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Bioreactor and Flow Reactor Sizing Guide

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0% found this document useful (0 votes)
16 views4 pages

Bioreactor and Flow Reactor Sizing Guide

Uploaded by

sharon khan
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

REEN 2001

Tutorial 1

Questions Only

Question 1

In bioreactors, the growth is autocatalytic in that the more cells you have, the greater the growth rate:

The cell growth rate, rg, and the rate of nutrient consumption, rs, are directly proportional to the
concentration of cells for a given set of conditions.

Given the Levenspiel plot of 1/-rs as a function of nutrient conversion [Xs where Xs = (CS0 –CS)/CS0],
answer the following:

For a nutrient feed rate of 1kg/hr with CS0 = 0.25 g/dm3, what chemostat (CSTR) size is necessary to
achieve:

a) 40% conversion of substrate


b) 80% conversion of substrate
c) What conversion would you achieve with an 80 dm3 CSTR? An 80dm3 PFR?

Question 2

The adiabatic exothermic irreversible gas-phase reaction

2A + B  2C

is to be carried out in a flow reactor for an equimolar feed of A and B. A Levenspiel plot for the reaction
was developed.
a) What PRF volume is necessary to achieve 50% conversion?
b) What CSTR volume is necessary to achieve 50% conversion?
c) What do you think of the Levenspiel plot and your answers to parts a and b?
Questions and Answers

Question 1

In bioreactors, the growth is autocatalytic in that the more cells you have, the greater the growth rate:

The cell growth rate, rg, and the rate of nutrient consumption, rs, are directly proportional to the
concentration of cells for a given set of conditions.

Given the Levenspiel plot of 1/-rs as a function of nutrient conversion [Xs where Xs = (CS0 –CS)/CS0],
answer the following:

For a nutrient feed rate of 1kg/hr with CS0 = 0.25 g/dm3, what chemostat (CSTR) size is necessary to
achieve:

a) 40% conversion of substrate 60dm3


b) 80% conversion of substrate 640dm3
c) What conversion would you achieve with an 80 dm3 CSTR? An 80dm3 PFR? For CSTR, X=55%; For
PFR, X=12%

Question 2

The adiabatic exothermic irreversible gas-phase reaction

2A + B  2C

is to be carried out in a flow reactor for an equimolar feed of A and B. A Levenspiel plot for the reaction
was developed.
a) What PRF volume is necessary to achieve 50% conversion? 150,000 m3
b) What CSTR volume is necessary to achieve 50% conversion? 50,000 m3
c) What do you think of the Levenspiel plot and your answers to parts a and b? Most known
rate laws would not give such a weird shape. The reactor volumes are unrealistic because
they are way too large.

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