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Emulsions in Pharmaceutics Overview

1. The document outlines the curriculum for a Pharmaceutics theory and practical course, including 50 hours of theory and 75 hours of practical work. 2. The theory section will cover topics like pharmaceutical dosage forms, weights and measures, prescription handling, and incompatibility. The practical section lists 14 experiments involving preparations like syrups, suspensions, emulsions, and semisolids. 3. Evaluation of students will include a synopsis, major experiments, minor experiments, and viva voce, with a total of 70 marks. Reference books and minimum laboratory equipment are also provided.

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0% found this document useful (0 votes)
245 views3 pages

Emulsions in Pharmaceutics Overview

1. The document outlines the curriculum for a Pharmaceutics theory and practical course, including 50 hours of theory and 75 hours of practical work. 2. The theory section will cover topics like pharmaceutical dosage forms, weights and measures, prescription handling, and incompatibility. The practical section lists 14 experiments involving preparations like syrups, suspensions, emulsions, and semisolids. 3. Evaluation of students will include a synopsis, major experiments, minor experiments, and viva voce, with a total of 70 marks. Reference books and minimum laboratory equipment are also provided.

Uploaded by

pranavi
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
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  • Pharmaceutics Theory
  • Pharmaceutics Practicals
  • Additional Information

1.

2 PHARMACEUTICS (THEORY)
50 hours ; 2 hours/week
1. Historical background and development of profession of pharmacy.
Development of Indian pharmacopoeia and introduction to other pharmacopoeias
such as B.P, U.S.P, European pharmacopoeia, Extra pharmacopoeia and Indian
National Formulary. 4 hours; 6-8 marks
2. Weights and measures: Different types of weights and measures, modern methods of
weighing, errors in weighing. Calculations involving percentage of solutions,
allegation method, proof sprit, isotonic solutions. 4 hours; 6-8 marks
a) Prescription: Definition, parts of prescription, handling and sources of errors.
b) Posology: Definition, factors affecting dose selection, calculation of child and
infant doses.
c) Incompatibility: Introduction to physical and chemical incompatibility. Discussion
of therapeutic incompatibility with examples. 5 hours; 8-10 marks
3. Introduction to dosage forms: Classification and definitions. Theoretical aspects
including commonly used vehicles, essential adjuvants like stabilizers, colorants and
flavourants with relevance to monophasic liquid dosage forms. 6 hours; 10-12 marks

4. Biphasic liquid dosage forms:


1. Suspensions: Definition, classification, advantages and disadvantages. Study of
diffusible and in-diffusible solids, flocculated and deflocculated suspension.
Settling in suspension, discussion on wetting, controlled flocculation and
flocculation in structured vehicles.
2. Emulsions: Definition, classification and identification of types of emulsion,
mechanism of action of emulsifying agents, theories of emulsification. Formulation
of emulsion; stability of emulsions. 8 hours; 13-15 marks

5. Powders and granules: Classification, advantages and disadvantages and methods of


mixing of powders. Preparation of simple powders, compound powders, insufflations,
dusting powders, Eutectic powders. Study of effervescent granules.4hours;6-8 marks

6. Semi solid dosage forms: Definition, types, semi-solid bases, their selection.
Formulation of semi solids such as ointments, creams, pastes, gels, suppositories,
packaging, and their evaluation. 8 hours; 13-15 marks

7. Galenicals: Definition of infusion, decoction and expression. Detailed study of


maceration and percolation and Soxhlet extraction. 4 hours; 6-8 marks

8. Surgical Aids: Study of surgical dressings namely bandages, absorbent cotton and
POP. Definition and types of surgical sutures and ligatures. Manufacturing,
standardization and sterilization of surgical catgut. 4 hours; 6-8 marks

9. Radiopharmaceuticals: Uses in diagnosis and treatment, methods of preparations,


handling and safety precautions. 3 hours; 5-7 marks
PHARMACEUTICS (PRACTICALS)
75 Hours ; 3 hours/week
1. Syrups:
a) Simple syrup IP *
b) Syrup of ephedrine hydrochloride NF*
2. Elixirs:
a) Piperazine citrate elixir BP*
b) Paracetamol paediatric elixir BPC*
3. Linctuses:
a) Simple linctus BPC*
b) Paediatric compound tolu linctus*
4. Solutions:
a) Solution of cresol with soap IP**
b) Aqueous iodine solution IP*
c) Strong ammonium acetate solution IP**
5. Galenicals:
a) Tincture of benzoin*
b) Spirit of camphor USP*
6. Gargle:
a) Potassium chlorate gargle*
7. Mouth wash:
a) Antiseptic mouth wash*
8. Enema:
a) Glycerin enema*
9. Liniments:
a) Liniment of turpentine IP**
b) Liniment of camphor BPC**
[Link]:
a) Calamine lotion IP**
b) Benzyl benzoate lotion USP*
[Link]:
a) Magnesium hydroxide mixture BP**
b) Preparation of deflocculated and flocculated suspensions and their
evaluation**
[Link]:
a) Cod liver oil emulsion**
b) Liquid paraffin emulsion. Preparation and evaluation**
[Link]:
a) Eutectic powder*
b) Dusting powder*
c) Effervescent granules**
[Link] solids:
a) Simple ointment*
b) Zinc and Salicylic acid paste*
c) Diclofenac gel**
d) Boric acid suppository**
e) Lactic acid pessaries**
Note: ** Denotes major experiments * Denotes minor experiments
SCHEME OF EXAMINATION

1. Synopsis -10 Marks


2. Major experiment (indicated by **) -30 Marks
3. Minor experiment (indicated by *) -20 Marks
4. Viva voce -10 Marks
Total =70 Marks

PHARMACEUTICS REFERENCE BOOKS

1. Aulton ME. Pharmaceutics, The science of dosage form design. 2 nd ed.


Edinburgh:Churchill Livingstone;2002.
2. Bharat S. Pharmaceutics. New Delhi:Dorling Kindersley (India) Pvt Ltd;2013.
3. British Pharmacopoeia (BP), United States Pharmacopoeia (USP), Extra
Pharmacopoeia, Merck Index, and British Pharmaceutical Codex (BPC).
4. Carter SJ. Cooper and Gunn's Dispensing for pharmaceutical students. 12th ed.
New Delhi:CBS Publishers;2000.
5. Carter SJ. Cooper and Gunn’s Tutorial pharmacy. 6th ed. New Delhi:CBS
Publishers;2000.
6. Gennaro AL. Remington: The science and practice of pharmacy, Vol I and II. 20th
ed. Philadelphia:Lippincott Williams and Wilkns;2000.
7. Indian Pharmacopoeia. Delhi:The Controller of Publications;1966, 1977, 1985,
1996, 2007, 2014.
8. Loyd VA, Nicholas GP, Howard CA. Ansel’s pharmaceutical dosage forms and
drug delivery systems. 8th ed. Noida: BI Publications Pvt Ltd;2005.
9. Mehta RM. Dispensing Pharmacy. Delhi:Vallabh Prakashan;2013.
10. Mehta RM. Pharmaceutics I. Delhi:Vallabh Prakashan;2014.
11. Mitchell JS, Howard CA. Pharmaceutical calculations. 10th ed. New Delhi:BI
Waverley Pvt Ltd;1996.
12. Rawlins EA. Bentley’s textbook of pharmaceutics. 8th ed. New Delhi:Reed
Elsevier India Pvt Ltd;2010.
13. Subrahmanyam CVS. Textbook of physical pharmaceutics. 2nd ed. Delhi:Vallabh
Prakashan;2003.

LIST OF MINIMUM EQUIPMENTS REQUIRED

1. Electronic balances 02 nos.


2. Homogeniser 02 nos.
3. Mechanical stirrers 10 nos.
4. Oven 01 no.
5. pH meter 01 no.
6. Suppository moulds 20 nos.

Common questions

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The selection of semisolid bases in pharmaceuticals is critical for both the efficacy and stability of products like ointments and gels. Theoretically, the base determines the release rate of active pharmaceutical ingredients (APIs) by affecting their solubility and diffusion. Practically, it influences the application properties such as spreadability, absorption, and stability under storage conditions. Different bases like hydrophobic or hydrophilic compounds are chosen based on the desired therapeutic effect and the nature of the active ingredients, impacting patient adherence and treatment outcomes .

Maceration is a technique where the plant material is immersed in a solvent to dissolve compounds over time, while percolation involves the continuous passage of the solvent through the material with subsequent continuous extraction of active compounds. Soxhlet extraction, unlike the other two, uses a special apparatus to continuously extract compounds using a solvent that is heated to evaporate and continuously cycled back over the material. Maceration is generally simpler but may be less efficient, whereas percolation and Soxhlet extraction are more efficient but require specialized equipment .

Flocculated suspensions involve aggregates of particles that settle quickly but can be easily redispersed with shaking, which enhances dosage accuracy and stability. In contrast, deflocculated suspensions have particles that remain independent, leading to a more stable sediment that is harder to redisperse. Flocculated suspensions are preferred in situations where quick redispersion is desirable for dosing accuracy, while deflocculated suspensions might be suitable for sustained release applications where sediment stability is more critical .

Posology, the study of dosages, is vital in determining appropriate drug dosages for various patient demographics, taking into account factors like age, weight, gender, and individual health conditions. It helps in tailoring medication dosages to maximize therapeutic effects while minimizing side effects. For instance, posology procedures include calculations for child and infant doses since children metabolize drugs differently than adults. This scientific approach ensures accurate dosing across different groups, enhancing treatment efficacy and patient safety .

Pharmacopoeias play a crucial role in the field of pharmacy by providing an authoritative standard for the preparation and dispensation of medicines. They help to ensure the quality, safety, and efficacy of pharmaceutical products. Different pharmacopoeias like the Indian Pharmacopoeia (IP), British Pharmacopoeia (BP), and United States Pharmacopoeia (USP) establish standardized methods and guidelines for the formulation and compounding of drugs, which facilitates international trade and regulatory compliance. These documents also guide pharmacists and healthcare professionals in ensuring that pharmaceuticals meet rigorous quality specifications, thereby protecting public health .

Incorporating both major and minor experiments in the pharmaceutics curriculum provides comprehensive educational benefits. Major experiments, denoted by '**', often focus on complex formulations and provide an in-depth understanding of important pharmaceutical processes. Minor experiments, noted by '*', offer foundational skills and hands-on experience with simpler formulations. This dual approach builds a robust understanding of pharmaceutical practice by reinforcing theoretical knowledge with practical skills, fostering problem-solving abilities, and preparing students for real-world challenges in drug formulation and pharmacy practice .

Radiopharmaceuticals are pivotal in modern medicine for both diagnostic and therapeutic purposes. Diagnostically, they are used in imaging techniques such as PET and SPECT scans to visualize biological processes and assess abnormal activity, improving the accuracy of diagnoses. Therapeutically, certain radiopharmaceuticals provide targeted radiation to treat specific conditions, such as cancers, without extensive damage to surrounding tissues. Handling and safety precautions are critical due to the radioactive nature of these compounds, ensuring the safety of both healthcare providers and patients .

The stability of emulsions is influenced by factors such as droplet size, emulsion type (oil-in-water or water-in-oil), temperature, pH, and the presence of electrolytes. Instability can result in creaming, coalescence, or phase separation. Addressing these issues requires careful choice of emulsifying agents that lower interfacial tension, use of stabilizers that maintain droplet size, and control over environmental conditions like temperature and pH. Formulation techniques such as homogenization also enhance stability by producing smaller droplets, increasing the emulsion's resistance to separation .

Surgical aids, including sutures and ligatures, are standardized through rigorous guidelines to ensure they meet specific tensile strength, flexibility, and biodegradability requirements. Sterilization processes, such as autoclaving or gamma irradiation, are implemented to eliminate microbial contamination and ensure patient safety. The manufacturing process adheres to standardized protocols to maintain consistency and reliability, which is critical in surgical applications where any deviation could result in complications such as infection or wound dehiscence. Proper sterilization complements standardization by ensuring that surgical aids are safe for clinical use .

Advancements in weighing methods have significant impacts on pharmaceutical practice by enhancing precision and accuracy in the formulation of medications. Modern techniques, such as the use of electronic balances, reduce errors that were prevalent with older methods, thereby improving the consistency and reliability of drug dosages. This ensures that medications are safe and effective for patient use, minimizing risks related to dosage errors and ensuring compliance with pharmaceutical standards .

1.2  PHARMACEUTICS (THEORY) 
 
50 hours ; 2 hours/week 
1. Historical 
background 
and 
development 
of 
profession 
of 
phar
PHARMACEUTICS (PRACTICALS) 
75 Hours ; 3 hours/week 
1. Syrups: 
a) Simple syrup IP * 
b) Syrup of ephedrine hydrochloride NF
SCHEME OF EXAMINATION 
 
1. Synopsis                                               
 
 
-10 Marks 
2. Major experiment (indic

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