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Biostatistics Exercises and Probability Analysis

This document provides 10 biostatistics exercises involving probability, confidence intervals, hypothesis testing, and other statistical concepts. The exercises cover topics like the probability of patient survival rates, normal distributions of uric acid and hospital stay values, confidence intervals for mean cholesterol and survey response rates, hypothesis testing for mean DMFT index and hospital census values, percentiles of birth weights, and comparing remission rates between treatment groups using a confidence interval. Statistical techniques like z-tests and finding probabilities, means, and percentiles are required to solve the exercises.

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0% found this document useful (0 votes)
21 views2 pages

Biostatistics Exercises and Probability Analysis

This document provides 10 biostatistics exercises involving probability, confidence intervals, hypothesis testing, and other statistical concepts. The exercises cover topics like the probability of patient survival rates, normal distributions of uric acid and hospital stay values, confidence intervals for mean cholesterol and survey response rates, hypothesis testing for mean DMFT index and hospital census values, percentiles of birth weights, and comparing remission rates between treatment groups using a confidence interval. Statistical techniques like z-tests and finding probabilities, means, and percentiles are required to solve the exercises.

Uploaded by

alyemerem7
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Biostatistics Exercise (Due date: December 6, 2023 COB)

1. The probability that a patient entering to a certain hospital will survive is 0.90.
(From previous figures). Assuming this pattern remain unchanged over the
subsequent years, what is the probability that among 60 randomly selected
patients,

a. None will survive?


b. Exactly 50 will survive?
c. At least three will survive?
2. If the uric acid values in normal adult males are approximately normally
distributed with mean 4.7 mgs and standard deviation 1mg find the probability
that a sample of size 9 will yield a mean.
a. greater than 4
b. between 5 and 6
c. less than 5.2
3. Suppose the rate of number of stays patients in a hospital is approximately
normally distributed. If 75% of rates are 37 day or less, and if 10% of rates are 23
day or less, then find the distribution mean and standard deviation respectively.
4. The mean serum cholesterol level in a certain population of normal healthy men
is 245 mg/dl and the standard deviation is 45 mg/dl. A clinical researcher
interested in comparing cholesterol levels in this healthy population with those
in men with coronary artery disease measured serum cholesterol level in a
random sample of 100men who had undergone coronary bypass surgery during
the preceding two year period. The mean serum cholesterol level for sampling
was 267 mg/dl
a. What is the 95% confidence interval estimate of the mean cholesterol level for
all men under going bypass surgery? Assume that the standard deviation of
serum cholesterol measurement for this population is the same as that of the
healthy population ( i.e., 40mg/dl)
b. Based on this estimate, can the researcher conclude that the mean serum
cholesterol of men undergoing coronary bypass surgery differs from that of
healthy men? (Show all the steps)
5. A survey showed that 83% of the random sample of 1506 people interviewed
favored drug tests for professional athletes. 78% said that professional athletics
using drug for the first time should be banned or suspended from the
professional sports. Find 95% confidence interval for the proportion of the public
who favored drug tests for professional athletes.
6. A study was to investigate the oral status of a group of patients diagnosed with
thalassemia major (TM). One of the outcome measures was the decayed, missing,
and filled teeth index (DMFT). In a sample of 18 patients the mean DMFT index
value was 11.3 with a standard deviation of 6.3. Is this sufficient evidence to
allow us to conclude that the mean DMFT index is greater than 9.0 in a
population of similar subjects? Let alpha=5% (show all the steps)
7. A survey of 100 similar-sized hospitals revealed a mean daily census in the
pediatrics service of 27 with a standard deviation of 5. Do these data provide
sufficient evidence to indicate that the population mean is less than 22? Let a =
.05.
8. The mean birth weight for Ethiopian babies is μ =3.1 kg with sd (σ=0.5 kg)
A) What weight values encompass the 95% newborns?
B) If the cut of point for low birth weight is 2.5kg, what proportion of the new
borns are lbw?
C) Find the 10th percentile birth weight.
9. Each of two groups consists of 100 patients who have leukaemia. A new drug is given to
the first group but not to the second (the control group). It is found that in the first
group 60 people have remission for 2 years; but only 40 in the second group. Find 95%
CI.
10. A health officer is trying to study the malaria situation of Ethiopia. From the records of
seasonal blood survey (SBS) results he came to understand that the proportion of people
having malaria in Ethiopia was 3.8% in 1978 (Eth. Cal). The size of the sample
considered was 15000. He also realised that during the year that followed (1979), blood
samples were taken from 10,000 randomly selected persons. The result of the 1979
seasonal blood survey showed that 200 persons were positive for malaria. Help the
health officer in testing the hypothesis that the malaria situation of 1979 did not show
any significant difference from that of 1978 (take the level of significance, α =.01).

Common questions

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Perform a one-sample t-test. Null hypothesis H0: μ ≥ 22. Calculate t = (27 - 22)/(5/sqrt(100)) = 10. Compare with critical t-value for df = 99 at α=0.05. Since the calculated t-value is much greater, the evidence is not sufficient to indicate the mean is less than 22 .

The 95% CI for the mean cholesterol level is calculated as: 267 ± 1.96*(45/sqrt(100)). This gives (257.2, 276.8). Because 245 is not within this interval, the researcher can conclude that there is a significant difference between the populations .

Conduct a one-sample t-test. Null hypothesis H0: μ = 9. Alternative hypothesis Ha: μ > 9. Compute the test statistic t = (11.3 - 9)/(6.3/sqrt(18)) and compare with the critical t-value for df = 17 at α = 0.05. Calculate p-value; if p < 0.05, reject H0 .

Let p₁ = 0.038 for 1978, sample size n₁ = 15000, and p₂ = 200/10000 for 1979. Test H0: p₁ = p₂. Use Z = (p₂ - p₁) / sqrt[p₀(1-p₀)(1/n₁ + 1/n₂)], where p₀ is pooled proportion; α = 0.01. If Z falls in the critical region, reject H0 .

Use z-scores for 95%: z = ±1.96. Calculate boundaries: Lower = 3.1 - 1.96*0.5 = 2.12 kg, Upper = 3.1 + 1.96*0.5 = 4.08 kg. Therefore, 95% of newborn weights fall between 2.12 kg and 4.08 kg .

Using p = 0.83, calculate SE = sqrt(p(1-p)/1506). Then, 95% CI = p ± 1.96*SE, resulting in 0.83 ± 0.019, or (0.811, 0.849).

Given that 75% have stays of 37 days or less (P₇₅) and 10% have stays of 23 days or less (P₁₀), we use the normal distribution properties. Let z₀.₇₅ = 0.675 and z₀.₁₀ = -1.28. Set up two equations: μ + 0.675σ = 37 and μ - 1.28σ = 23. Solving these equations simultaneously gives μ ≈ 31.312 and σ ≈ 8.438.

The probability that none will survive is given by the binomial probability formula. For none surviving (zero successes), we have P(X=0) = (60 choose 0) * (0.90)^0 * (0.10)^60. This simplifies to 1 * 1 * (0.10)^60, which is an extremely small number, effectively close to 0.

To calculate the probability, we use the standard normal distribution. We calculate the standard error (SE) as 1/sqrt(9) = 0.33. The Z-score is (4 - 4.7)/0.33 = -2.12. Using the Z-table, we find P(Z > -2.12), which is approximately 0.983. Thus, the probability is 98.3%.

First, calculate the standard error, SE = 1/sqrt(9) = 0.33. For the mean 5, Z = (5-4.7)/0.33 = 0.91 and for 6, Z = (6-4.7)/0.33 = 3.94. Using Z-tables, find P(0.91 < Z < 3.94). This gives us a probability of roughly 0.8194.

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