HEMATOLOGY 1 LECTURE
LESSON 3
ERYTHROCYTE METABOLISM AND MEMBRANE STRUCTURE AND
FUNCTION
REPASO, C. | FRIDAY 1:00 PM - 4:00 PM
OUTLINE
I. Introduction III. RBC Membrane
II. Normoblastic Maturation
III. Glycolysis Diversion
Pathways (Shunts)
I. Introduction
B. RBC Membrane Proteins
● proteins make up 52% of the membrane structure by mass.
● transmembrane proteins serve many functions including: transport
sites, adhesion sites, and signaling receptors.
● Blood group antigens are located in membrane macromolecular
Hypoxia - the stimulus to red blood cell production
complexes that serve as transporters, structural components,
enzymes, receptors, and adhesion molecules.
II. Energy Production - Anaerobic Glycolysis ● phosphatidylinositol (PI) resides in the outer, plasma-side layer of
the membrane. Pl serves as a base on which a glycan core of
A. Hydrogen Peroxide Reduction via Reduced sugar molecules is synthesized, forming the
Glutathione glycosylphosphatidylinositol (GPI) anchor
● Cytoskeletal Proteins
III. Glycolysis Diversion Pathways (Shunts)
A. Methemoglobin Reductase Pathway
● Heme iron is constantly exposed to oxygen and peroxide.8 Peroxide
oxidizes heme iron from the ferrous (2+) to the ferric (3+) state.
● methemoglobin
- when the iron state is ferric, the affected hemoglobin molecule
● methemoglobin reductase
- reduction of methemoglobin by NADPH
IV. RBC Membrane
A. RBC Membrane Deformability
● RBC deformability depends not only on RBC geometry but also on
relative cytoplasmic (hemoglobin) viscosity