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Understanding B-cell
Development
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Common lymphoid
progenitor
Thymus Bone marrow
T-cell precursor
B-cell precursor
(haematogone)
A common lymphoid progenitor differentiates into T-cell
precursors in the thymus and B-cell precursors
(haematogones) in the bone marrow.
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+
CD10 CD19 +
CD45dim
+ + +
CD34 CD20 TdT
+ +
CD38 CD22
dim
CD19
Stage 1 haematogone
CD22dim
Early hematogone differentiation starts with dim
expression of CD19 and CD22, and bright expression of
CD38. CD19 intensity increases between stage 1 & 2
haematogones, while bright CD22 levels are typically
seen only in mature B-cells.
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Stage 1 haematogones
CD19
Stage 2
haematogones
CD22
Stage 1
Stage 3 haematogones
haematogones Stage 2
haematogones
Stage 2 Stage 3
CD10
CD20
haematogones haematogones
Stage 1 Mature B-
haematogones cells
CD34 CD20
Transitioning from stage 1 to 2 haematogones involves
loss of CD34 and TdT, decreased CD10 intensity, and the
acquisition of dim CD20 and immunoglobulin heavy/light
chain surface expression.
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Stage 2
haematogone
⬆️ CD20
Immunoglobulin
Stage 3
haematogone
CD20 levels continue rising between stage 2 and 3
haematogones, and surface immunoglobulin
expression is gained during this phase.
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Stage 3
haematogone
⬇️ CD10
⬆️ CD22
⬆️ CD45
Mature B-cell
The maturation of B-cells is marked by further
decreases in CD10 and increased CD22 & CD45
expression, indicating a final differentiation step.
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Mature B-cell
⬆️ CD10
⬆️ CD38
CD138+
Plasma cell
Mature B-cells undergo additional changes outside the
bone marrow, including increased CD10 & CD38 expression
within lymph node germinal centers, and CD38 & CD138
gain during differentiation into plasma cells.
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