11.00 (1H, b s, exchangeable NH).
IR (KBr) group of phenacyl moiety) and 1514 (C=N
cm-1: 3440 (NH stretching), 1706 (carbonyl stretching vibration).
group of the ester), 1648 (carbonyl group of
phenacyl moiety) and 1512 (C=N stretching Ethyl 6-methyl-4-(4-methylphenyl)-2-(4-
vibration). methoxyphenacylthio)-1,4-dihydropyrimi-
dine-5-carboxylate hydrobromide (2v)
1
Ethyl 6-methyl-4-(4-chlorophenyl)-2-(4- H-NMR (DMSO-d6) : 1.16 (3H, t,
nitrophenacylthio)-1,4-dihydropyrimidine-5- CH2CH3); 2.30 (3H, s, CH3-C6H4-); 2.50 (3H, s,
carboxylate hydrobromide (2r) CH3); 3.83 (3H, s, OCH3); 3.60-4.33 (4H, m,
1
H-NMR (DMSO-d6) : 1.00 (3H, t, SCH2, CH2CH3); 5.50 (1H, s, pyr. C4); 6.60-
CH2CH3); 2.33(3H, s, CH3); 3.66-4.66(4H, m, 8.20 (8H, m, Ar-H); 11.55 (1H, b s,
SCH2, CH2CH3); 5.40(1H, s, pyr. C4); 6.66- exchangeable NH). IR (KBr) cm-1: 3410 (NH
8.33 (8H, m, Ar-H); 11.30 (1H, b s, stretching), 1695 (carbonyl group of the ester),
exchangeable NH). IR (KBr) cm-1: 3440 (NH 1643 (carbonyl group of phenacyl moiety) and
stretching), 1707 (carbonyl group of the ester), 1499 (C=N stretching vibration).
1652 (carbonyl group of phenacyl moiety) and
1515 (C=N stretching vibration). Ethyl 6-methyl-4-(4-methylphenyl)-2-(4-
methylphenacylthio)-1,4-dihydropyrimi-
Ethy 6-methyl-4-(4-methylphenyl)-2- dine-5-carboxylate hydrobromide (2w)
1
phenacylthio-1,4-dihydropyrimidine-5- H-NMR (DMSO-d6) : 1.20 (3H, t,
carboxylate hydrobromide (2s) CH2CH3); 2.30 (6H, s, 2CH3-C6H4-); 2.50 (3H,
1
H-NMR (DMSO-d6) : 1.16 (3H, t, s, CH3); 3.90-4.40 (4H, m, SCH2, CH2CH3);
CH2CH3); 2.30 (3H, s, CH3-C6H4-); 2.50 (3H, s, 5.80 (1H, s, pyr. C4); 7.00-8.20 (8H, m, Ar-H);
CH3); 3.80-4.40 (4H, m, SCH2, CH2CH3); 5.50 11.20 (1H, b s, exchangeable NH). IR (KBr)
(1H, s, pyr. C4); 6.60-8.00 (9H, m, Ar-H); cm-1: 3390 (NH stretching), 1698 (carbonyl
12.39 (1H, b s, exchangeable NH). IR (KBr) group of the ester), 1662 (carbonyl group of
cm-1: 3405 (NH stretching), 1702 (carbonyl phenacyl moiety) and 1500 (C=N stretching
group of the ester), 1657 (carbonyl group of vibration).
phenacyl moiety) and 1519 (C=N stretching
vibration). Ethyl 6-methyl-4-(4-methylphenyl)-2-(4-
nitrophenacylthio)-1,4-dihydropyrimidine-5-
Ethyl 6-methyl-4-(4-methylphenyl)-2-(4- carboxylate hydrobromide (2x)
1
bromophenacylthio)-1,4-dihydropyrimidine- H-NMR (DMSO-d6) : 1.10 (3H, t,
5-carboxylate hydrobromide (2t) CH2CH3); 2.20 (3H, s, CH3-C6H4-); 2.43 (3H, s,
1
H-NMR (DMSO-d6) : 1.16 (3H, t, CH3); 3.80-4.30 (4H, m, SCH2, CH2CH3); 5.43
CH2CH3); 2.30 (3H, s, CH3-C6H4-); 2.50 (3H, s, (1H, s, pyr. C4); 6.50-8.00 (8H, m, Ar-H);
CH3); 3.86-4.33 (4H, m, SCH2, CH2CH3); 5.50 12.69 (1H, b s, exchangeable NH). IR (KBr)
(1H, s, pyr. C4); 6.60-8.00 (8H, m, Ar-H); cm-1: 3425 (NH stretching), 1707 (carbonyl
12.00 (1H, b s exchangeable NH). IR (KBr) cm- group of the ester), 1651 (carbonyl group of
1
: 3430 (NH stretching), 1707 (carbonyl group phenacyl moiety) and 1514 (C=N stretching
of the ester), 1647 (carbonyl group of phenacyl vibration).
moiety) and 1515 (C=N stretching vibration).
Antimicrobial screening
Ethyl 6-methyl-4-(4-methylphenyl)-2-(4-
chlorophenacylthio)-1,4-dihydropyrimidine- Antibacterial activity
5-carboxylate hydrobromide (2u) Organisms
1
H-NMR (DMSO-d6) : 1.10 (3H, t, Five bacterial species representing both
CH2CH3); 2.26 (3H, s, CH3-C6H4-); 2.46 (3H, s, Gram-positive and Gram-negative strains were
CH3); 3.60-4.33 (4H, m, SCH2, CH2CH3); 5.43 used to test the antibacterial activities of the
(1H, s, pyr. C4); 6.50-8.33 (8H, m, Ar-H); new compounds: Staphylococcus aureus
12.45 (1H, b s, N1H exchangeable NH). IR (AUMC No. B-54) and Bacillus cereus
(KBr) cm-1: 3390 (NH stretching), 1707 (AUMC NoB-5) as representatives of Gram-
(carbonyl group of the ester), 1648 (carbonyl positive strains, and Escherichia coli (AUMC
41