Presented by Group 1
Systemic Lupus
Erythematosus
(SLE)
What is SLE?
It is an autoimmune disease.
Autoimmune disease happens when the body’s natural defense system CANNOT
tell the difference between your own cells and foreign cells, causing the body to
mistakenly attack normal cells.
It can affect the skin, joints, kidneys,
brain, lungs, circulating blood cells
and heart
This attack causes inflammation, and in some cases
permanent tissue damage, which can be widespread
What Causes SLE?
Dysfunctional immune Results in
system that causes inflammation of the
overproduction of veins and arteries.
autoantibodies.
Source is a combination of
genetics, hormones, environmental
factors, viruses, and medications.
Signs and Symptoms
Joint pains and
Chest pain when
swelling (Classic
taking a deep
sign)
breath
Pericarditis
Sunlight sensitivity Fatigue
Skin rash (Butterfly Fever
rash) Malaise
Swollen lymph nodes Hair loss
Headaches Weight loss
Depression nad
Mouth sores
psychosis
Assessment and Diagnostic Findings
Complete Blood Count
Complete History Antinuclear antibody(ANA)
Physical examination Chest x-ray
Blood Tests Urinalysis
Serum Creatinine
Risk Factors
mostly affects women, who are nine to ten
Gender: times more likely to develop the condition
commonly diagnosed in individuals during
Age:
their 20s and 30s.
Race: more common in African-American, Hispanic,
Asian, and Native American women
Relatives of people with lupus have a higher
Family:
risk of developing the disease, but only about
2% of children born to mothers with lupus will
also develop it.
Treatment
Aspirin Immunosuppressants:
NSAIDs azathioprine( Imuran)
Antianemics : Ferrous Scheduled rest periods
Sulfate (Feosol) If renal failure,
Cytotoxic drugs: hemodialysis or kidney
methotrexate ( Folex) transplant
Antirheumatic: dietary iron, protein,
hydroxychloroquine vitamins
( Plaquelin) Plasmapheresis.
Steroids: prednisone
(Deltasone)
Wear protective
clothing, sunglasses,
and sunscreen when in
the sun.
Get preventive heart If you have SLE, it is
care.
Stay up-to-date with also important to:
immunizations.
Have tests to screen for
thinning of the bones
(osteoporosis).
Avoid tobacco and drink
minimal amounts of
alcohol.
Pathophysiology
References:
Lupus Risk Factors. (2023, December 18). Johns Hopkins Medicine.
[Link]
risk-factors
Thank you for your
attention