Shrikant Sir
Chemistry Structure of substances
Organic Inorganic Biochemistry Physical Analytical
Pharmaceutical Chemistry
Structure of Drugs/ Pharmaceutical
Organic Inorganic Biochemistry Analytical
Physical
All used in Pharmacy add prefix Pharmaceutical
Material Science
Physics
Pharmacy Chemistry
Research Biology
Medicine/Drug Geology
Drug Actions Analytical Chemistry Environmental
Clinical Science
Examination Agriculture
Toxicology
Investigation Forensics
Inspection Martial Science
Survey Engineering
Scanning
Analysis Provide Tools and Methods to provide answer of four word for Substance
⧃ What ?
⧃ How Much?
⧃ Arrangement / Structure /Form?
⧃ Where?
GPAT/ NIPER
Pharmaceutical Analysis Syllabus
How Can Cover ?
Section 6
Section 5
Section 4
Section 3
Section 2
Section 1
Pharmaceutical Analysis Syllabus
Section 1
⧃ Introduction Pharmaceutical Analysis
⧃ Importance of quality control in pharmacy
⧃ Accuracy Precision Errors and Calibrations
Section 2
⧃ Electromagnetic Radiations
⧃ General principles of spectroscopy
⧃ Ultraviolet-visible Spectroscopy
⧃ Infrared Spectroscopy
⧃ Nuclear Magnetic Resonance Spectroscopy
⧃ Mass spectroscopy
⧃ Electron Spin Resonance Spectroscopy
⧃ Raman Spectroscopy
⧃ Spectroflorimetry
⧃ Nephelometry & Turbidimetry
⧃ Flame photometry
⧃ Atomic absorption spectrometry
⧃ Atomic emission spectrometry
⧃ X Ray Methods
Section 3
⧃ Chromatography
Section 4
⧃ Acid-base titrations
⧃ Gravimetry
⧃ Non-aqueous titrations
⧃ Oxidation-reduction titrations
⧃ Precipitation titrations
⧃ Complexometric titrations
⧃ Miscellaneous Titrations
Section 5
⧃ Potentiometry
⧃ Polarography
⧃ Amperometry
⧃ Coulometry
⧃ Voltammetry
⧃ Polarimetry
Section 6
⧃ Thermal Methods
⧃ Classical Methods
⧃ Extraction Methods
⧃ Assay Methods
⧃ Miselleneous Methods
Recommended Books
Lectures and GDC Modules are Sufficient
◊ Silverstein- Spectrometric identification of organic compounds
◊ Pavia- Introduction to Spectroscopy
◊ Y. R. Sharma -Elementary Organic Spectroscopy
◊ Chatwal Instrumental Methods of Chemical Analysis
◊ Remington's Pharmaceutical Sciences
Analytical chemistry is the branch of chemistry that deals with the analysis
of different substances.
Pharmaceuticals
Pharmaceutical Analysis
Separation Quantification Identification
Role of Pharmaceutical Analysis
The pharmaceutical manufacturer is responsible for ensuring the
following for each drug product
Quality
Purity
Identity
Strength
Isolation Identification Analysis
Cinchona Bark
API- Quinine
Pharmaceutical Analysis- Main Techniques
Titrations
Spectroscopy
Chromatography
Electroanalyis
Miselleneous
Titrations
Spectroscopy
Absorption Spectroscopy Emission Spectroscopy
Pharma
Company 2
Pharma
Humanity
Company 1
Chromatography
Separation
Mixture
Mobile Phase Stationary Phase Separation
Shrikant Sir
Pharmaceutical Analysis- Main Techniques
Titrations
Spectroscopy
Chromatography
Electroanalyis
Miselleneous
Analytical Chemistry Methods
Classical Methods Instrumental Methods
Acid test for gold Spectroscopy- UV, IR, NMR
Kastle-Meyer test Mass spectroscopy
Flame tests Chromatography
Volumetric analysis Potentiometry
Gravimetric analysis Polarography
Checking for the presence or absence Amperometry
Conductometry
Titrations
Volumetric Titrations Gravimetric Titrations
Aqueous
Acid Base Titration
Non Aqueous
Redox Titrations
Precipitation Titration
Complexometric Titration
Potentiometric Titration
Diazotization
Instrumental Methods
Spectroscopy Electroanalytical Miscellaneous Chromatography
UV -Visible Potentiometry Thermal Methods
IR Amperometry Polarimetry Hyphenated
technique
NMR Voltammetry RIA
Chromatography
Mass Polarography ELISA
ESR Coulometry Karl Fisher Spectroscopy
AAS & AES Chronopotentiometry Kjeldahl Method
X -Ray Electrogravimetry
Flame Phtometry
Types of Assay/Test
Chemical Assay Biological Assay
Spectroflurimetry Bioassay
Spectrophotometric Assay Immunological Assay
Chromatography Microbiological Assay
Non Instrumental Methods
Basic Principal of Instrumental Analytical Methods
Reading
Analytical Methods Sample Production of Signals Device
Change in Physical and Chemical Properties
How can Work Instrumental Analytical Methods
Production of Signal Signals produced from Sample
Transduction Transformation of signal to different Nature
Amplifications Increases the sensitivity
Presentation Display of Results
Nature Analytical Methods
Destructive Methods Nondestructive Methods
Sample affected Sample not affected
Not reused Reused if required
Permanent and irreversible
chemical changes
Used minor Quantity
Branches of Analytical Chemistry
1. Quantitative Analysis
⍣ Quantitative Analysis is a method of determining the absolute or relative
quantity regarding the concentration of one or more substances present
in a sample or compound.
2. Qualitative Analysis
⍣ Quality means the standard or the feature of one substance.
⍣ Yes or NO
⍣ Presence or Absence
Target of Analytical Methods
Elemental analysis Molecular Analysis
Qualitative Quantitative
Qualitative Quantitative
Methods of Analysis
Properties Measured Methods
Volume ◊ Volumetric Titration
Weight ◊ Gravimetric Titration
Complex Formation ◊ Complexation Titration
Precipitate Formation ◊ Precipitate Titration
Concentration in Rate Law ◊ Kinetic Methods of Analysis
Nuclear Reactions ◊ Gamma Rays Methods
Inner Shell Electronic Changes ◊ X Ray Analysis Methods
Methods of Analysis
Properties Measured Methods
Absorption of Radiation ◊ Spectrophotometry [UV Visible, IR]
◊ NMR
◊ ESR
◊ X Ray
◊ Atomic Absorption Spectroscopy
◊ Colorimetric
Emission of Radiation ◊ Emission spectroscopy [UV Visible, IR]
◊ Flame Photometry
◊ Fluorescence
Mass to Charge Ratio ◊ Mass Spectroscopy
Properties Measured Methods
Scattering of radiation ◊ Turbidimetry
◊ Nephelometry
◊ Raman Spectroscopy
Refraction of Radiation ◊ Reflectometry
◊ Interferometry
Diffraction of radiation ◊ X Ray diffraction
◊ Electron Detraction Methods
Properties Measured Methods
Rotation of radiation ◊ Polarimetry
◊ Optical Rotatory dispersion
◊ Circulars Dichroism
Electrical Potential ◊ Potentiometry
◊ Chronopotentiometry
Electrical Conductance ◊ Conductometry
Electrical Current ◊ Polarography
◊ Amperometric Titration
Physical Properties Measured Methods
Quantity of electricity ◊ Coulometry
Thermal Properties ◊ TGA
◊ Deferential Thermal Scanning
Partitions ◊ Chromatography
Adsorption
Ion Exchange
Affinity
Size Exclusion
Q.1. Kastle-Meyer test-
(a) Detection of Hb
(b) Detection of Metals
(c) Detection of Acid
(d) All
Q.2. Analysis on Biological System Known as
(a) Spectroscopy
(b) Bioassay
(c) Titrations
(d) None
Q.3. All Methods have use volume of titrant except
(a) Polarimetry
(b) Potentiometry
(c) Amperometry
(d) Voltammetry
Q.4. UV Spectroscopy responsible for
(a) Electronic transitions
(b) Vibration Transitions
(c) Spin Transitions
(d) None
Q.5. NMR Spectroscopy Used----- rays of EMR
(a) NMR
(b) UV
(c) IR
(d) Radio waves
Q.6. Principle of Chromatography and UV visible spectroscopy
(a) Absorption & Adsorption
(b) Partition & Adsorption
(c) Partition & Absorption
(d) Absorption & Partition
Q.7. Nature of sample for analytical methods
(a) Molecular
(b) Elemental
(c) Both
(d) None
Q.8. Measurement of Current
(a) Polarimetry
(b) Polarography
(c) Coulometry
(d) Potentiometry
Q.9. Choose methods that adsorption of Radiation
(a) UV
(b) IR
(c) Both
(d) None
Q.10. Measurement of Potential
(a) Polarimetry
(b) Polarography
(c) Coulometry
(d) Potentiometry
Q.11. Mass to Charge ratio measured in
(a) Flame Photometry
(b) NMR
(c) UV Absorption
(d) Mass Spectroscopy
Q.12. Measurement of rotation of radiation
(a) Polarimetry
(b) Polarography
(c) Coulometry
(d) Potentiometry
Q.13. Principle of chromatography except
(a) Absorption
(b) Partitions
(c) Affinity
(d) None
Q.14. Techniques used for Separation
(a) Polarimetry
(b) Chromatography
(c) UV Spectroscopy
(d) Potentiometry
Q.15. Principle of chromatography
(a) Absorption
(b) Partitions
(c) Affinity
(d) B &C
Q.16. Infrared analysis can be operated by
(a) Absorption
(b) Emission
(c) Both
(d) None
Shrikant Sir
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