UNICOOL R-407C

Wilhelmsen Ships Service AS

Catalogue number: 905624 Issue Date: 07/20/2024
Version No: 2.2 Print Date: 08/08/2024
Safety Data Sheet (Conforms to Regulation (EC) No 2015/830) [Link]

SECTION 1 IDENTIFICATION OF THE SUBSTANCE / MIXTURE AND OF THE COMPANY / UNDERTAKING

1.1. Product Identifier

Product name UNICOOL R-407C

Synonyms Product Part No.: 905624 (11 kg) 905607 (52 kg)
REFRIGERANT GAS R 407C (Difluoromethane, pentafluoroethane, and 1,1,1,2- tetrafluoroethane zeotropic mixture with
Proper shipping name
approximately 23% difluoromethane and 25% pentafluoroethane)

Other means of
905624, 905607, 905624
identification

1.2. Relevant identified uses of the substance or mixture and uses advised against
Relevant identified The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating
uses atmosphere developing. Before starting consider control of exposure by mechanical ventilation.

Uses advised against Not Applicable

1.3. Details of the supplier of the safety data sheet

For quotations or product
Registered company
Wilhelmsen Ships Service AS Wilhelmsen Ships Service AS* information contact your local
name
Customer Services
Other offices:
Willem Barentszstraat 50 Rotterdam Willem Barentszstraat 50 Rotterdam
Address [Link]
3165AB Netherlands 3165AB Netherlands
/#/networkdirectory Norway

Telephone +31 4877 777 +31 10 4877 777 Not Available

Fax Not Available +31 10 4877888 Not Available

[Link]
Website [Link] Not Available
/maritime/compan

Email [Link]@[Link] [Link]@[Link] Not Available

1.4. Emergency telephone number

Association /
Not Available Not Available Not Available
Organisation
Emergency telephone
+ 31 30 274 88 88 + 44 1865 407333 Not Available
numbers
Other emergency
Not Available + 31 30 274 88 88 Not Available
telephone numbers

SECTION 2 HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

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UNICOOL R-407C

Classification
according to
Gas under Pressure (Liquefied gas)
regulation (EC) No
[1]
1272/2008 [CLP]
1. Classified by Chemwatch; 2. Classification drawn from EC Directive 67/548/EEC - Annex I ; 3. Classification drawn from EC
Legend:
Directive 1272/2008 - Annex VI

2.2. Label elements

CLP label elements

SIGNAL WORD WARNING

Hazard statement(s)
H280 Contains gas under pressure; may explode if heated.

Supplementary statement(s)
EUH044 Risk of explosion if heated under confinement.

CLP classification (additional)

Not Applicable

Precautionary statement(s) Prevention

P101 If medical advice is needed, have product container or label at hand.

P102 Keep out of reach of children.

Precautionary statement(s) Response

Not Applicable

Precautionary statement(s) Storage

P410+P403 Protect from sunlight. Store in a well-ventilated place.

Precautionary statement(s) Disposal

Not Applicable
REACh - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date.

SECTION 3 COMPOSITION / INFORMATION ON INGREDIENTS

[Link]
See 'Composition on ingredients' in Section 3.2

[Link]
[Link] No
[Link] No
%[weight] Name Classification according to regulation (EC) No 1272/2008 [CLP]
[Link] No
[Link] No
1.354-33-6
2.206-557-8 [1]
25 pentafluoroethane Gas under Pressure (Liquefied gas); H280, EUH044
[Link] Available
4.01-2119485636-25-XXXX

1.811-97-2
2.212-377-0 1,1,1,2- [1]
52 Gas under Pressure (Liquefied gas); H280, EUH044
[Link] Available tetrafluoroethane
4.01-2119459374-33-XXXX
1.75-10-5
2.200-839-4 Flammable Gas Category 1, Gas under Pressure (Compressed gas); H220, H280,
23 difluoromethane [1]
[Link] Available EUH044
4.01-2119471312-47-XXXX

Legend: 1. Classified by Chemwatch; 2. Classification drawn from EC Directive 67/548/EEC - Annex I ; 3. Classification drawn from EC
Directive 1272/2008 - Annex VI 4. Classification drawn from C&L
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UNICOOL R-407C

SECTION 4 FIRST AID MEASURES

4.1. Description of first aid measures

If skin contact occurs:
Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
In case of cold burns (frost-bite):
Move casualty into warmth before thawing the affected part; if feet are affected carry if possible
Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if
possible and without rubbing
DO NOT apply hot water or radiant heat.
Apply a clean, dry, light dressing of "fluffed-up" dry gauze bandage
If a limb is involved, raise and support this to reduce swelling
If an adult is involved and where intense pain occurs provide pain killers such as paracetomol
Transport to hospital, or doctor
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.
If product comes in contact with eyes remove the patient from gas source or contaminated area.
Take the patient to the nearest eye wash, shower or other source of clean water.
Open the eyelid(s) wide to allow the material to evaporate.
Gently rinse the affected eye(s) with clean, cool water for at least 15 minutes. Have the patient lie or sit down and tilt the
head back. Hold the eyelid(s) open and pour water slowly over the eyeball(s) at the inner corners, letting the water run out
of the outer corners.
The patient may be in great pain and wish to keep the eyes closed. It is important that the material is rinsed from the eyes
to prevent further damage.
Ensure that the patient looks up, and side to side as the eye is rinsed in order to better reach all parts of the eye(s)
Transport to hospital or doctor.
General
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
If the patient cannot tolerate light, protect the eyes with a clean, loosely tied bandage.
Ensure verbal communication and physical contact with the patient.
DO NOT allow the patient to rub the eyes
DO NOT allow the patient to tightly shut the eyes
DO NOT introduce oil or ointment into the eye(s) without medical advice
DO NOT use hot or tepid water.
Following exposure to gas, remove the patient from the gas source or contaminated area.
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be
required to assure the safety of the rescuer.
Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid
procedures.
If the patient is not breathing spontaneously, administer rescue breathing.
If the patient does not have a pulse, administer CPR.
If medical oxygen and appropriately trained personnel are available, administer 100% oxygen.
Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control
Centre for further instruction.
Keep the patient warm, comfortable and at rest while awaiting medical care.
MONITOR THE BREATHING AND PULSE, CONTINUOUSLY.
Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as
trained) or CPR if necessary.
Not considered a normal route of entry.
Avoid giving milk or oils.
Avoid giving alcohol.

If product comes in contact with eyes remove the patient from gas source or contaminated area.
Take the patient to the nearest eye wash, shower or other source of clean water.
Open the eyelid(s) wide to allow the material to evaporate.
Gently rinse the affected eye(s) with clean, cool water for at least 15 minutes. Have the patient lie or sit down and tilt the
head back. Hold the eyelid(s) open and pour water slowly over the eyeball(s) at the inner corners, letting the water run out
of the outer corners.
The patient may be in great pain and wish to keep the eyes closed. It is important that the material is rinsed from the eyes
to prevent further damage.
Eye Contact Ensure that the patient looks up, and side to side as the eye is rinsed in order to better reach all parts of the eye(s)
Transport to hospital or doctor.
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
If the patient cannot tolerate light, protect the eyes with a clean, loosely tied bandage.
Ensure verbal communication and physical contact with the patient.
DO NOT allow the patient to rub the eyes
DO NOT allow the patient to tightly shut the eyes
DO NOT introduce oil or ointment into the eye(s) without medical advice
DO NOT use hot or tepid water.
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UNICOOL R-407C

If skin contact occurs:

Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
In case of cold burns (frost-bite):
Move casualty into warmth before thawing the affected part; if feet are affected carry if possible
Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if
Skin Contact
possible and without rubbing
DO NOT apply hot water or radiant heat.
Apply a clean, dry, light dressing of "fluffed-up" dry gauze bandage
If a limb is involved, raise and support this to reduce swelling
If an adult is involved and where intense pain occurs provide pain killers such as paracetomol
Transport to hospital, or doctor
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.

Following exposure to gas, remove the patient from the gas source or contaminated area.
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be
required to assure the safety of the rescuer.
Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid
procedures.
If the patient is not breathing spontaneously, administer rescue breathing.
If the patient does not have a pulse, administer CPR.
Inhalation
If medical oxygen and appropriately trained personnel are available, administer 100% oxygen.
Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control
Centre for further instruction.
Keep the patient warm, comfortable and at rest while awaiting medical care.
MONITOR THE BREATHING AND PULSE, CONTINUOUSLY.
Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as
trained) or CPR if necessary.
Not considered a normal route of entry.
Ingestion Avoid giving milk or oils.
Avoid giving alcohol.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11

4.3. Indication of any immediate medical attention and special treatment needed
for intoxication due to Freons/ Halons;
A: Emergency and Supportive Measures
Maintain an open airway and assist ventilation if necessary
Treat coma and arrhythmias if they occur. Avoid (adrenaline) epinephrine or other sympathomimetic amines that may precipitate ventricular
arrhythmias. Tachyarrhythmias caused by increased myocardial sensitisation may be treated with propranolol, 1-2 mg IV or esmolol 25-100
microgm/kg/min IV.
Monitor the ECG for 4-6 hours
B: Specific drugs and antidotes:
There is no specific antidote
C: Decontamination
Inhalation; remove victim from exposure, and give supplemental oxygen if available.
Ingestion; (a) Prehospital: Administer activated charcoal, if available. DO NOT induce vomiting because of rapid absorption and the risk of abrupt onset
CNS depression. (b) Hospital: Administer activated charcoal, although the efficacy of charcoal is unknown. Perform gastric lavage only if the ingestion
was very large and recent (less than 30 minutes)
D: Enhanced elimination:
There is no documented efficacy for diuresis, haemodialysis, haemoperfusion, or repeat-dose charcoal.
POISONING and DRUG OVERDOSE, Californian Poison Control System Ed. Kent R Olson; 3rd Edition
Do not administer sympathomimetic drugs unless absolutely necessary as material may increase myocardial irritability.
No specific antidote.
Because rapid absorption may occur through lungs if aspirated and cause systematic effects, the decision of whether to induce vomiting or not should
be made by an attending physician.
If lavage is performed, suggest endotracheal and/or esophageal control.
Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach.
Treatment based on judgment of the physician in response to reactions of the patient
For frost-bite caused by liquefied petroleum gas:
If part has not thawed, place in warm water bath (41-46 C) for 15-20 minutes, until the skin turns pink or red.
Analgesia may be necessary while thawing.
If there has been a massive exposure, the general body temperature must be depressed, and the patient must be immediately rewarmed by whole-body
immersion, in a bath at the above temperature.
Shock may occur during rewarming.
Administer tetanus toxoid booster after hospitalization.
Prophylactic antibiotics may be useful.
The patient may require anticoagulants and oxygen.
[Shell Australia 22/12/87]
For gas exposures:
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UNICOOL R-407C

--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
Establish a patent airway with suction where necessary.
Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Administer oxygen by non-rebreather mask at 10 to 15 l/min.
Monitor and treat, where necessary, for pulmonary oedema .
Monitor and treat, where necessary, for shock.
Anticipate seizures.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory arrest has occurred.
Positive-pressure ventilation using a bag-valve mask might be of use.
Monitor and treat, where necessary, for arrhythmias.
Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers solution. Fluid overload might create complications.
Drug therapy should be considered for pulmonary oedema.
Hypotension with signs of hypovolaemia requires the cautious administration of fluids. Fluid overload might create complications.
Treat seizures with diazepam.
Proparacaine hydrochloride should be used to assist eye irrigation.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994

SECTION 5 FIREFIGHTING MEASURES

5.1. Extinguishing media

SMALL FIRE: Use extinguishing agent suitable for type of surrounding fire.
LARGE FIRE: Cool cylinder.

5.2. Special hazards arising from the substrate or mixture

Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may
Fire Incompatibility
result

5.3. Advice for firefighters

--------------------------------------------------------------
GENERAL
Fire Fighting --------------------------------------------------------------
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus and protective gloves.
Containers may explode when heated - Ruptured cylinders may rocket
Fire exposed containers may vent contents through pressure relief devices.
High concentrations of gas may cause asphyxiation without warning.
Fire/Explosion Hazard
Decomposition may produce toxic fumes of:, carbon monoxide (CO) Combustion products include:, carbon dioxide (CO2),
hydrogen fluoride , other pyrolysis products typical of burning organic material
Vented gas is more dense than air and may collect in pits, basements.

SECTION 6 ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

See section 8

6.2. Environmental precautions

See section 12

6.3. Methods and material for containment and cleaning up

Minor Spills Avoid breathing vapour and any contact with liquid or gas. Protective equipment including respirator should be used.

Clear area of all unprotected personnel and move upwind.

Alert Emergency Authority and advise them of the location and nature of hazard.
Major Spills Remove leaking cylinders to a safe place.
Fit vent pipes.
DO NOT exert excessive pressure on valve; DO NOT attempt to operate damaged valve.

6.4. Reference to other sections

Personal Protective Equipment advice is contained in Section 8 of the SDS.
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SECTION 7 HANDLING AND STORAGE

7.1. Precautions for safe handling

· Consider use in closed pressurised systems, fitted with temperature, pressure and safety relief valves which are vented
for safe dispersal. Use only properly specified equipment which is suitable for this product, its supply pressure and
temperature
Safe handling
· The tubing network design connecting gas cylinders to the delivery system should include appropriate pressure indicators
and vacuum or suction lines.
DO NOT transfer gas from one cylinder to another.

Fire and explosion

See section 5
protection
Cylinders should be stored in a purpose-built compound with good ventilation, preferably in the open.
Other information
Such compounds should be sited and built in accordance with statutory requirements.

7.2. Conditions for safe storage, including any incompatibilities

DO NOT use aluminium or galvanised containers
Cylinder:
Suitable container
Ensure the use of equipment rated for cylinder pressure.
Ensure the use of compatible materials of construction.
Haloalkanes:
are highly reactive:some of the more lightly substituted lower members are highly flammable; the more highly substituted
Storage may be used as fire suppressants, not always with the anticipated results.
incompatibility may react with the lighter divalent metals to produce more reactive compounds analogous to Grignard reagents.
Compressed gases may contain a large amount of kinetic energy over and above that potentially available from the
energy of reaction produced by the gas in chemical reaction with other substances

+ + + + + + +

X — Must not be stored together

0 — May be stored together with specific preventions
+ — May be stored together

7.3. Specific end use(s)

See section 1.2

SECTION 8 EXPOSURE CONTROLS / PERSONAL PROTECTION

8.1. Control parameters

DERIVED NO EFFECT LEVEL (DNEL)

Not Available

PREDICTED NO EFFECT LEVEL (PNEC)

Not Available

OCCUPATIONAL EXPOSURE LIMITS (OEL)

INGREDIENT DATA

Source Ingredient Material name TWA STEL Peak Notes

Not Available Not Available Not Available Not Available Not Available Not Available Not Available

EMERGENCY LIMITS

Ingredient Material name TEEL-1 TEEL-2 TEEL-3

1,1,1,2-tetrafluoroethane Tetrafluoroethane, 1,1,1,2-; (HFC 134a) Not Available Not Available Not Available
difluoromethane Methylene fluoride; (Difluoromethane; HFC-32) 1,300 ppm 1300 ppm 39000 ppm

Ingredient Original IDLH Revised IDLH

pentafluoroethane Not Available Not Available

1,1,1,2-tetrafluoroethane Not Available Not Available

difluoromethane Not Available Not Available

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UNICOOL R-407C

MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historically occupational exposure
standards for these irritants have been based on observation of workers' responses to various airborne concentrations.
May act as a simple asphyxiants; these are gases which, when present in high concentrations, reduce the oxygen content in air below that required to
support breathing, consciousness and life; loss of consciousness, with death by suffocation may rapidly occur in an oxygen deficient atmosphere.
CARE: Most simple asphyxiants are odourless or possess low odour and there is no warning on entry into an oxygen deficient atmosphere.

8.2. Exposure controls

Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed
8.2.1. Appropriate
engineering controls can be highly effective in protecting workers and will typically be independent of worker interactions to
engineering controls
provide this high level of protection.

8.2.2. Personal
protection

Eye and face Chemical goggles.

protection Full face shield may be required for supplementary but never for primary protection of eyes.

Skin protection See Hand protection below

When handling sealed and suitably insulated cylinders wear cloth or leather gloves.
Insulated gloves:
Hands/feet protection NOTE: Insulated gloves should be loose fitting so that may be removed quickly if liquid is spilled upon them. Insulated
gloves are not made to permit hands to be placed in the liquid; they provide only short-term protection from accidental
contact with the liquid.

Body protection See Other protection below

Protective overalls, closely fitted at neck and wrist.

Other protection
Eye-wash unit.

Thermal hazards Not Available

Respiratory protection
Cartridge respirators should never be used for emergency ingress or in areas of unknown vapour concentrations or oxygen content. The wearer must be
warned to leave the contaminated area immediately on detecting any odours through the respirator. The odour may indicate that the mask is not
functioning properly, that the vapour concentration is too high, or that the mask is not properly fitted. Because of these limitations, only restricted use of
cartridge respirators is considered appropriate.
Positive pressure, full face, air-supplied breathing apparatus should be used for work in enclosed spaces if a leak is suspected or the primary
containment is to be opened (e.g. for a cylinder change)
Air-supplied breathing apparatus is required where release of gas from primary containment is either suspected or demonstrated.

8.2.3. Environmental exposure controls

See section 12

SECTION 9 PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Appearance Liquefied pressure gas with sweet ether-like odour; insoluble in water.

Relative density
Physical state Liquified Gas 1.16
(Water = 1)

Partition coefficient
Odour Not Available Not Available
n-octanol / water

Auto-ignition
Odour threshold Not Available >700
temperature (°C)

Decomposition
pH (as supplied) Not Applicable Not Available
temperature

Melting point /
<-100-760 Viscosity (cSt) Not Available
freezing point (°C)

Initial boiling point Molecular weight

-44.8-760 Not Available
and boiling range (°C) (g/mol)

Flash point (°C) Not Available Taste Not Available

Evaporation rate Not Available Explosive properties Not Available

Flammability Not Available Oxidising properties Not Available

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Upper Explosive Limit Surface Tension

Not Available Not Available
(%) (dyn/cm or mN/m)

Lower Explosive Limit Volatile Component

Not Available Not Available
(%) (%vol)
Vapour pressure (kPa) 781 Gas group Not Available

Solubility in water
Immiscible pH as a solution (1%) Not Available
(g/L)
Vapour density (Air =
3.0 VOC g/L Not Available
1)

9.2. Other information

Not Available

SECTION 10 STABILITY AND REACTIVITY

[Link] See section 7.2

10.2. Chemical Unstable in the presence of incompatible materials.

stability Product is considered stable.

10.3. Possibility of
See section 7.2
hazardous reactions
10.4. Conditions to
See section 7.2
avoid

10.5. Incompatible
See section 7.2
materials

10.6. Hazardous
decomposition See section 5.3
products

SECTION 11 TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

Inhalation of vapours may cause drowsiness and dizziness. This may be accompanied by narcosis, reduced alertness, loss
of reflexes, lack of coordination and vertigo.
Inhalation of vapours or aerosols (mists, fumes), generated by the material during the course of normal handling, may be
damaging to the health of the individual.
Limited evidence or practical experience suggests that the material may produce irritation of the respiratory system, in a
significant number of individuals, following inhalation. In contrast to most organs, the lung is able to respond to a chemical
insult by first removing or neutralising the irritant and then repairing the damage.
Exposure to high concentrations of fluorocarbons may produce cardiac arrhythmias or cardiac arrest due sensitisation of the
Inhaled
heart to adrenalin or noradrenalin. Deaths associated with exposures to fluorocarbons (specifically halogenated aliphatics)
have occurred in occupational settings and in inhalation of bronchodilator drugs.

Material is highly volatile and may quickly form a concentrated atmosphere in confined or unventilated areas. The vapour
may displace and replace air in breathing zone, acting as a simple asphyxiant.
Symptoms of asphyxia (suffocation) may include headache, dizziness, shortness of breath, muscular weakness, drowsiness
and ringing in the ears. If the asphyxia is allowed to progress, there may be nausea and vomiting, further physical weakness
and unconsciousness and, finally, convulsions, coma and death.

Not normally a hazard due to physical form of product.

Ingestion
Considered an unlikely route of entry in commercial/industrial environments

Skin contact is not thought to have harmful health effects (as classified under EC Directives); the material may still produce
health damage following entry through wounds, lesions or abrasions.

Limited evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a
substantial number of individuals following direct contact, and/or produces significant inflammation when applied to the
healthy intact skin of animals, for up to four hours, such inflammation being present twenty-four hours or more after the end
of the exposure period. Skin irritation may also be present after prolonged or repeated exposure; this may result in a form of
contact dermatitis (nonallergic).
Skin Contact
In common with other halogenated aliphatics, fluorocarbons may cause dermal problems due to a tendency to remove natural
oils from the skin causing irritation and the development of dry, sensitive skin. They do not appear to be appreciably
absorbed.
Vapourising liquid causes rapid cooling and contact may cause cold burns, frostbite, even through normal gloves. Frozen skin
tissues are painless and appear waxy and yellow.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury
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with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably
protected.

Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may
Eye produce transient discomfort characterised by tearing or conjunctival redness (as with windburn).
Direct contact with the eye may not cause irritation because of the extreme volatility of the gas; however concentrated
atmospheres may produce irritation after brief exposures..
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects
involving organs or biochemical systems.
Principal route of occupational exposure to the gas is by inhalation.
Chronic
It is generally accepted that the fluorocarbons are less toxic than the corresponding halogenated aliphatic based on chlorine.
Repeated inhalation exposure to the fluorocarbon FC-11 does not produce pathologic lesions of the liver and other visceral
organs in experimental animals.

TOXICITY IRRITATION
UNICOOL R-407C
Not Available Not Available

TOXICITY IRRITATION

Inhalation (rat) LC50: >709000 ppm/4h *[ [2] Nil reported * [

pentafluoroethane
Inhalation (rat) LC50: 2910 mg/L/4hr[2]

Inhalation (rat) LC50: 800000 ppm/4h* [2]

1,1,1,2- TOXICITY IRRITATION

tetrafluoroethane [2] Not Available

Inhalation (rat) LC50: 1500 mg/L/4hr

TOXICITY IRRITATION

Inhalation (rat) LC50: >760000 ppm/4h *)[2] Nil reported (DuPont)

difluoromethane [2]
Inhalation (rat) LC50: 1890 mg/L/4hr

Oral (rat) LD50: 1890 mg/kg[2]

Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2.* Value obtained from manufacturer's SDS.
Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances

PENTAFLUOROETHANE Cardiac sensitisation threshold limit >245400 mg/m3 Anaesthetic effects threshold limit 490800 mg/m3 * DuPont SDS

1,1,1,2- * with added oxygen - ZhongHao New Chemical Materials MSDS Excessive concentration can have a narcotic effect;
TETRAFLUOROETHANE inhalation of high concentrations of decomposition products can cause lung oedema.

Disinfection by products (DBPs) re formed when disinfectants such as chlorine, chloramine, and ozone react with organic and
inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and
3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over
the possible adverse health effects of DBPs. To date, several hundred DBPs have been identified.
Numerous haloalkanes and haloalkenes have been tested for carcinogenic and mutagenic activities. n general, the genotoxic
potential is dependent on the nature, number, and position of halogen(s) and the molecular size of the compound. Short-chain
monohalogenated (excluding fluorine) alkanes and alkenes are potential direct-acting alkylating agents, particularly if the
halogen is at the terminal end of the carbon chain or at an allylic position. Dihalogenated alkanes are also potential alkylating
or cross-linking agents (either directly or after GSH conjugation),particularly if they are vicinally substituted (e.g.,
1,2-dihaloalkane) or substituted at the two terminal ends of a short to medium-size (e.g., 2-7) alkyl moiety (i.e., alpha,
UNICOOL R-407C & omega-dihaloalkane). Fully halogenated haloalkanes tend to act by free radical or nongenotoxic mechanisms (such as
1,1,1,2- generating peroxisome-proliferative intermediates) or undergo reductive dehalogenation to yield haloalkenes that in turn could
TETRAFLUOROETHANE be activated to epoxides.
Haloalkenes are of concern because of potential to generate genotoxic intermediates after epoxidation. The concern for
haloalkenes may be diminished if the double bond is internal or sterically hindered.
The cancer concern levels of the 14 haloalkanes and haloalkenes, have been rated based on available screening cancer
bioassay (pulmonary adenoma assay) and genotoxicity data. Five brominated and iodinated methane and ethane derivatives
are given a moderate rating. Beyond the fact that bromine and iodine are better leaving groups than chlorine, there is also
evidence that brominated THMs may be preferentially activated by a theta-class glutathione S-transferase (GSTT1-1) to
mutagens in Salmonella even at low substrate concentrations Furthermore, there are human carcinogenicity implications
because of polymorphism in GSTT1-1. Human subpopulations with expressed GSTT1-1 may be at a greater risk to brominate
THMs than humans who lack the gene.
Six, two, and one haloalkanes/ haloalkene(s) are given low-moderate, marginal, and low concern, respectively.

Acute Toxicity Carcinogenicity

Skin
Reproductivity
Irritation/Corrosion
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Serious Eye STOT - Single

Damage/Irritation Exposure

Respiratory or Skin STOT - Repeated

sensitisation Exposure
Mutagenicity Aspiration Hazard

Legend: – Data available but does not fill the criteria for classification
– Data required to make classification available
– Data Not Available to make classification

SECTION 12 ECOLOGICAL INFORMATION

12.1. Toxicity
Ingredient Endpoint Test Duration (hr) Species Value Source

pentafluoroethane EC50 384 Crustacea 10.310mg/L 3

pentafluoroethane LC50 96 Fish 43.427mg/L 3

pentafluoroethane NOEC 96 Fish 10mg/L 2

pentafluoroethane EC50 48 Crustacea >97.9mg/L 2

pentafluoroethane EC50 72 Algae or other aquatic plants >114mg/L 2

1,1,1,2-
EC50 384 Crustacea 7.065mg/L 3
tetrafluoroethane
1,1,1,2-
EC50 96 Algae or other aquatic plants 97.260mg/L 3
tetrafluoroethane

1,1,1,2-
LC50 96 Fish 29.671mg/L 3
tetrafluoroethane

1,1,1,2-
EC50 48 Crustacea 980mg/L 5
tetrafluoroethane

1,1,1,2-
NOEC 72 Algae or other aquatic plants ca.13.2mg/L 2
tetrafluoroethane
difluoromethane EC50 384 Crustacea 17.989mg/L 3

difluoromethane LC50 96 Fish 77.251mg/L 3

difluoromethane NOEC 96 Fish 10mg/L 2

difluoromethane EC50 48 Crustacea >97.9mg/L 2

difluoromethane EC50 72 Algae or other aquatic plants >114mg/L 2

Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity
3. EPIWIN Suite V3.12 - Aquatic Toxicity Data (Estimated) 4. US EPA, Ecotox database - Aquatic Toxicity Data 5. ECETOC
Legend:
Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8. Vendor
Data

In addition to carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), the greenhouse gases mentioned in the Kyoto Protocol include synthetic
substances that share the common feature of being highly persistent in the atmosphere and exhibiting very high specific radiative forcing (radiative
forcing is the change in the balance between radiation coming into the atmosphere and radiation out; a positive radiative forcing tends on average to warm
the surface of the earth). These synthetic substances include hydrocarbons that are partially fluorinated (HCFs) or totally fluorinated (PFCs) as well as
sulfur hexafluoride (SF6).
DO NOT discharge into sewer or waterways.

12.2. Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
pentafluoroethane HIGH HIGH

1,1,1,2-tetrafluoroethane HIGH HIGH

difluoromethane LOW LOW

12.3. Bioaccumulative potential

Ingredient Bioaccumulation
pentafluoroethane LOW (LogKOW = 1.5472)
1,1,1,2-tetrafluoroethane LOW (LogKOW = 1.68)

difluoromethane LOW (LogKOW = 0.2)

12.4. Mobility in soil

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UNICOOL R-407C

Ingredient Mobility
pentafluoroethane LOW (KOC = 154.4)
1,1,1,2-tetrafluoroethane LOW (KOC = 96.63)
difluoromethane LOW (KOC = 23.74)

[Link] of PBT and vPvB assessment

P B T
Relevant available data Not Available Not Available Not Available

PBT Criteria fulfilled? Not Available Not Available Not Available

12.6. Other adverse effects

No data available

SECTION 13 DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Product / Packaging Evaporate residue at an approved site.
disposal Return empty containers to supplier.

Waste treatment
Not Available
options
Sewage disposal
Not Available
options

SECTION 14 TRANSPORT INFORMATION

Labels Required

Marine Pollutant NO

Land transport (ADR)

[Link] number 3340

[Link] proper REFRIGERANT GAS R 407C (Difluoromethane, pentafluoroethane, and 1,1,1,2- tetrafluoroethane zeotropic mixture with
shipping name approximately 23% difluoromethane and 25% pentafluoroethane)

14.3. Transport hazard Class 2.2

class(es) Subrisk Not Applicable

[Link] group Not Applicable

[Link]
Not Applicable
hazard

Hazard identification (Kemler) 20

Classification code 2A
14.6. Special
Hazard Label 2.2
precautions for user
Special provisions 662

Limited quantity 120 ml

Air transport (ICAO-IATA / DGR)

14.1. UN number 3340

14.2. UN proper
Refrigerant gas R 407C
shipping name

14.3. Transport hazard ICAO/IATA Class 2.2

class(es) ICAO / IATA Subrisk Not Applicable
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UNICOOL R-407C

ERG Code 2L

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

Special provisions Not Applicable

Cargo Only Packing Instructions 200

Cargo Only Maximum Qty / Pack 150 kg

14.6. Special
Passenger and Cargo Packing Instructions 200
precautions for user
Passenger and Cargo Maximum Qty / Pack 75 kg
Passenger and Cargo Limited Quantity Packing Instructions Forbidden

Passenger and Cargo Limited Maximum Qty / Pack Forbidden

Sea transport (IMDG-Code / GGVSee)

14.1. UN number 3340

14.2. UN proper
REFRIGERANT GAS R 407C
shipping name

14.3. Transport hazard IMDG Class 2.2

class(es) IMDG Subrisk Not Applicable

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

EMS Number F-C, S-V

14.6. Special
Special provisions Not Applicable
precautions for user
Limited Quantities 120 mL

Inland waterways transport (ADN)

14.1. UN number 3340

14.2. UN proper REFRIGERANT GAS R 407C (Difluoromethane, pentafluoroethane, and 1,1,1,2-tetrafluoroethane zeotropic mixture with
shipping name approximately 23% difluoromethane and 25% pentafluoroethane)

14.3. Transport hazard

2.2 Not Applicable
class(es)

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

Classification code 2A
Special provisions 662
14.6. Special
Limited quantity 120 ml
precautions for user
Equipment required PP

Fire cones number 0

Transport in bulk according to Annex II of MARPOL and the IBC code

Not Applicable

SECTION 15 REGULATORY INFORMATION

15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture

PENTAFLUOROETHANE(354-33-6) IS FOUND ON THE FOLLOWING REGULATORY LISTS

European Customs Inventory of Chemical Substances ECICS (English) European Union - European Inventory of Existing Commercial Chemical
Substances (EINECS) (English)

1,1,1,2-TETRAFLUOROETHANE(811-97-2) IS FOUND ON THE FOLLOWING REGULATORY LISTS

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European Customs Inventory of Chemical Substances ECICS (English) European Union - European Inventory of Existing Commercial Chemical
Substances (EINECS) (English)

DIFLUOROMETHANE(75-10-5) IS FOUND ON THE FOLLOWING REGULATORY LISTS

EU REACH Regulation (EC) No 1907/2006 - Annex XVII - Restrictions on European Union - European Inventory of Existing Commercial Chemical
the manufacture, placing on the market and use of certain dangerous Substances (EINECS) (English)
substances, mixtures and articles International Air Transport Association (IATA) Dangerous Goods Regulations
European Customs Inventory of Chemical Substances ECICS (English) - Prohibited List Passenger and Cargo Aircraft

This safety data sheet is in compliance with the following EU legislation and its adaptations - as far as applicable - : 67/548/EEC, 1999/45/EC, 98/24/EC,
92/85/EC, 94/33/EC, 91/689/EEC, 1999/13/EC, Commission Regulation (EU) 2015/830, Regulation (EC) No 1272/2008 and their amendments as well as
the following British legislation: - The Control of Substances Hazardous to Health Regulations (COSHH) 2002 - COSHH Essentials - The Management of
Health and Safety at Work Regulations 1999

15.2. Chemical safety assessment

For further information please look at the Chemical Safety Assessment and Exposure Scenarios prepared by your Supply Chain if available.

ECHA SUMMARY
Ingredient CAS number Index No ECHA Dossier
pentafluoroethane 354-33-6 Not Available 01-2119485636-25-XXXX

Harmonisation (C&L
Hazard Class and Category Code(s) Pictograms Signal Word Code(s) Hazard Statement Code(s)
Inventory)
1 Press. Gas. GHS04, Wng H280

2 Press. Gas., Liq. Gas, STOT SE 2 GHS04, Wng, GHS08 H280, H371
Harmonisation Code 1 = The most prevalent classification. Harmonisation Code 2 = The most severe classification.

Ingredient CAS number Index No ECHA Dossier

1,1,1,2-tetrafluoroethane 811-97-2 Not Available 01-2119459374-33-XXXX

Harmonisation (C&L Pictograms Signal Word Hazard Statement

Hazard Class and Category Code(s)
Inventory) Code(s) Code(s)
Liq. Gas, Press. Gas., Not Classified, STOT SE 1, STOT
2 GHS04, Wng, GHS08, Dgr H280, H370
SE 2

Harmonisation Code 1 = The most prevalent classification. Harmonisation Code 2 = The most severe classification.

Ingredient CAS number Index No ECHA Dossier

difluoromethane 75-10-5 Not Available 01-2119471312-47-XXXX

Harmonisation (C&L Pictograms Signal Word Hazard Statement

Hazard Class and Category Code(s)
Inventory) Code(s) Code(s)
1 Flam. Gas 1, Liq. Gas GHS02, GHS04, Dgr H220, H280
Flam. Gas 1, Liq. Gas, Muta. 1B, Carc. 1A, Press.
2 GHS02, GHS04, Dgr, Wng H220, H280, H312
Gas.

Harmonisation Code 1 = The most prevalent classification. Harmonisation Code 2 = The most severe classification.

National Inventory Status

Australia - AICS Y

Canada - DSL Y

Canada - NDSL N (difluoromethane; pentafluoroethane; 1,1,1,2-tetrafluoroethane)

China - IECSC N (difluoromethane)

Europe - EINEC /
Y
ELINCS / NLP

Japan - ENCS Y

Korea - KECI Y
New Zealand - NZIoC Y

Philippines - PICCS Y

USA - TSCA Y

Y = All ingredients are on the inventory

Legend: N = Not determined or one or more ingredients are not on the inventory and are not exempt from listing(see specific ingredients
in brackets)
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SECTION 16 OTHER INFORMATION

CONTACT POINT
- For quotations contact your local Customer Services - [Link] - - Responsible for safety data sheet
Wilhelmsen Ships Service AS - Prepared by: Product HSE Manager, - Email: Email: [Link]@[Link] - Telephone: Tel.: +31 10
4877775

Full text Risk and Hazard codes

H220 Extremely flammable gas.

H312 Harmful in contact with skin.

H370 Causes damage to organs.

H371 May cause damage to organs.

Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the
Chemwatch Classification committee using available literature references.
A list of reference resources used to assist the committee may be found at:
[Link]

The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are
Risks in the workplace or other settings.

For detailed advice on Personal Protective Equipment, refer to the following EU CEN Standards:
EN 166 Personal eye-protection
EN 340 Protective clothing
EN 374 Protective gloves against chemicals and micro-organisms
EN 13832 Footwear protecting against chemicals
EN 133 Respiratory protective devices

Definitions and abbreviations

PC－TWA: Permissible Concentration-Time Weighted Average
PC－STEL: Permissible Concentration-Short Term Exposure Limit
IARC: International Agency for Research on Cancer
ACGIH: American Conference of Governmental Industrial Hygienists
STEL: Short Term Exposure Limit
TEEL: Temporary Emergency Exposure Limit。
IDLH: Immediately Dangerous to Life or Health Concentrations
OSF: Odour Safety Factor
NOAEL :No Observed Adverse Effect Level
LOAEL: Lowest Observed Adverse Effect Level
TLV: Threshold Limit Value
LOD: Limit Of Detection
OTV: Odour Threshold Value
BCF: BioConcentration Factors
BEI: Biological Exposure Index

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Apart from any fair dealing for the purposes of private study, research, review or criticism, as permitted under the Copyright Act, no part may be
reproduced by any process without written permission from CHEMWATCH.