EVELYN HON E COLLEGE MANAGEMENT
PHARMACY SECTION
PHARMACEUTICAL CALCULATIONS PROMOTIONAL EXAM
TIME : 3:00 HRS
Instructions: Answer all the questions in this paper.
1. If 500 rnL of a 15% v/v solution are diluted to 1500 rnL, what will be the percentage
strength (v/v)?
2. If 50 rnL of a 1: 20 w/v solution are diluted to 1000 rnL, what is the ratio strength (w/v)?
3. How many milliliters of a 1:5000 w/v solution of the preservative lauralkonium chloride
can be made from 125 rnL of a 0.2% solution?
4. How many milliliters of a 1 :400 w/v stock solution should be used to make 4 liters of a
1:2000 w/v solution?
5. How many milliliters of a 1% stock solution of a certified red dye should be used in
preparing 4000 rnL of a mouthwash that is to contain 1 :20,000 w/v of the certified red
dye as a coloring agent?
6. How much water should be mixed with 5000 mL of 85% v/v alcohol to make 50% v/v
alcohol?
7. How much water should be added to 4000 g of90% w/w alcohol to make 40% w/w
alcohol?
8. How many milliliters of 3 7% w/w hydrochloric acid having a specific gravity of 1.20 are
required to make 1000 mL of diluted hydrochloric acid 10% w/v?
9. How many grams of a 1: 10 trituration are required to obtain 25 mg of drug?
10. What is the percentage strength (v/v) of alcohol in a mixture of3000 mL of 40% v/v
alcohol, 1000 mL of 60% v/v alcohol, and 1000 mL of 70% v/v alcohol? Assume no
contraction of volume after mixing.
11. In what proportion should alcohols of 95% and 50% strengths be mixed to make 70%
alcohol?
12. In what proportion should a 20% zinc oxide ointment be mixed with white petrolatum
(diluent) to produce a 3% zinc oxide ointment?
13. In what proportion should 20% benzocaine ointment be mixed with an ointment base to
produce a 2.5% benzocaine ointment?
14. How many grams of sodium chloride should be used in compounding the following
prescription? E-value = 0.23
ll Pilocarpine Nitrate 0.3 g E Value 0 .23
Sodium Chloride q.s.
Purified Water qs 30mL
Make isoton. sol.
Sig. For the eye.
15. How many grams of boric acid should be used in compounding the following
prescription? E-value of boric acid is 0.52
r
Phenacai nc Hydroch lorid e 1% E Value 0.20
Chlorobutano l 1;2% E Value 0.24
Boric Acid q.s.
Purified Water ad 60mls
Make isoton. sol.
Sig. One drop in each eye.
16. How many mi lligrams each ofNaphazoline HCL and NaCl are needed to prepare 15ml of
a 2.5% solution ofNaphazoline HCL isotonic with the nasal mucosa? The freezing-point
depression of a 1% (w/v) solution of Naphazoline HCL is 0.16 °c and that of NaCl
solution is 0.576 °C.
17. How many milligrams of NaCl must be used to dispense the following prescription
isotonic? Use the freezing- point depression method.
R N aphazo line HCL I% (freezing point= 0.16)
Sodium chloride q.s
Steril Purified water ad 15mL
18. If IO tablets contain 5g of Paracetamol, How many tablets should contain 20g?
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19. The 11sual dose of the drug is 150 mcg/ Kg body weight. How many milligrams should a
be given to a person weighing 154 lbs ( I kg = 2.2 lb)
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20. If the adult dose of c;t. drug is 50mg, calculate the dose of a child with BSA of0.79 m2
21 . If 100 inL of Sulfuric acid weigh 180 g, what is the specific gravity?
22. How many drops would be prescribed in each dose of a liquid medicament if 20mL
contained 80 doses? The dispensing dropper calibrates 32 drops per mL.
; 23. How many millilitres of a "mixture" will provide a patient with a teaspoonful (tsp) dose
to be taken four times a day for 14 days?
24. How many grams ofMetopr~lol will be required to prepare 75 dosage forms if each dose
is to contain 25 mg?
2s. If a pharmaceutical formulation cantains 7.5 g of a drug substance in 500 mL, how many
grammes are present duly in each tablespoon/ul dose?
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26. A "coug h Syrup" comprises 72mg of Hydromorphone He/ in IO fl .oz. How many
milligrams of hydromorphone Hcl are present in each two teaspoonf uls (tsp) dose ? (
[Link] = 6 tsp)
27. If 57.92 mL of oil weighs 49.2 g, what is the specific gravity?
28. }"'hat would be the percentage error of 25 mL are measured in the same graduate?
29/~ ~articular prescription calls for 0.5ml of HCl using a IO mL graduate calibrated from 2
to IO Ml in 1 ml divisions, explain how one would obtain the desired quantum of HCl by
1 the aliquot method.
30. A graduate weighs 35.825g. When 10 mL of water are mea~;ured in it, the weight of the
graduate and water is 45 .835 g. calculate the weight of the water and express any
deviation from 10 g as a percentage error.
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