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Role of Doping Agents in Toxicology

The document discusses various topics related to doping in sports including: 1. The definition and meaning of doping as well as different types like blood doping. 2. Banned substances and methods according to organizations like the IOC and WADA including stimulants, narcotics, anabolic agents, and blood doping. 3. The negative health effects of various doping substances on athletes.

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0% found this document useful (0 votes)
29 views4 pages

Role of Doping Agents in Toxicology

The document discusses various topics related to doping in sports including: 1. The definition and meaning of doping as well as different types like blood doping. 2. Banned substances and methods according to organizations like the IOC and WADA including stimulants, narcotics, anabolic agents, and blood doping. 3. The negative health effects of various doping substances on athletes.

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V veeran
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

1

Meaning of Doping

Doping may be defined as the use of chemical substances, foreign to the body, to
improve athletic performance. Doping is the use of substances or the employment of means
in an attempt to augment artificially the performance of an athlete, during, either
participation or preparation. This is rather broader concept of doping than the simple use
of drugs- it could encompass other artificial means of trying to change the outcome of a
race, for instance a programmer of deliberate starvation, or dehydration, the transfusion of
the athlete’s own stored blood.

International Olympic Committee (IOC) has banned the use of performance enhancing
drugs in sports since 1964.

Since 2004, World Anti- Doping Agency (WADA), has taken over the IOC and has
redefined doping as violations of one or more of the anti- doping rules mentioned in WADA
code.

Blood Doping

Blood doping or blood boosting or blood transfusion is the injection of either whole
blood or packed red blood cells (RBC’s) into the participant the day prior to competition
in the hope of increasing the blood volume and its oxygen carrying capacity, and thus
improving endurance performance. Blood doping may be the injection of an individual’s
own blood which was withdrawn several weeks prior to reinjection. Training continues and
this apparently allows time for the body to regenerate new RBC’s in which to restore the
normal hemoglobin level. The ergogenic effects from the blood doping is considered to be
unethical.

1. It causes infections of the blood.

2. Blood doping leads to intravascular blood clotting.

3. When attempted by an untrained and physician it leads to mismatch blood


transfusion.

The Prevention of Doping

Methods for the prevention of doping fall into three broad categories – control by
government or inter-governmental legislation, regulation by athletic association and gentle
persuasion.

1. Regular weight records should be maintained

2. The trainer must explain the effects of drugs rationally rather than emotionally.
All types of drugs have no place in sports because of both immediate and long-term harmful
effects.
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Ergogenic Aids

Ergogenic aids consist substance, drugs, procedures and even devices that are
intended to improve athletic performance.
Some form of simulating beverages and dietary helps have been in common usage
amongst the sportsmen, since ancient times. The Roman gladiators believed that raw ox
meat and testes give better results in the field. Five important ergogenic aids are –

i. Anabolic Agents: They are synthetic chemicals designed to have effects similar to
a natural steroid produced in the body, the hormone testosterone. Natural
testosterone provides anabolic (building) and androgenic (musculinizing) effects.
Anabolic agents are misused in sports to increase muscle strength and bulk and to
promote aggressiveness and as a result increases athletic performance.
ii. Stimulants: Stimulants are drugs, which increase alertness and reduce fatigue and
may increase competitiveness and hostility. They are used because they can produce
a psychological and physical stimulus, which may improve athletic performance.
iii. Beta-Blockers: Drugs commonly used for heart disease to lower blood pressure and
decrease the heart rate. They may also be used in the treatment of migraines and to
tremors.(shooting and Archery)
iv. Narcotic Analgesics: They are powerful analgesics and are mainly used for
management of severe pain. They produce a sensation of euphoria or psychological
stimulation, a false feeling of invincibility and illusions of athletic process beyond
the athlete’s inherent ability.
v. Diuretics: Diuretics have important therapeutic indications for the elimination of
excess body fluids from the tissues in certain pathological condition and for
management of high blood pressure. Diuretics are sometimes misused by
competitions for two main reasons, namely: to reduce weight quickly in sports
where weight categories are involved and to reduce the concentration of drugs by
passing urine.

Bad Effects of Doping on Sports Persons

Winning in sports at all costs does not permit the philosophy of sports to degenerate
merely into a competition amongst laboratories, scientists and athletes. Increased use of
drugs in sports to gain an upper edge threatens the safety, health and longevity of athletes
while preventing the original intent or sports.

(i) Effect of Stimulants:

(a) Aggressiveness, anxiety and tremors which can lead to poor judgement
placing the individual at greater risk of injury.

(b) Dehydration and decreased circulation.


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(c) Increased heart rate and blood pressure.

(ii) Effect of Narcotic Analgesics: -

(a) The narcotic analgesics may increase the pain threshold so that the athlete
may fail to recognize it. Thus leading to more serious injury.

(b) Can cause physical and psychological dependence leading to many problems
associated with addiction withdrawal.

(c) Dose related respiratory depression.

(iii) Effects of Anabolic Agents:

(a) Masculinization (features like males) among females.

(b) Increase aggressiveness, mood swings, depression, abnormal menstrual


cycles, excessive hair growth on the body, in females.

(c) Deepening of voice in females

(d) Acne, reduction in the size of testicles in males, decreased sperm production.

(e) Potential for kidney, liver dysfunction.

(f) Premature aging, enlargement of prostate gland Prostate gland, chestnut-


shaped reproductive organ, located directly beneath the urinary bladder in
the male, which adds secretions to the sperm during
the ejaculation of semen.)

These effects may be permanent with prolonged use.

(g) In adolescents, premature closure of the growth centers of the long bones
may occur, resulting in stunted growth.

(iv) Effects of Diuretics:

(a) May cause dehydration, muscle weakening.

(b) A drop in blood pressure

(c) Cardiac irregularities caused by electrolytic imbalance

(v) Effects of Beta Blockers;

(a) Can cause heart failure

(b) Asthma

(c) Depression
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(d) Sleep disorders

(e) Sexual dysfunction

The banned of substances’ and methods

the definition of doping established by the medical commission of the international


Olympic committee is based on the prohibition of certain types of pharmaceuticals this
definition also bane new substances which may have been developed by laboratories
specifically for doping purposes

The list of banned substances and method

list of banned substances

stimulants (amphetamine, cocaine)

Narcotics both natural and synthetic (dextromoramid propoxyphene, morphine)

Anabolic Agent (nandrolone, Testosterone)

Diuretic (Ethacrynic acid, Furosemide, canerone)

Peptide and glycoprotein hormones and analogs (HGH, LH EPO

Banned methods

* Doping it is a method of increasing the number of red blood cells in the body which in
turn carry more oxygen to the muscles it is most often used by athletes who compete in
endurance races like cycling or cross country skiing in the past a little blood would be
removed from an athlete's system and then frozen and stored for several weeks a day or
two before decrease the stored blood would be injected into the athlete system creating
extra red blood cells these extra red blood cells would carry more oxygen to the muscles
giving the athlete an advantage over the other races who don't use blood doping

* Pharmacological, chemical or physical manipulation

List of Banned substances

*alcohol

*Marijuana

*Local Anesthetics

*corticosteroids

*Beta blockers (Pindolol, Acebutol, Propranolol).

Common questions

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Strict anti-doping policies maintain the integrity of sports by ensuring a level playing field and protecting athletes from health risks associated with performance-enhancing drugs. Arguments against may cite individual autonomy or technological advances in sports, but these do not outweigh ethical concerns and the health of athletes .

Diuretics pose health risks, including dehydration, muscle weakening, and cardiac irregularities. Athletes might use them to quickly lose weight in sports with weight categories or to dilute the concentration of drugs in urine, despite these health risks. This choice underscores the pressure to meet performance or competition requirements at the expense of health .

Ergogenic aids such as anabolic agents, stimulants, beta-blockers, narcotic analgesics, and diuretics are used to enhance athletic performance by increasing muscle strength, alertness, and reducing pain or weight. However, they have side effects like increased aggression, dehydration, cardiovascular problems, dependency, and physical changes, such as masculinization in females and stunted growth in adolescents .

Traditionally, stimulants, narcotics, anabolic agents, diuretics, peptide hormones, and blood doping methods have been banned by the IOC. The ban also extends to new substances developed specifically for doping purposes, highlighting an ongoing struggle to keep up with pharmacological advances .

In precision sports like shooting and archery, beta-blockers help reduce heart rate and tremors, giving athletes a steadier hand. However, misuse can lead to negative side effects such as heart failure, asthma, depression, and impaired ability to handle stress, which might affect an athlete's overall health and performance longevity .

Narcotic analgesics increase the pain threshold, making athletes less aware of injuries, which can lead to more serious conditions. Long-term impacts include physical dependence, addiction withdrawal problems, and potential respiratory depression, which can severely affect an athlete's career and health .

Blood doping poses several ethical issues due to its artificial enhancement of performance, violating fair competition principles. Health risks include infections of the blood, intravascular blood clotting, and potential mismatches in blood transfusion, especially when conducted by untrained individuals. These risks are considered unethical as they prioritize winning over the athletes' health and safety .

Stimulants increase alertness and reduce fatigue, potentially improving competitiveness and performance. However, they can cause aggressiveness, anxiety, tremors, increased heart rate, and blood pressure, which may all result in poor judgment and a higher risk of injury .

The definition of doping has evolved from being solely about the use of drugs to enhance performance, to a broader concept that includes any artificial means to augment athletic performance. The International Olympic Committee (IOC) initially banned performance-enhancing drugs in 1964, but since 2004, the World Anti-Doping Agency (WADA) has taken over and redefined doping as violations of one or more anti-doping rules outlined in the WADA code .

In females, anabolic agents can lead to masculinization, mood swings, and altered menstrual cycles. In males, they may cause acne, testicular shrinkage, and reduced sperm count. Both genders face risks like aggressiveness, liver dysfunction, and stunted growth in adolescents .

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