHILS : Prevalance of folliculitis.

·
3-9 times more chances in HIV
.
Painless ulcer becomes painful dit super-infection.
:
·
1 lesion :
-

2lesion LES MALIGNA2suphillis vasculitis malaiseHei

a
+ headache +
: = + fever
..
-
 ② Angiomatosis
Bacillary
By Bartonra heneral
.

B. quintanc
· MK see in late
stage hiv (CDU <
100 cu/ml)
·

small viotaceus papuls >

- modules

COBACTERIAL ACTIONS
· seem is
easy HV infection
Clinical
·
presentation >
-

sonfulodeeme
-

papules
noduls
kecalde
-

r
palmal/planta
-non-healing users
CULTIS MILIARIS ACUTA GENERMUSATA
-OBERCOSES
carical lymphadeiks
.
-

Adverse Ryn to ATT-ISONIAID in HIV

pts-
-

FUNUAL INFECTIONS
nuvovaginal
① as .

. cutaneous

dIAM)
.

oropharyngeal
e div mic opport in
infection
O
pseudomembranous
prepa -

·
angular cheilin (perleche)
 ~Pseudoimbricata

j
-

② Dermatophytosis- urpusic lesions

Masochi's
-

atypical presentations granuloma

seen in HIV/AIDS

na
Pedis Mic
-
>
- .

Linea-IRIS have been reported

↑
-
Cuptococcoss
By
·

cyprococcus reoformans
·
fungal pamoge g meningitis in AIDS
(Cyprococcal)
meningitis
·
M/c fungal inf as . IRIS
so

·
eymemahrs papulinodular neclizing skin lesion central
I - umblication
↑

&

over head/neck region) TIt AMPHOTERICIN-B

-
: -
X10-14 days
10 7 - Img/kg/day)·
·
.

Dx = Lumbar pumtre
-

① HISTOPLASMOSD

my so
.

- sam

by H ·

capsulatum -Pneumocystis Firoveci

o
pulmonary invorrent MCC
skin lesio Mkc on
face extremility , true
·

PASITIC NFESTATIONS

I
scabies O Demoder
-

occurs in
·
early stages Demodex follicular
Norwegian
· Scabies
(CRUSTED SCABIES)
- MK in AIV/AIDS pts e
0
also seem inIRIS
Responsive to
·

ERMECTIN .
 #NINFECTIONS
MANIFESTATIONS

⑦ Leb Dermabin > MK-non-inf disorder asso HIV

.
. .

Extensive/atypical thick greasy necrosis

scales .

(Histo-Keratinocyte .
tht
)
② Princ Papules Ecuption REASONS FOR PARADOXICAL worsening
of PSORIASS In HIV

forimlibs -I Langerhans
men
cosinophilic pussuas Cells
.

~Potential epidermal proliferative effect of

syndrome Reiter's HIV-1
- Alt CDB 2D4
: .
Ratio.

⑤ Psoriasis ↑
~ of NO
Synthesis by macrophages
.

~ Alt cytokine profile

.

a
-4 colonization of skin by
manifestations S aureus
.

pseudomembrations Candidians
ORAL-Manifestations in HIV
·
eynemators condidiates -
·
Highly prevalent
indicate failure/success of HAART.
angular cheilins ·
·

Oval leukoplakic
· > 4 concurrent ora
resi S
·
hairy
Candidiasis M/c cause
gingivitis
.
· :
·

·
necrotizing periodousin's · Parotid enlargement common in
·

Kaposi's Sarcomas children

.
·

Hairy leukoplakic Specific

linear
·gingival erythema
NUL ·

gingivitis
·

indicators of ulcerative
- Necrotizing .

AIR
M
CHANGES dingmunity AutnecrotizingPeriodowihgingivitis oe
Oth- +

G
-

"Palm Tree" appearance on

·

in Root Sheath
Keratinocytes
Biopsy dltnceotic
/Lena -

dysophy
flair shaft .

Changes
-clubbing ukonychia
- Transverse
⑧
Nail pigmentation
-ginal
&
lines &

melanomychia alt zidovudine

-
onychoschizia
--
·

& Anolumula · Red Crescentric band in distal

nail-bed ~
 & NEOPLASMS asso i HIV
. .

1) KAPOSI's
-
JARCOMA
2) AIDS-related B-We
Hodgkin's lymphoma
3) Anal carcinoma & CIN also i
. .
HPV
-

4) Intra-oral ,
multiple SCC
.
-

5) Bowen's
.
do

6) Metastatic BCC
.
-

7) M meldnoud
lignant .

APOSI'S SARCOMA .
*
·
vascular-neoplastic disorder

CASCAL/SPORADIC
assification olimited to solitary lesion on lower extremity
(not severe)
ENDEMIL/AFRICAN
> in Subsaharan Afric
.
-

#linical subypes MINICALLY

3 stages of KS
. -

.
1) MACULE/PATCH Faint pink
-

·
Benigh nodular macules/patches along
skin lines
.
- cleavage
·

Aggressive localized PLAQUE lesions darken

2)
·

indurated plaques of
brown
& develop
raised firm
· well-disseminated florid KS
. .
colour
-
3)NODULE dome-shaped
elevated

Lymphadenopathic
·
,

variant
,
·

purple,timwerdeahardmats)
,
tumor
.

>
- HIV related KS has
aggressive/unpredictable course .
 OF .

-
skin lesions
·
single/multiple
mucosal visceral involvement
·
, ,
lymphatic
(internal lesion develops for every 5 cutaneous
lesions)
HE =
Atypical SPINDLE CELLS &

Hemosiderin laden macrophages

.

It
-
=
localized--cryotherapy
-

·
I 1
. .

Chemotherapy (UNBLASTINE)

Advanced = Systemic
chemotherapy
Stage
Crincristine , vinblastine)
HAART = Beneficial role
.

-
-
T
-
~
-

~
a

=
~

~
~

CLASSIFICATION
.
&

X
S
=
& --- c
5)
S

F
I

·
·
*
bigrid
*
f
hancod,
· looks like chance
.
;
·

By Haemophilus duccey
indurated
access not
·

Single/multiple , superficia ,
fender ,

(unlike syphilitic chance which is non-tender &

indurated
·
painful inguinal lymphadenitis .
I Buso [50 17
.
~
"
E
Intra-

seeu.
Myoepithelial
a
 CrTON's NIS

Perisynovitis Knee Joint/elbow

of
8

~
Blu age 3-15 yes
.
#
·

Painles
·

swelling
·
insidious in onsel-

· cheoni course

·
Mobility preserved
Xpay -Joint space
:
O

enlarge
·
Bonychange
No

dit -
persninig
improves gradually
·

---
Adjacent Bone Erosion = von Sie
Jaint
Rarely sees.

It
-
don't
-
: its cause of hypeneuilinity Pollide
Norjointspace
,

respond to anti-supliine -- in
 ·
Mis
T
*
T & --
T

↓ Og
i
-