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Clonidine: Uses, Dosage, and Effects

The document provides an overview of the drug Clonidine including its category, mechanism of action, pharmacokinetics, medical uses, side effects, drug interactions, and dosage forms. Clonidine is an alpha-2 adrenergic receptor agonist used to treat hypertension and other conditions by reducing sympathetic nervous system activity.

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Ukash sukarman
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5 views22 pages

Clonidine: Uses, Dosage, and Effects

The document provides an overview of the drug Clonidine including its category, mechanism of action, pharmacokinetics, medical uses, side effects, drug interactions, and dosage forms. Clonidine is an alpha-2 adrenergic receptor agonist used to treat hypertension and other conditions by reducing sympathetic nervous system activity.

Uploaded by

Ukash sukarman
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

CAMPUS

Dep: C/Pharmacy

4th Year Degree Program

Group Assignment Of DI
Group II
Name ID
1. Abdi Isak 0153
2. Ukash Mustefa 0110
3. Mohammed Jemal 0131
CLONIDINE
Overview
Clonidine category
Clonidine Mechanism of action
Clonidine Pharmacokinetics
Clonidine Medical use
Side effects
Drug drug interactions
Drug food interactions
CLONIDINE

Clonidine:Category alpha 2 adrenergic receptor

The treatment of hypertension

Brand name _Catapres


Alpha 2-RECEPTOR

The Apha2 Adrenergic Receptor is an inhibitory


G-protein coupled receptor that binds
norepinephrine and is present in both CNS and
sympathetic arm of the ANS.
Cont's

• with in sympathetic fibers ,alpha2 receptor are


uniquely found on the pre synaptic terminal of
postganglionic.
Mechanism Of Action

• Clonidine treats high blood pressure by


stimulating alpha2 receptor in the brain ,thus
inhibiting the release of norepinephrine ,and
then decreases peripheral vascular resistance,
Cont's

will become vasodilation and the pressure will


decrease.

It has specificity toward presynaptic alpha2


receptor in the vasomotor center in the
brainstem.
Pharmacokinetics
• Bioavailability:immediate release(75-85%)
• Protein bound:20-40%
• Duration:6-10hr
• Metabolism in liver
• Elimination half life:12-16hr
• Excretion in urine
Medical Uses
1. Hypertention
2. Severe dysmenorrhea
3. Vascular migraine headache
4. Treatment of alcohol withdrawal used in
conjunction with benzodiazepines
5. Attention-deficit hyperactivity disorder(ADHD)
6. Restless leg syndrome
7. Tourettes syndrome
Dosage Form
[Link] Tablet

0.1mg

0.2mg

0.3mg

2 times a day(morning and bedtime) to


0.1mg
[Link] solution
[Link] patch

0.1mg/day

0.2mg/day

0.3mg/day

Change every 7 days


Side effect

Very common side effects

• Dizziness

• Skin reactions(if given transdermally)

• Orthostatic

• Somnolence dose dependent


Cont's

Common side effects

• Constipation

• Vomiting

• Rash

• Weight gain/loss
Cont's

Rare side effects

• Hallucination

• Pruritus

• Nasal dryness

• alopecia
Clonidine and Pregnancy

Pregnancy category C

Clonidine may be pass through the barrier of


placenta then enter blood circulation of fetus and
cause decrease blood pressure of the fetus with
decrease heart [Link] can pass into
breast milk and may harm the baby;
contraindicated in pregnant women
Drug-drug Interaction

Asprin
Using asprin
Drug-Food Interactions

Ginseng:may affect the action of the clonidine


and can increase the boold pressure.
THE END

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