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Patient Teaching: Sustenna (Paliperidone)
and Invega Hafyera
Medication Overview:
+ Sustenna (Paliperidone): A long-acting injectable
antipsychotic used to treat schizophrenia and
schizoaffective disorder. It helps reduce symptoms like
hallucinations and prevents relapse.
+ Invega Hafyera: A 6-month extended-release injection for
adults stabilized on monthly (PP1M) or 3-month (PP3M)
injections.
Dosage:
+ Invega Hafyera Initial Dose: Given intramuscularly in the
gluteal muscle, either 1092 mg or 1560 mg, depending on
previous medication.
+ Maintenance Dose: Administered every 6 months; dosage
can be adjusted.
How It Works (Pharmacokinetics):
+ Peak Effect: Within 24 hours.
+ Elimination Half-Life: 23 hours.
+ Excretion: Mostly through urine (80%) and feces (11%).
+ Protein Binding: Greater than 74%.
Possible Side Effects:
+ Central Nervous System (CNS):
+ Drowsiness, insomnia, anxiety, headaches, dizziness, and
agitation.
+ Rare but serious: seizures, neuroleptic malignant syndrome,
suicidal thoughts.
+ Cardiovascular:
+ Orthostatic hypotension (dizziness when standing),
tachycardia, QT prolongation.
+ Metabolic/Endocrine:
+ Weight gain, hyperglycemia, and cholesterol changes. + Other:
+ Blurred vision, nausea, menstrual irregularities, back pain,
allergic reactions like angioedema.
Safety Instructions:
+ Medication Adherence:
+ Attend all appointments and follow the prescribed schedule
for injections.
+ Precautions for Dizziness/Low Blood Pressure:
+ Stand up slowly to prevent falls.
+ Avoid hot tubs or hot showers as these may worsen
dizziness.
+ Drug Interactions and Alcohol:
+ Avoid over-the-counter medications unless approved by
your doctor.
+ Do not drink alcohol, as it can increase drowsiness.
+ Avoid Abrupt Stopping:
+ Stopping suddenly may cause side effects. If
discontinuation is needed, consult your doctor to taper the
medication safely.
+ Safety in Daily Activities:
+ Avoid driving or hazardous tasks if you feel drowsy or dizzy.
+ Heat Precautions:
+ Protect yourself in hot weather to prevent heat stroke. Stay
cool and hydrated.
+ Pregnancy and Breastfeeding:
+ Use contraception. Inform your doctor if pregnant, planning
to become pregnant, or breastfeeding.
When to Call Your Doctor:
+ Unusual muscle movements or tremors.
+ Vision problems or severe dizziness.
+ — Signs of an allergic reaction (swelling, difficulty breathing).
+ Changes in mood or thoughts of self-harm. By following these instructions, you can safely manage your
treatment and stay on track with your recovery.