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Endocrine and Nervous System Overview

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Endocrine and Nervous System Overview

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Science Reviewer

Module 1: Endocrine System


Endocrine system – is composed of glands that secrete different types of hormones that
affect almost every cell, organ,and function of our [Link] – are organic substances
released by the glands of the endocrine system into the bloodstream.

Glands and their functions:


Pituitary – produces hormones that stimulate growth, and controls the functions of other
glands.
Thyroid – produces hormones that regulate body metabolism and storage of calcium in
bones
.Parathyroid – produces hormones that control the calcium levels in your body,
and normalizes bone growth.
Thymus – Produces hormones that enable the body to produce T cells before puberty
.Adrenal – produces hormones that affects metabolism, immune system and blood
pressure, stress reaction
.Pancreas – produces hormones that regulate blood sugar levels.
Testes and ovaries – produce testosterone and estrogen respectively for reproductive
purposes and the development of secondary male/female sexual characteristics.
Pineal – produces a hormone that regulates the biological clock in some animal (melatonin)

Module 2: Female hormones and Menstrual Cycle

Endocrine Gland Hormone Function

Anterior Pituitary Follicle Stimulating  Stimulates follicular growth in ovaries


Hormone (FSH)  Stimulates estrogen secretion from
developing follicles (small sac containing
eggs)
Luteinizing Hormone (LH)  Surge causes ovulation  Results in the
formation of a corpus luteum (a structure
formed as a mature egg pops out of a
follicle)  Triggers corpus luteum to
secrete progesterone
Ovaries Estrogen  Thickens endometrium
 Stimulates the pituitary gland to release
LH causing ovulation
 Stops FSH being produced so that only
one egg matures in a cycle
Progesterone  Thickens endometrium
 Inhibits FSH and LH (luteal phase)
Pituitary gland secretes FSH and LH that will go to the testes
Hypothalamus regulates pituitary gland
Testosterone production Is regulated by the brain
Testes will produce testosterone and sperm cells

Lesson 3: The Nervous System


Two major divisions:
I. Central Nervous System (CNS) – c o n s i s t s o f b r a i n
(cerebrum, cerebellum, brain stem) and spinal cord.
II. Peripheral Nervous System – c o n n e c t s t h e c e n t r a l n e r v o u s
system to the organs and limbs.
H a s t w o divisions:
A. Somatic Nervous System – associated with the voluntary control
of body movements and consists of spinal and cranial nerves.
B. Autonomic Nervous System – associated with the involuntary
control of the body movements and has two division: Sympathetic NS
(stress mode) and Parasympathetic NS (relaxed mode)

The nerve cell (neuron)


Cell body – contains the nucleus.
Dendrites – carry impulses toward the cell body Axon – carry impulses away from the cell
body
Synapse – the distance between neurons

.Feedback mechanisms – are used by most of the body systems to maintain homeostasis. To
achieve homeostasis, the nervous and endocrine systems work with each other to maintain a
normal range of many processes and substances in the body such as:
• Temperature of the body
• Amount of water in the body
• Amount of metabolic wastes in the cell
• Blood calcium level
Lesson 4: Protein Synthesis What are the roles and functions of proteins?
•channels in membranes – control the movement of molecules in and out of the cell
•structural molecules – for example, making up hair or muscle in animals
•hormones – to regulate the activity of cells
•antibodies – in the immune system
•enzymes – to act as catalysts in biological systems.
DNA:
•Double-stranded, helical molecule
•Made up of four types of nucleotides: adenine, guanine, cytosine, and thymine
•Carries genetic information of an organism (Blueprint of life)
•Process of DNA replication creates a copy of DNA before cell division RNA:
•Single-stranded molecule
•Three main types: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA
(rRNA)
• Involved in the process of protein synthesis
• mRNA carries genetic information from DNA to the ribosome
•tRNA carries amino acids to the ribosome
•rRNA helps form the structure of the ribosome Transcription:
•Process by which DNA is used as a template to synthesize RNA
•RNA polymerase binds to the promoter region of DNA and adds complementary nucleotides
to the RNA strand Translation:
•Process by which the genetic information in mRNA is used to synthesize a protein
•mRNA is read by a ribosome
•Ribosome matches codons to the appropriate tRNA molecules
•Ribosome links amino acids together to form a polypeptide chain

There are 3 types of RNA:


1. Messenger RNA (mRNA)- transcribes the DNA nucleotide bases to RNA nucleotide bases
2. Ribosomal RNA (rRNA)- binds the mRNA and tRNA to ensure that codons are translated
correctly
3. Transfer RNA (tRNA)- translates the mRNA codons into the correct amino acids

Common questions

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During translation, ribosomal RNA (rRNA) aids in forming the ribosome structure, providing a site for protein synthesis. Messenger RNA (mRNA) carries the genetic code from DNA, which dictates the sequence of amino acids. Transfer RNA (tRNA) translates this code by bringing the correct amino acids to the ribosome, matching its anticodon to the mRNA codon. This coordinated action of the three types of RNA ensures accurate translation of genetic information into a polypeptide chain .

The hypothalamus regulates reproductive hormones by controlling the release of gonadotropin-releasing hormone (GnRH), which signals the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are crucial for controlling ovulation and stimulating the production of estrogen in the ovaries and testosterone in the testes, thus playing a vital role in reproductive processes .

Blood calcium levels are regulated by the parathyroid hormone from the parathyroid glands, which increases calcium levels by stimulating bone resorption and increasing calcium absorption in the intestine and kidneys. The nervous system monitors calcium levels through feedback mechanisms, relaying information to maintain homeostasis. This interaction ensures that appropriate adjustments are made to physiological processes to maintain calcium levels within a narrow range, crucial for nerve conduction and muscle function .

Transcription is the process where DNA is used as a template to synthesize messenger RNA (mRNA), with RNA polymerase adding complementary nucleotides to form the RNA strand. In contrast, translation involves the mRNA being read by a ribosome, where transfer RNA (tRNA) matches mRNA codons to the correct amino acids, forming a polypeptide chain. During transcription, mRNA carries genetic information from the DNA out of the nucleus, while translation uses mRNA, tRNA, and ribosomal RNA (rRNA) to synthesize proteins .

Feedback mechanisms are crucial for maintaining homeostasis as they allow the body to adjust processes to stabilize internal conditions. A typical example is the regulation of blood glucose levels. Insulin and glucagon, hormones produced by the pancreas, work through a negative feedback loop. When blood glucose levels rise, insulin promotes glucose uptake by cells, lowering blood sugar. Alternatively, glucagon is released when levels drop, stimulating glucose release into the blood. This dynamic adjustment exemplifies homeostatic regulation .

Protein synthesis exemplifies the central dogma of molecular biology, which states that genetic information flows from DNA to RNA to protein. During transcription, DNA is transcribed into mRNA, which carries the genetic code out of the nucleus. In the cytoplasm, translation occurs as the ribosome reads the mRNA and synthesizes protein using tRNA as adaptor molecules. This process translates genetic information into functional proteins, reflecting the sequential flow from nucleic acids to proteins .

An imbalance in thyroid hormone production can significantly alter metabolism. Hyperthyroidism, an overproduction of thyroid hormones, accelerates metabolic processes, leading to weight loss, increased heart rate, and heightened sensitivity to heat. Conversely, hypothyroidism slows down metabolism, causing weight gain, fatigue, and cold intolerance due to decreased energy production. Both conditions exemplify how thyroid hormones are pivotal regulators of basal metabolic rate and energy utilization .

The adrenal glands produce hormones that affect metabolism and the body's stress reaction. Specifically, they release cortisol and adrenaline during stress. These hormones increase blood sugar levels, enhance brain function, and alter immune system responses, thus preparing the body to react to stressors. The release of these hormones also connects to metabolic processes, as they help in energy production and utilization, crucial for handling stress .

Melatonin, produced by the pineal gland, regulates biological rhythms such as sleep-wake cycles by signaling nighttime, thus inducing sleep. Its production is influenced by light exposure; darkness stimulates and light inhibits its secretion. This hormone helps synchronize circadian rhythms with environmental light-dark cycles, influencing sleep patterns and seasonal biological functions .

The sympathetic and parasympathetic nervous systems work together to maintain homeostasis by balancing the body's responses to stress (sympathetic) and relaxation (parasympathetic). The sympathetic nervous system triggers 'fight or flight' responses, increasing heart rate and directing blood to muscles. In contrast, the parasympathetic nervous system promotes rest and digestion, lowering heart rate and conserving energy. This balance ensures that the body's internal environment remains stable despite external changes .

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