UNICOOL R-404A

Wilhelmsen Ships Service

Part Number: 905623 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
Safety Data Sheet according to OSHA HazCom Standard (2012) requirements [Link]

SECTION 1 Identification

Product Identifier
Product name UNICOOL R-404A

Chemical Name Not Applicable

Synonyms Product Part Number: 905623 (9.5 kg), 905606 (45 kg)
Proper shipping name Refrigerant gas R 404A
Chemical formula Not Applicable
Other means of
905623, 905606, 905706, 905723, 905765, 905766, 905806, 905823 | UFI:KA2W-CKHU-820Q-K377
identification

Recommended use of the chemical and restrictions on use

The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating
Relevant identified uses
atmosphere developing. Before starting consider control of exposure by mechanical ventilation.

Name, address, and telephone number of the chemical manufacturer, importer, or other responsible party
Outback (M)SDS portal:
Wilhelmsen Ships Service AS*
Registered company name Wilhelmsen Ships Service [Link]
Central Warehouse
login=wilhelmsen
--------Use our Outback portal to obtain our (M)SDSs
9400 New Century Drive in other languages and/or format.--------- For
Willem Barentszstraat 50
Address Pasadena, TX 77507 United questions relating to our SDSs please use Email:
Rotterdam Netherlands
States [Link]@[Link] ---------
Norway
Telephone +1 281 867 2000 +31 10 4877 777 Not Available

Fax Not Available Not Available Not Available

Website [Link] [Link] [Link]

Email [Link]@[Link] [Link]@[Link] [Link]@[Link]

Emergency phone number

Association / Organisation 24hrs - Chemwatch Dutch nat. poison centre 24hrs - Chemwatch

Emergency telephone
+31-10-4877700 + 31 88 7558561 +31-10-4877700
numbers

Other emergency
+31-10-4877700 + 31 10 4877700 +31-10-4877700
telephone numbers

Association / Organisation CHEMWATCH EMERGENCY RESPONSE (24/7)

Emergency telephone
+1 855-237-5573
numbers

Other emergency
+61 3 9573 3188
telephone numbers

Once connected and if the message is not in your preferred language then please dial 01

Page 1 continued...
Part Number: 905623 Page 2 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Una vez conectado y si el mensaje no está en su idioma preferido, por favor marque 02

SECTION 2 Hazard(s) identification

Classification of the substance or mixture

NFPA 704 diamond

Note: The hazard category numbers found in GHS classification in

section 2 of this SDSs are NOT to be used to fill in the NFPA 704
diamond. Blue = Health Red = Fire Yellow = Reactivity White =
Special (Oxidizer or water reactive substances)

Classification Gases Under Pressure (Liquefied Gas), Skin Corrosion/Irritation Category 2, Simple Asphyxiant

Label elements

Hazard pictogram(s)

Signal word Warning

Hazard statement(s)
H280 Contains gas under pressure; may explode if heated.
H315 Causes skin irritation.

May displace oxygen and cause rapid suffocation

Hazard(s) not otherwise classified

Not Applicable

Precautionary statement(s) General

P101 If medical advice is needed, have product container or label at hand.
P102 Keep out of reach of children.
P103 Read label before use.

Precautionary statement(s) Prevention

P280 Wear protective gloves and protective clothing.
P264 Wash all exposed external body areas thoroughly after handling.

Precautionary statement(s) Response

P302+P352 IF ON SKIN: Wash with plenty of water and soap.
P332+P313 If skin irritation occurs: Get medical advice/attention.

P362+P364 Take off contaminated clothing and wash it before reuse.

Precautionary statement(s) Storage

P410+P403 Protect from sunlight. Store in a well-ventilated place.

Precautionary statement(s) Disposal

Not Applicable

SECTION 3 Composition / information on ingredients

Substances
See section below for composition of Mixtures

Mixtures

Continued...
Part Number: 905623 Page 3 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

CAS No %[weight] Name

354-33-6 44 pentafluoroethane
811-97-2 4 1,1,1,2-tetrafluoroethane
420-46-2 52 1,1,1-trifluoroethane

SECTION 4 First-aid measures

Description of first aid measures

If product comes in contact with eyes remove the patient from gas source or contaminated area.
Take the patient to the nearest eye wash, shower or other source of clean water.
Open the eyelid(s) wide to allow the material to evaporate.
Gently rinse the affected eye(s) with clean, cool water for at least 15 minutes. Have the patient lie or sit down and tilt the
head back. Hold the eyelid(s) open and pour water slowly over the eyeball(s) at the inner corners, letting the water run out of
the outer corners.
The patient may be in great pain and wish to keep the eyes closed. It is important that the material is rinsed from the eyes to
prevent further damage.
Eye Contact Ensure that the patient looks up, and side to side as the eye is rinsed in order to better reach all parts of the eye(s)
Transport to hospital or doctor.
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
If the patient cannot tolerate light, protect the eyes with a clean, loosely tied bandage.
Ensure verbal communication and physical contact with the patient.
DO NOT allow the patient to rub the eyes
DO NOT allow the patient to tightly shut the eyes
DO NOT introduce oil or ointment into the eye(s) without medical advice
DO NOT use hot or tepid water.
If skin contact occurs:
Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
In case of cold burns (frost-bite):
Move casualty into warmth before thawing the affected part; if feet are affected carry if possible
Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if possible
Skin Contact
and without rubbing
DO NOT apply hot water or radiant heat.
Apply a clean, dry, light dressing of "fluffed-up" dry gauze bandage
If a limb is involved, raise and support this to reduce swelling
If an adult is involved and where intense pain occurs provide pain killers such as paracetomol
Transport to hospital, or doctor
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.
Following exposure to gas, remove the patient from the gas source or contaminated area.
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be
required to assure the safety of the rescuer.
Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid
procedures.
If the patient is not breathing spontaneously, administer rescue breathing.
If the patient does not have a pulse, administer CPR.
Inhalation
If medical oxygen and appropriately trained personnel are available, administer 100% oxygen.
Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control Centre
for further instruction.
Keep the patient warm, comfortable and at rest while awaiting medical care.
MONITOR THE BREATHING AND PULSE, CONTINUOUSLY.
Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as
trained) or CPR if necessary.
Not considered a normal route of entry.
Avoid giving milk or oils.
Ingestion
Avoid giving alcohol.
For advice, contact a Poisons Information Centre or a doctor.

Most important symptoms and effects, both acute and delayed

See Section 11

Indication of any immediate medical attention and special treatment needed

for intoxication due to Freons/ Halons;
A: Emergency and Supportive Measures
Maintain an open airway and assist ventilation if necessary
Treat coma and arrhythmias if they occur. Avoid (adrenaline) epinephrine or other sympathomimetic amines that may precipitate ventricular arrhythmias.
Tachyarrhythmias caused by increased myocardial sensitisation may be treated with propranolol, 1-2 mg IV or esmolol 25-100 microgm/kg/min IV.
Monitor the ECG for 4-6 hours
B: Specific drugs and antidotes:
There is no specific antidote
C: Decontamination
Continued...
Part Number: 905623 Page 4 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Inhalation; remove victim from exposure, and give supplemental oxygen if available.
Ingestion; (a) Prehospital: Administer activated charcoal, if available. DO NOT induce vomiting because of rapid absorption and the risk of abrupt onset CNS
depression. (b) Hospital: Administer activated charcoal, although the efficacy of charcoal is unknown. Perform gastric lavage only if the ingestion was very
large and recent (less than 30 minutes)
D: Enhanced elimination:
There is no documented efficacy for diuresis, haemodialysis, haemoperfusion, or repeat-dose charcoal.
POISONING and DRUG OVERDOSE, Californian Poison Control System Ed. Kent R Olson; 3rd Edition
Do not administer sympathomimetic drugs unless absolutely necessary as material may increase myocardial irritability.
No specific antidote.
Because rapid absorption may occur through lungs if aspirated and cause systematic effects, the decision of whether to induce vomiting or not should be
made by an attending physician.
If lavage is performed, suggest endotracheal and/or esophageal control.
Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach.
Treatment based on judgment of the physician in response to reactions of the patient
For frost-bite caused by liquefied petroleum gas:
If part has not thawed, place in warm water bath (41-46 C) for 15-20 minutes, until the skin turns pink or red.
Analgesia may be necessary while thawing.
If there has been a massive exposure, the general body temperature must be depressed, and the patient must be immediately rewarmed by whole-body
immersion, in a bath at the above temperature.
Shock may occur during rewarming.
Administer tetanus toxoid booster after hospitalization.
Prophylactic antibiotics may be useful.
The patient may require anticoagulants and oxygen.
[Shell Australia 22/12/87]
For gas exposures:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
Establish a patent airway with suction where necessary.
Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Administer oxygen by non-rebreather mask at 10 to 15 l/min.
Monitor and treat, where necessary, for pulmonary oedema .
Monitor and treat, where necessary, for shock.
Anticipate seizures.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory arrest has occurred.
Positive-pressure ventilation using a bag-valve mask might be of use.
Monitor and treat, where necessary, for arrhythmias.
Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers solution. Fluid overload might create complications.
Drug therapy should be considered for pulmonary oedema.
Hypotension with signs of hypovolaemia requires the cautious administration of fluids. Fluid overload might create complications.
Treat seizures with diazepam.
Proparacaine hydrochloride should be used to assist eye irrigation.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994

SECTION 5 Fire-fighting measures

Extinguishing media
SMALL FIRE: Use extinguishing agent suitable for type of surrounding fire.
LARGE FIRE: Cool cylinder.
DO NOT direct water at source of leak or venting safety devices as icing may occur.

Special hazards arising from the substrate or mixture

Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may
Fire Incompatibility
result

Special protective equipment and precautions for fire-fighters

--------------------------------------------------------------
GENERAL
--------------------------------------------------------------
Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus and protective gloves.
Fire Fighting
Fight fire from a safe distance, with adequate cover.
Use water delivered as a fine spray to control fire and cool adjacent area.
DO NOT approach cylinders suspected to be hot.
Cool fire exposed cylinders with water spray from a protected location.
If safe to do so, remove cylinders from path of fire.

Continued...
Part Number: 905623 Page 5 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Containers may explode when heated - Ruptured cylinders may rocket

Fire exposed containers may vent contents through pressure relief devices.
High concentrations of gas may cause asphyxiation without warning.
May decompose explosively when heated or involved in fire.
Contact with gas may cause burns, severe injury and/ or frostbite.
Decomposition may produce toxic fumes of:
,
carbon monoxide (CO)
Fire/Explosion Hazard Combustion products include:
,
carbon dioxide (CO2)
,
hydrogen fluoride
,
other pyrolysis products typical of burning organic material.
Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
Vented gas is more dense than air and may collect in pits, basements.

SECTION 6 Accidental release measures

Personal precautions, protective equipment and emergency procedures

See section 8

Environmental precautions
See section 12

Methods and material for containment and cleaning up

Environmental hazard - contain spillage.
Avoid breathing vapour and any contact with liquid or gas. Protective equipment including respirator should be used.
DO NOT enter confined spaces where gas may have accumulated.
Minor Spills Increase ventilation.
Clear area of personnel.
Stop leak only if safe to so do.
Remove leaking cylinders to safe place.
Environmental hazard - contain spillage.
Clear area of all unprotected personnel and move upwind.
Alert Emergency Authority and advise them of the location and nature of hazard.
Wear breathing apparatus and protective gloves.
Prevent by any means available, spillage from entering drains and water-courses.
Consider evacuation.
Major Spills
Increase ventilation.
No smoking or naked lights within area.
Remove leaking cylinders to a safe place.
Fit vent pipes. Release pressure under safe, controlled conditions
Burn issuing gas at vent pipes.
DO NOT exert excessive pressure on valve; DO NOTattempt to operate damaged valve.

Personal Protective Equipment advice is contained in Section 8 of the SDS.

SECTION 7 Handling and storage

Precautions for safe handling

· Consider use in closed pressurised systems, fitted with temperature, pressure and safety relief valves which are vented for safe
dispersal. Use only properly specified equipment which is suitable for this product, its supply pressure and temperature
· The tubing network design connecting gas cylinders to the delivery system should include appropriate pressure indicators and
vacuum or suction lines.
· Fully-welded types of pressure gauges, where the bourdon tube sensing element is welded to the gauge body, are
recommended.
· Before connecting gas cylinders, ensure manifold is mechanically secure and does not containing another gas. Before
Safe handling
disconnecting gas cylinder, isolate supply line segment proximal to cylinder, remove trapped gas in supply line with aid of
vacuum pump
· When connecting or replacing cylinders take care to avoid airborne particulates violently ejected when system pressurises.
· Consider the use of doubly-contained piping; diaphragm or bellows sealed, soft seat valves; backflow prevention devices; flash
arrestors; and flow monitoring or limiting devices. Gas cabinets, with appropriate exhaust treatment, are recommended, as is
automatic monitoring of the secondary enclosures and work areas for release.
DO NOT transfer gas from one cylinder to another.

Other information · Do NOT store halogenated aliphatics in areas containing alkali or alkaline earth metals such as powdered
aluminum, zinc, or beryllium
Cylinders should be stored in a purpose-built compound with good ventilation, preferably in the open.
Such compounds should be sited and built in accordance with statutory requirements.
The storage compound should be kept clear and access restricted to authorised personnel only.

Continued...
Part Number: 905623 Page 6 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Cylinders stored in the open should be protected against rust and extremes of weather.
Cylinders in storage should be properly secured to prevent toppling or rolling.
Cylinder valves should be closed when not in use.
Where cylinders are fitted with valve protection this should be in place and properly secured.

Conditions for safe storage, including any incompatibilities

DO NOT use aluminium or galvanised containers
Cylinder:
Ensure the use of equipment rated for cylinder pressure.
Ensure the use of compatible materials of construction.
Valve protection cap to be in place until cylinder is secured, connected.
Suitable container
Cylinder must be properly secured either in use or in storage.
Cylinder valve must be closed when not in use or when empty.
Segregate full from empty cylinders.

WARNING: Suckback into cylinder may result in rupture.

As a general rule, hydrofluorocarbons tend to be flammable unless they contain more fluorine atoms than hydrogen atoms.
Haloalkanes:
are highly reactive:some of the more lightly substituted lower members are highly flammable; the more highly substituted
may be used as fire suppressants, not always with the anticipated results.
may react with the lighter divalent metals to produce more reactive compounds analogous to Grignard reagents.
may produce explosive compounds following prolonged contact with metallic or other azides
may react on contact with potassium or its alloys - although apparently stable on contact with a wide rage of halocarbons,
reaction products may be shock-sensitive and may explode with great violence on light impact; severity generally increases
Storage incompatibility with the degree of halocarbon substitution and potassium-sodium alloys give extremely sensitive mixtures .
BRETHERICK L.: Handbook of Reactive Chemical Hazards
react with metal halides and active metals, eg. sodium (Na), potassium (K), lithium (Li),calcium (Ca), zinc (Zn), powdered
aluminium (Al) and aluminium alloys, magnesium (Mg) and magnesium alloys.
may react with brass and steel.
may react explosively with strong oxidisers
may degrade rubber, and plastics such as methacrylate polymers, polyethylene and polystyrene, paint and coatings
Compressed gases may contain a large amount of kinetic energy over and above that potentially available from the energy of
reaction produced by the gas in chemical reaction with other substances

+ x + o + + +

X — Must not be stored together

0 — May be stored together with specific preventions
+ — May be stored together

Note: Depending on other risk factors, compatibility assessment based on the table above may not be relevant to storage situations, particularly where large volumes
of dangerous goods are stored and handled. Reference should be made to the Safety Data Sheets for each substance or article and risks assessed accordingly.

SECTION 8 Exposure controls / personal protection

Control parameters

Occupational Exposure Limits (OEL)

INGREDIENT DATA
Not Available

Emergency Limits

Ingredient TEEL-1 TEEL-2 TEEL-3

1,1,1,2-tetrafluoroethane Not Available Not Available Not Available

Ingredient Original IDLH Revised IDLH

pentafluoroethane Not Available Not Available
1,1,1,2-tetrafluoroethane Not Available Not Available
1,1,1-trifluoroethane Not Available Not Available

MATERIAL DATA
Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or throat. Historically occupational exposure standards for
these irritants have been based on observation of workers' responses to various airborne concentrations. Present day expectations require that nearly every
individual should be protected against even minor sensory irritation and exposure standards are established using uncertainty factors or safety factors of 5 to 10 or
more. On occasion animal no-observable-effect-levels (NOEL) are used to determine these limits where human results are unavailable. An additional approach,
typically used by the TLV committee (USA) in determining respiratory standards for this group of chemicals, has been to assign ceiling values (TLV C) to rapidly
acting irritants and to assign short-term exposure limits (TLV STELs) when the weight of evidence from irritation, bioaccumulation and other endpoints combine to

Continued...
Part Number: 905623 Page 7 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

warrant such a limit. In contrast the MAK Commission (Germany) uses a five-category system based on intensive odour, local irritation, and elimination half-life.
However this system is being replaced to be consistent with the European Union (EU) Scientific Committee for Occupational Exposure Limits (SCOEL); this is
more closely allied to that of the USA.
May act as a simple asphyxiants; these are gases which, when present in high concentrations, reduce the oxygen content in air below that required to support
breathing, consciousness and life; loss of consciousness, with death by suffocation may rapidly occur in an oxygen deficient atmosphere.
CARE: Most simple asphyxiants are odourless or possess low odour and there is no warning on entry into an oxygen deficient atmosphere. If there is any doubt,
oxygen content can be checked simply and quickly. It may not be appropriate to only recommend an exposure standard for simple asphyxiants rather it is
essential that sufficient oxygen be maintained. Air normally has 21 percent oxygen by volume, with 18 percent regarded as minimum under normal atmospheric
pressure to maintain consciousness / life. At pressures significantly higher or lower than normal atmospheric pressure, expert guidance should be sought.

Exposure controls
Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed
engineering controls can be highly effective in protecting workers and will typically be independent of worker interactions to
provide this high level of protection.
The basic types of engineering controls are:
Appropriate engineering
Process controls which involve changing the way a job activity or process is done to reduce the risk.
controls
Enclosure and/or isolation of emission source which keeps a selected hazard "physically" away from the worker and ventilation
that strategically "adds" and "removes" air in the work environment. Ventilation can remove or dilute an air contaminant if
designed properly. The design of a ventilation system must match the particular process and chemical or contaminant in use.
Employers may need to use multiple types of controls to prevent employee overexposure.

Individual protection
measures, such as
personal protective
equipment

Chemical goggles.
Full face shield may be required for supplementary but never for primary protection of eyes.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy
Eye and face protection document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task. This should
include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience.
Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the
event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable.
Skin protection See Hand protection below
Butyl rubber gloves
· Butyl rubber gloves should be used when handling halogenated aliphatics .
· Nitrile, PVC-coated nitrile, and PVC protective equipment are not recommended
When handling sealed and suitably insulated cylinders wear cloth or leather gloves.
Hands/feet protection
Insulated gloves:
NOTE: Insulated gloves should be loose fitting so that may be removed quickly if liquid is spilled upon them. Insulated gloves
are not made to permit hands to be placed in the liquid; they provide only short-term protection from accidental contact with
the liquid.
Body protection See Other protection below
· Halogen-selective detectors use a specialized sensor that allows the monitor to detect compounds containing
fluorine, chlorine, bromine, and iodine with-out interference from other [Link] detectors are typically easy to
use, feature higher sensitivity than the nonselective detectors (detection limits are typically <5 ppm when used as an
area monitor and <1.4 gm/yr [<0.05 oz/yr] when used as a leak pinpointer).
· Compound-Specific Detectors are typically capable of detecting the presence of a single compound without
Other protection interference from other compounds.
Protective overalls, closely fitted at neck and wrist.
Eye-wash unit.
Ensure availability of lifeline in confined spaces.
Staff should be trained in all aspects of rescue work.
Rescue gear: Two sets of SCBA breathing apparatus Rescue Harness, lines etc.

Respiratory protection
Type AX Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent)

Selection of the Class and Type of respirator will depend upon the level of breathing zone contaminant and the chemical nature of the contaminant. Protection
Factors (defined as the ratio of contaminant outside and inside the mask) may also be important.

Required minimum protection Maximum gas/vapour concentration present in air p.p.m. (by Half-face Full-Face
factor volume) Respirator Respirator
up to 10 1000 AX-AUS / Class1 -
up to 50 1000 - AX-AUS / Class 1
up to 50 5000 Airline * -
up to 100 5000 - AX-2
up to 100 10000 - AX-3
100+ Airline**

* - Continuous Flow ** - Continuous-flow or positive pressure demand

Continued...
Part Number: 905623 Page 8 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

A(All classes) = Organic vapours, B AUS or B1 = Acid gasses, B2 = Acid gas or hydrogen cyanide(HCN), B3 = Acid gas or hydrogen cyanide(HCN), E = Sulfur
dioxide(SO2), G = Agricultural chemicals, K = Ammonia(NH3), Hg = Mercury, NO = Oxides of nitrogen, MB = Methyl bromide, AX = Low boiling point organic
compounds(below 65 degC)

Cartridge respirators should never be used for emergency ingress or in areas of unknown vapour concentrations or oxygen content.
The wearer must be warned to leave the contaminated area immediately on detecting any odours through the respirator. The odour may indicate that the mask
is not functioning properly, that the vapour concentration is too high, or that the mask is not properly fitted. Because of these limitations, only restricted use of
cartridge respirators is considered appropriate.
Cartridge performance is affected by humidity. Cartridges should be changed after 2 hr of continuous use unless it is determined that the humidity is less than
75%, in which case, cartridges can be used for 4 hr. Used cartridges should be discarded daily, regardless of the length of time used
Positive pressure, full face, air-supplied breathing apparatus should be used for work in enclosed spaces if a leak is suspected or the primary containment is to
be opened (e.g. for a cylinder change)
Air-supplied breathing apparatus is required where release of gas from primary containment is either suspected or demonstrated.

SECTION 9 Physical and chemical properties

Information on basic physical and chemical properties

Appearance Liquefied pressure gas

Relative density (Water =

Physical state Liquified Gas 10
1)
Partition coefficient n-
Odour Not Available Not Available
octanol / water
Auto-ignition temperature
Odour threshold Not Available >700
(°C)
Decomposition
pH (as supplied) Not Applicable Not Available
temperature (°C)
Melting point / freezing
<-100-760 Viscosity (cSt) Not Available
point (°C)
Initial boiling point and
-46.6-760 Molecular weight (g/mol) Not Available
boiling range (°C)
Flash point (°C) Not Available Taste Not Available
Evaporation rate Not Available BuAC = 1 Explosive properties Not Available
Flammability Not Available Oxidising properties Not Available
Surface Tension (dyn/cm
Upper Explosive Limit (%) Not Available Not Available
or mN/m)
Lower Explosive Limit (%) Not Available Volatile Component (%vol) Not Available
Vapour pressure (kPa) 690 Gas group Not Available
Solubility in water Immiscible pH as a solution (1%) Not Available
Vapour density (Air = 1) 3.42 VOC g/L Not Available

SECTION 10 Stability and reactivity

Reactivity See section 7

Unstable in the presence of incompatible materials.
Product is considered stable.
Chemical stability
Hazardous polymerisation will not occur.
Extremely high temperatures.
Possibility of hazardous
See section 7
reactions
Conditions to avoid See section 7
Incompatible materials See section 7
Hazardous decomposition
See section 5
products

SECTION 11 Toxicological information

Information on toxicological effects

Inhaled The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC Directives
using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable
control measures be used in an occupational setting.
Exposure to high concentrations of fluorocarbons may produce cardiac arrhythmias or cardiac arrest due sensitisation of the
heart to adrenalin or noradrenalin. Deaths associated with exposures to fluorocarbons (specifically halogenated aliphatics) have
occurred in occupational settings and in inhalation of bronchodilator drugs.

Continued...
Part Number: 905623 Page 9 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Bronchospasm consistently occurs in human subjects inhaling fluorocarbons. At a measured concentration of 1700 ppm of one
of the commercially available aerosols there is a biphasic change in ventilatory capacity, the first reduction occurring within a few
minutes and the second delayed up to 30 minutes. Most subjects developed bradycardia (reduced pulse rate).
Bradycardia is encountered in dogs when administration is limited to upper respiratory tract (oropharyngeal and nasal areas).
Cardiac arrhythmias can be experimentally induced in animals (species dependency is pronounced with dogs and monkeys
requiring lesser amounts of fluorocarbon FC-11 than rats or mice).
Acute intoxication by halogenated aliphatic hydrocarbons appears to take place over two stages. Signs of a reversible narcosis
are evident in the first stage and in the second stage signs of injury to organs may become evident, a single organ alone is
(almost) never involved.
Depression of the central nervous system is the most outstanding effect of most halogenated aliphatic hydrocarbons. Inebriation
and excitation, passing into narcosis, is a typical reaction. In severe acute exposures there is always a danger of death from
respiratory failure or cardiac arrest due to a tendency to make the heart more susceptible to catecholamines (adrenalin)
Material is highly volatile and may quickly form a concentrated atmosphere in confined or unventilated areas. The vapour may
displace and replace air in breathing zone, acting as a simple asphyxiant. This may happen with little warning of overexposure.
Symptoms of asphyxia (suffocation) may include headache, dizziness, shortness of breath, muscular weakness, drowsiness and
ringing in the ears. If the asphyxia is allowed to progress, there may be nausea and vomiting, further physical weakness and
unconsciousness and, finally, convulsions, coma and death. Significant concentrations of the non-toxic gas reduce the oxygen
level in the air. As the amount of oxygen is reduced from 21 to 14 volume %, the pulse rate accelerates and the rate and volume
of breathing increase. The ability to maintain attention and think clearly is diminished and muscular coordination is somewhat
disturbed. As oxygen decreases from 14-10% judgement becomes faulty; severe injuries may cause no pain. Muscular exertion
leads to rapid fatigue.
Not normally a hazard due to physical form of product.
Ingestion
Considered an unlikely route of entry in commercial/industrial environments

Evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a substantial
number of individuals following direct contact, and/or produces significant inflammation when applied to the healthy intact skin of
animals, for up to four hours, such inflammation being present twenty-four hours or more after the end of the exposure period.
Skin irritation may also be present after prolonged or repeated exposure; this may result in a form of contact dermatitis
(nonallergic). The dermatitis is often characterised by skin redness (erythema) and swelling (oedema) which may progress to
blistering (vesiculation), scaling and thickening of the epidermis. At the microscopic level there may be intercellular oedema of
the spongy layer of the skin (spongiosis) and intracellular oedema of the epidermis.
The material may accentuate any pre-existing dermatitis condition
Skin contact is not thought to have harmful health effects (as classified under EC Directives); the material may still produce
Skin Contact health damage following entry through wounds, lesions or abrasions.

In common with other halogenated aliphatics, fluorocarbons may cause dermal problems due to a tendency to remove natural
oils from the skin causing irritation and the development of dry, sensitive skin. They do not appear to be appreciably absorbed.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury with
harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
Vapourising liquid causes rapid cooling and contact may cause cold burns, frostbite, even through normal gloves. Frozen skin
tissues are painless and appear waxy and yellow. Signs and symptoms of frost-bite may include "pins and needles", paleness
followed by numbness, a hardening an stiffening of the skin, a progression of colour changes in the affected area, (first white,
then mottled and blue and eventually black; on recovery, red, hot, painful and blistered).

Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may produce
Eye transient discomfort characterised by tearing or conjunctival redness (as with windburn).
Direct contact with the eye may not cause irritation because of the extreme volatility of the gas; however concentrated
atmospheres may produce irritation after brief exposures..
Long-term exposure to the product is not thought to produce chronic effects adverse to health (as classified by EC Directives
Chronic using animal models); nevertheless exposure by all routes should be minimised as a matter of course.
Principal route of occupational exposure to the gas is by inhalation.

TOXICITY IRRITATION
UNICOOL R-404A
Not Available Not Available

TOXICITY IRRITATION

pentafluoroethane Inhalation (Rat) LC50: >709000 ppm4h[2] Eye: no adverse effect observed (not irritating)[1]

Skin: no adverse effect observed (not irritating)[1]

TOXICITY IRRITATION

Inhalation (Rat) LC50: 359453.102 ppm4h[2] Eye: adverse effect observed (irritating)[1]
1,1,1,2-tetrafluoroethane
Skin: adverse effect observed (irritating)[1]

Skin: no adverse effect observed (not irritating)[1]

TOXICITY IRRITATION
1,1,1-trifluoroethane
Inhalation (Rat) LC50: >540000 ppm4h[2] Not Available

Continued...
Part Number: 905623 Page 10 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS.
Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances

PENTAFLUOROETHANE Cardiac sensitisation threshold limit >245400 mg/m3 Anaesthetic effects threshold limit 490800 mg/m3 * DuPont SDS
1,1,1,2- * with added oxygen - ZhongHao New Chemical Materials MSDS Excessive concentration can have a narcotic effect; inhalation
TETRAFLUOROETHANE of high concentrations of decomposition products can cause lung oedema.
NOTE: Substance has been shown to be mutagenic in at least one assay, or belongs to a family of chemicals producing damage
1,1,1-TRIFLUOROETHANE
or change to cellular DNA.
Disinfection by products (DBPs) re formed when disinfectants such as chlorine, chloramine, and ozone react with organic and
inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and 3-
chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over the
possible adverse health effects of DBPs. To date, several hundred DBPs have been identified.
Numerous haloalkanes and haloalkenes have been tested for carcinogenic and mutagenic activities. n general, the genotoxic
potential is dependent on the nature, number, and position of halogen(s) and the molecular size of the compound. Short-chain
UNICOOL R-404A & 1,1,1,2-
monohalogenated (excluding fluorine) alkanes and alkenes are potential direct-acting alkylating agents, particularly if the halogen
TETRAFLUOROETHANE
is at the terminal end of the carbon chain or at an allylic position. Dihalogenated alkanes are also potential alkylating or cross-
linking agents (either directly or after GSH conjugation),particularly if they are vicinally substituted (e.g., 1,2-dihaloalkane) or
substituted at the two terminal ends of a short to medium-size (e.g., 2-7) alkyl moiety (i.e., alpha, omega-dihaloalkane). Fully
halogenated haloalkanes tend to act by free radical or nongenotoxic mechanisms (such as generating peroxisome-proliferative
intermediates) or undergo reductive dehalogenation to yield haloalkenes that in turn could be activated to epoxides.
Haloalkenes are of concern because of potential to generate genotoxic intermediates after epoxidation.

Acute Toxicity Carcinogenicity

Skin Irritation/Corrosion Reproductivity
Serious Eye
STOT - Single Exposure
Damage/Irritation
Respiratory or Skin
STOT - Repeated Exposure
sensitisation
Mutagenicity Aspiration Hazard

Legend: – Data either not available or does not fill the criteria for classification
– Data available to make classification

SECTION 12 Ecological information

Toxicity

Endpoint Test Duration (hr) Species Value Source

UNICOOL R-404A Not Not Not
Not Available Not Available
Available Available Available

Endpoint Test Duration (hr) Species Value Source

EC50 72h Algae or other aquatic plants >114mg/l 2
EC50 48h Crustacea >97.9mg/l 2
pentafluoroethane
LC50 96h Fish >81.8mg/l 2
NOEC(ECx) 96h Fish 10mg/l 2
EC50 96h Algae or other aquatic plants 142mg/l 2

Endpoint Test Duration (hr) Species Value Source

EC50 72h Algae or other aquatic plants >114mg/l 2
EC50 48h Crustacea 980mg/L 5
1,1,1,2-tetrafluoroethane
EC50 96h Algae or other aquatic plants 142mg/l 2
NOEC(ECx) 72h Algae or other aquatic plants ~13.2mg/l 2
LC50 96h Fish 450mg/l 2

Endpoint Test Duration (hr) Species Value Source

1,1,1-trifluoroethane EC50 72h Algae or other aquatic plants ~71mg/l 2

EC0(ECx) 96h Algae or other aquatic plants >44mg/l 2

Legend: Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity
4. US EPA, Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) -
Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8. Vendor Data

On the basis of the available evidence concerning properties and predicted or observed environmental fate and behavior, the material may present a danger to the
structure and/ or functioning of the stratospheric ozone layer.

Continued...
Part Number: 905623 Page 11 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

In addition to carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), the greenhouse gases mentioned in the Kyoto Protocol include synthetic substances
that share the common feature of being highly persistent in the atmosphere and exhibiting very high specific radiative forcing (radiative forcing is the change in the
balance between radiation coming into the atmosphere and radiation out; a positive radiative forcing tends on average to warm the surface of the earth). These
synthetic substances include hydrocarbons that are partially fluorinated (HCFs) or totally fluorinated (PFCs) as well as sulfur hexafluoride (SF6).
The greenhouse potential of these substances, expressed as multiples of that of CO2, are within the range of 140 to 11,700 for HFCs, from 6500 to 9,200 for
PFCs and 23,900 for SF6. Once emitted into the atmosphere, these substances have an impact on the environment for decades, centuries, or in certain
instances, for thousands of years.
Many of these substances have only been commercialised for a few years, and still only contribute only a small percentage of those gases released to the
atmosphere by humans (anthropogenic) which increase the greenhouse effect. However, a rapid increase can be seen in their consumption and emission, and
therefore in their contribution to the anthropogenic increase in the greenhouse effect.
Since the adoption of the Kyoto Protocol, new fluorinated substances have appeared on the market, which are stable in air and have a high greenhouse potential;
these include nitrogen trifluoride (NF3) and fluoroethers.

Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
pentafluoroethane HIGH HIGH
1,1,1,2-tetrafluoroethane HIGH HIGH

1,1,1-trifluoroethane HIGH HIGH

Bioaccumulative potential
Ingredient Bioaccumulation
pentafluoroethane LOW (LogKOW = 1.5472)
1,1,1,2-tetrafluoroethane LOW (LogKOW = 1.68)
1,1,1-trifluoroethane LOW (LogKOW = 1.7393)

Mobility in soil
Ingredient Mobility
pentafluoroethane LOW (Log KOC = 154.4)
1,1,1,2-tetrafluoroethane LOW (Log KOC = 96.63)

1,1,1-trifluoroethane LOW (Log KOC = 48.64)

SECTION 13 Disposal considerations

Waste treatment methods

Evaporate residue at an approved site.
Product / Packaging Return empty containers to supplier. If containers are marked non-returnable establish means of disposal with manufacturer
disposal prior to purchase.
Ensure damaged or non-returnable cylinders are gas-free before disposal.

SECTION 14 Transport information

Labels Required

Marine Pollutant NO

Shipping container, transport vehicle placarding, and labeling may vary from the below information. This depends on the quantity shipped, the applicability of
excepted quantity requirements, limited quantity requirements, and/or special provisions according to US DOT, IATA and IMDG regulations. In case of reshipment,
it is the responsibility of the shipper to determine the appropriate labels and markings in accordance with applicable transport regulations.

Land transport (DOT)

14.1. UN number or ID
3337
number
14.2. UN proper shipping
Refrigerant gas R 404A
name

14.3. Transport hazard Class 2.2

class(es) Subsidiary Hazard Not Applicable

Continued...
Part Number: 905623 Page 12 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

14.6. Special precautions Hazard Label 2.2

for user Special provisions T50

Air transport (ICAO-IATA / DGR)

14.1. UN number 3337
14.2. UN proper shipping
Refrigerant gas R 404A
name

ICAO/IATA Class 2.2

14.3. Transport hazard
ICAO / IATA Subsidiary Hazard Not Applicable
class(es)
ERG Code 2L

14.4. Packing group Not Applicable

14.5. Environmental
Not Applicable
hazard

Special provisions Not Applicable

Cargo Only Packing Instructions 200

Cargo Only Maximum Qty / Pack 150 kg
14.6. Special precautions
Passenger and Cargo Packing Instructions 200
for user
Passenger and Cargo Maximum Qty / Pack 75 kg
Passenger and Cargo Limited Quantity Packing Instructions Forbidden

Passenger and Cargo Limited Maximum Qty / Pack Forbidden

Sea transport (IMDG-Code / GGVSee)

14.1. UN number 3337
14.2. UN proper shipping
REFRIGERANT GAS R 404A
name

14.3. Transport hazard IMDG Class 2.2

class(es) IMDG Subsidiary Hazard Not Applicable

14.4. Packing group Not Applicable

14.5 Environmental hazard Not Applicable

EMS Number F-C , S-V

14.6. Special precautions
Special provisions Not Applicable
for user
Limited Quantities 120 mL

14.7.1. Transport in bulk according to Annex II of MARPOL and the IBC code
Not Applicable

14.7.2. Transport in bulk in accordance with MARPOL Annex V and the IMSBC Code
Product name Group
pentafluoroethane Not Available

1,1,1,2-tetrafluoroethane Not Available

1,1,1-trifluoroethane Not Available

14.7.3. Transport in bulk in accordance with the IGC Code

Product name Ship Type
pentafluoroethane Not Available

1,1,1,2-tetrafluoroethane Not Available

1,1,1-trifluoroethane Not Available

Continued...
Part Number: 905623 Page 13 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

SECTION 15 Regulatory information

Safety, health and environmental regulations / legislation specific for the substance or mixture

pentafluoroethane is found on the following regulatory lists

US AIHA Workplace Environmental Exposure Levels (WEELs)

US EPA Integrated Risk Information System (IRIS)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US Toxicology Excellence for Risk Assessment (TERA) Workplace Environmental Exposure Levels (WEEL)

1,1,1,2-tetrafluoroethane is found on the following regulatory lists

International Agency for Research on Cancer (IARC) - Agents Classified by the IARC Monographs - Not Classified as Carcinogenic
US AIHA Workplace Environmental Exposure Levels (WEELs)
US DOE Temporary Emergency Exposure Limits (TEELs)
US EPA Integrated Risk Information System (IRIS)
US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US Toxicology Excellence for Risk Assessment (TERA) Workplace Environmental Exposure Levels (WEEL)

1,1,1-trifluoroethane is found on the following regulatory lists

US AIHA Workplace Environmental Exposure Levels (WEELs)

US Toxic Substances Control Act (TSCA) - Chemical Substance Inventory
US Toxicology Excellence for Risk Assessment (TERA) Workplace Environmental Exposure Levels (WEEL)

Additional Regulatory Information

Not Applicable

Federal Regulations

Superfund Amendments and Reauthorization Act of 1986 (SARA)

Section 311/312 hazard categories

Flammable (Gases, Aerosols, Liquids, or Solids) No

Gas under pressure Yes

Explosive No
Self-heating No

Pyrophoric (Liquid or Solid) No

Pyrophoric Gas No

Corrosive to metal No
Oxidizer (Liquid, Solid or Gas) No

Organic Peroxide No
Self-reactive No

In contact with water emits flammable gas No

Combustible Dust No

Carcinogenicity No

Acute toxicity (any route of exposure) No

Reproductive toxicity No

Skin Corrosion or Irritation Yes

Respiratory or Skin Sensitization No

Serious eye damage or eye irritation No

Specific target organ toxicity (single or repeated exposure) No

Aspiration Hazard No
Germ cell mutagenicity No

Simple Asphyxiant Yes

Hazards Not Otherwise Classified No

US. EPA CERCLA Hazardous Substances and Reportable Quantities (40 CFR 302.4)
None Reported

US. EPCRA Section 313 Toxic Release Inventory (TRI) (40 CFR 372)
None Reported

Continued...
Part Number: 905623 Page 14 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

Additional Federal Regulatory Information

Not Applicable

State Regulations

US. California Proposition 65

None Reported

Additional State Regulatory Information

Not Applicable

National Inventory Status

National Inventory Status
Australia - AIIC / Australia
Yes
Non-Industrial Use

Canada - DSL Yes

Canada - NDSL No (pentafluoroethane; 1,1,1,2-tetrafluoroethane; 1,1,1-trifluoroethane)

China - IECSC Yes

Europe - EINEC / ELINCS /
Yes
NLP

Japan - ENCS Yes

Korea - KECI Yes

New Zealand - NZIoC Yes

Philippines - PICCS Yes

USA - TSCA Yes

Taiwan - TCSI Yes

Mexico - INSQ Yes

Vietnam - NCI Yes

Russia - FBEPH Yes

Yes = All CAS declared ingredients are on the inventory
Legend: No = One or more of the CAS listed ingredients are not on the inventory. These ingredients may be exempt or will require
registration.

SECTION 16 Other information

Revision Date 29/03/2023

Initial Date 18/06/2016

CONTACT POINT
- For quotations contact your local Customer Services - [Link] - - Responsible for safety data sheet Wilhelmsen
Ships Service AS - Prepared by: Compliance Manager, - Email: Email: [Link]@[Link] - Telephone: Tel.: +47 67584000

SDS Version Summary

Version Date of Update Sections Updated

5.7 29/03/2023 Identification of the substance / mixture and of the company / undertaking - Synonyms

Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch
Classification committee using available literature references.

The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks
in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available
engineering controls must be considered.

Definitions and abbreviations

PC TWA: Permissible Concentration-Time Weighted Average
PC STEL: Permissible Concentration-Short Term Exposure Limit
IARC: International Agency for Research on Cancer
ACGIH: American Conference of Governmental Industrial Hygienists
STEL: Short Term Exposure Limit
TEEL: Temporary Emergency Exposure Limit
IDLH: Immediately Dangerous to Life or Health Concentrations

Continued...
Part Number: 905623 Page 15 of 15 Issue Date: 29/03/2023
Version No: 6.7 Print Date: 08/08/2024
UNICOOL R-404A

ES: Exposure Standard

OSF: Odour Safety Factor
NOAEL: No Observed Adverse Effect Level
LOAEL: Lowest Observed Adverse Effect Level
TLV: Threshold Limit Value
LOD: Limit Of Detection
OTV: Odour Threshold Value
BCF: BioConcentration Factors
BEI: Biological Exposure Index
DNEL: Derived No-Effect Level
PNEC: Predicted no-effect concentration

AIIC: Australian Inventory of Industrial Chemicals

DSL: Domestic Substances List
NDSL: Non-Domestic Substances List
IECSC: Inventory of Existing Chemical Substance in China
EINECS: European INventory of Existing Commercial chemical Substances
ELINCS: European List of Notified Chemical Substances
NLP: No-Longer Polymers
ENCS: Existing and New Chemical Substances Inventory
KECI: Korea Existing Chemicals Inventory
NZIoC: New Zealand Inventory of Chemicals
PICCS: Philippine Inventory of Chemicals and Chemical Substances
TSCA: Toxic Substances Control Act
TCSI: Taiwan Chemical Substance Inventory
INSQ: Inventario Nacional de Sustancias Químicas
NCI: National Chemical Inventory
FBEPH: Russian Register of Potentially Hazardous Chemical and Biological Substances

Powered by AuthorITe, from Chemwatch.

end of SDS